Abstract: Epidermal Growth Factor (EGF, Mw=6,045) has been
reported to have high efficiency of wound repair and anti-wrinkle
effect. However, the half-life of EGF in the body is too short to exert
the biological activity effectively when applied in free form. Growth
Factors can be stabilized by immobilization with carbohydrates from
thermal and proteolytic degradation. Low molecular weight chitosan
(LMCS) and its derivate prepared by hydrogen peroxide has high
solubility. LM6A6DC was successfully prepared as a reactive
carbohydrate for the stabilization of EGF by the reactions of LMCS
with alkalization, tosylation, azidation and reduction. The structure of
LM6A6DC was confirmed by FT-IR, 1H NMR and elementary
analysis. For enhancing the stability of free EGF, EGF was attached
with LM6A6DC by using water-soluble carbodiimide.
EGF-LM6A6DC conjugates did not show any cytotoxicity on the
Normal Human Dermal Fibroblast (NHDF) 3T3 proliferation at least
under 100 μg/ml. In the result, it was considered that LM6A6DC is
suitable to immobilize of growth factor.
Abstract: Surface modification and functionalization has been
an important tool for scientists in order to open new frontiers in
nanoscience and nanotechnology. Desired surface characteristics for
the intended applications can be achieved with surface
functionalization.
In this work, the effect of water soluble ligands on the adsorption
capabilities of silver nanoparticles onto AC which was synthesized
from German beech wood was investigated. Sodium borohydride
(NaBH4) and polyvinyl alcohol (PVA) were used as the ligands.
Silver nanoparticles with different surface coatings have average
sizes range from 10 to 13 nm. They were synthesized in aqueous
media by reducing Ag (I) ion in the presence of ligands. These
particles displayed adsorption tendencies towards AC when they
were mixed together and shaken in distilled water.
Silver nanoparticles (NaBH4-AgNPs) reduced and stabilized by
NaBH4 adsorbed onto AC with a homogenous dispersion of
aggregates with sizes in the range of 100-400 nm. Beside, silver
nanoparticles, which were prepared in the presence of both NaBH4
and PVA (NaBH4/PVA-Ag NPs), demonstrated that NaBH4/PVA-Ag
NPs adsorbed and dispersed homogenously but, they aggregated with
larger sizes on the AC surface (range from 300 to 600 nm). In
addition, desorption resistance of Ag nanoparticles were investigated
in distilled water. According to the results AgNPs were not desorbed
on the AC surface in distilled water.
Abstract: Over the past few years, the online multimedia
collection has grown at a fast pace. Several companies showed
interest to study the different ways to organise the amount of audio
information without the need of human intervention to generate
metadata. In the past few years, many applications have emerged on
the market which are capable of identifying a piece of music in a
short time. Different audio effects and degradation make it much
harder to identify the unknown piece. In this paper, an audio
fingerprinting system which makes use of a non-parametric based
algorithm is presented. Parametric analysis is also performed using
Gaussian Mixture Models (GMMs). The feature extraction methods
employed are the Mel Spectrum Coefficients and the MPEG-7 basic
descriptors. Bin numbers replaced the extracted feature coefficients
during the non-parametric modelling. The results show that nonparametric
analysis offer potential results as the ones mentioned in
the literature.
Abstract: Today, the pollution due to non-degradable material
such as plastics, has led to studies about the development of
environmental-friendly material. Because of biodegradability
obtained from natural sources, polylactid acid (PLA) and ijuk fiber
are interesting to modify into a composite. This material is also
expected to reduce the impact of environmental pollution. Surface
modification of ijuk fiber through alkalinization with 0.25 M NaOH
solution for 30 minutes was aimed to enhance its compatibility to
PLA, in order to improve properties of the composite such as the
mechanical properties. Alkalinization of the ijuk fibers annihilates
some surface components such as lignin, wax and hemicelloluse, so
the pore on the surface clearly appeared, decreasing of the density
and diameter of the ijuk fibers. The change of the ijuk fiber properties
leads to increase the mechanical properties of PLA composites
reinforced the ijuk fibers through strengthening of the mechanical
interlocking with the PLA matrix. An addition to enhance the
distribution of the fibers in the PLA matrix, the stirring during DCM
solvent evaporation from the mixture of the ijuk fibers and the
dissolved-PLA can reduce amount of the trapped-voids and fibers
pull-out phenomena, which can decrease the mechanical properties of
the composite.
Abstract: In this paper, performances of shuffled frog leaping
algorithm was investigated on the stealth laser dicing process. Effect
of problem on the performance of the algorithm was based on the
tolerance of meandering data. From the customer specification it
could be less than five microns with the target of zero microns.
Currently, the meandering levels are unsatisfactory when compared
to the customer specification. Firstly, the two-level factorial design
was applied to preliminarily study the statistically significant effects
of five process variables. In this study one influential process variable
is integer. From the experimental results, the new operating condition
from the algorithm was superior when compared to the current
manufacturing condition.
Abstract: The present work analyses different parameters of end
milling to minimize the surface roughness for AISI D2 steel. D2 Steel
is generally used for stamping or forming dies, punches, forming
rolls, knives, slitters, shear blades, tools, scrap choppers, tyre
shredders etc. Surface roughness is one of the main indices that
determines the quality of machined products and is influenced by
various cutting parameters. In machining operations, achieving
desired surface quality by optimization of machining parameters, is a
challenging job. In case of mating components the surface roughness
become more essential and is influenced by the cutting parameters,
because, these quality structures are highly correlated and are
expected to be influenced directly or indirectly by the direct effect of
process parameters or their interactive effects (i.e. on process
environment). In this work, the effects of selected process parameters
on surface roughness and subsequent setting of parameters with the
levels have been accomplished by Taguchi’s parameter design
approach. The experiments have been performed as per the
combination of levels of different process parameters suggested by
L9 orthogonal array. Experimental investigation of the end milling of
AISI D2 steel with carbide tool by varying feed, speed and depth of
cut and the surface roughness has been measured using surface
roughness tester. Analyses of variance have been performed for mean
and signal-to-noise ratio to estimate the contribution of the different
process parameters on the process.
Abstract: Iron is an essential nutrient with limited
bioavailability. Nutritional anemia caused mainly by iron deficiency
is the most recognized nutritional problem in both countries as well
as affluent societies. Rice (Oryza sativa L.) has become the most
important cereal crop for the improvement of human health due to the
starch, protein, oil, and the majority of micronutrients, particularly in
Asian countries. In this study, the iron availability and profile lipid
were evaluated for the extracts from Cibeusi varieties (black rices) of
ancient rice brans.
Results: The quality of K, B, R, E diets groups shows the same
effect on the growth of rats. Hematocrit and MCHC levels of rats fed
K, B, R and E diets were not significantly (P
Abstract: This study estimates the seismic demands of tall
buildings with central symmetric setbacks by using nonlinear time
history analysis. Three setback structures, all 60-story high with
setback in three levels, are used for evaluation. The effects of
irregularities occurred by setback are evaluated by determination of
global-drift, story-displacement and story drift. Story-displacement is
modified by roof displacement and first story displacement and story
drift is modified by global drift. All results are calculated at the
center of mass and in x and y direction. Also the absolute values of
these quantities are determined. The results show that increasing of
vertical irregularities increases the global drift of the structure and
enlarges the deformations in the height of the structure. It is also
observed that the effects of geometry irregularity in the seismic
deformations of setback structures are higher than those of mass
irregularity.
Abstract: Flow blockages referring to the increase in flow are
being considered as a vital equipment for marine current energy
conversion. However, the shape of these devices will result in
extracted energy under the operation. The present work investigates
the effect of two configurations of a grating, convergent and
divergent that located upstream, to the water flow velocity. The flow
characteristics are studied by Computational Fluid Dynamic
simulation by using the ANSYS Fluent solver for these specified
arrangements of the grating. The results indicate that distinguished
characteristics of flow velocity between “convergent” and
“divergent” grating placements is up to 10% in confined conditions.
Furthermore, the velocity in case of convergent grating is higher
than that of divergent grating.
Abstract: Housing loans play an important role in CEE
countries’ economies. This fact is based on their share in total loans
to households and their importance for economic activity and growth
in CEE countries. Therefore, it is important to find out key
determinants of housing loans demand in these countries. The aim of
this study is to research and analyze the determinants of the demand
for housing loans in Croatia. In this regard, the effect of economic
activity, loan terms and real estate prices were analyzed. Also, the
aim of this study is to find out what motivates people to take housing
loans. Therefore, primarily empirical study was conducted among the
Croatian residents. The results show that demand for housing loans is
positively affected by economic growth, higher personal income and
flexible loan terms, while it is negatively affected by interest rate rise.
Abstract: Diminished antioxidant defense or increased
production of reactive oxygen species in the biological system can
result in oxidative stress which may lead to various
neurodegenerative diseases including Alzheimer’s disease (AD).
Microglial activation also contributes to the progression of AD by
producing several proinflammatory cytokines, nitric oxide (NO) and
prostaglandin E2 (PGE2). Oxidative stress and inflammation have
been reported to be possible pathophysiological mechanisms
underlying AD. In addition, the cholinergic hypothesis postulates that
memory impairment in patient with AD is also associated with the
deficit of cholinergic function in the brain. Although a number of
drugs have been approved for the treatment of AD, most of these
synthetic drugs have diverse side effects and yield relatively modest
benefits. Marine algae have great potential in pharmaceutical and
biomedical applications as they are valuable sources of bioactive
properties such as anticoagulation, antimicrobial, antioxidative,
anticancer and anti-inflammatory. Hence, this study aimed to provide
an overview of the properties of Malaysian seaweeds (Padina
australis, Sargassum polycystum and Caulerpa racemosa) in
inhibiting oxidative stress, neuroinflammation and cholinesterase
enzymes. These seaweeds significantly exhibited potent DPPH and
moderate superoxide anion radical scavenging ability (P
Abstract: In this paper, the author studied the possibilities of
using Rice Husk Ash (RHA) available in India; to produce concrete.
Experiments conducted with RHA obtained from West Bengal, India;
to replace cement partially to produce concrete of grade M10, M15,
M20, M25 and M30. The concrete produced in the laboratory by
replacing cement by 5%, 10%, 15%, 20%, 25% and 30% RHA.
Compressive strength tests carried out to determine the strength of
concrete. Cost analysis and comparison done to show the cost
effectiveness of RHA Concrete. Traditional uses of Rice Husk in
India pointed out and the advantages of using RHA in making
concrete highlighted. Suggestion provided regarding prospective
application of RHA concrete in India; which in turn will definitely
reduce the cost of concrete and environmental friendly due to
utilization of waste and replacement of Cement.
Abstract: Due to the rapid increase of Internet, web opinion
sources dynamically emerge which is useful for both potential
customers and product manufacturers for prediction and decision
purposes. These are the user generated contents written in natural
languages and are unstructured-free-texts scheme. Therefore, opinion
mining techniques become popular to automatically process customer
reviews for extracting product features and user opinions expressed
over them. Since customer reviews may contain both opinionated and
factual sentences, a supervised machine learning technique applies
for subjectivity classification to improve the mining performance. In
this paper, we dedicate our work is the task of opinion
summarization. Therefore, product feature and opinion extraction is
critical to opinion summarization, because its effectiveness
significantly affects the identification of semantic relationships. The
polarity and numeric score of all the features are determined by
Senti-WordNet Lexicon. The problem of opinion summarization
refers how to relate the opinion words with respect to a certain
feature. Probabilistic based model of supervised learning will
improve the result that is more flexible and effective.
Abstract: In this research paper were investigated the main
regularities of a radical bromination reaction of decalin. There had
been studied the temperature effect, durations of reaction, frequency
rate of process, a ratio of initial components, type and number of the
initiator on decalin bromination degree.
There were specified optimum conditions of synthesis of a
perbromodecalin by the method of a decalin bromination. There are
developed the technological flowchart of receiving a
perbromodecalin and the mass balance of process on the first and the
subsequent loadings of components.
The results of research of antibacterial and antifungal activity of
synthesized bromoderivatives have been represented.
Abstract: Internet financial reporting and corporate governance
issues are in the focus of academic and professional studies due to
their attributed importance by stakeholders of corporations. Major
aim of this study is to reveal the relationship between internet
financial reporting which is held as dependent variable and some
indicators of corporate governance such as the ratio of managerial
ownership, blockholder ownership, number of independent members
in the board of directors, frequency of meetings by audit committee
and education level of audit committee members which are held as
independent variables. Main purpose is to reveal the effect of
corporate governance on the voluntary efforts of Internet Financial
reporting. The scope of the research is limited to the Turkish
Corporations listed in Borsa Istanbul (Istanbul Stock Exchange) and
findings which are generated by means of SPSS software are revealed
in results section and interpreted in conclusions.
Abstract: With drug resistance becoming widespread in
Plasmodium falciparum infections, the development of the alternative
drugs is the desired strategy for prevention and cure of malaria. Three
drug targets were selected to screen promising drug molecules from
the GSK library of 13469 molecules. Using an in silico structure-based
drug designing approach, the differences in binding energies of
the substrate and inhibitor were exploited between target sites of
parasite and human to design a drug molecule against Plasmodium.
The docking studies have shown several promising molecules from
GSK library with more effective binding as compared to the already
known inhibitors for the drug targets. Though stronger interaction has
been shown by several molecules as compared to the reference, few
molecules have shown the potential as drug candidates though in
vitro studies are required to validate the results. In case of
thymidylate synthase-dihydrofolatereductase (TS-DHFR), three
compounds have shown promise for future studies as potential drugs.
Abstract: The impact of Special Economic Zones (SEZs) has
been analyzed for many years by researchers. There are lot of
theoretical studies proving the SEZs importance for regional
development, however, there is lack of empirical studies (and they
are mainly focused on China market) that are based on available data.
The theoretical studies indicate the various impacts of enterprises
operating within SEZs on the economy. The article proves that, in
case of Poland, locating SEZs in municipalities is an important part
of increasing municipalities’ income. Therefore SEZs have a positive
impact on regional development. Municipality income is understood
as taxes paid by taxpayers who depend on SEZ companies’
performance. The analysis includes the Corporate Income Tax (CIT),
Personal Income Tax (PIT) and real estate tax. The effects of SEZs
on regional development were narrowed to a few variables that are
most significant for the financial system. The analysis indicates the
significant impact of SEZs on the amount of taxes influencing the
municipality budget.
Abstract: This paper presents the results and findings from a
parametric study on the water surface elevation at upstream of bridge
constriction for subcritical flow. In this study, the influence of
Manning's Roughness Coefficient of main channel (nmc) and
floodplain (nfp), and bridge opening (b) flow rate (Q), contraction
(kcon) and expansion coefficients (kexp) were investigated on
backwater level. The DECK bridge models with different span widths
and without any pier were investigated within the two stage channel
having various roughness conditions. One of the most commonly
used commercial one-dimensional HEC-RAS model was used in this
parametric study. This study showed that the effects of main channel
roughness (nmc) and flow rate (Q) on the backwater level are much
higher than those of the floodplain roughness (nfp). Bridge opening
(b) with contraction (kcon) and expansion coefficients (kexp) have very
little effect on the backwater level within this range of parameters.
Abstract: The aim of this study is to analyze the role and
effectiveness of internal mechanism (audit committee) of corporate
governance on credit institutions performance in Croatia. Based on
research objective, sample of 78 credit institutions listed on Zagreb
Stock Exchange, from 2007 to 2012, has been collected and
efficiency index of audit committee (EIAC) has been created. Based
on the sample and created EIAC, conclusions are as follows: audit
committees of credit institutions have medium efficiency, based on
EIAC measurement; there is a significant difference in audit
committee effectiveness, in observed period; there is no positive
relationship between audit committee effectiveness and credit
institution performance; there is a significant difference between
level of audit committee effectiveness and audit firm type. Future
research should contain increased number of elements in EIAC
creation and increased sample, for all obligators who need to
establish audit committee.
Abstract: This study investigated some results of the use of
digital art tools by junior school children in order to discover if these
tools could promote artistic ability and creativity. The study considers
the ease of use and usefulness of the tools as well as how to assess
artwork produced by digital means. As the use of these tools is a
relatively new development in Art education, this study may help
educators in their choice of which tools to use and when to use them.
The study also aims to present a model for the assessment of
students’ artistic development and creativity by studying their artistic
activity. This model can help in determining differences in students’
creative ability and could be useful both for teachers, as a means of
assessing digital artwork, and for students, by providing the
motivation to use the tools to their fullest extent. Sixteen students
aged nine to ten years old were observed and recorded while they
used the digital drawing tools. The study found that, according to the
students’ own statements, it was not the ease of use but the successful
effects the tools provided which motivated the children to use them.