Abstract: Camptothecin (CPT) is a cytotoxic quinoline alkaloid,
which inhibits the DNA enzyme topoisomerase I (topo I). It was
discovered in 1966 by M. E. Wall and M. C. Wani in systematic
screening of natural products for anticancer drugs. It was isolated
from the bark and stem of Camptotheca acuminata (Camptotheca,
Happy tree), a tree native in China. CPT showed remarkable
anticancer activity in preliminary clinical trials but also low
solubility and (high) adverse drug reaction. Because of these
disadvantages synthetic and medicinal chemists have developed
numerous syntheses of Camptothecine [1][2][3] and various
derivatives to increase the benefits of the chemical, with good results.
In our method CPT analogues has be six steps starting from available
material DL Malic acid.
Abstract: The objective of this study was to develop vaginal
suppository containing lactobacillus. Four kinds of vaginal
suppositories containing Lactobacillus paracasei HL32 were
formulated: 1) a conventional suppository with Witepsol H-15 as a
base, 2) a conventional suppository with mixed polyethylene glycols
(PEGs) as a base, 3) a hollow-type suppository with Witepsol H-15
as a base and 4) a hollow-type suppository with mixed PEGs as a
base. The release studies demonstrated that the hollow-type
suppository with mixed PEGs as the base gave the highest release of
L. paracasei HL32 and was microbiological stable after storage at 2-
8°C over the period of 3 months.
Abstract: Numerical studies on race car aerodynamics at wing
in ground effect have been carried out using a steady 3d, double
precision, pressure-based, and standard k-epsilon turbulence model.
Through various parametric analytical studies we have observed that
at a particular speed and ground clearance of the wings a favorable
negative lift was found high at a particular angle of attack for all the
physical models considered in this paper. The fact is that if the
ground clearance height to chord length (h/c) is too small, the
developing boundary layers from either side (the ground and the
lower surface of the wing) can interact, leading to an altered variation
of the aerodynamic characteristics at wing in ground effect. Therefore
a suitable ground clearance must be predicted throughout the racing
for a better performance of the race car, which obviously depends
upon the coupled effects of the topography, wing orientation with
respect to the ground, the incoming flow features and/or the race car
speed. We have concluded that for the design of high performance
and high speed race cars the adjustable wings capable to alter the
ground clearance and the angles of attack is the best design option for
any race car for racing safely with variable speeds.
Abstract: The study aimed to investigate characteristics of
vegetative tissue for taxonomic purpose and possibly trend of waste
application in industry. Stems and branches of 15 species in Solanum
found in Thailand were prepared for fiber and examined by light
microscopy. Microstructural characteristic data of fiber i.e. fiber
length and width, fiber lumen diameter and fiber cell wall thickness
were recorded. The longest average fiber cell length (>3.9 mm.) were
obtained in S. lycopersicum L. and S. tuberosum L. Fiber cells from
S. lycopersicum also revealed the widest average diameter of whole
cell and its lumen at >45.5 μm and >29 μm respectively. However
fiber cells with thickest wall of > 9.6 μm were belonged to the
ornamental tree species, S. wrightii Benth. The results showed that
the slenderness ratio, Runkel ratio, and flexibility coefficient, with
potentially suitable for feedstock in paper industry fell in 4 exotic
species, i.e. Solanumamericanum L., S. lycopersicum, S.
seaforthianum Andr., and S. tuberosum L
Abstract: This paper presents a implementation of an object tracking system in a video sequence. This object tracking is an important task in many vision applications. The main steps in video analysis are two: detection of interesting moving objects and tracking of such objects from frame to frame. In a similar vein, most tracking algorithms use pre-specified methods for preprocessing. In our work, we have implemented several object tracking algorithms (Meanshift, Camshift, Kalman filter) with different preprocessing methods. Then, we have evaluated the performance of these algorithms for different video sequences. The obtained results have shown good performances according to the degree of applicability and evaluation criteria.
Abstract: In this paper a new fast simplification method is
presented. Such method realizes Karnough map with large
number of variables. In order to accelerate the operation of the
proposed method, a new approach for fast detection of group
of ones is presented. Such approach implemented in the
frequency domain. The search operation relies on performing
cross correlation in the frequency domain rather than time one.
It is proved mathematically and practically that the number of
computation steps required for the presented method is less
than that needed by conventional cross correlation. Simulation
results using MATLAB confirm the theoretical computations.
Furthermore, a powerful solution for realization of complex
functions is given. The simplified functions are implemented
by using a new desigen for neural networks. Neural networks
are used because they are fault tolerance and as a result they
can recognize signals even with noise or distortion. This is
very useful for logic functions used in data and computer
communications. Moreover, the implemented functions are
realized with minimum amount of components. This is done
by using modular neural nets (MNNs) that divide the input
space into several homogenous regions. Such approach is
applied to implement XOR function, 16 logic functions on one
bit level, and 2-bit digital multiplier. Compared to previous
non- modular designs, a clear reduction in the order of
computations and hardware requirements is achieved.
Abstract: Script identification is one of the challenging steps in the development of optical character recognition system for bilingual or multilingual documents. In this paper an attempt is made for identification of English numerals at word level from Punjabi documents by using Gabor features. The support vector machine (SVM) classifier with five fold cross validation is used to classify the word images. The results obtained are quite encouraging. Average accuracy with RBF kernel, Polynomial and Linear Kernel functions comes out to be greater than 99%.
Abstract: In this paper we present an efficient approach for the prediction of two sunspot-related time series, namely the Yearly Sunspot Number and the IR5 Index, that are commonly used for monitoring solar activity. The method is based on exploiting partially recurrent Elman networks and it can be divided into three main steps: the first one consists in a “de-rectification" of the time series under study in order to obtain a new time series whose appearance, similar to a sum of sinusoids, can be modelled by our neural networks much better than the original dataset. After that, we normalize the derectified data so that they have zero mean and unity standard deviation and, finally, train an Elman network with only one input, a recurrent hidden layer and one output using a back-propagation algorithm with variable learning rate and momentum. The achieved results have shown the efficiency of this approach that, although very simple, can perform better than most of the existing solar activity forecasting methods.
Abstract: In high bitrate information hiding techniques, 1 bit is
embedded within each 4 x 4 Discrete Cosine Transform (DCT)
coefficient block by means of vector quantization, then the hidden bit
can be effectively extracted in terminal end. In this paper high bitrate
information hiding algorithms are summarized, and the scheme of
video in video is implemented. Experimental result shows that the host
video which is embedded numerous auxiliary information have little
visually quality decline. Peak Signal to Noise Ratio (PSNR)Y of host
video only degrades 0.22dB in average, while the hidden information
has a high percentage of survives and keeps a high robustness in
H.264/AVC compression, the average Bit Error Rate(BER) of hiding
information is 0.015%.
Abstract: The Czech Republic is a country whose economy has
undergone a transformation since 1989. Since joining the EU it has
been striving to reduce the differences in its economic standard and
the quality of its institutional environment in comparison with
developed countries. According to an assessment carried out by the
World Bank, the Czech Republic was long classed as a country
whose institutional development was seen as problematic. For many
years one of the things it was rated most poorly on was its bankruptcy
law. The new Insolvency Act, which is a modern law in terms of its
treatment of bankruptcy, was first adopted in the Czech Republic in
2006. This law, together with other regulatory measures, offers debtridden
Czech economic subjects legal instruments which are well
established and in common practice in developed market economies.
Since then, analyses performed by the World Bank and the London
EBRD have shown that there have been significant steps forward in
the quality of Czech bankruptcy law. The Czech Republic still lacks
an analytical apparatus which can offer a structured characterisation
of the general and specific conditions of Czech company and
household debt which is subject to current changes in the global
economy. This area has so far not been given the attention it
deserves. The lack of research is particularly clear as regards analysis
of household debt and householders- ability to settle their debts in a
reasonable manner using legal and other state means of regulation.
We assume that Czech households have recourse to a modern
insolvency law, yet the effective application of this law is hampered
by the inconsistencies in the formal and informal institutions
involved in resolving debt. This in turn is based on the assumption
that this lack of consistency is more marked in cases of personal
bankruptcy. Our aim is to identify the symptoms which indicate that
for some time the effective application of bankruptcy law in the
Czech Republic will be hindered by factors originating in
householders- relative inability to identify the risks of falling into
debt.
Abstract: The in vitro culture procedure of purple nutsedge
(Cyperus rotundus L.) for multiple shoot induction and tuber
formation was established. Multiple shoots were significantly
induced from a single shoot of about 0.5 – 0.8 cm long, on Murashige
and Skoog (MS) medium supplemented with 4.44 μM 6-
benzyladinine (BA) alone or in combination with 2.85 μM 1-
indoleacetic acid (IAA), providing 17.6 and 15.3 shoots per explant
with 31.2 and 27.5 leaves per explant, respectively, within 6 weeks of
culturing. Moreover, MS medium supplemented with 4.44 μM BA
and 2.85 μM IAA was suitable for tuber induction, obtaining 5.9
tubers with 3.4 rhizomes per explant. In combination with ancymidol
and higher concentration of sucrose, 11.1 μM BA and 60 g/L sucrose
or 11.1 μM BA, 7.8 μM ancymidol and 60 g/L sucrose induced 3.5
tubers with 1.6 rhizomes or 3.5 tubers without rhizome, respectively.
However, MS medium containing 3.9 or 7.8 μM ancymidol in
combination with either 60 or 80 g/L sucrose enchanced significant
root formation at 20.9 – 23.6 roots per explant.
Abstract: The goal of speech parameterization is to extract the relevant information about what is being spoken from the audio signal. In speech recognition systems Mel-Frequency Cepstral Coefficients (MFCC) and Relative Spectral Mel-Frequency Cepstral Coefficients (RASTA-MFCC) are the two main techniques used. It will be shown in this paper that it presents some modifications to the original MFCC method. In our work the effectiveness of proposed changes to MFCC called Modified Function Cepstral Coefficients (MODFCC) were tested and compared against the original MFCC and RASTA-MFCC features. The prosodic features such as jitter and shimmer are added to baseline spectral features. The above-mentioned techniques were tested with impulsive signals under various noisy conditions within AURORA databases.
Abstract: The alternative technique for sterilization of culture
medium to replace autoclaving was carried out. For sterilization of
culture medium without autoclaving, some commercial pure essential
oils, bergamot oil, betel oil, cinnamon oil, lavender oil and turmeric
oil, were tested alone or in combinations with some disinfectants,
10% povidone-iodine and 2% iodine + 2.4% potassium iodide. Each
essential oil or combination was added to 25-mL Murashige and
Skoog (MS) medium before medium was solidified in a 120-mL
container, kept for 2 weeks before evaluating sterile conditions.
Treated media, supplemented with essential oils, were compared to
control medium, autoclaved at 121 degree Celsius for 15 min. In
vitro sterile conditions were found 20 – 100% from these treated
media compared to 100% sterile condition from autoclaved medium.
Treated media obtained 100% sterile conditions were chosen for
culturing chrysanthemum shoots. It was found that 10% povidoneiodine
in combination with cinnamon oil (3:1) and 2% iodine + 2.4%
potassium iodide in combination with lavender oil (1:3) at the
concentration of 36 3L/25 mL medium provided the promising
growth of shoot explants.
Abstract: Two species of Physalis, P.angulataL. and P.
peruviana L. were used as models for comparative study to
understand the values of micro-morphological, -anatomical and
architectural characteristics of leaf for taxonomic purposes and
possibly breeding and commercial applications. Both speciespossess
amphistomaticleaves with 1-layer epidermis, 3-4-layer spongy
mesophyll andbicollateral bundle midrib. Palisade parenchyma cells
of P. angulatawere almost twice longer (65-75 μm) than the other
one. Type of stomata was similar as anomocyticbut stomatal
index(SI) at adaxial surface and abaxial surface of P. angulata were
less than of P. peruvianaas 3.57, 4.00 and6.25, 6.66 respectively.
Some leaf architectural characteristics such as leaf shape, order of
venationalsoprovided information of taxonomic significance
Abstract: Depressurization and pressurization streams in
industrial systems constitute a work exchange network (WEN). In this
paper, a novel graphical approach for targeting energy conservation
potential of a WEN is proposed. Through constructing the composite
work curves in the pressure-work diagram and assuming all of the
mechanical energy of the depressurization streams is recovered by
expanders, the maximum work target of a WEN can be determined via
the proposed targeting steps. A WEN in an ammonia production
process is used as a case study to illustrate the applicability of the
proposed graphical approach.
Abstract: In this study, a novel approach of image embedding is introduced. The proposed method consists of three main steps. First, the edge of the image is detected using Sobel mask filters. Second, the least significant bit LSB of each pixel is used. Finally, a gray level connectivity is applied using a fuzzy approach and the ASCII code is used for information hiding. The prior bit of the LSB represents the edged image after gray level connectivity, and the remaining six bits represent the original image with very little difference in contrast. The proposed method embeds three images in one image and includes, as a special case of data embedding, information hiding, identifying and authenticating text embedded within the digital images. Image embedding method is considered to be one of the good compression methods, in terms of reserving memory space. Moreover, information hiding within digital image can be used for security information transfer. The creation and extraction of three embedded images, and hiding text information is discussed and illustrated, in the following sections.
Abstract: In this paper, an intelligent algorithm for optimal
document archiving is presented. It is kown that electronic archives
are very important for information system management. Minimizing
the size of the stored data in electronic archive is a main issue to
reduce the physical storage area. Here, the effect of different types of
Arabic fonts on electronic archives size is discussed. Simulation
results show that PDF is the best file format for storage of the Arabic
documents in electronic archive. Furthermore, fast information
detection in a given PDF file is introduced. Such approach uses fast
neural networks (FNNs) implemented in the frequency domain. The
operation of these networks relies on performing cross correlation in
the frequency domain rather than spatial one. It is proved
mathematically and practically that the number of computation steps
required for the presented FNNs is less than that needed by
conventional neural networks (CNNs). Simulation results using
MATLAB confirm the theoretical computations.
Abstract: An exact algorithm for a n-link manipulator movement amidst arbitrary unknown static obstacles is presented.
The algorithm guarantees the reaching of a target configuration of the manipulator in a finite number of steps. The algorithm is
reduced to a finite number of calls of a subroutine for planning a trajectory in the presence of known forbidden states. The polynomial approximation algorithm which is used as the subroutine is presented. The results of the exact algorithm
implementation for the control of a seven link (7 degrees of
freedom, 7DOF) manipulator are given.
Abstract: We propose a new approach on how to obtain the approximate solutions of Hamilton-Jacobi (HJ) equations. The process of the approximation consists of two steps. The first step is to transform the HJ equations into the virtual time based HJ equations (VT-HJ) by introducing a new idea of ‘virtual-time’. The second step is to construct the approximate solutions of the HJ equations through a computationally iterative procedure based on the VT-HJ equations. It should be noted that the approximate feedback solutions evolve by themselves as the virtual-time goes by. Finally, we demonstrate the effectiveness of our approximation approach by means of simulations with linear and nonlinear control problems.
Abstract: In Geographic Information System, one of the sources
of obtaining needed geographic data is digitizing analog maps and
evaluation of aerial and satellite photos. In this study, a method will
be discussed which can be used to extract vectorial features and
creating vectorized drawing files for aerial photos. At the same time
a software developed for these purpose. Converting from raster to
vector is also known as vectorization and it is the most important step
when creating vectorized drawing files. In the developed algorithm,
first of all preprocessing on the aerial photo is done. These are;
converting to grayscale if necessary, reducing noise, applying some
filters and determining the edge of the objects etc. After these steps,
every pixel which constitutes the photo are followed from upper left
to right bottom by examining its neighborhood relationship and one
pixel wide lines or polylines obtained. The obtained lines have to be
erased for preventing confusion while continuing vectorization
because if not erased they can be perceived as new line, but if erased
it can cause discontinuity in vector drawing so the image converted
from 2 bit to 8 bit and the detected pixels are expressed as a different
bit. In conclusion, the aerial photo can be converted to vector form
which includes lines and polylines and can be opened in any CAD
application.