Abstract: The theory of rough sets is generalized by using a
filter. The filter is induced by binary relations and it is used to
generalize the basic rough set concepts. The knowledge
representations and processing of binary relations in the style of
rough set theory are investigated.
Abstract: Hypertension is characterized with stress on the heart and blood vessels thus increasing the risk of heart attack and renal diseases. The Renin angiotensin system (RAS) plays a major role in blood pressure control. Renin is the enzyme that controls the RAS at the rate-limiting step. Our aim is to develop new drug-like leads which can inhibit renin and thereby emerge as therapeutics for hypertension. To achieve this, molecular dynamics (MD) simulation and receptor-based pharmacophore modeling were implemented, and three rennin-inhibitor complex structures were selected based on IC50 value and scaffolds of inhibitors. Three pharmacophore models were generated considering conformations induced by inhibitor. The compounds mapped to these models were selected and subjected to drug-like screening. The identified hits were docked into the active site of renin. Finally, hit1 satisfying the binding mode and interaction energy was selected as possible lead candidate to be used in novel renin inhibitors.
Abstract: For scores of years now, several microfinance
organizations, non governmental organizations and other welfare
organizations have, with a view to aiding the progress of
communities rooted in poverty have been focusing on creating
microentrepreneurs, besides taking several other measures. In recent
times, business corporations have joined forces to combat poverty by
taking up microenterprise development. Hindustan Unilever Limited
(HUL), the Indian subsidiary of Unilever Limited exemplifies this
through its Project Shakti. The company through the Project creates
rural women entrepreneurs by making them direct to home sales
distributors of its products in villages that have thus far been ignored
by multinational corporations. The members participating in Project
Shakti are largely self help group members. The paper focuses on
assessing the impact made by the company on the members engaged
in Project Shakti. The analysis involves use of quantitative methods
to study the effect of Project Shakti on those self help group
members engaged in Project Shakti and those not engaged with
Project Shakti. Path analysis has been used to study the impact made
on those members engaged in Project Shakti. Significant differences
were observed on fronts of entrepreneurial development, economic
empowerment and social empowerment between members associated
with Project Shakti and those not associated with Project Shakti.
Path analysis demonstrated that involvement in Project Shakti led to
entrepreneurial development resulting in economic empowerment
that in turn led to social empowerment and that these three elements
independently induced a feeling of privilege in the women for being
associated with the Project.
Abstract: Although current competitive challenges induced by today-s digital economy place their main emphasis on organizational knowledge, customer knowledge has been overlooked. On the other hand, the business community has finally begun to realize the important role customer knowledge can play in the organizational boundaries of the corporate arena. As a result, there is an emerging market for the tools and utilities whose objective is to provide the intelligence for knowledge sharing between the businesses and their customers. In this paper, we present a conceptual model of customer knowledge management by identifying and analyzing the existing tools in the market. The focus will be upon the emerging British dotcom industry whose customer based B2C behavior has been an influential part of the knowledge based intelligence tools in existence today.
Abstract: In this study, three strains of Vibrio parahaemolyticus
(690, BCRC 13023 and BCRC 13025) were subjected to acid
adaptation at pH 5.5 for 90 min. The survival of acid-adapted and
non-adapted V. parahaemolyticus strains under simulated gastric
condition and their protein expression profiles were investigated.
Results showed that acid adaptation increased the survival of the test
V. parahaemolyticus strains after exposure to simulated gastric juice
(pH 3). Additionally, acid adaptation also affected the protein
expression in these V. parahaemolyticus strains. Nine proteins,
identified as atpA, atpB, DnaK, GroEL, OmpU, enolase,
fructose-bisphosphate aldolase, phosphoglycerate kinase and
triosephosphate isomerase, were induced by acid adaptation in two or
three of the test strains. These acid-adaptive proteins may play
important regulatory roles in the acid tolerance response (ATR) of V.
parahaemolyticus.
Abstract: A rare phenomenon of SDS-induced activation of a latent protease activity associated with the purified silkworm excretory red fluorescent protein (SE-RFP) was noticed. SE-RFP aliquots incubated with SDS for different time intervals indicated that the protein undergoes an obligatory breakdown into a number of subunits which exhibit autoproteolytic (acting upon themselves) and/or heteroproteolytic (acting on other proteins) activities. A strong serine protease activity of SE-RFP subunits on Bombyx mori nucleopolyhedrovirus (BmNPV) polyhedral protein was detected by zymography technique. A complete inhibition of BmNPV infection to silkworms was observed by the oral administration assay of the SE-RFP. Here, it is proposed that the SE-RFP prevents the initial infection of BmNPV to silkworms by obliterating the polyhedral protein. This is the first report on a silkworm red fluorescent protein that exhibits a protease activity on exposure to SDS. The present studies would help in understanding the antiviral mechanism of silkworm red fluorescent proteins.
Abstract: This paper presents the results of corrosion fatigue
crack growth behaviour of a Ni-Cr-Mn steel commonly used in
marine applications. The effect of mechanical variables such as
frequency and load ratio on fatigue crack growth rate at various
stages has been studied using compact tension (C(T)) specimens
along the rolling direction of steel plate under 3.5% saturated NaCl
aqueous environment. The significance of crack closure on corrosion
fatigue, and the validity of Elber-s empirical linear crack closure
model with the ASTM compliance offset method have been
examined.
Fatigue crack growth rate is higher and threshold stress intensities
are lower in aqueous environment compared to the lab air conditions.
It is also observed that the crack growth rate increases at lower
frequencies. The higher stress ratio promotes the crack growth. The
effect of oxidization and corrosion pit formation is very less as the
stress ratio is increased. It is observed that as stress ratios are
increased, the Elber-s crack closure model agrees well with the crack
closure estimated by the ASTM compliance offset method for tests
conducted at 5Hz frequency compared to tests conducted at 1Hz in
corrosive environment.
Abstract: A numerical simulation of vortex-induced vibration of
a 2-dimensional elastic circular cylinder with two degree of freedom
under the uniform flow is calculated when Reynolds is 200.
2-dimensional incompressible Navier-Stokes equations are solved
with the space-time finite element method, the equation of the cylinder
motion is solved with the new explicit integral method and the mesh
renew is achieved by the spring moving mesh technology. Considering
vortex-induced vibration with the low reduced damping parameter, the
variety trends of the lift coefficient, the drag coefficient, the
displacement of cylinder are analyzed under different oscillating
frequencies of cylinder. The phenomena of locked-in, beat and
phases-witch were captured successfully. The evolution of vortex
shedding from the cylinder with time is discussed. There are very
similar trends in characteristics between the results of the one degree
of freedom cylinder model and that of the two degree of freedom
cylinder model. The streamwise vibrations have a certain effect on the
lateral vibrations and their characteristics.
Abstract: A new mechanism responsible for structural life
consumption due to resonant fatigue in turbine blades, or vanes, is
presented and explained. A rotating blade or vane in a gas turbine can
change its contour due to erosion and/or material build up, in any of
these instances, the surface pressure distribution occurring on the
suction and pressure sides of blades-vanes can suffer substantial
modification of their pressure and temperatures envelopes and flow
characteristics. Meanwhile, the relative rotation between the blade
and duct vane while the pressurized gas flows and the consequent
wake crossings, will induce a fluctuating thrust force or lift that will
excite the blade.
An actual totally used up set of vane-blade components in a HP
turbine power stage in a gas turbine is analyzed. The blade suffered
some material erosion mostly at the trailing edge provoking a
peculiar surface pressure envelope which evolved as the relative
position between the vane and the blade passed in front of each other.
Interestingly preliminary modal analysis for this eroded blade
indicates several natural frequencies within the aeromechanic power
spectrum, moreover, the highest frequency component is 94% of one
natural frequency indicating near resonant condition.
Independently of other simultaneously occurring fatigue cycles
(such as thermal, centrifugal stresses).
Abstract: The aspiration of this research article is to target and
focus the gains of university-Industry (U-I) collaborations and
exploring those hurdles which are the obstacles for attaining these
gains. University-Industry collaborations have attained great
importance since 1980 in USA due to its application in all fields of
life. U-I collaboration is a bilateral process where academia is a
proactive member to make such alliances. Universities want to
ameliorate their academic-base with the technicalities of technobabbles.
U-I collaboration is becoming an essential lane for achieving
innovative goals in this century. Many developed nations have set
successful examples to prove this phenomenon as a catalyst to reduce
costs, efforts and personnel for R&D projects. This study is exploits
amplitudes of UI collaboration incentives in the light of success
stories of developed countries. Many universities in USA, UK,
Canada and various European Countries have been engaged with
enterprises for numerous collaborative agreements. A long list of
strategic and short term R&D projects has been executed in
developed countries to accomplish their intended purposes. Due to
the lack of intentions, genuine research and research-oriented
environment, the mentioned field could not grow very well in
developing countries. During last decade, a new wave of research
has induced the institutes of developing countries to promote R&D
culture especially in Pakistan. Higher Education Commission (HEC)
has initiated many projects and funding supports for universities
which have collaborative intentions with industry.
Findings show that rapid innovation, overwhelm the technological
complexities and articulated intellectual-base are major incentives
which steer both partners to establish faculty-industry alliances. Everchanging
technologies, concerned about intellectual property,
different research environment and culture, research relevancy (Basic
or applied), exposure differences and diversity of knowledge
(bookish or practical) are main barriers to establish and retain joint
ventures. Findings also concluded that, it is dire need to support and
enhance cooperation among academia and industry to promote highly
coordinated research behaviors. Author has proposed a roadmap for
developing countries to promote R&D clusters among faculty and
industry to deal the technological challenges and innovation
complexities. Based on our research findings, Model for R&D
Collaboration for developing countries also have been proposed to
promote articulated R&D environment. If developing countries
follow this phenomenon, rapid innovations can be achieved with
limited R&D budget heads.
Abstract: The flow filed around a flatted-roof compound has
been investigated by means of 2D and 3D numerical simulations. A
constant wind velocity profile, based both on the maximum reference
wind speed in the building site (peak gust speed worked out for a 50-
year return period) and on the local roughness coefficient, has been
simulated in order to determine the wind-induced loads on top of the
roof. After determining the influence of the incoming wind directions
on the induced roof loads, a 2D analysis of the most severe load
condition has been performed, achieving a numerical quantification
of the expected wind-induced forces on the PV panels on top of the
roof.
Abstract: The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections, 5mg/kg, each) was given 1 hour and 12 hours following acetaminophen administration. Acetaminophen administration caused significant elevations of serum alanine aminotransferase, and hepatic malondialdehyde, and nitric oxide levels, and a significant decrease in hepatic reduced glutathione. Cannabidiol significantly attenuated the deterioration in the measured biochemical parameters resulted from acetaminophen administration. Also, histopathological examination showed that cannabidiol markedly attenuated ameliorated acetaminophen-induced liver tissue damage. These results emphasize that cannabidiol represents a potential therapeutic option to protect against acetaminophen hepartotoxicity which is a common clinical problem.
Abstract: Kwashiorkor is one of nutritional problem in
Indonesia, which lead to decrease immune system. This condition
causes susceptibility to infectious disease, especially tuberculosis.
Development of new tuberculosis vaccine will be an important
strategy to eliminate tuberculosis in kwashiorkor. Previous research
showed that 38-kDa Mycobacterium tuberculosis protein is one of the
potent immunogen. However, the role of oral immunization with 38-
kDa Mycobacterium tuberculosis protein to the number of
lymphocytes in the rat model of kwashiorkor is still unknown. We
used kwashiorkor rat model groups with 4% and 2% low protein diet.
Oral immunization with 38-kDa Mycobacterium tuberculosis protein
given with 2 booster every week. The lymphocytes number were
measured by flowcytometry. There was no significant difference
between the number of lymphocytes in the normal rat group and the
kwashiorkor rat groups. It may reveal the role of 38-kDa
Mycobacterium tuberculosis protein as a potent immunogen that can
increase the lymphocytes number from kwashiorkor rat model same
as normal rat.
Abstract: In this work we report on preliminary analysis of a novel optoelectronic gas sensor based on an optical fiber integrated with a tetrakis(4-sulfonatophenyl)porphyrin (TPPS) thin film. The sensitive materials are selectively deposited on the core region of a fiber tip by UV light induced deposition technique. A simple and cheap process which can be easily extended to different porphyrin derivatives. When the TPPS film on the fiber tip is exposed to acid and/or base vapors, dramatic changes occur in the aggregation structure of the dye molecules in the film, from J- to H-type, resulting in a profound modification of their corresponding reflectance spectra. From the achieved experimental results it is evident that the presence of intense and narrow band peaks in the reflected spectra could be monitored to detect hazardous vapors.
Abstract: This paper investigates vortex shedding processes
occurring at the end of a stack of parallel plates, due to an oscillating
flow induced by an acoustic standing wave within an acoustic
resonator. Here, Particle Image Velocimetry (PIV) is used to quantify
the vortex shedding processes within an acoustic cycle
phase-by-phase, in particular during the “ejection" of the fluid out of
the stack. Standard hot-wire anemometry measurement is also applied
to detect the velocity fluctuations near the end of the stack.
Combination of these two measurement techniques allowed a detailed
analysis of the vortex shedding phenomena. The results obtained show
that, as the Reynolds number varies (by varying the plate thickness
and drive ratio), different flow patterns of vortex shedding are
observed by the PIV measurement. On the other hand, the
time-dependent hot-wire measurements allow obtaining detailed
frequency spectra of the velocity signal, used for calculating
characteristic Strouhal numbers. The impact of the plate thickness and
the Reynolds number on the vortex shedding pattern has been
discussed. Furthermore, a detailed map of the relationship between the
Strouhal number and Reynolds number has been obtained and
discussed.
Abstract: The current study has investigated the ageing
phenomena of silica optical fibres in relation to water activity which might be accelerated when exposed to a supplementary energy, such as microwaves. A controlled stress by winding fibres onto accurate
diameter mandrel was applied. Taking into account that normally a
decrease in fibre strength is induced in time by chemical action of water, the effects of cumulative reagents such as: water, applied stress and supplementary energy (microwave) in some cases acted in
the opposite manner. The microwave effect as a structural relaxation
catalyst appears unexpected, even if the overall gain in fibre strength is not high, but the stress corrosion factor revealed significant
increase in certain simulation conditions.
Abstract: A greenhouse experiment was conducted to investigate the effects of different types of nutrients induced salinity on the growth, membrane permeability, nitrate reductase activity, proline content and macronutrient concentrations of tomato plants. The plants were subjected to six different treatments: 1 (control) containing basic solution, 2 basic solution+40mM of NaCl, 3 basic solution+40 mM of KNO3, 4 basic solution+20 mM of Ca(NO3)2.4H2O, 5 basic solution+20 mM of Mg(NO3)2.6H2O and 6 basic solution+20 mM of KNO3+5 mM of Ca(NO3)2.4H2O+5 mM of Mg(NO3)2.6H2O. Membrane permeability was increased significantly only with addition of NaCl, and then decreased to its lower level with addition of Ca(NO3)2.4H2O and Mg(NO3)2.6H2O. Proline accumulation were followed the same trend of results when they had been exposed to NaCl salinity. Nitrate reductase activity (NRA) was significantly affected by addition of different types of nutrient induced salinity.
Abstract: Mushrooms are a group of fleshy macroscopic fungi.
They have been valued throughout the world as both edible and
medicine. They are highly nutritious with good amount of quality
proteins, vitamins and minerals. An edible mushroom, Calocybe
indica was selected to validate its nutritional and medicinal
properties. Since tissue damage in hyperglycemia has been related to
oxidative stress, we evaluated the enzymatic and non-enzymatic
antioxidant status in the serum, liver and kidney since they are the
target organs in diabetic complications. From the results, increased
oxidative stress and decreased antioxidants might be related to the
causation of diabetes mellitus. The treatment in the diabetic rats with
the Calocybe indica showed an increase in the antioxidant system
and decrease in the production of free radicals. The mushrooms
which contain antioxidant phytochemicals has potential free radical
scavenging capacity and hence can induce the antioxidant system in
the body significantly reduces the generated free radicals thereby
maintaining the normal levels of the antioxidants
Abstract: Understanding how precipitation inter-annually
changes and its implication in agricultural drought and production change in winter wheat (Triticum aestivum L.) growth season is critical for crop production in China. MODIS Temperature-Vegetation Dryness Index (TVDI) and daily mean precipitation time series for the main growth season(Feb. to May) of winter wheat from 2000 to 2010
were used to analyze the distribution of trends of precipitation,
agricultural drought and winter wheat yield change respectively, and
relationships between them in North China region(Huang-huai-hai
region, HHH region), China. The results indicated that the trend of
precipitation in HHH region past 11 years was increasing, which had
induced generally corresponding decreasing trend of agricultural
drought and increasing trend of wheat yield, while the trend of drought
was spatially diverse. The study could provide a basis for agricultural
drought research during winter wheat season in HHH region under the
ground of climate change.
Abstract: An induced graphoidal cover of a graph G is a collection ψ of (not necessarily open) paths in G such that every path in ψ has at least two vertices, every vertex of G is an internal vertex of at most one path in ψ, every edge of G is in exactly one path in ψ and every member of ψ is an induced cycle or an induced path. The minimum cardinality of an induced graphoidal cover of G is called the induced graphoidal covering number of G and is denoted by ηi(G) or ηi. Here we find induced graphoidal cover for some classes of graphs.