Ameliorative Effect of Calocybe indica, a Tropical Indian Edible Mushroom on Hyperglycemia Induced Oxidative Stress
Mushrooms are a group of fleshy macroscopic fungi.
They have been valued throughout the world as both edible and
medicine. They are highly nutritious with good amount of quality
proteins, vitamins and minerals. An edible mushroom, Calocybe
indica was selected to validate its nutritional and medicinal
properties. Since tissue damage in hyperglycemia has been related to
oxidative stress, we evaluated the enzymatic and non-enzymatic
antioxidant status in the serum, liver and kidney since they are the
target organs in diabetic complications. From the results, increased
oxidative stress and decreased antioxidants might be related to the
causation of diabetes mellitus. The treatment in the diabetic rats with
the Calocybe indica showed an increase in the antioxidant system
and decrease in the production of free radicals. The mushrooms
which contain antioxidant phytochemicals has potential free radical
scavenging capacity and hence can induce the antioxidant system in
the body significantly reduces the generated free radicals thereby
maintaining the normal levels of the antioxidants
<p>[1] Chang, R., 1996. Functional properties of edible mushrooms, Nutr. Rev.
54: S91–S93.
[2] Ferreira, I.C.F.R., Vaz, J.A., Vasconcelos, M.A. and Martins, A., 2010.
Compounds from wild mushrooms with antitumor potential. Anti Cancer
Agents Medicinal Chemistry 10, 424–436.
[3] Kalac, P., 2009. Chemical composition and nutritional value of
European species of wild growing mushrooms: A review. Food
Chemistry 113, 9–16.
[4] Sonnenberg, A.S.M., Baars, J.J.P., Hendrickx, P.M., and Kerrigan, R.W.,
2005. Breeding mushroom: State of the art, Acta Edulis Fungi, 1: 163–
173.
[5] Mattila, P., Suonpaa, K., and Piironen, V. 2000. Functional properties of
edible mushrooms. Nutrition, 16, 694–696.
[6] Davis, S., 2006. Insulin, oral hypoglycemic agents and the
pharmacology of the endocrine pancreas. In: Brunton, L., Lazo, J.,
Parker, K. (Eds.), Goodman and Gilman’s. The Pharmacological Basis
of Therapeutics, 11th ed. McGraw Hill Publishing, pp. 1613–1646.
[7] Lefebvre, P., 2005. Diabetes yesterday, today and tomorrow. The action
of the International Diabetes Federation. Revue Medicale de Liege 60,
273– 277.
[8] Panunti, B., Jawa, A.A. and Fonseca, V.A., 2004. Mechanisms and
therapeutic targets in type 2 diabetes mellitus. Drug Discovery Today:
Disease Mechanisms 1, 151–157.
[9] Davi, G., Falco, A. and Patrono, C., 2005. Lipid peroxidation in diabetes
mellitus. Antioxid. Redox Signal 7, 256–268.
[10] Obaid, M. and Turtle, J.R., 2004. Type 2 diabetes: an epidemic in the
making. American Diabetes Foundation. 5, 29-34.
[11] Upadhyay, O.P., Singh, R.M. and Dutta, K., 1996. Studies on
antidiabetic medicinal plants used in Indian folk-lore. Aryavaidyan 9 (3),
159–167.
[12] Rang, H.P. and Dale, M.M., 1991. The Endocrine System
Pharmacology, second ed. Longman Group Ltd, United Kingdom pp.
504–508.
[13] Ajith, T. A. and Janardhanan, K. K. 2007. Indian medicinal mushrooms
as a source of antioxidant and antitumor agents. Journal of Clinical
Biochemistry and Nutrition, 40, 157–162.
[14] De la Fuente, M. (2002). Effects of antioxidants on immune system
ageing. European Journal of Clinical Nutrition, 56(3), S5–S8.
[15] Elmastas, M., Isildak, O., Turkekul, I. and Temur, N., 2007.
Determination of antioxidant activity and antioxidant compounds in wild
edible mushrooms. Journal of Food Composition and Analysis 20, 337–
345.
[16] Manzi, P., Aguzzi, A. and Pizzoferrato, L., 2001. Nutritional value of
mushrooms widely consumed in Italy. Food Chemistry 73, 321–325.
[17] Kathleen, A.H., 1996. Type 1-diabetes: Prevention of the disease and its
complications. Alternative Med Rev 2, 256-281.
[18] Mahalingam Gayathri and Krishnan Kannabiran., 2008. Antidiabetic and
ameliorative potential of ficus bengalensis bark extract in streptozotocin
induced diabetic rats. Indian Journal of Clinical Biochemistry 23 (4),
394-400.
[19] Baynes, J.W., 1995. Reactive oxygen in the aetiology and complications
of diabetes. Drug, diet and disease, Mechanistic approach to diabetes. In:
Ioannides C, Flatt PR editors. Ellis Horwood Limited, Hertfordshire 2,
2003-2231.
[20] Hayath Basha, S.K. and Subramanian, S., 2011. Biochemical evaluation
of antidiabetic and antioxidant potentials of Annona squamosa leaves
extracts studied in STZ induced diabetic rats. IJPSR 2(3), 643-655.
[21] Campbell, R.K., White, J.R. and Saulie, B.A., 1996. Metformin: a new
oral biguanide. Clinical Therapeutics 18, 360–71.
[22] Saxena, A.K., Srivastava, P., Kale, R.K. and Baquer, N.Z., 1993.
Impaired anti-oxidant status in diabetic rat liver: Effect of vanadate.
Biochem. Pharmacol 45, 539-542.
[23] Picton, S.F., Flatt, P.R., and Mcclenghan, N.H., 2001. Differential acute
and long term actions of succinic acid monomethyl ester exposure on
insulin secreting BRAIN-BD 11 cells. Int. J. Exp. Diabetes Res. 2, 19–
27.
[24] Sheela, C.G., and Angusti, K., 1995. Antiperoxide effects of S-allyl
cystein sulphoxide isolated from Allium sativum Linn and gugulipid in
chlosterol diet fed rats. Ind. J. Exp. Biol. 33, 337–341.
[25] Lai, L.S., Chou, S.T. and Chao, W.W., 2001. Studies on the
antioxidative activities of Hsian-tsao (Mesona procumbens Hemsl) leaf
gum. Journal of Agricultural and Food Chemistry 49, 963−968.
[26] Gulcin, Y., Buyukokuroglu, M.E., Oktay, M. and Kufrevioglu, O.Y.,
2003. Antioxidant and analgesic activities of turpentine of Pinus nigra
Arn. Subsp pallsiana (Lamb.) Holmboe. Journal of Ethnopharmacology
86, 51-58.</p>
<p>[1] Chang, R., 1996. Functional properties of edible mushrooms, Nutr. Rev.
54: S91–S93.
[2] Ferreira, I.C.F.R., Vaz, J.A., Vasconcelos, M.A. and Martins, A., 2010.
Compounds from wild mushrooms with antitumor potential. Anti Cancer
Agents Medicinal Chemistry 10, 424–436.
[3] Kalac, P., 2009. Chemical composition and nutritional value of
European species of wild growing mushrooms: A review. Food
Chemistry 113, 9–16.
[4] Sonnenberg, A.S.M., Baars, J.J.P., Hendrickx, P.M., and Kerrigan, R.W.,
2005. Breeding mushroom: State of the art, Acta Edulis Fungi, 1: 163–
173.
[5] Mattila, P., Suonpaa, K., and Piironen, V. 2000. Functional properties of
edible mushrooms. Nutrition, 16, 694–696.
[6] Davis, S., 2006. Insulin, oral hypoglycemic agents and the
pharmacology of the endocrine pancreas. In: Brunton, L., Lazo, J.,
Parker, K. (Eds.), Goodman and Gilman’s. The Pharmacological Basis
of Therapeutics, 11th ed. McGraw Hill Publishing, pp. 1613–1646.
[7] Lefebvre, P., 2005. Diabetes yesterday, today and tomorrow. The action
of the International Diabetes Federation. Revue Medicale de Liege 60,
273– 277.
[8] Panunti, B., Jawa, A.A. and Fonseca, V.A., 2004. Mechanisms and
therapeutic targets in type 2 diabetes mellitus. Drug Discovery Today:
Disease Mechanisms 1, 151–157.
[9] Davi, G., Falco, A. and Patrono, C., 2005. Lipid peroxidation in diabetes
mellitus. Antioxid. Redox Signal 7, 256–268.
[10] Obaid, M. and Turtle, J.R., 2004. Type 2 diabetes: an epidemic in the
making. American Diabetes Foundation. 5, 29-34.
[11] Upadhyay, O.P., Singh, R.M. and Dutta, K., 1996. Studies on
antidiabetic medicinal plants used in Indian folk-lore. Aryavaidyan 9 (3),
159–167.
[12] Rang, H.P. and Dale, M.M., 1991. The Endocrine System
Pharmacology, second ed. Longman Group Ltd, United Kingdom pp.
504–508.
[13] Ajith, T. A. and Janardhanan, K. K. 2007. Indian medicinal mushrooms
as a source of antioxidant and antitumor agents. Journal of Clinical
Biochemistry and Nutrition, 40, 157–162.
[14] De la Fuente, M. (2002). Effects of antioxidants on immune system
ageing. European Journal of Clinical Nutrition, 56(3), S5–S8.
[15] Elmastas, M., Isildak, O., Turkekul, I. and Temur, N., 2007.
Determination of antioxidant activity and antioxidant compounds in wild
edible mushrooms. Journal of Food Composition and Analysis 20, 337–
345.
[16] Manzi, P., Aguzzi, A. and Pizzoferrato, L., 2001. Nutritional value of
mushrooms widely consumed in Italy. Food Chemistry 73, 321–325.
[17] Kathleen, A.H., 1996. Type 1-diabetes: Prevention of the disease and its
complications. Alternative Med Rev 2, 256-281.
[18] Mahalingam Gayathri and Krishnan Kannabiran., 2008. Antidiabetic and
ameliorative potential of ficus bengalensis bark extract in streptozotocin
induced diabetic rats. Indian Journal of Clinical Biochemistry 23 (4),
394-400.
[19] Baynes, J.W., 1995. Reactive oxygen in the aetiology and complications
of diabetes. Drug, diet and disease, Mechanistic approach to diabetes. In:
Ioannides C, Flatt PR editors. Ellis Horwood Limited, Hertfordshire 2,
2003-2231.
[20] Hayath Basha, S.K. and Subramanian, S., 2011. Biochemical evaluation
of antidiabetic and antioxidant potentials of Annona squamosa leaves
extracts studied in STZ induced diabetic rats. IJPSR 2(3), 643-655.
[21] Campbell, R.K., White, J.R. and Saulie, B.A., 1996. Metformin: a new
oral biguanide. Clinical Therapeutics 18, 360–71.
[22] Saxena, A.K., Srivastava, P., Kale, R.K. and Baquer, N.Z., 1993.
Impaired anti-oxidant status in diabetic rat liver: Effect of vanadate.
Biochem. Pharmacol 45, 539-542.
[23] Picton, S.F., Flatt, P.R., and Mcclenghan, N.H., 2001. Differential acute
and long term actions of succinic acid monomethyl ester exposure on
insulin secreting BRAIN-BD 11 cells. Int. J. Exp. Diabetes Res. 2, 19–
27.
[24] Sheela, C.G., and Angusti, K., 1995. Antiperoxide effects of S-allyl
cystein sulphoxide isolated from Allium sativum Linn and gugulipid in
chlosterol diet fed rats. Ind. J. Exp. Biol. 33, 337–341.
[25] Lai, L.S., Chou, S.T. and Chao, W.W., 2001. Studies on the
antioxidative activities of Hsian-tsao (Mesona procumbens Hemsl) leaf
gum. Journal of Agricultural and Food Chemistry 49, 963−968.
[26] Gulcin, Y., Buyukokuroglu, M.E., Oktay, M. and Kufrevioglu, O.Y.,
2003. Antioxidant and analgesic activities of turpentine of Pinus nigra
Arn. Subsp pallsiana (Lamb.) Holmboe. Journal of Ethnopharmacology
86, 51-58.</p>
@article{"International Journal of Biological, Life and Agricultural Sciences:59599", author = "Shanmugasundaram Krishnakumari and Paramasivam Rajeswari and Subramanian Kathiravan", title = "Ameliorative Effect of Calocybe indica, a Tropical Indian Edible Mushroom on Hyperglycemia Induced Oxidative Stress", abstract = "Mushrooms are a group of fleshy macroscopic fungi.
They have been valued throughout the world as both edible and
medicine. They are highly nutritious with good amount of quality
proteins, vitamins and minerals. An edible mushroom, Calocybe
indica was selected to validate its nutritional and medicinal
properties. Since tissue damage in hyperglycemia has been related to
oxidative stress, we evaluated the enzymatic and non-enzymatic
antioxidant status in the serum, liver and kidney since they are the
target organs in diabetic complications. From the results, increased
oxidative stress and decreased antioxidants might be related to the
causation of diabetes mellitus. The treatment in the diabetic rats with
the Calocybe indica showed an increase in the antioxidant system
and decrease in the production of free radicals. The mushrooms
which contain antioxidant phytochemicals has potential free radical
scavenging capacity and hence can induce the antioxidant system in
the body significantly reduces the generated free radicals thereby
maintaining the normal levels of the antioxidants
", keywords = "Antioxidants, Calocybe indica, diabetes mellitus,
edible mushroom, oxidative stress.", volume = "7", number = "7", pages = "631-4", }
