Abstract: This paper deals with the design of an intelligent control structure for a bioprocess of Hansenula polymorpha yeast cultivation. The objective of the process control is to produce biomass in a desired physiological state. The work demonstrates that the designed Hybrid Control Techniques (HCT) are able to recognize specific evolution bioprocess trajectories using neural networks trained specifically for this purpose, in order to estimate the model parameters and to adjust the overall bioprocess evolution through an expert system and a fuzzy structure. The design of the control algorithm as well as its tuning through realistic simulations is presented. Taking into consideration the synergism of different paradigms like fuzzy logic, neural network, and symbolic artificial intelligence (AI), in this paper we present a real and fulfilled intelligent control architecture with application in bioprocess control.
Abstract: Bioprocesses are appreciated as difficult to control because their dynamic behavior is highly nonlinear and time varying, in particular, when they are operating in fed batch mode. The research objective of this study was to develop an appropriate control method for a complex bioprocess and to implement it on a laboratory plant. Hence, an intelligent control structure has been designed in order to produce biomass and to maximize the specific growth rate.
Abstract: The current study has investigated the ageing
phenomena of silica optical fibres in relation to water activity which might be accelerated when exposed to a supplementary energy, such as microwaves. A controlled stress by winding fibres onto accurate
diameter mandrel was applied. Taking into account that normally a
decrease in fibre strength is induced in time by chemical action of water, the effects of cumulative reagents such as: water, applied stress and supplementary energy (microwave) in some cases acted in
the opposite manner. The microwave effect as a structural relaxation
catalyst appears unexpected, even if the overall gain in fibre strength is not high, but the stress corrosion factor revealed significant
increase in certain simulation conditions.
Abstract: Despite the extensive use of eLearning systems, there
is no consensus on a standard framework for evaluating this kind of
quality system. Hence, there is only a minimum set of tools that can
supervise this judgment and gives information about the course
content value. This paper presents two kinds of quality set evaluation
indicators for eLearning courses based on the computational process
of three known metrics, the Euclidian, Hamming and Levenshtein
distances. The “distance" calculus is applied to standard evaluation
templates (i.e. the European Commission Programme procedures vs.
the AFNOR Z 76-001 Standard), determining a reference point in the
evaluation of the e-learning course quality vs. the optimal concept(s).
The case study, based on the results of project(s) developed in the
framework of the European Programme “Leonardo da Vinci", with
Romanian contractors, try to put into evidence the benefits of such a
method.
Abstract: Bioprocesses are appreciated as difficult to control because their dynamic behavior is highly nonlinear and time varying, in particular, when they are operating in fed batch mode. The research objective of this study was to develop an appropriate control method for a complex bioprocess and to implement it on a laboratory plant. Hence, an intelligent control structure has been designed in order to produce biomass and to maximize the specific growth rate.
Abstract: An immunomodulator bioproduct is prepared in a
batch bioprocess with a modified bacterium Pseudomonas
aeruginosa. The bioprocess is performed in 100 L Bioengineering
bioreactor with 42 L cultivation medium made of peptone, meat
extract and sodium chloride. The optimal bioprocess parameters were
determined: temperature – 37 0C, agitation speed - 300 rpm, aeration
rate – 40 L/min, pressure – 0.5 bar, Dow Corning Antifoam M-max.
4 % of the medium volume, duration - 6 hours. This kind of
bioprocesses are appreciated as difficult to control because their
dynamic behavior is highly nonlinear and time varying. The aim of
the paper is to present (by comparison) different models based on
experimental data.
The analysis criteria were modeling error and convergence rate.
The estimated values and the modeling analysis were done by using
the Table Curve 2D.
The preliminary conclusions indicate Andrews-s model with a
maximum specific growth rate of the bacterium in the range of
0.8 h-1.
Abstract: Accurate assessment of the primary tumor response to
treatment is important in the management of breast cancer. This
paper introduces a new set of treatment evaluation indicators for
breast cancer cases based on the computational process of three
known metrics, the Euclidian, Hamming and Levenshtein distances.
The distance principals are applied to pairs of mammograms and/or
echograms, recorded before and after treatment, determining a
reference point in judging the evolution amount of the studied
carcinoma. The obtained numerical results are indeed very
transparent and indicate not only the evolution or the involution of
the tumor under treatment, but also a quantitative measurement of the
benefit in using the selected method of treatment.