Abstract: In order to implement flexibility as well as survivable
capacities over passive optical network (PON), a new automatic
random fault-recovery mechanism with array-waveguide-grating
based (AWG-based) optical switch (OSW) is presented. Firstly,
wavelength-division-multiplexing and optical code-division
multiple-access (WDM/OCDMA) scheme are configured to meet the
various geographical locations requirement between optical network
unit (ONU) and optical line terminal (OLT). The AWG-base optical
switch is designed and viewed as central star-mesh topology to
prohibit/decrease the duplicated redundant elements such as fiber and
transceiver as well. Hence, by simple monitoring and routing switch
algorithm, random fault-recovery capacity is achieved over
bi-directional (up/downstream) WDM/OCDMA scheme. When error
of distribution fiber (DF) takes place or bit-error-rate (BER) is higher
than 10-9 requirement, the primary/slave AWG-based OSW are
adjusted and controlled dynamically to restore the affected ONU
groups via the other working DFs immediately.
Abstract: The cyberspace is an instrument through which
internet users could get new experiences. It could contribute to foster
one-s own growth, widening cognitive, creative and communicative
abilities and promoting relationships. In the cyberspace, in fact, it is
possible to create virtual learning communities where internet users
improve their interpersonal sphere, knowledge and skills. The main
element of e-learning is the establishment of online relationships, that
are often collaborative.
Abstract: In the present study, changes of morphology and
mechanical characteristics in the lumbar vertebrae of the
ovariectomised (OVX) rat were investigated. In previous researches,
there were many studies about morphology like volume fraction and
trabecular thickness based on Micro - Computed Tomography (Micro
- CT). However, detecting and tracking long-term changes in the
trabecular bone of the lumbar vertebrae for the OVX rat were few. For
this study, one female Sprague-Dawley rat was used: an OVX rat. The
4th Lumbar of the OVX rat was subjected to in-vivo micro-CT.
Detecting and tracking long-term changes could be investigated in the
trabecular bone of the lumbar vertebrae for an OVX rat using in-vivo
micro-CT. An OVX rat was scanned at week 0 (just before surgery), at
week 4, at week 8, week 16, week 22 and week 56 after surgery. Finite
element (FE) analysis was used to investigate mechanical
characteristics of the lumbar vertebrae for an OVX rat. When the OVX
rat (at week 56) was compared with the OVX rat (at week 0), volume
fraction was decreased by 80% and effective modulus was decreased
by 75%.
Abstract: To identify an endothelial cell-specific promoter suitable for vascular-specific targeting, we tested five promoters in vitro--Tie2SE, Tie2LE, ICAM2, Flt-1 and vWF--for promoter activity and specificity in endothelial cells, smooth muscle cells and non-vascular resident cells as well as tissues. These promoters, except for vWF, exhibited good endothelial activity and specificity in vitro. In a syngenic heart transplantation model, the ICAM2 promoter was variably functional in coronary endothelial cells of donor hearts. Thus, the ICAM2, Flt-1, Tie2SE and Tie2LE promoters hold promise for endothelial-specific targeting, but in vitro expression may not predict in vivo expression.
Abstract: The purpose of this study is to present a non invasive
method for the marginal adaptation evaluation in class V composite
restorations. Standardized class V cavities, prepared in human
extracted teeth, were filled with Premise (Kerr) composite. The
specimens were thermo cycled. The interfaces were examined by
Optical Coherence Tomography method (OCT) combined with the
confocal microscopy and fluorescence. The optical configuration
uses two single mode directional couplers with a superluminiscent
diode as the source at 1300 nm. The scanning procedure is similar to
that used in any confocal microscope, where the fast scanning is enface
(line rate) and the depth scanning is much slower (at the frame
rate). Gaps at the interfaces as well as inside the composite resin
materials were identified. OCT has numerous advantages which
justify its use in vivo as well as in vitro in comparison with
conventional techniques.
Abstract: This research was carried out to determine the
possible effects of low electromagnetic field (EMF) exposure to the
developing mice fetuses. Pregnant mice were exposed to EMF
exposure at 0mT (sham) and 1.2 mT for six hours per session, carried
out on gestation day 3, 6, 9, 12 and 15. Samples from the stillborn
offspring were observed for morphological defects. The heart didn-t
show progressive cellular damage, the lungs were congested and
emphysemics. The bones were in advance stage of hypertrophy.
Spectrums of morphological defects were observed over 70% of the
surviving offspring. These results indicate that even at lower
exposure to low EMF, is enough to induce morphological defects in
prenatal mice.
Abstract: We consider the topological entropy of maps that in
general, cannot be described by one-dimensional dynamics. In particular,
we show that for a multivalued map F generated by singlevalued
maps, the topological entropy of any of the single-value map bounds the topological entropy of F from below.
Abstract: It is well recognized that the green house gases such
as Chlorofluoro Carbon (CFC), CH4, CO2 etc. are responsible
directly or indirectly for the increase in the average global temperature
of the Earth. The presence of CFC is responsible for
the depletion of ozone concentration in the atmosphere due to
which the heat accompanied with the sun rays are less absorbed
causing increase in the atmospheric temperature of the Earth. The
gases like CH4 and CO2 are also responsible for the increase in
the atmospheric temperature. The increase in the temperature level
directly or indirectly affects the dynamics of interacting species
systems. Therefore, in this paper a mathematical model is proposed
and analysed using stability theory to asses the effects of increasing
temperature due to greenhouse gases on the survival or extinction of
populations in a prey-predator system. A threshold value in terms
of a stress parameter is obtained which determines the extinction or
existence of populations in the underlying system.
Abstract: Leonotisleonurus a shrub indigenous to Southern
Africa is widely used in traditional medicine to treat a variety of
conditions ranging from skin diseases and cough to epileptic fits and
‘heart problems’. Studies on the aqueous extract of the leaves have
indicated cycloxegenase enzyme inhibitory activity and an
antihypertensive effect.
Five methanol leaf extract fractions (MLEa - MLEe) of L.
leonurus were tested on anaesthetized normotensive male Wistar rats
(AWR) and isolated perfused working rat hearts (IWH). Fraction
MLEc (0.01mg/kg – 0.05mg/kg) induced significant increases in BP
and HR in AWR and positive chronotropic and inotropic effects in
IWH (1.0mg/ml – 5.0mg/ml). Pre-administration of atenolol
(2.0mg/kg) and prazosin (60μg/kg) significantly inhibited MLEc
effect on HR and MAP respectively in vivo, while atenolol
(7.0mg/ml) pre-perfusion significantly inhibited MLEc effect in vitro.
The hypertensive effect of MLEc is probably via β1agonism.
Results also indicate the presence of multiple cardioactive
compounds in L. leonurus.
Abstract: Although achieving zero-defect software release is
practically impossible, software industries should take maximum
care to detect defects/bugs well ahead in time allowing only bare
minimums to creep into released version. This is a clear indicator of
time playing an important role in the bug detection. In addition to
this, software quality is the major factor in software engineering
process. Moreover, early detection can be achieved only through
static code analysis as opposed to conventional testing.
BugCatcher.Net is a static analysis tool, which detects bugs in .NET®
languages through MSIL (Microsoft Intermediate Language)
inspection. The tool utilizes a Parser based on Finite State Automata
to carry out bug detection. After being detected, bugs need to be
corrected immediately. BugCatcher.Net facilitates correction, by
proposing a corrective solution for reported warnings/bugs to end
users with minimum side effects. Moreover, the tool is also capable
of analyzing the bug trend of a program under inspection.
Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: The Siemens Healthcare Sector is one of the world's
largest suppliers to the healthcare industry and a trendsetter in
medical imaging and therapy, laboratory diagnostics, medical
information technology, and hearing aids.
Siemens offers its customers products and solutions for the entire
range of patient care from a single source – from prevention and
early detection to diagnosis, and on to treatment and aftercare. By
optimizing clinical workflows for the most common diseases,
Siemens also makes healthcare faster, better, and more cost effective.
The optimization of clinical workflows requires a
multidisciplinary focus and a collaborative approach of e.g. medical
advisors, researchers and scientists as well as healthcare economists.
This new form of collaboration brings together experts with deep
technical experience, physicians with specialized medical knowledge
as well as people with comprehensive knowledge about health
economics.
As Charles Darwin is often quoted as saying, “It is neither the
strongest of the species that survive, nor the most intelligent, but the
one most responsive to change," We believe that those who can
successfully manage this change will emerge as winners, with
valuable competitive advantage.
Current medical information and knowledge are some of the core
assets in the healthcare industry. The main issue is to connect
knowledge holders and knowledge recipients from various
disciplines efficiently in order to spread and distribute knowledge.
Abstract: In vitro plant regeneration has been successfully obtained from basal shoot explant of Vetiveria zizanioides through indirect organogenesis. The explant was cultured in Murashige & Skoog’s (MS) media supplemented with 2,4-D, IAA, and kinetin in various concentrations. Callus was well induced in media supplemented with 2 ppm 2,4-D, 1 ppm IAA, and 1 ppm kinetin. This callus was then transferred to MS media supplemented with 1 - 5 ppm of BAP for shoot regeneration. The media supplemented with 3 ppm BAP was a suitable medium for shoot induction, as well as for shoot multiplication. Rooting was well developed in shoot following transferred to half MS media containing 0.2 ppm IBA. Plantlet was then transferred to husk charcoal for acclimatization, and almost all (90%) of plantlets were survived during acclimatization.
Abstract: The PAX6, a transcription factor, is essential for the morphogenesis of the eyes, brain, pituitary and pancreatic islets. In rodents, the loss of Pax6 function leads to central nervous system defects, anophthalmia, and nasal hypoplasia. The haplo-insufficiency of Pax6 causes microphthalmia, aggression and other behavioral abnormalities. It is also required in brain patterning and neuronal plasticity. In human, heterozygous mutation of Pax6 causes loss of iris [aniridia], mental retardation and glucose intolerance. The 3- deletion in Pax6 leads to autism and aniridia. The phenotypes are variable in peneterance and expressivity. However, mechanism of function and interaction of PAX6 with other proteins during development and associated disease are not clear. It is intended to explore interactors of PAX6 to elucidated biology of PAX6 function in the tissues where it is expressed and also in the central regulatory pathway. This report describes In-silico approaches to explore interacting proteins of PAX6. The models show several possible proteins interacting with PAX6 like MITF, SIX3, SOX2, SOX3, IPO13, TRIM, and OGT. Since the Pax6 is a critical transcriptional regulator and master control gene of eye and brain development it might be interacting with other protein involved in morphogenesis [TGIF, TGF, Ras etc]. It is also presumed that matricelluar proteins [SPARC, thrombospondin-1 and osteonectin etc] are likely to interact during transport and processing of PAX6 and are somewhere its cascade. The proteins involved in cell survival and cell proliferation can also not be ignored.
Abstract: Natural disasters, including earthquake, kill many people around the world every year. Society rescue actions, which start after the earthquake and are called LAST in abbreviation, include locating, access, stabilization and transportation. In the present article, we have studied the process of local accessibility to the injured and transporting them to health care centers. With regard the heavy traffic load due to earthquake, the destruction of connecting roads and bridges and the heavy debris in alleys and street, which put the lives of the injured and the people buried under the debris in danger, accelerating the rescue actions and facilitating the accessibilities are of great importance, obviously. Tehran, the capital of Iran, is among the crowded cities in the world and is the center of extensive economic, political, cultural and social activities. Tehran has a population of about 9.5 millions and because of the immigration of people from the surrounding cities. Furthermore, considering the fact that Tehran is located on two important and large faults, a 6 Richter magnitude earthquake in this city could lead to the greatest catastrophe during the entire human history. The present study is a kind of review and a major part of the required information for it, has been obtained from libraries all of the rescue vehicles around the world, including rescue helicopters, ambulances, fire fighting vehicles and rescue boats, and their applied technology, and also the robots specifically designed for the rescue system and the advantages and disadvantages of them, have been investigated. The studies show that there is a significant relationship between the rescue team-s arrival time at the incident zone and the number of saved people; so that, if the duration of burial under debris 30 minutes, the probability of survival is %99.3, after a day is %81, after 2days is %19 and after 5days is %7.4. The exiting transport systems all have some defects. If these defects are removed, more people could be saved each hour and the preparedness against natural disasters is increased. In this study, transport system has been designed for the rescue team and the injured; which could carry the rescue team to the incident zone and the injured to the health care centers. In addition, this system is able to fly in the air and move on the earth as well; so that the destruction of roads and the heavy traffic load could not prevent the rescue team from arriving early at the incident zone. The system also has the equipment required firebird for debris removing, optimum transport of the injured and first aid.
Abstract: In this paper we propose a mixture of two different
distributions such as Exponential-Gamma, Exponential-Weibull and
Gamma-Weibull to model heterogeneous survival data. Various
properties of the proposed mixture of two different distributions are
discussed. Maximum likelihood estimations of the parameters are
obtained by using the EM algorithm. Illustrative example based on
real data are also given.
Abstract: The temporal nature of negative selection is an under exploited area. In a negative selection system, newly generated antibodies go through a maturing phase, and the survivors of the phase then wait to be activated by the incoming antigens after certain number of matches. These without having enough matches will age and die, while these with enough matches (i.e., being activated) will become active detectors. A currently active detector may also age and die if it cannot find any match in a pre-defined (lengthy) period of time. Therefore, what matters in a negative selection system is the dynamics of the involved parties in the current time window, not the whole time duration, which may be up to eternity. This property has the potential to define the uniqueness of negative selection in comparison with the other approaches. On the other hand, a negative selection system is only trained with “normal" data samples. It has to learn and discover unknown “abnormal" data patterns on the fly by itself. Consequently, it is more appreciate to utilize negation selection as a system for pattern discovery and recognition rather than just pattern recognition. In this paper, we study the potential of using negative selection in discovering unknown temporal patterns.
Abstract: For any country the project management has been a
vital part for its development. The highly competitive business world
has created tremendous pressure on the project managers to achieve
success. The pressure is derived from survival and profit building in
business organizations which compels the project managers to pursue
unethical practices. As a result unethical activities in business
projects can be found easily where situations or issues arise due to
dubious business practice, high corruption, or absolute violation of
the law. The recent spur on Commonwealth games to be organized in
New Delhi indicates towards the same. It has been seen that the
project managers mainly focus on cost, time, and quality rather than
social impact and long term effects of the project. Surprisingly the
literature as well as the practitioner-s perspective also does not
identify the role of ethics in project success. This paper identifies
ethics as the fourth most important dimension in the project based
organizations. The paper predicts that the approach of considering
ethics will result in sustainability of the project. It will increase
satisfaction and loyalty of the customers as well as create harmony,
trust, brotherhood, values and morality among the team members.
This paper is conceptual in nature as inadequate literature exists
linking the project success with an ethical approach.
Abstract: Bus networks design is an important problem in
public transportation. The main step to this design, is determining the
number of required terminals and their locations. This is an especial
type of facility location problem, a large scale combinatorial
optimization problem that requires a long time to be solved.
The genetic algorithm (GA) is a search and optimization technique
which works based on evolutionary principle of natural
chromosomes. Specifically, the evolution of chromosomes due to the
action of crossover, mutation and natural selection of chromosomes
based on Darwin's survival-of-the-fittest principle, are all artificially
simulated to constitute a robust search and optimization procedure.
In this paper, we first state the problem as a mixed integer
programming (MIP) problem. Then we design a new crossover and
mutation for bus terminal location problem (BTLP). We tested the
different parameters of genetic algorithm (for a sample problem) and
obtained the optimal parameters for solving BTLP with numerical try
and error.
Abstract: A scaffold is necessary for tooth regeneration because of its three-dimensional geometry. For restoration of defect, it is necessary for the scaffold to be prepared in the shape of the defect. Sponges made from polyvinyl alcohol with formalin cross-linking (PVF sponge) have been used for scaffolds for bone formation in vivo. To induce osteogenesis within the sponge, methods of growing rat bone marrow cells (rBMCs) among the fiber structures in the sponge might be considered. Storage of rBMCs among the fibers in the sponge coated with dextran (10 kDa) was tried. After seeding of rBMCs to PVF sponge immersed in dextran solution at 2 g/dl concentration, osteogenesis was recognized in subcutaneously implanted PVF sponge as a scaffold in vivo. The level of osteocalcin was 25.28±5.71 ng/scaffold and that of Ca was 129.20±19.69 µg/scaffold. These values were significantly higher than those in sponges without dextran coating (p