Abstract: The evaluation of unit cell neutronic parameters and
lifetime for some innovant reactors without on sit-refuling will be
held in this work. the behavior of some small and medium reactors
without on site refueling with triso and cermet fuel. For the FBNR
long life except we propose to change the enrichment of the Cermet
MFE to 9%. For the AFPR reactor we can see that the use of the
Cermet MFE can extend the life of this reactor but to maintain the
same life period for AFPR-SC we most use burnup poison to have the
same slope for Kinf (Burnup). PFPWR50 cell behaves almost in
same way using both fuels Cermet and TRISO. So we can conclude
that PFPWR50 reactor, with CERMET Fuel, is kept among the long
cycle reactors and with the new configuration we avoid subcriticality
at the beginning of cycle. The evaluation of unit cell neutronic
parameters reveals a good agreement with the goal of BWR-PB
concept. It is found out that the Triso fuel assembly lifetime can be
extended for a reasonably long period without being refueled,
approximately up to 48GWd/t burnup. Using coated particles fuels
with the Cermet composition can be more extended the fuel assembly
life time, approximately 52 GWd/t.
Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.