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ISTER (Immune System - Tumor Efficiency Rate): An Important Key for Planning in Radiotherapic Facilities

Year: 2010 Volume: 4 Issue: 5 197 - 200 Pages

• Authors:
• O. Sotolongo-Grau
• D. Rodriguez-Perez
• J. A. Santos-Miranda
• M. M. Desco
• O. Sotolongo-Costa
• J. C. Antoranz

Abstract: The use of the oncologic index ISTER allows for a more effective planning of the radiotherapic facilities in the hospitals. Any change in the radiotherapy treatment, due to unexpected stops, may be adapted by recalculating the doses to the new treatment duration while keeping the optimal prognosis. The results obtained in a simulation model on millions of patients allow the definition of optimal success probability algorithms.

• Keywords:
• Mathematical model
• radiation oncology
• dynamical systems applications.

Identification of Complex Sense-antisense Gene's Module on 17q11.2 Associated with Breast Cancer Aggressiveness and Patient's Survival

Year: 2009 Volume: 3 Issue: 10 289 - 298 Pages

• Authors:
• O. Grinchuk
• E. Motakis
• V. Kuznetsov

Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.

• Keywords:
• Sense-antisense gene pair
• complex genome architecture
• TMEM97
• IFT20
• TNFAIP1
• POLDIP2
• TMEM199
• 17q11.2
• breast cancer
• transcription regulation
• survival analysis
• prognosis.

Recent Trends in Nonlinear Methods of HRV Analysis: A Review

Year: 2011 Volume: 5 Issue: 3 93 - 98 Pages

• Authors:
• Ramesh K. Sunkaria

Abstract: The linear methods of heart rate variability analysis such as non-parametric (e.g. fast Fourier transform analysis) and parametric methods (e.g. autoregressive modeling) has become an established non-invasive tool for marking the cardiac health, but their sensitivity and specificity were found to be lower than expected with positive predictive value

• Keywords:
• chaos
• nonlinear dynamics
• sample entropy
• approximate entropy
• detrended fluctuation analysis.