Abstract: Along with the global aging of population, the number of people with somatic diseases is increasing, including such interrelated pathologies as obesity, osteoarthritis (OA) and osteoporosis (OP). The objective of the study is to examine the connection between body mass index (BMI), OA and bone mineral density (BMD) of lumbar spine, femoral neck and trabecular bone score (TBS) in postmenopausal women with OA. We have observed 359 postmenopausal women (50-89 years old) and divided them into four groups by age: 50-59 yrs, 60-69 yrs, 70-79 yrs and over 80 years old. In addition, according to the American College of Rheumatology (ACR) Clinical classification criteria for knee and hip OA, we divided them into 2 groups: group I – 117 females with symptomatic OA (including 89 patients with knee OA, 28 patients with hip OA) and group II –242 women with a normal functional activity of large joints. Analysis of data was performed taking into account their BMI, classified by World Health Organization (WHO). Diagnosis of obesity was established when BMI was above 30 kg/m2. In woman with obesity, a symptomatic OA was detected in 44 postmenopausal women (41.1%), a normal functional activity of large joints - in 63 women (58.9%). However, in women with normal BMI – 73 women, who account for 29.0% of cases, a symptomatic OA was detected. According to a chi-squared (χ2) test, a significantly higher level of BMI was detected in postmenopausal women with OA (χ2 = 5.05, p = 0.02). Women with a symptomatic OA had a significantly higher BMD of lumbar spine compared with women who had a normal functional activity of large joints. No significant differences of BMD of femoral necks or TBS were detected in either the group with OA or with a normal functional activity of large joints.
Abstract: Medical, social, and economic relevance of osteoporosis is caused by reducing quality of life, increasing disability and mortality of the patients as a result of fractures due to the low-energy trauma. This study is aimed to examine the associations of metabolic syndrome components, bone mineral density (BMD) and trabecular bone score (TBS) in menopausal women with non-vertebral fractures. 1161 menopausal women aged 50-79 year-old were examined and divided into three groups: A included 419 women with increased body weight (BMI - 25.0-29.9 kg/m2), B – 442 females with obesity (BMI >29.9 kg/m2)i and C – 300 women with metabolic syndrome (diagnosis according to IDF criteria, 2005). BMD of lumbar spine (L1-L4), femoral neck, total body and forearm was investigated with usage of dual-energy X-ray absorptiometry. The bone quality indexes were measured according to Med-Imaps installation. All analyses were performed using Statistical Package 6.0. BMD of lumbar spine (L1-L4), femoral neck, total body, and ultradistal radius was significant higher in women with obesity and metabolic syndrome compared to the pre-obese ones (p
Abstract: Osteoporosis is a common disease characterized by low bone mass and deterioration of micro-architectural bone tissue, which provokes an increased risk of fracture. This work treats the texture characterization of trabecular bone radiographs. The aim was to analyze according to clinical research a group of 174 subjects: 87 osteoporotic patients (OP) with various bone fracture types and 87 control cases (CC). To characterize osteoporosis, Fractal and MultiFractal (MF) methods were applied to images for features (attributes) extraction. In order to improve the results, a new method of MF spectrum based on the q-stucture function calculation was proposed and a combination of Fractal and MF attributes was used. The Support Vector Machines (SVM) was applied as a classifier to distinguish between OP patients and CC subjects. The features fusion (fractal and MF) allowed a good discrimination between the two groups with an accuracy rate of 96.22%.
Abstract: Osteoporosis and obesity are widespread diseases in people over 50 years associated with changes in structure and body composition. Нigher body mass index (BMI) values are associated with greater bone mineral density (BMD). However, trabecular bone score (TBS) indirectly explores bone quality, independently of BMD. The aim of our study was to evaluate the relationship between the BMD and TBS parameters in Ukrainian men suffering from obesity. We examined 396 men aged 40-89 years. Depending on their BMI all the subjects were divided into two groups: Group I – patients with obesity whose BMI was ≥ 30 kg/m2 (n=129) and Group II – patients without obesity and BMI of < 30 kg/m2 (n=267). The BMD of total body, lumbar spine L1-L4, femoral neck and forearm were measured by DXA (Prodigy, GEHC Lunar, Madison, WI, USA). The TBS of L1- L4 was assessed by means of TBS iNsight® software installed on DXA machine (product of Med-Imaps, Pessac, France). In general, obese men had a significantly higher BMD of lumbar spine L1-L4, femoral neck, total body and ultradistal forearm (p < 0.001) in comparison with men without obesity. The TBS of L1-L4 was significantly lower in obese men compared to non-obese ones (p < 0.001). BMD of lumbar spine L1-L4, femoral neck and total body significantly differ in men aged 40-49, 50-59, 60-69, and 80-89 years (p < 0.05). At the same time, in men aged 70-79 years, BMD of lumbar spine L1-L4 (p=0.46), femoral neck (p=0.18), total body (p=0.21), ultra-distal forearm (p=0.13), and TBS (p=0.07) did not significantly differ. A significant positive correlation between the fat mass and the BMD at different sites was observed. However, the correlation between the fat mass and TBS of L1-L4 was also significant, though negative.
Abstract: Osteoporosis is one of the important problems in postmenopausal women due to an increased risk of sudden and unexpected fractures. This study is aimed to determine the connection between bone mineral density (BMD) and trabecular bone score (TBS) in Ukrainian women suffering from metabolic syndrome. Participating in the study, 566 menopausal women aged 50-79 year-old were examined and divided into two groups: Group A included 336 women with no obesity (BMI ≤ 29.9 kg/m2), and Group B – 230 women with metabolic syndrome (diagnosis according to IDF criteria, 2005). Dual-energy X-ray absorptiometry was used for measuring of lumbar spine (L1-L4), femoral neck, total body and forearm BMD and bone quality indexes (last according to Med-Imaps installation). Data were analyzed using Statistical Package 6.0. A significant increase of lumbar spine (L1-L4), femoral neck, total body and ultradistal radius BMD was found in women with metabolic syndrome compared to those without obesity (p < 0.001) both in their totality and in groups of 50-59 years, 60-69 years, and 70-79 years. TBS was significantly higher in non-obese women compared to metabolic syndrome patients of 50-59 years and in the general sample (p < 0.05). Analysis showed significant positive correlation between body mass index (BMI) and BMD at all levels. Significant negative correlation between BMI and TBS (L1-L4) was established. Despite the fact that BMD indexes were significantly higher in women with metabolic syndrome, the frequency of vertebral and non-vertebral fractures did not differ significantly in the groups of patients.
Abstract: In the diagnostics of osteoporosis, the gold standard is considered to be bone mineral density; however, X-ray densitometry is not an accurate indicator of osteoporotic fracture risk under all circumstances. In this regard, the search for new methods that could determine the indicators not only of the mineral density, but of the bone tissue quality, is a logical step for diagnostic optimization. One of these methods is the evaluation of trabecular bone quality. The aim of this study was to examine the quality and mineral density of spine bone tissue, femoral neck, and body composition of women depending on the duration of the postmenopausal period, to determine the correlation of body fat with indicators of bone mineral density and quality. The study examined 179 women in premenopausal and postmenopausal periods. The patients were divided into the following groups: Women in the premenopausal period and women in the postmenopausal period at various stages (early, middle, late postmenopause). A general examination and study of the above parameters were conducted with General Electric X-ray densitometer. The results show that bone quality and mineral density probably deteriorate with advancing of postmenopausal period. Total fat and lean mass ratio is not likely to change with age. In the middle and late postmenopausal periods, the bone tissue mineral density of the spine and femoral neck increases along with total fat mass.
Abstract: Obesity and osteoporosis are the two diseases whose
increasing prevalence and high impact on the global morbidity and
mortality, during the two recent decades, have gained a status of
major health threats worldwide. Obesity purports to affect the bone
metabolism through complex mechanisms. Debated data on the
connection between the bone mineral density and fracture prevalence
in the obese patients are widely presented in literature. There is
evidence that the correlation of weight and fracture risk is sitespecific.
This study is aimed at determining the connection between
the bone mineral density (BMD) and trabecular bone score (TBS)
parameters in Ukrainian women suffering from obesity. We
examined 1025 40-89-year-old women, divided them into the groups
according to their body mass index: Group A included 360 women
with obesity whose BMI was ≥30 kg/m2, and Group B – 665 women
with no obesity and BMI of
Abstract: Knowledge of bone mechanical properties is important
for bone substitutes design and fabrication, and more efficient
prostheses development. The aim of this study is to characterize the
viscoelastic behavior of bone specimens, through stress relaxation
and fatigue tests performed to trabecular bone samples from bovine
femoral heads. Relaxation tests consisted on preloading the samples
at five different magnitudes and evaluate them for 1020 seconds,
adjusting the results to a KWW mathematical model. Fatigue tests
consisted of 700 load cycles and analyze their status at the end of the
tests. As a conclusion we have that between relaxation stress and
each preload there is linear relation and for samples with initial
Young´s modulus greater than 1.5 GPa showed no effects due fatigue
test loading cycles.
Abstract: The aim of this study is to evaluate the effects of the
laser and partial vibration stimulation on the mice tibia with
morphological characteristics. Twenty female C57BL/6 mice (12
weeks old) were used for the experiment. The study was carried out on
four groups of animals each consisting of five mice. Four groups of
mice were ovariectomized. Animals were scanned at 0 and 2 weeks
after ovariectomy by using micro computed tomography to estimate
morphological characteristics of tibial trabecular bone. Morphological
analysis showed that structural parameters of multi-stimuli group
appear significantly better phase in BV/TV, BS/BV, Tb.Th, Tb.N,
Tb.Sp, and Tb.pf than single stimulation groups. However, single
stimulation groups didn’t show significant effect on tibia with Sham
group. This study suggests that multi-stimuli may restrain the change
as the degenerate phase on osteoporosis in the mice tibia.
Abstract: In this work, the primary compressive strength
components of human femur trabecular bone are qualitatively
assessed using image processing and wavelet analysis. The Primary
Compressive (PC) component in planar radiographic femur trabecular
images (N=50) is delineated by semi-automatic image processing
procedure. Auto threshold binarization algorithm is employed to
recognize the presence of mineralization in the digitized images. The
qualitative parameters such as apparent mineralization and total area
associated with the PC region are derived for normal and abnormal
images.The two-dimensional discrete wavelet transforms are utilized
to obtain appropriate features that quantify texture changes in medical
images .The normal and abnormal samples of the human femur are
comprehensively analyzed using Harr wavelet.The six statistical
parameters such as mean, median, mode, standard deviation, mean
absolute deviation and median absolute deviation are derived at level
4 decomposition for both approximation and horizontal wavelet
coefficients. The correlation coefficient of various wavelet derived
parameters with normal and abnormal for both approximated and
horizontal coefficients are estimated. It is seen that in almost all cases
the abnormal show higher degree of correlation than normals. Further
the parameters derived from approximation coefficient show more
correlation than those derived from the horizontal coefficients. The
parameters mean and median computed at the output of level 4 Harr
wavelet channel was found to be a useful predictor to delineate the
normal and the abnormal groups.
Abstract: In the present study, changes of morphology and
mechanical characteristics in the lumbar vertebrae of the
ovariectomised (OVX) rat were investigated. In previous researches,
there were many studies about morphology like volume fraction and
trabecular thickness based on Micro - Computed Tomography (Micro
- CT). However, detecting and tracking long-term changes in the
trabecular bone of the lumbar vertebrae for the OVX rat were few. For
this study, one female Sprague-Dawley rat was used: an OVX rat. The
4th Lumbar of the OVX rat was subjected to in-vivo micro-CT.
Detecting and tracking long-term changes could be investigated in the
trabecular bone of the lumbar vertebrae for an OVX rat using in-vivo
micro-CT. An OVX rat was scanned at week 0 (just before surgery), at
week 4, at week 8, week 16, week 22 and week 56 after surgery. Finite
element (FE) analysis was used to investigate mechanical
characteristics of the lumbar vertebrae for an OVX rat. When the OVX
rat (at week 56) was compared with the OVX rat (at week 0), volume
fraction was decreased by 80% and effective modulus was decreased
by 75%.