Abstract: This paper presents the hardware design of a unified
architecture to compute the 4x4, 8x8 and 16x16 efficient twodimensional
(2-D) transform for the HEVC standard. This
architecture is based on fast integer transform algorithms. It is
designed only with adders and shifts in order to reduce the hardware
cost significantly. The goal is to ensure the maximum circuit reuse
during the computing while saving 40% for the number of operations.
The architecture is developed using FIFOs to compute the second
dimension. The proposed hardware was implemented in VHDL. The
VHDL RTL code works at 240 MHZ in an Altera Stratix III FPGA.
The number of cycles in this architecture varies from 33 in 4-point-
2D-DCT to 172 when the 16-point-2D-DCT is computed. Results
show frequency improvements reaching 96% when compared to an
architecture described as the direct transcription of the algorithm.
Abstract: The sequential morphologic changes of rabbit duodenal mucosa-submucosa were studied from primodial stage to birth in 15 fetuses and during the early days of life in 21 rabbit newborns till maturity using light, scanning and transmission electron microscopy. Fetal rabbit duodenum develops from a simple tube of stratified epithelium to a tube containing villus and intervillus regions of simple columnar epithelium. By day 21 of gestation, the first rudimentary villi were appeared and by day 24 the first true villi were appeared. The Crypts of Lieberkuhn did not appear until birth. By the first day of postnatal life the duodenal glands appeared. The histological maturity of the rabbit small intestine occurred one month after birth. In conclusion, at all stages, the sequential morphologic changes of the rabbit small intestine developed to meet the structural and physiological demands during the fetal stage to be prepared to extra uterine life.
Abstract: The efficiency of an image watermarking technique depends on the preservation of visually significant information. This is attained by embedding the watermark transparently with the maximum possible strength. The current paper presents an approach for still image digital watermarking in which the watermark embedding process employs the wavelet transform and incorporates Human Visual System (HVS) characteristics. The sensitivity of a human observer to contrast with respect to spatial frequency is described by the Contrast Sensitivity Function (CSF). The strength of the watermark within the decomposition subbands, which occupy an interval on the spatial frequencies, is adjusted according to this sensitivity. Moreover, the watermark embedding process is carried over the subband coefficients that lie on edges where distortions are less noticeable. The experimental evaluation of the proposed method shows very good results in terms of robustness and transparency.
Abstract: Use of microemulsion in enhanced oil recovery has become more attractive in recent years because of its high level of extraction efficiency. Experimental investigations have been made on characterization of microemulsions of oil-brinesurfactant/ cosurfactant system for its use in enhanced oil recovery (EOR). Sodium dodecyl sulfate, propan-1-ol and heptane were selected as surfactant, cosurfactant and oil respectively for preparation of microemulsion. The effects of salinity on the relative phase volumes and solubilization parameters have also been studied. As salinity changes from low to high value, phase transition takes place from Winsor I to Winsor II via Winsor III. Suitable microemulsion composition has been selected based on its stability and ability to reduce interfacial tension. A series of flooding experiments have been performed using the selected microemulsion. The flooding experiments were performed in a core flooding apparatus using uniform sand pack. The core holder was tightly packed with uniform sands (60-100 mesh) and saturated with brines of different salinities. It was flooded with the brine at 25 psig and the absolute permeability was calculated from the flow rate of the through sand pack. The sand pack was then flooded with the crude oil at 800 psig to irreducible water saturation. The initial water saturation was determined on the basis of mass balance. Waterflooding was conducted by placing the coreholder horizontally at a constant injection pressure at 200 pisg. After water flooding, when water-cut reached above 95%, around 0.5 pore volume (PV) of the above microemulsion slug was injected followed by chasing water. The experiments were repeated using different composition of microemulsion slug. The additional recoveries were calculated by material balance. Encouraging results with additional recovery more than 20% of original oil in place above the conventional water flooding have been observed.
Abstract: Verapamil has been shown to inhibit fentanyl uptake in vitro and is a potent P-glycoprotein inhibitor. Tissue partitioning of loperamide, a commercially available opioid, is closely controlled by the P-gp efflux transporter. The following studies were designed to evaluate the effect of opioids on verapamil partitioning in the lung and brain, in vivo. Opioid (fentanyl or loperamide) was administered by intravenous infusion to Sprague Dawley rats alone or in combination with verapamil and plasma, with lung and brain tissues were collected at 1, 5, 6, 8, 10 and 60 minutes. Drug dispositions were modeled by recirculatory pharmacokinetic models. Fentanyl slightly increased the verapamil lung (PL) partition coefficient yet decreased the brain (PB) partition coefficient. Furthermore, loperamide significantly increased PLand PB. Fentanyl reduced the verapamil volume of distribution (V1) and verapamil elimination clearance (ClE). Fentanyl decreased verapamil brain partitioning, yet increased verapamil lung partitioning. Also, loperamide increased lung and brain partitioning in vivo. These results suggest that verapamil and fentanyl may be substrates of an unidentified inward transporter in brain tissue and confirm that verapamil and loperamide are substrates of the efflux transporter P-gp.
Abstract: Biodiversity crisis is one of the many crises that
started at the turn of the millennia. Concrete form of expression is
still disputed, but there is a relatively high consensus regarding the
high rate of degradation and the urgent need for action. The strategy
of action outlines a strong economic component, together with the
recognition of market mechanisms as the most effective policies to
protect biodiversity. In this context, biodiversity and ecosystem
services are natural assets that play a key role in economic strategies
and technological development to promote development and
prosperity. Developing and strengthening policies for transition to an
economy based on efficient use of resources is the way forward.
To emphasize the co-viability specific to the connection economyecosystem
services, scientific approach aimed on one hand how to
implement policies for nature conservation and on the other hand, the
concepts underlying the economic expression of ecosystem services-
value, in the context of current technology. Following the analysis of
business opportunities associated with changes in ecosystem services
was concluded that development of market mechanisms for nature
conservation is a trend that is increasingly stronger individualized
within recent years. Although there are still many controversial issues
that have already given rise to an obvious bias, international
organizations and national governments have initiated and
implemented in cooperation or independently such mechanisms.
Consequently, they created the conditions for convergence between
private interests and social interests of nature conservation, so there
are opportunities for ongoing business development which leads,
among other things, the positive effects on biodiversity. Finally,
points out that markets fail to quantify the value of most ecosystem
services. Existing price signals reflect at best, only a proportion of the
total amount corresponding provision of food, water or fuel.
Abstract: Viral influenza A subtypes H5N1 and pandemic
H1N1 (pH1N1) have worldwide emerged and transmitted. The most
common anti-influenza drug for treatment of both seasonal and
pandemic influenza viruses is oseltamivir that nowadays becomes
resistance to influenza neuraminidase. The novel long-acting drug,
laninamivir, was discovered for treatment of the patients infected
with influenza B and influenza A viruses. In the present study,
laninamivir complexed with wild-type strain of both H5N1 and
pH1N1 viruses were comparatively determined the structures and
drug-target interactions by means of molecular dynamics (MD)
simulations. The results show that the hydrogen bonding interactions
formed between laninamivir and its binding residues are likely
similar for the two systems. Additionally, the presence of
intermolecular interactions from laninamivir to the residues in the
binding pocket is established through their side chains in accordance
with hydrogen bond interactions.
Abstract: In order to enhance the aircraft survivability, the
infrared signatures emitted by hot engine parts should be determined
exactly. For its reduction it is necessary for the rear fuselage
temperature to be decreased. In this study, numerical modeling of flow
fields and heat transfer characteristics of an aircraft nozzle is
performed and its temperature distribution along each component wall
is predicted. The radiation shield is expected to reduce the skin
temperature of rear fuselage. The effect of material characteristic of
radiation shield on the heat transfer is also investigated. Through this
numerical analysis, design parameters related to the susceptibility of
aircraft are examined.
Abstract: High level synthesis (HLS) is a process which
generates register-transfer level design for digital systems from
behavioral description. There are many HLS algorithms and
commercial tools. However, most of these algorithms consider a
behavioral description for the system when a single token is
presented to the system. This approach does not exploit extra
hardware efficiently, especially in the design of digital filters where
common operations may exist between successive tokens. In this
paper, we modify the behavioral description to process multiple
tokens in parallel. However, this approach is unlike the full
processing that requires full hardware replication. It exploits the
presence of common operations between successive tokens. The
performance of the proposed approach is better than sequential
processing and approaches that of full parallel processing as the
hardware resources are increased.
Abstract: We propose a new approach on how to obtain the approximate solutions of Hamilton-Jacobi (HJ) equations. The process of the approximation consists of two steps. The first step is to transform the HJ equations into the virtual time based HJ equations (VT-HJ) by introducing a new idea of ‘virtual-time’. The second step is to construct the approximate solutions of the HJ equations through a computationally iterative procedure based on the VT-HJ equations. It should be noted that the approximate feedback solutions evolve by themselves as the virtual-time goes by. Finally, we demonstrate the effectiveness of our approximation approach by means of simulations with linear and nonlinear control problems.
Abstract: Bus Rapid Transit (BRT) has emerged as a cost-effective transport system for urban mobility. However its ability to stimulate land development remains largely unexplored. The study makes use of qualitative (interview method) and quantitative analysis (questionnaire survey and longitudinal analysis of property data) to investigate land development impact resulting from BRT in Beijing, China. The empirical analysis suggests that BRT has a positive impact on the residential and commercial property attractiveness along the busway corridor. The statistical analysis suggests that accessibility advantage conferred by BRT is capitalized into higher property price. The average price of apartments adjacent to a BRT station has gained a relatively faster increase than those not served by the BRT system. The capitalization effect mostly occurs after the full operation of BRT, and is more evident over time and particularly observed in areas which previously lack alternative mobility opportunity.
Abstract: Harmonic pollution and low power factor in power
systems caused by power converters have been of great concern. To
overcome these problems several converter topologies using
advanced semiconductor devices and control schemes have been
proposed. This investigation is to identify a low cost, small size,
efficient and reliable ac to dc converter to meet the input performance
index of UPS. The performance of single phase and three phase ac to
dc converter along with various control techniques are studied and
compared. The half bridge converter topology with linear current
control is identified as most suitable. It is simple, energy efficient
because of single switch power loss and transformer-less operation of
UPS. The results are validated practically using a prototype built
using IGBT and analog controller. The performance for both single
and three-phase system is verified. Digital implementation of closed
loop control achieves higher reliability. Its cost largely depends on
chosen bit precision. The minimal bit precision for optimum
converter performance is identified as 16-bit with fixed-point
operation. From the investigation and practical implementation it is
concluded that half bridge ac – dc converter along with digital linear
controller meets the performance index of UPS for single and three
phase systems.
Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: In this paper, we propose a routing scheme that guarantees
the residual lifetime of wireless sensor networks where each
sensor node operates with a limited budget of battery energy. The
scheme maximizes the communications QoS while sustaining the
residual battery lifetime of the network for a specified duration.
Communication paths of wireless nodes are translated into a directed
acyclic graph(DAG) and the maximum-flow algorithm is applied to
the graph. The found maximum flow are assigned to sender nodes, so
as to maximize their communication QoS. Based on assigned flows,
the scheme determines the routing path and the transmission rate of
data packet so that any sensor node on the path would not exhaust
its battery energy before a specified duration.
Abstract: In this paper, we demonstrate the adaptive
least-mean-square (LMS) filter modeling using SystemC. SystemC is
a modeling language that allows designer to model both hardware and
software component and makes it possible to design from high level
system of abstraction to low level system of abstraction. We produced
five adaptive least-mean-square filter models that are classed as five
abstraction levels using SystemC proceeding from the abstract model
to the more concrete model.
Abstract: So much energy is used in high rise buildings to fulfill
the basic needs of users such as lighting and thermal comfort.
Malaysia has hot and humid climate, buildings especially high rise
buildings receive unnecessary solar radiation that cause more solar
heat gain. Energy use specially electricity consumption in high rise
buildings has increased. There have been growing concerns about
energy consumption and its effect on environment. Building, energy
and the environment are important issues that the designers should
consider to them. Self protected form is one of possible ways against
the impact of solar radiation in high rise buildings. The Energy
performance of building envelopes was investigated in term of the
Overall Thermal Transfer Value (OTTV ).In this paper, the amount
of OTTV reduction was calculated through OTTV Equations to
clear the effectiveness of self shading strategy on minimizing energy
consumption for cooling interior spaces in high rise buildings which
has considerable envelope areas against solar radiation. Also increasing
the optimum window area was investigated using self-shading
strategy in designing high rise buildings. As result, the significant
reduction in OTTV was shown based on WWR.In addition slight
increase was demonstrated in WWR that can influence on visible
comfort interior spaces.
Abstract: An effort has been taken to simulate the combustion
and performance characteristics of biodiesel fuel in direct injection
(D.I) low heat rejection (LHR) diesel engine. Comprehensive
analyses on combustion characteristics such as cylinder pressure,
peak cylinder pressure, heat release and performance characteristics
such as specific fuel consumption and brake thermal efficiency are
carried out. Compression ignition (C.I) engine cycle simulation was
developed and modified in to LHR engine for both diesel and
biodiesel fuel. On the basis of first law of thermodynamics the
properties at each degree crank angle was calculated. Preparation and
reaction rate model was used to calculate the instantaneous heat
release rate. A gas-wall heat transfer calculations are based on the
ANNAND-s combined heat transfer model with instantaneous wall
temperature to analyze the effect of coating on heat transfer. The
simulated results are validated by conducting the experiments on the
test engine under identical operating condition on a turbocharged D.I
diesel engine. In this analysis 20% of biodiesel (derived from
Jatropha oil) blended with diesel and used in both conventional and
LHR engine. The simulated combustion and performance
characteristics results are found satisfactory with the experimental
value.
Abstract: A numerical study of flow in a horizontally channel
partially filled with a porous screen with non-uniform inlet has been
performed by lattice Boltzmann method (LBM). The flow in porous
layer has been simulated by the Brinkman-Forchheimer model.
Numerical solutions have been obtained for variable porosity models
and the effects of Darcy number and porosity have been studied in
detail. It is found that the flow stabilization is reliant on the Darcy
number. Also the results show that the stabilization of flow field and
heat transfer is depended to Darcy number. Distribution of stream
field becomes more stable by decreasing Darcy number. Results
illustrate that the effect of variable porosity is significant just in the
region of the solid boundary. In addition, difference between constant
and variable porosity models is decreased by decreasing the Darcy
number.
Abstract: Numerical parametric study is conducted to study the effects of ampoule rotation on the flows and the dopant segregation in vertical bridgman (vb) crystal growth. Calculations were performed in unsteady state. The extended darcy model, which includes the time derivative and coriolis terms, has been employed in the momentum equation. It’s found that the convection, and dopant segregation can be affected significantly by ampoule rotation, and the effect is similar to that by an axial magnetic field. Ampoule rotation decreases the intensity of convection and stretches the flow cell axially. When the convection is weak, the flow can be suppressed almost completely by moderate ampoule rotation and the dopant segregation becomes diffusion-controlled. For stronger convection, the elongated flow cell by ampoule rotation may bring dopant mixing into the bulk melt reducing axial segregation at the early stage of the growth. However, if the cellular flow cannot be suppressed completely, ampoule rotation may induce larger radial segregation due to poor mixing.
Abstract: Industrial robots play a vital role in automation
however only little effort are taken for the application of robots in
machining work such as Grinding, Cutting, Milling, Drilling,
Polishing etc. Robot parallel manipulators have high stiffness,
rigidity and accuracy, which cannot be provided by conventional
serial robot manipulators. The aim of this paper is to perform the
modeling and the workspace analysis of a 3 DOF Parallel
Manipulator (3 DOF PM). The 3 DOF PM was modeled and
simulated using 'ADAMS'. The concept involved is based on the
transformation of motion from a screw joint to a spherical joint
through a connecting link. This paper work has been planned to
model the Parallel Manipulator (PM) using screw joints for very
accurate positioning. A workspace analysis has been done for the
determination of work volume of the 3 DOF PM. The position of the
spherical joints connected to the moving platform and the
circumferential points of the moving platform were considered for
finding the workspace. After the simulation, the position of the joints
of the moving platform was noted with respect to simulation time and
these points were given as input to the 'MATLAB' for getting the
work envelope. Then 'AUTOCAD' is used for determining the work
volume. The obtained values were compared with analytical
approach by using Pappus-Guldinus Theorem. The analysis had been
dealt by considering the parameters, link length and radius of the
moving platform. From the results it is found that the radius of
moving platform is directly proportional to the work volume for a
constant link length and the link length is also directly proportional
to the work volume, at a constant radius of the moving platform.