Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: Even it has been recognized that Shape Memory
Alloys (SMA) have a significant potential for deployment actuators,
the number of applications of SMA-based actuators to the present
day is still quite small, due to the need of deep understanding of the
thermo-mechanical behavior of SMA, causing an important need for
a mathematical model able to describe all thermo-mechanical
properties of SMA by relatively simple final set of constitutive
equations. SMAs offer attractive potentials such as: reversible strains
of several percent, generation of high recovery stresses and high
power / weight ratios. The paper tries to provide an overview of the
shape memory functions and a presentation of the designed and
developed temperature control system used for a gripper actuated by
two pairs of differential SMA active springs. An experimental setup
was established, using electrical energy for actuator-s springs heating
process. As for holding the temperature of the SMA springs at certain
level for a long time was developed a control system in order to
avoid the active elements overheating.
Abstract: In this investigation, anatase TiO2 thin films were
grown by radio frequency magnetron sputtering on glass substrates at
a high sputtering pressure and room temperature. The anatase films
were then annealed at 300-600 °C in air for a period of 1 hour. To
examine the structure and morphology of the films, X-ray diffraction
(XRD) and atomic force microscopy (AFM) methods were used
respectively. From X-ray diffraction patterns of the TiO2 films, it was
found that the as-deposited film showed some differences compared
with the annealed films and the intensities of the peaks of the
crystalline phase increased with the increase of annealing
temperature. From AFM images, the distinct variations in the
morphology of the thin films were also observed. The optical
constants were characterized using the transmission spectra of the
films obtained by UV-VIS-IR spectrophotometer. Besides, optical
thickness of the film deposited at room temperature was calculated
and cross-checked by taking a cross-sectional image through SEM.
The optical band gaps were evaluated through Tauc model. It was
observed that TiO2 films produced at room temperatures exhibited
high visible transmittance and transmittance decreased slightly with
the increase of annealing temperatures. The films were found to be
crystalline having anatase phase. The refractive index of the films
was found from 2.31-2.35 in the visible range. The extinction
coefficient was nearly zero in the visible range and was found to
increase with annealing temperature. The allowed indirect optical
band gap of the films was estimated to be in the range from 3.39 to
3.42 eV which showed a small variation. The allowed direct band
gap was found to increase from 3.67 to 3.72 eV. The porosity was
also found to decrease at a higher annealing temperature making the
film compact and dense.
Abstract: A complex valued neural network is a neural network
which consists of complex valued input and/or weights and/or thresholds
and/or activation functions. Complex-valued neural networks
have been widening the scope of applications not only in electronics
and informatics, but also in social systems. One of the most important
applications of the complex valued neural network is in signal
processing. In Neural networks, generalized mean neuron model
(GMN) is often discussed and studied. The GMN includes a new
aggregation function based on the concept of generalized mean of all
the inputs to the neuron. This paper aims to present exhaustive results
of using Generalized Mean Neuron model in a complex-valued neural
network model that uses the back-propagation algorithm (called
-Complex-BP-) for learning. Our experiments results demonstrate the
effectiveness of a Generalized Mean Neuron Model in a complex
plane for signal processing over a real valued neural network. We
have studied and stated various observations like effect of learning
rates, ranges of the initial weights randomly selected, error functions
used and number of iterations for the convergence of error required on
a Generalized Mean neural network model. Some inherent properties
of this complex back propagation algorithm are also studied and
discussed.
Abstract: Image convolution similar to the receptive fields
found in mammalian visual pathways has long been used in
conventional image processing in the form of Gabor masks.
However, no VLSI implementation of parallel, multi-layered pulsed
processing has been brought forward which would emulate this
property. We present a technical realization of such a pulsed image
processing scheme. The discussed IC also serves as a general testbed
for VLSI-based pulsed information processing, which is of interest
especially with regard to the robustness of representing an analog
signal in the phase or duration of a pulsed, quasi-digital signal, as
well as the possibility of direct digital manipulation of such an
analog signal. The network connectivity and processing properties
are reconfigurable so as to allow adaptation to various processing
tasks.
Abstract: In this study, an ablation, mechanical and thermal properties of a rocket motor insulation from phenolic/ fiber matrix composites forming a laminate with different fiber between fiberglass and locally available synthetic fibers. The phenolic/ fiber matrix composites was mechanics and thermal properties by means of tensile strength, ablation, TGA and DSC. The design of thermal insulation involves several factors.Determined the mechanical properties according to MIL-I-24768: Density >1.3 g/cm3, Tensile strength >103 MPa and Ablation
Abstract: Post growth annealing of solution grown ZnO
nanowire array is performed under controlled oxygen ambience. The
role of annealing over surface defects and their consequence on
dark/photo-conductivity and photosensitivity of nanowire array is
investigated. Surface defect properties are explored using various
measurement tools such as contact angle, photoluminescence, Raman
spectroscopy and XPS measurements. The contact angle of the NW
films reduces due to oxygen annealing and nanowire film surface
changes from hydrophobic (96°) to hydrophilic (16°). Raman and
XPS spectroscopy reveal that oxygen annealing improves the crystal
quality of the nanowire films. The defect band emission intensity
(relative to band edge emission, ID/IUV) reduces from 1.3 to 0.2 after
annealing at 600 °C at 10 SCCM flow of oxygen. An order
enhancement in dark conductivity is observed in O2 annealed
samples, while photoconductivity is found to be slightly reduced due
to lower concentration of surface related oxygen defects.
Abstract: Compacted clay liners (CCLs) are the main materials
used in waste disposal landfills due to their low permeability. In this
study, the effect on the shear resistant of clays with inorganic salt
solutions as permeate fluid was experimentally investigated. For this
purpose, NaCl inorganic salt solution at concentrations of 2, 5, 10%
and deionized water were used. Laboratory direct shear and Vane
shear tests were conducted on three compacted clays with low,
medium and high plasticity. Results indicated that the solutions type
and its concentration affect the shear properties of the mixture. In the
light of this study, the influence magnitude of these inorganic salts in
varies concentrations in different clays were determined and more
suitable compacted clay with the compare of plasticity were found.
Abstract: In this paper, the signal transmission analysis of the
semicircle-shaped via structure for the differential pairs is presented in
the frequency range up to 10 GHz. In order to improve the signal
transmission properties in the differential pairs, single via is separated
centrally into two semicircle-shaped sections, which are
interconnected with the traces of differential pairs respectively. This
via structure make possible to route differential pairs using only one
via. In addition, it can improve impedance discontinuity around its
region and then enhance the signal transmission properties in the
differential pairs. The electrical analysis such as S-parameter
calculation and eye diagram simulation has been performed to
investigate the improvement of the signal transmission property in the
differential pairs with new via structure.
Abstract: Modeling of Panel Zone (PZ) seismic behavior,
because of its role in overall ductility and lateral stiffness of steel
moment frames, has been considered a challenge for years. There are
some studies regarding the effects of different doubler plates
thicknesses and geometric properties of PZ on its seismic behavior.
However, there is not much investigation on the effects of number of
provided continuity plates in case of presence of one triangular
haunch, two triangular haunches and rectangular haunch (T shape
haunches) for exterior columns. In this research first detailed finite
element models of 12tested connection of SAC joint venture were
created and analyzed then obtained cyclic behavior backbone curves
of these models besides other FE models for similar tests were used
for neural network training. Then seismic behavior of these data is
categorized according to continuity plate-s arrangements and
differences in type of haunches. PZ with one-sided haunches have
little plastic rotation. As the number of continuity plates increases
due to presence of two triangular haunches (four continuity plate),
there will be no plastic rotation, in other words PZ behaves in its
elastic range. In the case of rectangular haunch, PZ show more plastic
rotation in comparison with one-sided triangular haunch and
especially double-sided triangular haunches. Moreover, the models
that will be presented in case of triangular one-sided and double-
sided haunches and rectangular haunches as a result of this study
seem to have a proper estimation of PZ seismic behavior.
Abstract: Solidification cracking and hydrogen cracking are some defects generated in the fusion welding of ultrahigh carbon steels. However, friction stir welding (FSW) of such steels, being a solid-state technique, has been demonstrated to alleviate such problems encountered in traditional welding. FSW include different process parameters that must be carefully defined prior processing. These parameters included but not restricted to: tool feed, tool RPM, tool geometry, tool tilt angle. These parameters form a key factor behind avoiding warm holes and voids behind the tool and in achieving a defect-free weld. More importantly, these parameters directly affect the microstructure of the weld and hence the final mechanical properties of weld. For that, 3D finite element (FE) thermo-mechanical model was developed using DEFORM 3D to simulate FSW of carbon steel. At points of interest in the joint, tracking is done for history of critical state variables such as temperature, stresses, and strain rates. Typical results found include the ability to simulate different weld zones. Simulations predictions were successfully compared to experimental FSW tests. It is believed that such a numerical model can be used to optimize FSW processing parameters to favor desirable defect free weld with better mechanical properties.
Abstract: In this study, the thermal and mechanical properties of
basalt fibre reinforced concrete were investigated. The volume
fractions of basalt fibre of (0.1, 0.2, 0.3, and 0.5% by total mix
volume) were used. Properties such as heat transfer, compressive and
splitting tensile strengths were examined. Results indicated that the
strength increases with increase the fibre content till 0.3% then there
is a slight reduction when 0.5% fibre used. Lower amount of heat
conducted through the thickness of concrete specimens than the
conventional concrete was also recorded.
Abstract: This study was conducted in order to determine the physical properties and stability of mayonnaise-like emulsions as affected by modified yam starches. Native yam starch was modified via pre-gelatinization and cross-linking phosphorylation procedures. The emulsions (50% oil dispersed phase) were prepared with 0.3% native potato, native yam, pre-gelatinized yam and cross-linking phosphorylation yam starches. The droplet size of surface weighted mean diameter was found to be significantly (p < 0.05) lower in the sample with cross-linking phosphorylation yam starch as compared to other samples. Moreover, the viscosity of the sample with pregelatinized yam starch was observed to be higher than that of other samples. The phase separation stability was low in the freshly prepared and stored (45 days, 5°C) emulsions containing native yam starch. This study thus generally suggested that modified yam starches were more suitable (i.e. better physical properties and stability) to be used as stabilizers in a similar system i.e. light mayonnaises, rather than a native yam starch.
Abstract: The objective of this research is to study principal
component analysis for classification of 67 soil samples collected from
different agricultural areas in the western part of Thailand. Six soil
properties were measured on the soil samples and are used as original
variables. Principal component analysis is applied to reduce the
number of original variables. A model based on the first two
principal components accounts for 72.24% of total variance. Score
plots of first two principal components were used to map with
agricultural areas divided into horticulture, field crops and wetland.
The results showed some relationships between soil properties and
agricultural areas. PCA was shown to be a useful tool for agricultural
areas classification based on soil properties.
Abstract: The objective of this work is to study the influence of the properties of the substrate on the retrofit (thin repair) of damaged concrete elements, with the SCC. Fluidity, principal characteristic of the SCC, would enable it to cover and adhere to the concrete to be repaired. Two aspects of repair are considered, the bond (Adhesion) and the tensile strength and the cracking. The investigation is experimental; It was conducted over test specimens made up of ordinary concrete prepared and hardened in advance (the material to be repaired) over which a self compacting concrete layer is cast. Three alternatives of SC concrete and one ordinary concrete (comparison) were tested. It appears that the self-compacting concrete constitutes a good material for repairing. It follows perfectly the surfaces- forms to be repaired and allows a perfect bond. Fracture tests made on specimens of self-compacting concrete show a brittle behaviour. However when a small percentage of fibres is added, the resistance to cracking is very much improve.
Abstract: Gasoline Octane Number is the standard measure of
the anti-knock properties of a motor in platforming processes, that is
one of the important unit operations for oil refineries and can be
determined with online measurement or use CFR (Cooperative Fuel
Research) engines. Online measurements of the Octane number can
be done using direct octane number analyzers, that it is too
expensive, so we have to find feasible analyzer, like ANFIS
estimators.
ANFIS is the systems that neural network incorporated in fuzzy
systems, using data automatically by learning algorithms of NNs.
ANFIS constructs an input-output mapping based both on human
knowledge and on generated input-output data pairs.
In this research, 31 industrial data sets are used (21 data for training
and the rest of the data used for generalization). Results show that,
according to this simulation, hybrid method training algorithm in
ANFIS has good agreements between industrial data and simulated
results.
Abstract: In this paper we introduce the notion of protein interaction
network. This is a graph whose vertices are the protein-s
amino acids and whose edges are the interactions between them.
Using a graph theory approach, we identify a number of properties of
these networks. We compare them to the general small-world network
model and we analyze their hierarchical structure.
Abstract: Application of wood in rural construction is diffused
all around the world since remote times. However, its inclusion in
structural design deserves strong support from broad knowledge of
material properties. The pertinent literature reveals the application of
optical methods in determining the complete field displacement on
bodies exhibiting regular as well as irregular surfaces. The use of
moiré techniques in experimental mechanics consists in analyzing the
patterns generated on the body surface before and after deformation.
The objective of this research work is to study the qualitative
deformation behavior of wooden testing specimens under specific
loading situations. The experiment setup follows the literature
description of shadow moiré methods. Results indicate strong
anisotropy influence of the generated displacement field. Important
qualitative as well as quantitative stress and strain distribution were
obtained wooden members which are applicable to rural
constructions.
Abstract: The spin (ms) and orbital (mo) magnetic moment of
the antiferromagnetic NiO and MnO have been studied in the local
spin density approximation (LSDA+U) within full potential linear
muffin-tin orbital (FP-LMTO method with in the coulomb interaction
U varying from 0 to 10eV, exchange interaction J, from 0 to 1.0eV,
and volume compression VC in range of 0 to 80%. Our calculated
results shown that the spin magnetic moments and the orbital
magnetic moments increase linearly with increasing U and J. While
the interesting behaviour appears when volume compression is
greater than 70% for NiO and 50% for MnO at which ms collapses.
Further increase of volume compression to be at 80% leads to the
disappearance of both magnetic moments.
Abstract: Polymers are one of the most widely used materials in our every day life. The subject of renewable resources has attracted great attention in the last period of time. New polymeric materials derived from renewable resources, like carbohydrates draw attention to public eye especially because of their biocompatibility and biodegradability. The aim of our paper was to obtain environmentally compatible polymers from monosaccharides. Novel glycopolymers based on D-glucose have been obtained from copolymerization of a new monomer carrying carbohydrate moiety with methyl methacrylate (MMA) via free radical bulk polymerization. Differential scanning calorimetry (DSC) was performed in order to study the copolymerization process of the monomer into the chosen co-monomer; the activation energy of this process was evaluated using Ozawa method. The copolymers obtained were characterized using ATR-FTIR spectroscopy. The thermal stability of the obtained products was studied by thermogravimetry (TG).