Abstract: MicroRNAs are small non-coding RNA found in
many different species. They play crucial roles in cancer such as
biological processes of apoptosis and proliferation. The identification
of microRNA-target genes can be an essential first step towards to
reveal the role of microRNA in various cancer types. In this paper,
we predict miRNA-target genes for lung cancer by integrating
prediction scores from miRanda and PITA algorithms used as a
feature vector of miRNA-target interaction. Then, machine-learning
algorithms were implemented for making a final prediction. The
approach developed in this study should be of value for future studies
into understanding the role of miRNAs in molecular mechanisms
enabling lung cancer formation.
Abstract: Cavities are frequently found beneath conduits on pile
foundations in old embankments. Cavity reduces seepage length
significantly and consequently causes piping failure of embankments.
Case studies of embankment failures indicate that the relative
settlement between ground and pile supported-concrete conduit was
the main reason of the cavity. In this paper, an attempt to simulate the
cavity-induced piping failure mechanism was made using finite
element numerical method. Piping potential is examined by carrying
out parametric study for influencing factors such as cavity length,
water level, and flow conditions. The concentration of hydraulic
gradient adjacent to cavity was found. It is found that the hydraulic
gradient close to the cavity exceeds considerably the critical hydraulic
gradient causing piping. Piping failure potential due to the existence of
cavity is evaluated and contour map for the potential risk of an
embankment for piping failure is proposed.
Abstract: In recent years, a wide variety of applications are developed with Support Vector Machines -SVM- methods and Artificial Neural Networks -ANN-. In general, these methods depend on intrusion knowledge databases such as KDD99, ISCX, and CAIDA among others. New classes of detectors are generated by machine learning techniques, trained and tested over network databases. Thereafter, detectors are employed to detect anomalies in network communication scenarios according to user’s connections behavior. The first detector based on training dataset is deployed in different real-world networks with mobile and non-mobile devices to analyze the performance and accuracy over static detection. The vulnerabilities are based on previous work in telemedicine apps that were developed on the research group. This paper presents the differences on detections results between some network scenarios by applying traditional detectors deployed with artificial neural networks and support vector machines.
Abstract: Electric field is an important fundamental concept in
electrostatics. In high-school, generally Thai students have already
learned about definition of electric field, electric field due to a point
charge, and superposition of electric fields due to multiple-point
charges. Those are the prerequisite basic knowledge students holding
before entrancing universities. In the first-year university level,
students will be quickly revised those basic knowledge and will be
then introduced to a more complicated topic—electric field due to
continuous charged distributions. We initially found that our
freshman students, who were from the Faculty of Science and
enrolled in the introductory physic course (SCPY 158), often
seriously struggled with the basic physics concepts—superposition of
electric fields and inverse square law and mathematics being relevant
to this topic. These also then resulted on students’ understanding of
advanced topics within the course such as Gauss's law, electric
potential difference, and capacitance. Therefore, it is very important
to determine students' understanding of electric field due to
continuous charged distributions. The open-ended question about
sketching net electric field vectors from a uniformly charged
insulating rod was administered to 260 freshman science students as
pre- and post-tests. All of their responses were analyzed and
classified into five levels of understandings. To get deep
understanding of each level, 30 students were interviewed toward
their individual responses. The pre-test result found was that about
90% of students had incorrect understanding. Even after completing
the lectures, there were only 26.5% of them could provide correct
responses. Up to 50% had confusions and irrelevant ideas. The result
implies that teaching methods in Thai high schools may be
problematic. In addition for our benefit, these students’ alternative
conceptions identified could be used as a guideline for developing the
instructional method currently used in the course especially for
teaching electrostatics.
Abstract: The aim of this article is to identify the measures
companies undertake in order to adapt to the environment as well as
discussing their diversity and effectiveness. The research methods
used in the study include an in-depth analysis of the literature and a
case study, which helps to illustrate the issue in question. Referring to
the concept of agility, which is firmly embedded in the theory of
strategic management and has been developed with the aim of
adapting to the environment and its changes, the paper first examines
different types of adaptation measures for companies. Then the issue
under discussion is illustrated with the example of the company
Hortimex. This company is an eminent representative of the world’s
leading manufacturers of food additives and ingredients. The
company was established in 1988 and is a family business, which in
practice means that it conducts business in a responsible manner,
observing the law and respecting the interests of society and the
environment. The company’s mission is to develop a market in
Poland for the products and solutions offered by their partners and to
share their knowledge of additives in food production and
consumption.
Abstract: In this paper, a desiccant solar unit for air
conditioning and desalination is presented first. Secondly, a dynamic
modelling study of the desiccant wheel is developed. After that, a
simulation study and an experimental investigation of the behaviour
of desiccant wheel are developed. The experimental investigation is
done in the chamber of commerce in Freiburg-Germany. Indeed, the
variations of calculated and measured temperatures and specific
humidity of dehumidified and rejected air are presented where a good
agreement is found when comparing the model predictions with
experimental data under the considered range of operating conditions.
Finally, the study of the compartments of desalination and water
condensation shows that the unit can produce an acceptable quantity
of water at the same time of the air conditioning operation.
Abstract: The tribological test with Pin-On-Disc configuration
measures friction and wear properties in dry or lubricated sliding
surfaces of a variety of materials and coatings. Polymeric matrix
composites loaded with mineral filler were used, 1%, 3%, 10%, 30%,
and 50% mass percentage of filler, to reduce the material cost by
using mineral tailings. Using a pin-on-disc tribometer to quantify
coefficient of friction and wear resistance of the specimens. The
parameters known to performing the test were 300 rpm rotation,
normal load of 16N and duration of 33.5 minutes. The composite
with 10% mineral filler performed better, considering that the wear
resistance was good when compared to the other compositions and an
average low coefficient of friction, in the order of μ ≤ 0.15.
Abstract: The Flexible AC Transmission System (FACTS)
technology is a new advanced solution that increases the reliability
and provides more flexibility, controllability, and stability of a power
system. The Unified Power Flow Controller (UPFC), as the most
versatile FACTS device for regulating power flow, is able to control
respectively transmission line real power, reactive power, and node
voltage. The main purpose of this paper is to analyze the effect of the
UPFC on the load flow, the power losses, and the voltage stability
using NEPLAN software modules, Newton-Raphson load flow is
used for the power flow analysis and the modal analysis is used for
the study of the voltage stability. The simulation was carried out on
the IEEE 14-bus test system.
Abstract: The combination of the properties of graphene oxide
(OG) and PVDF homopolymer makes their combined composite
materials as multifunctional systems with great potential. Knowledge
of the molecular structure is essential for better use. In this work, the
degradation of PVDF polymer exposed to gamma irradiation in
oxygen atmosphere in high dose rate has been studied and compared
to degradation of PVDF/OG composites. The samples were irradiated
with a Co-60 source at constant dose rate, with doses ranging from
100 kGy to 1,000 kGy. In FTIR data shown that the formation of
oxidation products was at the both samples with formation of
carbonyl and hydroxyl groups amongst the most prevalent products
in the pure PVDF samples. In the other hand, the composites samples
exhibit less presence of degradation products with predominant
formation of carbonyl groups, these results also seen in the UV-Vis
analysis. The results show that the samples of composites may have
greater resistance to the irradiation process, since they have less
degradation products than pure PVDF samples seen by spectroscopic
techniques.
Abstract: Autologous Chondrocyte Implantation (ACI) is used worldwide since 1998 to treat cartilage defect. GEL based ACI is a new tissue-engineering technique to treat full thickness cartilage defect with fibrin and thrombin as scaffold for chondrocytes. Purpose of this study is to see safety and efficacy of gel based ACI for knee cartilage defect in multiple centres with different surgeons. Gel-based Autologous Chondrocyte Implantation (GACI) has shown effectiveness in treating isolated cartilage defect of knee joint. Long term results are still needed to be studied. This study was followed-up up to two years and showed benefit to patients. All enrolled patients with a mean age of 28.5 years had an average defect size of3 square centimeters, and were grade IV as per ICRS grading. All patients were followed up several times and at several intervals at 6th week, 8th week, 11th week, 17th week, 29th week, 57th week after surgery. The outcomes were measured based on the IKDC (subjective and objective) and MOCART scores.
Abstract: Fe-2%Mn-0.5%Si-0.2C steel was welded and corroded
at 600, 700 and 800oC for 20 h in 1 atm of N2/H2S/H2O-mixed gas in
order to characterize the high-temperature corrosion behavior of the
welded joint. Corrosion proceeded fast and almost linearly. It
increased with an increase in the corrosion temperature. H2S formed
FeS owing to sulfur released from H2S. The scales were fragile and
nonadherent.
Abstract: HMS Industrial Networks AB has been recognized as
one of the most innovative companies in the industrial
communication industry worldwide. The creation of their Anybus
innovation during the 1990s contributed considerably to the
company’s success. From inception, HMS’ employees were
innovating for the purpose of creating new business (the creation
phase). After the Anybus innovation, they began the process of
internationalization (the commercialization phase), which in turn led
them to concentrate on cost reduction, product quality, delivery
precision, operational efficiency, and increasing growth (the growth
phase). As a result of this transformation, performing new radical
innovations have become more complicated. The purpose of our research was to explore the dynamics of
innovation at HMS from the aspect of key actors, activities, and
events, over the three phases, in order to understand what led to the
creation of their Anybus innovation, and why it has become
increasingly challenging for HMS to create new radical innovations
for the future. Our research methodology was based on a longitudinal,
retrospective study from the inception of HMS in 1988 to 2014, a
single case study inspired by the grounded theory approach. We
conducted 47 interviews and collected 1 024 historical documents for
our research. Our analysis has revealed that HMS’ success in creating the
Anybus, and developing a successful business around the innovation,
was based on three main capabilities – cultivating customer relations
on different managerial and organizational levels, inspiring business
relations, and balancing complementary human assets for the purpose
of business creation. The success of HMS has turned the management’s attention away
from past activities of key actors, of their behavior, and how they
influenced and stimulated the creation of radical innovations.
Nowadays, they are rhetorically focusing on creativity and
innovation. All the while, their real actions put emphasis on growth,
cost reduction, product quality, delivery precision, operational
efficiency, and moneymaking. In the process of becoming an
international company, HMS gradually refocused. In so doing they
became profitable and successful, but they also forgot what made
them innovative in the first place. Fortunately, HMS’ management
has come to realize that this is the case and they are now in search of
recapturing innovation once again. Our analysis indicates that HMS’ management is facing several
barriers to innovation related path dependency and other lock-in
phenomena. HMS’ management has been captured, trapped in their
mindset and actions, by the success of the past. But now their future has to be secured, and they have come to realize that moneymaking is
not everything. In recent years, HMS’ management have begun to
search for innovation once more, in order to recapture their past
capabilities for creating radical innovations. In order to unlock their
managerial perceptions of customer needs and their counter-innovation
driven activities and events, to utilize the full potential of
their employees and capture the innovation opportunity for the future.
Abstract: The exploitation of flow pulsation in micro- and
mini-channels is a potentially useful technique for enhancing cooling
of high-end photonics and electronics systems. It is thought that
pulsation alters the thickness of the hydrodynamic and thermal
boundary layers, and hence affects the overall thermal resistance
of the heat sink. Although the fluid mechanics and heat transfer
are inextricably linked, it can be useful to decouple the parameters
to better understand the mechanisms underlying any heat transfer
enhancement. Using two-dimensional, two-component particle image
velocimetry, the current work intends to characterize the heat transfer
mechanisms in pulsating flow with a mean Reynolds number of
48 by experimentally quantifying the hydrodynamics of a generic
liquid-cooled channel geometry. Flows circulated through the test
section by a gear pump are modulated using a controller to achieve
sinusoidal flow pulsations with Womersley numbers of 7.45 and
2.36 and an amplitude ratio of 0.75. It is found that the transient
characteristics of the measured velocity profiles are dependent on the
speed of oscillation, in accordance with the analytical solution for
flow in a rectangular channel. A large velocity overshoot is observed
close to the wall at high frequencies, resulting from the interaction
of near-wall viscous stresses and inertial effects of the main fluid
body. The steep velocity gradients at the wall are indicative of
augmented heat transfer, although the local flow reversal may reduce
the upstream temperature difference in heat transfer applications.
While unsteady effects remain evident at the lower frequency, the
annular effect subsides and retreats from the wall. The shear rate at
the wall is increased during the accelerating half-cycle and decreased
during deceleration compared to steady flow, suggesting that the flow
may experience both enhanced and diminished heat transfer during
a single period. Hence, the thickness of the hydrodynamic boundary
layer is reduced for positively moving flow during one half of the
pulsation cycle at the investigated frequencies. It is expected that the
size of the thermal boundary layer is similarly reduced during the
cycle, leading to intervals of heat transfer enhancement.
Abstract: Surface characteristics of Bacillus megaterium strain
were investigated; zeta potential, FTIR and contact angle were
measured. Surface energy components including Lifshitz-van der
Waals, Hamaker constant, and acid/base components (Lewis
acid/Lewis base) were calculated from the contact angle data. The
results showed that the microbial cells were negatively charged over
all pH regions with high values at alkaline region. A hydrophilic
nature for the strain was confirmed by contact angle and free energy
of adhesion between microbial cells. Adsorption affinity of the strain
toward dolomite was studied at different pH values. The results
showed that the cells had a high affinity to dolomite at acid pH
comparing to neutral and alkaline pH. Extended DLVO theory was
applied to calculate interaction energy between B. megaterium cells
and dolomite particles. The adsorption results were in agreement with
the results of Extended DLVO approach. Surface changes occurred
on dolomite surface after the bio-treatment were monitored; contact
angle decreased from 69° to 38° and the mineral’s floatability
decreased from 95% to 25% after the treatment.
Abstract: Sisal leaves were subjected to enzymatic retting
method to extract the sisal fibre. A portion of the fibre was pretreated
with alkali (NaOH), and further treated with benzoyl chloride
and silane treatment reagents. Both the treated and untreated Sisal
fibre composites were used to fabricate the composite by hand lay-up
technique using unsaturated polyester resin. Tensile, flexural, water
absorption, density, thickness swelling and chemical resistant tests
were conducted and evaluated on the composites. Results obtained
for all the parameters showed an increase in the treated fibre
compared to untreated fibre. FT-IR spectra results ascertained the
inclusion of benzoyl and silane groups on the fibre surface. Scanning
electron microscopy (SEM) result obtained showed variation in the
morphology of the treated and untreated fibre. Chemical modification
was found to improve adhesion of the fibre to the matrix, as well as
physico-mechanical properties of the composites.
Abstract: The railway transport is considered as a one of the
most environmentally friendly mode of transport. With future
prediction of increasing of freight transport there are lines facing
problems with demanded capacity. Increase of the track capacity
could be achieved by infrastructure constructive adjustments. The
contribution shows how the travel time can be minimized and the
track capacity increased by changing some of the basic infrastructure
and operation parameters, for example, the minimal curve radius of
the track, the number of tracks, or the usable track length at stations.
Calculation of the necessary parameter changes is based on the
fundamental physical laws applied to the train movement, and
calculation of the occupation time is dependent on the changes of
controlling the traffic between the stations.
Abstract: Strategic investment decisions are characterized by
high innovation potential and long-term effects on the
competitiveness of enterprises. Due to the uncertainty and risks
involved in this complex decision making process, the need arises for
well-structured support activities. A method that considers cost and
the long-term added value is the cost-benefit effectiveness estimation.
One of those methods is the “profitability estimation focused on
benefits – PEFB”-method developed at the Institute of Management
Cybernetics at RWTH Aachen University. The method copes with
the challenges associated with strategic investment decisions by
integrating long-term non-monetary aspects whilst also mapping the
chronological sequence of an investment within the organization’s
target system. Thus, this method is characterized as a holistic
approach for the evaluation of costs and benefits of an investment.
This participation-oriented method was applied to business
environments in many workshops. The results of the workshops are a
library of more than 96 cost aspects, as well as 122 benefit aspects.
These aspects are preprocessed and comparatively analyzed with
regards to their alignment to a series of risk levels. For the first time,
an accumulation and a distribution of cost and benefit aspects
regarding their impact and probability of occurrence are given. The
results give evidence that the PEFB-method combines precise
measures of financial accounting with the incorporation of benefits.
Finally, the results constitute the basics for using information
technology and data science for decision support when applying
within the PEFB-method.
Abstract: Cloud computing is a business model which provides
an easier management of computing resources. Cloud users can
request virtual machine and install additional softwares and configure
them if needed. However, user can also request virtual appliance
which provides a better solution to deploy application in much faster
time, as it is ready-built image of operating system with necessary
softwares installed and configured. Large numbers of virtual
appliances are available in different image format. User can
download available appliances from public marketplace and start
using it. However, information published about the virtual appliance
differs from each providers leading to the difficulty in choosing
required virtual appliance as it is composed of specific OS with
standard software version. However, even if user choses the
appliance from respective providers, user doesn’t have any flexibility
to choose their own set of softwares with required OS and
application. In this paper, we propose a referenced architecture for
dynamically customizing virtual appliance and provision them in an
easier manner. We also add our experience in integrating our
proposed architecture with public marketplace and Mi-Cloud, a cloud
management software.
Abstract: Recently developed cooperative diversity scheme
enables a terminal to get transmit diversity through the support of other
terminals. However, most of the introduced cooperative schemes have
a common fault of decreased transmission rate because the destination
should receive the decodable compositions of symbols from the source
and the relay. In order to achieve high data rate, we propose a
cooperative scheme that employs hierarchical modulation. This
scheme is free from the rate loss and allows seamless cooperative
communication.
Abstract: The aim of this research is to understand how the
emerging power bloc BRICS employs infrastructure development
narratives to construct a new world order. BRICS is an international
body consisting of five emerging countries that collaborate on
economic and political issues: Brazil, Russia, India, China, and South
Africa. This study explores the projection of infrastructure
development narratives through an analysis of BRICS’ attention to
infrastructure investment and financing, its support of the New
Partnership on African Development and the establishment of the
New Development Bank in Shanghai. The theory of Strategic
Narratives is used to explore BRICS’ commitment to infrastructure
development and to distinguish three layers: system narratives
(BRICS as a global actor to propose development reform), identity
narratives (BRICS as a collective identity joining efforts to act upon
development aspirations) and issue narratives (BRICS committed to a
range of issues of which infrastructure development is prominent).
The methodology that is employed is a narrative analysis of BRICS’
official documents, media statements, and website imagery. A
comparison of these narratives illuminates tensions at the three layers
and among the five member states. Identifying tensions among
development infrastructure narratives provides an indication of how
policymaking for infrastructure development could be improved.
Subsequently, it advances BRICS’ ability to act as a global actor to
construct a new world order.