Abstract: The objective of the present study was to evaluate the
potential of hollow microneedles for enhancing the transdermal
delivery of Bovine Serum Albumin (MW~66,000 Da)-Fluorescein
Isothiocyanate (BSA-FITC) conjugate, a hydrophilic large molecular
compound. Moreover, the effect of different formulations was
evaluated. The series of binary mixtures composed of propylene
glycol (PG) and pH 7.4 phosphate buffer solution (PBS) was
prepared and used as a medium for BSA-FITC. The results showed
that there was no permeation of BSA-FITC solution across the
neonatal porcine skin without using hollow microneedles, whereas
the cumulative amount of BSA-FITC released at 8 h through the
neonatal porcine skin was about 60-70% when using hollow
microneedles. Furthermore, the results demonstrated that the higher
volume of PG in binary mixtures injected, the lower cumulative
amount of BSA-FITC released and release rate of BSA-FITC from
skin. These release profiles of BSA-FITC in binary mixtures were
expressed by Fick-s law of diffusion. These results suggest the
utilization of hollow microneedle to enhance transdermal delivery of
protein and provide useful information for designing an effective
hollow microneedle system.
Abstract: A new concept for long-term reagent storage for Labon- a-Chip (LoC) devices is described. Here we present a polymer multilayer stack with integrated stick packs for long-term storage of several liquid reagents, which are necessary for many diagnostic applications. Stick packs are widely used in packaging industry for storing solids and liquids for long time. The storage concept fulfills two main requirements: First, a long-term storage of reagents in stick packs without significant losses and interaction with surroundings, second, on demand releasing of liquids, which is realized by pushing a membrane against the stick pack through pneumatic pressure. This concept enables long-term on-chip storage of liquid reagents at room temperature and allows an easy implementation in different LoC devices.
Abstract: HSDPA is a new feature which is introduced in
Release-5 specifications of the 3GPP WCDMA/UTRA standard to
realize higher speed data rate together with lower round-trip times.
Moreover, the HSDPA concept offers outstanding improvement of
packet throughput and also significantly reduces the packet call
transfer delay as compared to Release -99 DSCH. Till now the
HSDPA system uses turbo coding which is the best coding technique
to achieve the Shannon limit. However, the main drawbacks of turbo
coding are high decoding complexity and high latency which makes
it unsuitable for some applications like satellite communications,
since the transmission distance itself introduces latency due to
limited speed of light. Hence in this paper it is proposed to use LDPC
coding in place of Turbo coding for HSDPA system which decreases
the latency and decoding complexity. But LDPC coding increases the
Encoding complexity. Though the complexity of transmitter
increases at NodeB, the End user is at an advantage in terms of
receiver complexity and Bit- error rate. In this paper LDPC Encoder
is implemented using “sparse parity check matrix" H to generate a
codeword at Encoder and “Belief Propagation algorithm "for LDPC
decoding .Simulation results shows that in LDPC coding the BER
suddenly drops as the number of iterations increase with a small
increase in Eb/No. Which is not possible in Turbo coding. Also same
BER was achieved using less number of iterations and hence the
latency and receiver complexity has decreased for LDPC coding.
HSDPA increases the downlink data rate within a cell to a theoretical
maximum of 14Mbps, with 2Mbps on the uplink. The changes that
HSDPA enables includes better quality, more reliable and more
robust data services. In other words, while realistic data rates are
only a few Mbps, the actual quality and number of users achieved
will improve significantly.
Abstract: The study and development of an innovative material
for building insulation is really important for a sustainable society in order to improve comfort and reducing energy consumption. The aim of this work is the development of insulating panels for
sustainable buildings based on an innovative material made by
cardboard and Phase Change Materials (PCMs).
The research has consisted in laboratory tests whose purpose has been the obtaining of the required properties for insulation panels: lightweight, porous structures and mechanical resistance. PCMs have been used for many years in the building industry as
smart insulation technology because of their properties of storage and release high quantity of latent heat at useful specific temperatures [1]- [2].
The integration of PCMs into cellulose matrix during the waste paper recycling process has been developed in order to obtain a
composite material.
Experiments on the productive process for the realization of insulating panels were done in order to make the new material
suitable for building application. The addition of rising agents
demonstrated the possibility to obtain a lighter structure with better
insulation properties.
Several tests were conducted to verify the new panel properties. The results obtained have shown the possibility to realize an
innovative and sustainable material suitable to replace insulating panels currently used.
Abstract: The present study conducted experimental investigation on combustion and emission characteristics of compression ignition engine using diesel as pilot fuel and methane, hydrogen and methane/hydrogen mixture as gaseous fuels at 1800 rev min-1. The effect of gaseous fuel on peak cylinder pressure and heat release is modest at low to medium loads. At high load, the high combustion temperature and high quantity of pilot fuel contribute to better combustion efficiency for all kinds of gaseous fuels and increases the peak cylinder pressure. Enrichment of hydrogen in methane gradually increases the peak cylinder pressure. The brake thermal efficiency increases with higher hydrogen fraction at lower loads. Hydrogen addition in methane contributed to a proportional reduction of CO/CO2/HC emission without penalty of NOx. For particulate emission, methane and hydrogen, could both suppress the particle emission. 30% hydrogen fraction in methane is observed to be best in reducing the particulate emission.
Abstract: In this paper we present high performance
dynamically allocated multi-queue (DAMQ) buffer schemes for fault
tolerance systems on chip applications that require an interconnection
network. Two virtual channels shared the same buffer space. Fault
tolerant mechanisms for interconnection networks are becoming a
critical design issue for large massively parallel computers. It is also
important to high performance SoCs as the system complexity keeps
increasing rapidly. On the message switching layer, we make
improvement to boost system performance when there are faults
involved in the components communication. The proposed scheme is
when a node or a physical channel is deemed as faulty, the previous
hop node will terminate the buffer occupancy of messages destined
to the failed link. The buffer usage decisions are made at switching
layer without interactions with higher abstract layer, thus buffer
space will be released to messages destined to other healthy nodes
quickly. Therefore, the buffer space will be efficiently used in case
fault occurs at some nodes.
Abstract: The National Bridge Inventory (NBI) includes more
than 600,000 bridges within the United States of America.
Prestressed concrete girder bridges represent one of the most widely
used bridge systems. The majority of these girder bridges were
constructed using 0.5 and 0.6 inch diameter strands. The main
impediments to using larger strand diameters are: 1) lack of prestress
bed capacities, 2) lack of structural knowledge regarding the transfer
and development length of larger strands, and 3) the possibility of
developing wider end zone cracks upon strand release.
This paper presents a study about using 0.7 inch strands in girder
fabrication. Transfer and development length were evaluated, and
girders were fabricated using 0.7 inch strands at different spacings.
Results showed that 0.7 inch strands can be used at 2.0 inch spacing
without violating the AASHTO LRFD Specifications, while attaining
superior performance in shear and flexure.
Abstract: This work presents the mixed-mode II/III prestressed split-cantilever beam specimen for the fracture testing of composite materials. In accordance with the concept of prestressed composite beams one of the two fracture modes is provided by the prestressed state of the specimen, and the other one is increased up to fracture initiation by using a testing machine. The novel beam-like specimen is able to provide any combination of the mode-II and mode-III energy release rates. A simple closed-form solution is developed using beam theory as a data reduction scheme and for the calculation of the energy release rates in the new configuration. The applicability and the limitations of the novel fracture mechanical test are demonstrated using unidirectional glass/polyester composite specimens. If only crack propagation onset is involved then the mixed-mode beam specimen can be used to obtain the fracture criterion of transparent composite materials in the GII - GIII plane in a relatively simple way.
Abstract: Homogeneous Charge Compression (HCCI) Ignition technology has been around for a long time, but has recently received renewed attention and enthusiasm. This paper deals with experimental investigations of HCCI engine using hydrous methanol as a primary fuel and Dimethyl Ether (DME) as an ignition improver. A regular diesel engine has been modified to work as HCCI engine for this investigation. The hydrous methanol is inducted and DME is injected into a single cylinder engine. Hence, hydrous methanol is used with 15% water content in HCCI engine and its performance and emission behavior is documented. The auto-ignition of Methanol is enabled by DME. The quantity of DME varies with respect to the load. In this study, the experiments are conducted independently and the effect of the hydrous methanol on the engine operating limit, heat release rate and exhaust emissions at different load conditions are investigated. The investigation also proves that the Hydrous Methanol with DME operation reduces the oxides of Nitrogen and smoke to an extreme low level which is not possible by the direct injection CI engine. Therefore, it is beneficial to use hydrous methanol-DME HCCI mode while using hydrous methanol in internal Combustion Engines.
Abstract: Bicycle configuration is not as large as those of motorcycles or automobiles, while it indeed composes a complicated dynamic system. People-s requirements on comfortability, controllability and safety grow higher as the research and development technologies improve. The shock absorber affects the vehicle suspension performances enormously. The absorber takes the vibration energy and releases it at a suitable time, keeping the wheel under a proper contact condition with road surface, maintaining the vehicle chassis stability. Suspension design for mountain bicycles is more difficult than that of city bikes since it encounters dynamic variations on road and loading conditions. Riders need a stiff damper as they exert to tread on the pedals when climbing, while a soft damper when they descend downhill. Various switchable shock absorbers are proposed in markets, however riders have to manually switch them among soft, hard and lock positions. This study proposes a novel design of the bicycle shock absorber, which provides automatic smooth tuning of the damping coefficient, from a predetermined lower bound to theoretically unlimited. An automatic quick releasing valve is involved in this design so that it can release the peak pressure when the suspension fork runs into a square-wave type obstacle and prevent the chassis from damage, avoiding the rider skeleton from injury. This design achieves the automatic tuning process by innovative plunger valve and fluidic passage arrangements without any electronic devices. Theoretical modelling of the damper and spring are established in this study. Design parameters of the valves and fluidic passages are determined. Relations between design parameters and shock absorber performances are discussed in this paper. The analytical results give directions to the shock absorber manufacture.
Abstract: Solution for the complete removal of carbon
monoxide from the exhaust gases still poses a challenge to the
researchers and this problem is still under development. Modeling for
reduction of carbon monoxide is carried out using heterogeneous
reaction using low cost non-noble metal based catalysts for the
purpose of controlling emissions released to the atmosphere. A
simple one-dimensional model was developed for the monolith using
hopcalite catalyst. The converter is assumed to be an adiabatic
monolith operating under warm-up conditions. The effect of inlet gas
temperatures and catalyst loading on carbon monoxide reduction
during cold start period in the converter is analysed.
Abstract: Considering a reservoir with periodic states and
different cost functions with penalty, its release rules can be
modeled as a periodic Markov decision process (PMDP). First,
we prove that policy- iteration algorithm also works for the
PMDP. Then, with policy- iteration algorithm, we obtain the
optimal policies for a special aperiodic reservoir model with
two cost functions under large penalty and give a discussion
when the penalty is small.
Abstract: The systematic manipulations of shapes and sizes of
inorganic compounds greatly benefit the various application fields
including optics, magnetic, electronics, catalysis and medicine.
However shape control has been much more difficult to achieve.
Hence exploration of novel method for the preparation of differently
shaped nanoparticles is challenging research area. II-VI group of
semiconductor cadmium sulphide (CdS) nanostructure with different
morphologies (such as, acicular like, mesoporous, spherical shapes)
and of crystallite sizes vary from 11 to 16 nm were successfully
synthesized by chemical aqueous precipitation of Cd2+ ions with
homogeneously released S2- ions from decomposition of cadmium
sulphate (CdSO4) and thioacetamide (CH3CSNH2) by annealing at
different radiations (microwave, ultrasonic and sunlight) with matter
and systematic research has been done for various factors affecting
the controlled growth rate of CdS nanoparticles. The obtained
nanomaterials have been characterized by X-ray Diffraction (XRD),
Fourier Transform Infrared Spectroscopy (FTIR),
Thermogravometric (DSC-TGA) analysis and Scanning Electron
Microscopy (SEM). The result indicates that on increasing the
reaction time particle size increases but on increasing the molar ratios
grain size decreases.
Abstract: Grid computing is growing rapidly in the distributed
heterogeneous systems for utilizing and sharing large-scale resources
to solve complex scientific problems. Scheduling is the most recent
topic used to achieve high performance in grid environments. It aims
to find a suitable allocation of resources for each job. A typical
problem which arises during this task is the decision of scheduling. It
is about an effective utilization of processor to minimize tardiness
time of a job, when it is being scheduled. This paper, therefore,
addresses the problem by developing a general framework of grid
scheduling using dynamic information and an ant colony
optimization algorithm to improve the decision of scheduling. The
performance of various dispatching rules such as First Come First
Served (FCFS), Earliest Due Date (EDD), Earliest Release Date
(ERD), and an Ant Colony Optimization (ACO) are compared.
Moreover, the benefit of using an Ant Colony Optimization for
performance improvement of the grid Scheduling is also discussed. It
is found that the scheduling system using an Ant Colony
Optimization algorithm can efficiently and effectively allocate jobs
to proper resources.
Abstract: Malware is software which was invented and meant for doing harms on computers. Malware is becoming a significant threat in computer network nowadays. Malware attack is not just only involving financial lost but it can also cause fatal errors which may cost lives in some cases. As new Internet Protocol version 6 (IPv6) emerged, many people believe this protocol could solve most malware propagation issues due to its broader addressing scheme. As IPv6 is still new compares to native IPv4, some transition mechanisms have been introduced to promote smoother migration. Unfortunately, these transition mechanisms allow some malwares to propagate its attack from IPv4 to IPv6 network environment. In this paper, a proof of concept shall be presented in order to show that some existing IPv4 malware detection technique need to be improvised in order to detect malware attack in dual-stack network more efficiently. A testbed of dual-stack network environment has been deployed and some genuine malware have been released to observe their behaviors. The results between these different scenarios will be analyzed and discussed further in term of their behaviors and propagation methods. The results show that malware behave differently on IPv6 from the IPv4 network protocol on the dual-stack network environment. A new detection technique is called for in order to cater this problem in the near future.
Abstract: Although achieving zero-defect software release is
practically impossible, software industries should take maximum
care to detect defects/bugs well ahead in time allowing only bare
minimums to creep into released version. This is a clear indicator of
time playing an important role in the bug detection. In addition to
this, software quality is the major factor in software engineering
process. Moreover, early detection can be achieved only through
static code analysis as opposed to conventional testing.
BugCatcher.Net is a static analysis tool, which detects bugs in .NET®
languages through MSIL (Microsoft Intermediate Language)
inspection. The tool utilizes a Parser based on Finite State Automata
to carry out bug detection. After being detected, bugs need to be
corrected immediately. BugCatcher.Net facilitates correction, by
proposing a corrective solution for reported warnings/bugs to end
users with minimum side effects. Moreover, the tool is also capable
of analyzing the bug trend of a program under inspection.
Abstract: In this study the mixed mode fracture mechanics
parameters were investigated for high tensile steel butt welded joint
based on modified Arcan test and finite element analysis was used to
evaluate the effect of crack length on fracture criterion. The nondimensional
stress intensity factors, strain energy release rates and Jintegral
energy on crack tip were obtained for various in-plane
loading combinations on Arcan specimen starting from pure mode-I
to pure mode-II loading conditions. The specimen and apparatus were
modeled by finite element method and analyzed under various
loading angles (between 0 to 90 degrees with 15 degree interval) to
simulate the pure mode-I, II and mixed mode fracture. Since the
analytical results are independent from elasticity modules for
isotropic materials, therefore the results in elastic fields can be used
for Arcan specimens. The main objective of this study was to
evaluate the geometric calibration factors for modified Arcan test
specimen in order to obtain fracture toughness under mixed mode
loading conditions.
Abstract: Hazardous Material transportation by road is coupled
with inherent risk of accidents causing loss of lives, grievous injuries,
property losses and environmental damages. The most common type
of hazmat road accident happens to be the releases (78%) of
hazardous substances, followed by fires (28%), explosions (14%) and
vapour/ gas clouds (6 %.).
The paper is discussing initially the probable 'Impact Zones'
likely to be caused by one flammable (LPG) and one toxic (ethylene
oxide) chemicals being transported through a sizable segment of a
State Highway connecting three notified Industrial zones in Surat
district in Western India housing 26 MAH industrial units. Three
'hotspots' were identified along the highway segment depending on
the particular chemical traffic and the population distribution within
500 meters on either sides. The thermal radiation and explosion
overpressure have been calculated for LPG / Ethylene Oxide BLEVE
scenarios along with toxic release scenario for ethylene oxide.
Besides, the dispersion calculations for ethylene oxide toxic release
have been made for each 'hotspot' location and the impact zones
have been mapped for the LOC concentrations. Subsequently, the
maximum Initial Isolation and the protective zones were calculated
based on ERPG-3 and ERPG-2 values of ethylene oxide respectively
which are estimated taking the worst case scenario under worst
weather conditions. The data analysis will be helpful to the local
administration in capacity building with respect to rescue /
evacuation and medical preparedness and quantitative inputs to
augment the District Offsite Emergency Plan document.
Abstract: Sedimentation in reservoirs and the corresponding
loss of storage capacity is one of the most serious problems in dam
engineering. Pressurized flushing, a way to remove sediments from the reservoir, is flushing under a pressurized flow condition and
nearly constant water level. Pressurized flushing has only local
effects around the outlet. Sediment in the vicinity of the outlet openings is scoured and a funnel shaped crater is created. In this study, the temporal development of flushing cone under various
hydraulic conditions was studied experimentally. Time variations of
parameters such as maximum length and width of flushing and also
depth of scouring cone was measured. Results indicated that an
increase in flow velocity (and consequently in Froude number)
established new hydraulically conditions for flushing mechanism and
so a sudden growth was observed in the amount of sediment released
and also scouring dimenssions. In addition, a set of nondimensional
relationships were identified for temporal variations of flushing scour
dimenssions, which can eventuallt be used to estimate the development of flushing cone.
Abstract: Software Reliability is one of the key factors in the software development process. Software Reliability is estimated using reliability models based on Non Homogenous Poisson Process. In most of the literature the Software Reliability is predicted only in testing phase. So it leads to wrong decision-making concept. In this paper, two Software Reliability concepts, testing and operational phase are studied in detail. Using S-Shaped Software Reliability Growth Model (SRGM) and Exponential SRGM, the testing and operational reliability values are obtained. Finally two reliability values are compared and optimal release time is investigated.