Abstract: Yeast cells live in a constantly changing environment that requires the continuous adaptation of their genomic program in order to sustain their homeostasis, survive and proliferate. Due to the advancement of high throughput technologies, there is currently a large amount of data such as gene expression, gene deletion and protein-protein interactions for S. Cerevisiae under various environmental conditions. Mining these datasets requires efficient computational methods capable of integrating different types of data, identifying inter-relations between different components and inferring functional groups or 'modules' that shape intracellular processes. This study uses computational methods to delineate some of the mechanisms used by yeast cells to respond to environmental changes. The GRAM algorithm is first used to integrate gene expression data and ChIP-chip data in order to find modules of coexpressed and co-regulated genes as well as the transcription factors (TFs) that regulate these modules. Since transcription factors are themselves transcriptionally regulated, a three-layer regulatory cascade consisting of the TF-regulators, the TFs and the regulated modules is subsequently considered. This three-layer cascade is then modeled quantitatively using artificial neural networks (ANNs) where the input layer corresponds to the expression of the up-stream transcription factors (TF-regulators) and the output layer corresponds to the expression of genes within each module. This work shows that (a) the expression of at least 33 genes over time and for different stress conditions is well predicted by the expression of the top layer transcription factors, including cases in which the effect of up-stream regulators is shifted in time and (b) identifies at least 6 novel regulatory interactions that were not previously associated with stress-induced changes in gene expression. These findings suggest that the combination of gene expression and protein-DNA interaction data with artificial neural networks can successfully model biological pathways and capture quantitative dependencies between distant regulators and downstream genes.
Abstract: Exploring an autistic child in Elementary school is a
difficult task that must be fully thought out and the teachers should
be aware of the many challenges they face raising their child
especially the behavioral problems of autistic children. Hence there
arises a need for developing Artificial intelligence (AI)
Contemporary Techniques to help diagnosis to discover autistic
people.
In this research, we suggest designing architecture of expert
system that combine Cognitive Maps (CM) with Case Based
Reasoning technique (CBR) in order to reduce time and costs of
traditional diagnosis process for the early detection to discover
autistic children. The teacher is supposed to enter child's information
for analyzing by CM module. Then, the reasoning processor would
translate the output into a case to be solved a current problem by
CBR module. We will implement a prototype for the model as a
proof of concept using java and MYSQL.
This will be provided a new hybrid approach that will achieve new
synergies and improve problem solving capabilities in AI. And we
will predict that will reduce time, costs, the number of human errors
and make expertise available to more people who want who want to
serve autistic children and their families.
Abstract: In this paper, we propose a practical digital music matching system that is robust to variation in sound qualities. The proposed system is subdivided into two parts: client and server. The client part consists of the input, preprocessing and feature extraction modules. The preprocessing module, including the music onset module, revises the value gap occurring on the time axis between identical songs of different formats. The proposed method uses delta-grouped Mel frequency cepstral coefficients (MFCCs) to extract music features that are robust to changes in sound quality. According to the number of sound quality formats (SQFs) used, a music server is constructed with a feature database (FD) that contains different sub feature databases (SFDs). When the proposed system receives a music file, the selection module selects an appropriate SFD from a feature database; the selected SFD is subsequently used by the matching module. In this study, we used 3,000 queries for matching experiments in three cases with different FDs. In each case, we used 1,000 queries constructed by mixing 8 SQFs and 125 songs. The success rate of music matching improved from 88.6% when using single a single SFD to 93.2% when using quadruple SFDs. By this experiment, we proved that the proposed method is robust to various sound qualities.
Abstract: Synthetic juice clarification was done through spiral
wound ultrafiltration (UF) membrane module. Synthetic juice was
clarified at two different operating conditions, such as, with and
without permeates recycle at turbulent flow regime. The performance
of spiral wound ultrafiltration membrane was analyzed during
clarification of synthetic juice. Synthetic juice was the mixture of
deionized water, sucrose and pectin molecule. The operating
conditions are: feed flowrate of 10 lpm, pressure drop of 413.7 kPa
and Reynolds no of 5000. Permeate sample was analyzed in terms of
volume reduction factor (VRF), viscosity (Pa.s), ⁰Brix, TDS (mg/l),
electrical conductivity (μS) and turbidity (NTU). It was observe that
the permeate flux declined with operating time for both conditions of
with and without permeate recycle due to increase of concentration
polarization and increase of gel layer on membrane surface. For
without permeate recycle, the membrane fouling rate was faster
compared to with permeate recycle. For without permeate recycle,
the VRF rose up to 5 and for with recycle permeate the VRF is 1.9.
The VRF is higher due to adsorption of solute (pectin) molecule on
membrane surface and resulting permeateflux declined with VRF.
With permeate recycle, quality was within acceptable limit. Fouled
membrane was cleaned by applying different processes (e.g.,
deionized water, SDS and EDTA solution). Membrane cleaning was
analyzed in terms of permeability recovery.
Abstract: Transferring patient information between medical care
sites is necessary to deliver better patient care and to reduce medical
cost. So developing of electronic medical records is an important trend
for the world.The Continuity of Care Document (CCD) is product of
collaboration between CDA and CCR standards. In this study, we will
develop a system to generate medical records with entry level based on
CCD template module.
Abstract: The cost of developing the software from scratch can
be saved by identifying and extracting the reusable components from
already developed and existing software systems or legacy systems
[6]. But the issue of how to identify reusable components from
existing systems has remained relatively unexplored. We have used
metric based approach for characterizing a software module. In this
present work, the metrics McCabe-s Cyclometric Complexity
Measure for Complexity measurement, Regularity Metric, Halstead
Software Science Indicator for Volume indication, Reuse Frequency
metric and Coupling Metric values of the software component are
used as input attributes to the different types of Neural Network
system and reusability of the software component is calculated. The
results are recorded in terms of Accuracy, Mean Absolute Error
(MAE) and Root Mean Squared Error (RMSE).
Abstract: The technological concepts such as wireless hospital
and portable cardiac telemetry system require the development of
physiological signal acquisition devices to be easily integrated into
the hospital database. In this paper we present the low cost, portable
wireless ECG acquisition hardware that transmits ECG signals to a
dedicated computer.The front end of the system obtains and
processes incoming signals, which are then transmitted via a
microcontroller and wireless Bluetooth module. A monitoring
purpose Bluetooth based end user application integrated with patient
database management module is developed for the computers. The
system will act as a continuous event recorder, which can be used to
follow up patients who have been resuscitatedfrom cardiac arrest,
ventricular tachycardia but also for diagnostic purposes for patients
with arrhythmia symptoms. In addition, cardiac information can be
saved into the patient-s database of the hospital.
Abstract: Vacuum membrane distillation (VMD) process can be
used for water purification or the desalination of salt water. The
process simply consists of a flat sheet hydrophobic micro porous
PTFE membrane and diaphragm vacuum pump without a condenser
for the water recovery or trap. The feed was used aqueous NaCl
solution. The VMD experiments were performed to evaluate the heat
and mass transfer coefficient of the boundary layer in a membrane
module. The only operating parameters are feed inlet temperature,
and feed flow rate were investigated. The permeate flux was strongly
affected by the feed inlet temperature, feed flow rate, and boundary
layer heat transfer coefficient. Since lowering the temperature
polarization coefficient is essential enhance the process performance
considerable and maximizing the heat transfer coefficient for
maximizes the mass flux of distillate water. In this paper, the results
of VMD experiments are used to measure the boundary layer heat
transfer coefficient, and the experimental results are used to reevaluate
the empirical constants in the Dittus- Boelter equation.
Abstract: In this paper, the implementation of a rule-based
intuitive reasoner is presented. The implementation included two
parts: the rule induction module and the intuitive reasoner. A large
weather database was acquired as the data source. Twelve weather
variables from those data were chosen as the “target variables"
whose values were predicted by the intuitive reasoner. A “complex"
situation was simulated by making only subsets of the data available
to the rule induction module. As a result, the rules induced were
based on incomplete information with variable levels of certainty.
The certainty level was modeled by a metric called "Strength of
Belief", which was assigned to each rule or datum as ancillary
information about the confidence in its accuracy. Two techniques
were employed to induce rules from the data subsets: decision tree
and multi-polynomial regression, respectively for the discrete and the
continuous type of target variables. The intuitive reasoner was tested
for its ability to use the induced rules to predict the classes of the
discrete target variables and the values of the continuous target
variables. The intuitive reasoner implemented two types of
reasoning: fast and broad where, by analogy to human thought, the
former corresponds to fast decision making and the latter to deeper
contemplation. . For reference, a weather data analysis approach
which had been applied on similar tasks was adopted to analyze the
complete database and create predictive models for the same 12
target variables. The values predicted by the intuitive reasoner and
the reference approach were compared with actual data. The intuitive
reasoner reached near-100% accuracy for two continuous target
variables. For the discrete target variables, the intuitive reasoner
predicted at least 70% as accurately as the reference reasoner. Since
the intuitive reasoner operated on rules derived from only about 10%
of the total data, it demonstrated the potential advantages in dealing
with sparse data sets as compared with conventional methods.
Abstract: The use of hard and brittle material has become
increasingly more extensive in recent years. Therefore processing of
these materials for the parts fabrication has become a challenging
problem. However, it is time-consuming to machine the hard brittle
materials with the traditional metal-cutting technique that uses
abrasive wheels. In addition, the tool would suffer excessive wear as
well. However, if ultrasonic energy is applied to the machining
process and coupled with the use of hard abrasive grits, hard and
brittle materials can be effectively machined. Ultrasonic machining
process is mostly used for the brittle materials. The present research
work has developed models using finite element approach to predict
the mechanical stresses sand strains produced in the tool during
ultrasonic machining process. Also the flow behavior of abrasive
slurry coming out of the nozzle has been studied for simulation using
ANSYS CFX module. The different abrasives of different grit sizes
have been used for the experimentation work.
Abstract: Model Predictive Control has been previously applied
to supply chain problems with promising results; however hitherto
proposed systems possessed no information on future demand. A
forecasting methodology will surely promote the efficiency of
control actions by providing insight on the future. A complete supply
chain management framework that is based on Model Predictive
Control (MPC) and Time Series Forecasting will be presented in this
paper. The proposed framework will be tested on industrial data in
order to assess the efficiency of the method and the impact of
forecast accuracy on overall control performance of the supply chain.
To this end, forecasting methodologies with different characteristics
will be implemented on test data to generate forecasts that will serve
as input to the Model Predictive Control module.
Abstract: We present a simulation and realization of a battery
charge regulator (BCR) in microsatellite earth observation. The tests
were performed on battery pack 12volt, capacity 24Ah and the solar array open circuit voltage of 100 volt and optimum power of about
250 watt. The battery charge is made by solar module. The principle is to adapt the output voltage of the solar module to the battery by
using the technique of pulse width modulation (PWM). Among the different techniques of charge battery, we opted for the technique of
the controller ON/OFF is a standard technique and simple, it-s easy to
be board executed validation will be made by simulation "Proteus Isis
Professional software ". The circuit and the program of this prototype
are based on the PIC16F877 microcontroller, a serial interface connecting a PC is also realized, to view and save data and graphics
in real time, for visualization of data and graphs we develop an interface tool “visual basic.net (VB)--.
Abstract: The dramatic effect of information technology on
society is undeniable. In education, it is evident in the use of terms
like active learning, blended learning, electronic learning and mobile
learning (ubiquitous learning). This study explores the perceptions of
54 learners in a higher education institution regarding the use of
mobile devices in a third year module. Using semi-structured
interviews, it was found that mobile devices had a positive impact on
learner motivation, engagement and enjoyment. It also improved the
consistency of learning material, and the convenience and flexibility
(anywhere, anytime) of learning. User-interfacelimitation, bandwidth
and cognitive overload, however, were of concern. The use of cloud
based resources like Youtube and Google Docs, through mobile
devices, positively influenced learner perceptions, making them
prosumers (both consumers and producers) of education content.
Abstract: Since 2005, an SRF module of CESR type serves as the
accelerating cavity at the Taiwan Light Source in the National
Synchrotron Radiation Research Center. A 500-MHz niobium cavity
is immersed in liquid helium inside this SRF module. To reduce heat
load, the liquid helium vessel is thermally shielded by
liquid-nitrogen-cooled copper layer, and the beam chambers are also
anchored with pipes of the liquid nitrogen flow in middle of the liquid
helium vessel and the vacuum vessel. A strong correlation of the
movement of the cavity-s frequency tuner with the temperature
variation of parts cooled with liquid nitrogen was observed. A
previous study on a spare SRF module with the niobium cavity cooled
by liquid nitrogen instead of liquid helium, satisfactory suppression of
the thermal oscillation was achieved by attaching a temporary buffer
tank for the vented shielding nitrogen flow from the SRF module. In
this study, a home-made buffer tank is designed and integrated to the
spare SRF module with cavity cooled by liquid helium. Design,
construction, integration, and preliminary test results of this buffer
tank are presented.
Abstract: The goal of this project is to design a system to
recognition voice commands. Most of voice recognition systems
contain two main modules as follow “feature extraction" and “feature
matching". In this project, MFCC algorithm is used to simulate
feature extraction module. Using this algorithm, the cepstral
coefficients are calculated on mel frequency scale. VQ (vector
quantization) method will be used for reduction of amount of data to
decrease computation time. In the feature matching stage Euclidean
distance is applied as similarity criterion. Because of high accuracy
of used algorithms, the accuracy of this voice command system is
high. Using these algorithms, by at least 5 times repetition for each
command, in a single training session, and then twice in each testing
session zero error rate in recognition of commands is achieved.
Abstract: The main aim of this research is to investigate a novel technique for implementing a more natural and intelligent conversation system. Conversation systems are designed to converse like a human as much as their intelligent allows. Sometimes, we can think that they are the embodiment of Turing-s vision. It usually to return a predetermined answer in a predetermined order, but conversations abound with uncertainties of various kinds. This research will focus on an integrated natural language processing approach. This approach includes an integrated knowledge-base construction module, a conversation understanding and generator module, and a state manager module. We discuss effectiveness of this approach based on an experiment.
Abstract: In this work, we examine fluid mixing in a full three-stream mixing channel with longitudinal vortex generators (LVGs) built on the channel bottom by numerical simulation and experiment. The effects of the asymmetrical arrangement and the attack angle of the LVGs on fluid mixing are investigated. The results show that the micromixer with LVGs at a small asymmetry index (defined by the ratio of the distance from the center plane of the gap between the winglets to the center plane of the main channel to the width of the main channel) is superior to the micromixer with symmetric LVGs and that with LVGs at a large asymmetry index. The micromixer using five mixing modules of the LVGs with an attack angle between 16.5 degrees and 22.5 degrees can achieve excellent mixing over a wide range of Reynolds numbers. Here, we call a section of channel with two pairs of staggered asymmetrical LVGs a mixing module. Besides, the micromixer with LVGs at a small attack angle is more efficient than that with a larger attack angle when pressure losses are taken into account.
Abstract: The aged are faced with increasing risk for falls. The
aged have the easily fragile bones than others. When falls have
occurred, it is important to detect this emergency state because such
events often lead to more serious illness or even death. A
implementation of PDA system, for detection of emergency situation,
was developed using 3-axis accelerometer in this paper as follows.
The signals were acquired from the 3-axis accelerometer, and then
transmitted to the PDA through Bluetooth module. This system can
classify the human activity, and also detect the emergency state like
falls. When the fall occurs, the system generates the alarm on the
PDA. If a subject does not respond to the alarm, the system determines
whether the current situation is an emergency state or not, and then
sends some information to the emergency center in the case of urgent
situation. Three different studies were conducted on 12 experimental
subjects, with results indicating a good accuracy. The first study was
performed to detect the posture change of human daily activity. The
second study was performed to detect the correct direction of fall. The
third study was conducted to check the classification of the daily
physical activity. Each test was lasted at least 1 min. in third study.
The output of acceleration signal was compared and evaluated by
changing a various posture after attaching a 3-axis accelerometer
module on the chest. The newly developed system has some important
features such as portability, convenience and low cost. One of the
main advantages of this system is that it is available at home
healthcare environment. Another important feature lies in low cost to
manufacture device. The implemented system can detect the fall
accurately, so will be widely used in emergency situation.
Abstract: We introduce the notion of strongly ω -Gorenstein modules, where ω is a faithfully balanced self-orthogonal module. This gives a common generalization of both Gorenstein projective (injective) modules and ω-Gorenstein modules. We investigate some characterizations of strongly ω -Gorenstein modules. Consequently, some properties under change of rings are obtained.
Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.