Abstract: Grid scheduling is the process of mapping grid jobs to resources over multiple administrative domains. Traditionally, application-level schedulers have been tightly integrated with the application itself and were not easily applied to other applications. This design is generic that decouples the scheduler core (the search procedure) from the application-specific (e.g. application performance models) and platform-specific (e.g. collection of resource information) components used by the search procedure. In this decoupled approach the application details are not revealed completely to broker, but customer will give the application to resource provider for execution. In a decoupled approach, apart from scheduling, the resource selection can be performed independently in order to achieve scalability.
Abstract: The agriculture lignocellulosic by-products are receiving increased attention, namely in the search for filter materials that retain contaminants from water. These by-products, specifically almond and hazelnut shells are abundant in Portugal once almond and hazelnuts production is a local important activity. Hazelnut and almond shells have as main constituents lignin, cellulose and hemicelluloses, water soluble extractives and tannins. Along the adsorption of heavy metals from contaminated waters, water soluble compounds can leach from shells and have a negative impact in the environment. Usually, the chemical characterization of treated water by itself may not show environmental impact caused by the discharges when parameters obey to legal quality standards for water. Only biological systems can detect the toxic effects of the water constituents. Therefore, the evaluation of toxicity by biological tests is very important when deciding the suitability for safe water discharge or for irrigation applications.
The main purpose of the present work was to assess the potential impacts of waters after been treated for heavy metal removal by hazelnut and almond shells adsorption systems, with short term acute toxicity tests.
To conduct the study, water at pH 6 with 25 mg.L-1 of lead, was treated with 10 g of shell per litre of wastewater, for 24 hours. This procedure was followed for each bark. Afterwards the water was collected for toxicological assays; namely bacterial resistance, seed germination, Lemna minor L. test and plant grow. The effect in isolated bacteria strains was determined by disc diffusion method and the germination index of seed was evaluated using lettuce, with temperature and humidity germination control for 7 days. For aquatic higher organism, Lemnas were used with 4 days contact time with shell solutions, in controlled light and temperature. For terrestrial higher plants, biomass production was evaluated after 14 days of tomato germination had occurred in soil, with controlled humidity, light and temperature.
Toxicity tests of water treated with shells revealed in some extent effects in the tested organisms, with the test assays showing a close behaviour as the control, leading to the conclusion that its further utilization may not be considered to create a serious risk to the environment.
Abstract: This paper describes part of a project about Learningby-
Modeling (LbM). Studying complex systems is increasingly
important in teaching and learning many science domains. Many
features of complex systems make it difficult for students to develop
deep understanding. Previous research indicates that involvement
with modeling scientific phenomena and complex systems can play a
powerful role in science learning. Some researchers argue with this
view indicating that models and modeling do not contribute to
understanding complexity concepts, since these increases the
cognitive load on students. This study will investigate the effect of
different modes of involvement in exploring scientific phenomena
using computer simulation tools, on students- mental model from the
perspective of structure, behavior and function. Quantitative and
qualitative methods are used to report about 121 freshmen students
that engaged in participatory simulations about complex phenomena,
showing emergent, self-organized and decentralized patterns. Results
show that LbM plays a major role in students' concept formation
about complexity concepts.
Abstract: The purpose of present paper was to investigate
perceptions of Korean secondary school students about social issues
related to biological sciences. Twenty issues were selected based on
topics of articles in the newspaper from 2005 to 2010. The issues were
categorized into biotechnology, health-disease and environment
domains. Subjects were 541 high school students (male 253 and
female 288). On the survey, students were asked to answer on 5-point
Lickert scales how they thought of the effect of biological phenomena
or events related to biological issues on the individual life and the
society. They perceived that the biological issues would be more
effectible on the society than on the individual life. Female students
had a little more perceptions than males.
Abstract: This study proposes a basic molecular formula for all
proteins. A total of 10,739 proteins belonging to 9 different protein
groups classified on the basis of their functions were selected
randomly. They included enzymes, storage proteins, hormones,
signalling proteins, structural proteins, transport proteins,
immunoglobulins or antibodies, motor proteins and receptor proteins.
After obtaining the protein molecular formula using the ProtParam
tool, the H/C, N/C, O/C, and S/C ratios were determined for each
randomly selected sample. In this case, H, N, O, and S coefficients
were specified per carbon atom. Surprisingly, the results
demonstrated that H, N, O, and S coefficients for all 10,739 proteins
are similar and highly correlated. This study demonstrates that
despite differences in the structure and function, all known proteins
have a similar basic molecular formula CnH1.58 ± 0.015nN0.28 ± 0.005nO0.30
± 0.007nS0.01 ± 0.002n. The total correlation between all coefficients was
found to be 0.9999.
Abstract: The study of proteomics reached unexpected levels of
interest, as a direct consequence of its discovered influence over
some complex biological phenomena, such as problematic diseases
like cancer. This paper presents a new technique that allows for an
accurate analysis of the human interactome network. It is basically
a two-step analysis process that involves, at first, the detection of
each protein-s absolute importance through the betweenness centrality
computation. Then, the second step determines the functionallyrelated
communities of proteins. For this purpose, we use a community
detection technique that is based on the edge betweenness
calculation. The new technique was thoroughly tested on real biological
data and the results prove some interesting properties of those proteins that are involved in the carcinogenesis process. Apart from its
experimental usefulness, the novel technique is also computationally
effective in terms of execution times. Based on the analysis- results, some topological features of cancer mutated proteins are presented
and a possible optimization solution for cancer drugs design is suggested.
Abstract: Multiphasing of dc-dc converters has been known to give technical and economical benefits to low voltage high power buck regulator modules. A major advantage of multiphasing dc-dc converters is the improvement of input and output performances in the buck converter. From this aspect, a potential use would be in renewable energy where power quality plays an important factor. This paper presents the design of a 2-phase 200W boost converter for battery charging application. Analysis of results from hardware measurement of the boost converter demonstrates the benefits of using multiphase. Results from the hardware prototype of the 2-phase boost converter further show the potential extension of multiphase beyond its commonly used low voltage high current domains.
Abstract: The Bangnanglee Sub-district Administrative Office,
Thailand had initiated a policy to environmental protection with
encouraging household waste management in order to promote civil
responsibility for domestic hygienic. This research studied the
household behaviors on solid waste and wastewater management. A
sample population of 306 families answered a questionnaire. The
study showed that, on average, domestic activities had produced 1.93
kilograms of waste per household per day. It has been found that 79%
of the households made several attempts to reduce their own amount
of waste. 80% of the households stationed their own garbage bins.
71% managed their waste by selling recyclable products. As for the
rest of the waste, 51% burned them, while 29% disposed their waste
in the nearby public trashcans and other 13% have them buried. As
for wastewater, 60% of the households disposed it into the sewage,
whereas 30% disposed them right from their elevated house.
Abstract: The purpose of this study is two-fold. First, it attempts to explore potential opportunities for utilizing visual interactive simulations along with Business Intelligence (BI) as a decision support tool for strategic decision making. Second, it tries to figure out the essential top-level managerial requirements that would transform strategic decision simulation into an integral component of BI systems. The domain of particular interest was the application of visual interactive simulation capabilities in the field of supply chains. A qualitative exploratory method was applied, through the use of interviews with two leading companies. The collected data was then analysed to demonstrate the difference between the literature perspective and the practical managerial perspective on the issue. The results of the study suggest that although the use of simulation particularly in managing supply chains is very evident in literature, yet, in practice such utilization is still in its infancy, particularly regarding strategic decisions. Based on the insights a prototype of a simulation based BI-solution-extension was developed and evaluated.
Abstract: A state of the art Speaker Identification (SI) system
requires a robust feature extraction unit followed by a speaker
modeling scheme for generalized representation of these features.
Over the years, Mel-Frequency Cepstral Coefficients (MFCC)
modeled on the human auditory system has been used as a standard
acoustic feature set for speech related applications. On a recent
contribution by authors, it has been shown that the Inverted Mel-
Frequency Cepstral Coefficients (IMFCC) is useful feature set for
SI, which contains complementary information present in high
frequency region. This paper introduces the Gaussian shaped filter
(GF) while calculating MFCC and IMFCC in place of typical
triangular shaped bins. The objective is to introduce a higher
amount of correlation between subband outputs. The performances
of both MFCC & IMFCC improve with GF over conventional
triangular filter (TF) based implementation, individually as well as
in combination. With GMM as speaker modeling paradigm, the
performances of proposed GF based MFCC and IMFCC in
individual and fused mode have been verified in two standard
databases YOHO, (Microphone Speech) and POLYCOST
(Telephone Speech) each of which has more than 130 speakers.
Abstract: The antimicrobial, antiplasmid and cytotoxic activities of marine algae Halimeda opuntia and Sarconema filiforme were investigated. Antimicrobial bioassay against some human pathogenic bacteria and yeast were conducted using disc diffusion method. Halimeda extract exhibited antibacterial activity against six species of microrganisms, with significant inhibition against Staphylococcus aureus. While Sarconema extract was better potent as antifungal against Candida albicans. Comparative antibacterial studies showed that Halimeda extract showed equivalent or better activity as compared with commercial antibiotic when tested against Staphylococcus aureus. Further tests conducted using dilution method showed both extracts as having bacteriostatic mode of action against the tested microorganisms. Methanol extract of two species showed significant cytotoxicity (LC50
Abstract: This paper describes a practical approach to design
and develop a hybrid learning with acceleration feedback control
(HLC) scheme for input tracking and end-point vibration suppression
of flexible manipulator systems. Initially, a collocated proportionalderivative
(PD) control scheme using hub-angle and hub-velocity
feedback is developed for control of rigid-body motion of the system.
This is then extended to incorporate a further hybrid control scheme
of the collocated PD control and iterative learning control with
acceleration feedback using genetic algorithms (GAs) to optimize the
learning parameters. Experimental results of the response of the
manipulator with the control schemes are presented in the time and
frequency domains. The performance of the HLC is assessed in terms
of input tracking, level of vibration reduction at resonance modes and
robustness with various payloads.
Abstract: Since supply chains highly impact the financial
performance of companies, it is important to optimize and analyze
their Key Performance Indicators (KPI). The synergistic combination
of Particle Swarm Optimization (PSO) and Monte Carlo simulation is
applied to determine the optimal reorder point of warehouses in
supply chains. The goal of the optimization is the minimization of the
objective function calculated as the linear combination of holding and
order costs. The required values of service levels of the warehouses
represent non-linear constraints in the PSO. The results illustrate that
the developed stochastic simulator and optimization tool is flexible
enough to handle complex situations.
Abstract: A new strategy for oriented immobilization of proteins was proposed. The strategy contains two steps. The first step is to search for a docking site away from the active site on the protein surface. The second step is trying to find a ligand that is able to grasp the targeted site of the protein. To avoid ligand binding to the active site of protein, the targeted docking site is selected to own opposite charges to those near the active site. To enhance the ligand-protein binding, both hydrophobic and electrostatic interactions need to be included. The targeted docking site should therefore contain hydrophobic amino acids. The ligand is then selected through the help of molecular docking simulations. The enzyme α-amylase derived from Aspergillus oryzae (TAKA) was taken as an example for oriented immobilization. The active site of TAKA is surrounded by negatively charged amino acids. All the possible hydrophobic sites on the surface of TAKA were evaluated by the free energy estimation through benzene docking. A hydrophobic site on the opposite side of TAKA-s active site was found to be positive in net charges. A possible ligand, 3,3-,4,4- – Biphenyltetra- carboxylic acid (BPTA), was found to catch TAKA by the designated docking site. Then, the BPTA molecules were grafted onto silica gels and measured the affinity of TAKA adsorption and the specific activity of thereby immobilized enzymes. It was found that TAKA had a dissociation constant as low as 7.0×10-6 M toward the ligand BPTA on silica gel. The increase in ionic strength has little effect on the adsorption of TAKA, which indicated the existence of hydrophobic interaction between ligands and proteins. The specific activity of the immobilized TAKA was compared with the randomly adsorbed TAKA on primary amine containing silica gel. It was found that the orderly immobilized TAKA owns a specific activity twice as high as the one randomly adsorbed by ionic interaction.
Abstract: The Chichiawan stream in the Wulin catchment in
Taiwan is the natural habitat of Formosan landlocked salmon. Human
and agriculture activities gradually worsen water quality and impact
the fish habitat negatively. To protect and manage Formosan
landlocked salmon habitat, it is important to understand a variety
land-uses affect on the watershed responses to storms. This study
discusses watershed responses to the dry-day before a storm event and
a variety of land-uses in the Wulin catchment. Under the land-use
planning in the Wulin catchment, the peak flows during typhoon
events do not have noticeable difference. However, the nutrient
exports can be highly reduced under the strategies of restraining
agriculture activities. Due to the higher affinity of P for soil than that
of N, the exports of TN from overall Wuling catchment were much
greater than Ortho-P. Agriculture mainly centralized in subbasin A,
which is the important source of nutrients in nonpoint source discharge.
The subbasin A supplied about 26% of the TN and 32% of the Ortho-P
discharge in 2004, despite the fact it only covers 19% area of the
Wuling catchment. The subbasin analysis displayed that the
agricultural subbasin A exports higher nutrients per unit area than
other forest subbasins. Additionally, the agricultural subbasin A
contributed a higher percentage to total Ortho-P exports compares to
TN. The results of subbasin analysis might imply the transport of
Ortho-P was similar to the particulate matter which was mainly
influenced by the runoff and affected by the desorption from soil
particles while the TN (dominated as nitrate-N) was mainly influenced
by base-flow.
Abstract: Understanding the cell's large-scale organization is an interesting task in computational biology. Thus, protein-protein interactions can reveal important organization and function of the cell. Here, we investigated the correspondence between protein interactions and function for the yeast. We obtained the correlations among the set of proteins. Then these correlations are clustered using both the hierarchical and biclustering methods. The detailed analyses of proteins in each cluster were carried out by making use of their functional annotations. As a result, we found that some functional classes appear together in almost all biclusters. On the other hand, in hierarchical clustering, the dominancy of one functional class is observed. In the light of the clustering data, we have verified some interactions which were not identified as core interactions in DIP and also, we have characterized some functionally unknown proteins according to the interaction data and functional correlation. In brief, from interaction data to function, some correlated results are noticed about the relationship between interaction and function which might give clues about the organization of the proteins, also to predict new interactions and to characterize functions of unknown proteins.
Abstract: The problem of bin-packing in two dimensions (2BP) consists in placing a given set of rectangular items in a minimum number of rectangular and identical containers, called bins. This article treats the case of objects with a free orientation of 90Ôùª. We propose an approach of resolution combining optimization by colony of ants (ACO) and the heuristic method IMA to resolve this NP-Hard problem.
Abstract: Recently, the design is becoming important in product development. The technology which is a strong point of Japan is immediately caught up by the foreign countries, and the price competition begins. Therefore companies tend to plan differentiation of products by the design or a color. The purpose of my work was to consider the optimal color for using by product development. We needed to clarify the thing leading to color preference for this purpose. Two kinds of investigations were made. By the first investigation, we found out that a geographical factor difference existed in color preference. Then, investigation which regarded the difference as latitude was conducted. However, the result expected from the difference in latitude was not obtained. It seems that it is necessary to set up difference of latitude a little more greatly, or to reexamine by other geographical factors.
Abstract: The objective of this work which is based on the
approach of simultaneous engineering is to contribute to the
development of a CIM tool for the synthesis of functional design
dimensions expressed by average values and tolerance intervals. In
this paper, the dispersions method known as the Δl method which
proved reliable in the simulation of manufacturing dimensions is
used to develop a methodology for the automation of the simulation.
This methodology is constructed around three procedures. The first
procedure executes the verification of the functional requirements by
automatically extracting the functional dimension chains in the
mechanical sub-assembly. Then a second procedure performs an
optimization of the dispersions on the basis of unknown variables.
The third procedure uses the optimized values of the dispersions to
compute the optimized average values and tolerances of the
functional dimensions in the chains. A statistical and cost based
approach is integrated in the methodology in order to take account of
the capabilities of the manufacturing processes and to distribute
optimal values among the individual components of the chains.
Abstract: The Institute of Product Development is dealing
with the development, design and dimensioning of micro components
and systems as a member of the Collaborative Research
Centre 499 “Design, Production and Quality Assurance of
Molded micro components made of Metallic and Ceramic Materials".
Because of technological restrictions in the miniaturization
of conventional manufacturing techniques, shape and
material deviations cannot be scaled down in the same proportion
as the micro parts, rendering components with relatively
wide tolerance fields. Systems that include such components
should be designed with this particularity in mind, often requiring
large clearance. On the end, the output of such systems
results variable and prone to dynamical instability. To save
production time and resources, every study of these effects
should happen early in the product development process and
base on computer simulation to avoid costly prototypes. A
suitable method is proposed here and exemplary applied to a
micro technology demonstrator developed by the CRC499. It
consists of a one stage planetary gear train in a sun-planet-ring
configuration, with input through the sun gear and output
through the carrier. The simulation procedure relies on ordinary
Multi Body Simulation methods and subsequently adds
other techniques to further investigate details of the system-s
behavior and to predict its response. The selection of the relevant
parameters and output functions followed the engineering
standards for regular sized gear trains. The first step is to
quantify the variability and to reveal the most critical points of
the system, performed through a whole-mechanism Sensitivity
Analysis. Due to the lack of previous knowledge about the system-s
behavior, different DOE methods involving small and
large amount of experiments were selected to perform the SA.
In this particular case the parameter space can be divided into
two well defined groups, one of them containing the gear-s profile
information and the other the components- spatial location.
This has been exploited to explore the different DOE techniques
more promptly. A reduced set of parameters is derived for
further investigation and to feed the final optimization process,
whether as optimization parameters or as external perturbation
collective. The 10 most relevant perturbation factors and 4 to 6
prospective variable parameters are considered in a new, simplified
model. All of the parameters are affected by the mentioned
production variability. The objective functions of interest
are based on scalar output-s variability measures, so the
problem becomes an optimization under robustness and reliability constrains. The study shows an initial step on the development
path of a method to design and optimize complex micro
mechanisms composed of wide tolerated elements accounting
for the robustness and reliability of the systems- output.