Abstract: Bone material is treated as heterogeneous and hierarchical in nature therefore appropriate size of bone specimen is required to analyze its tensile properties at a particular hierarchical level. Tensile properties of cortical bone are important to investigate the effect of drug treatment, disease and aging as well as for development of computational and analytical models. In the present study tensile properties of buffalo as well as goat femoral and tibiae cortical bone are analyzed using sub-size tensile specimens. Femoral cortical bone was found to be stronger in tension as compared to the tibiae cortical bone and the tensile properties obtained using sub-size specimens show close resemblance with the tensile properties of full-size cortical specimens. A two dimensional finite element (FE) modal was also applied to simulate the tensile behavior of sub-size specimens. Good agreement between experimental and FE model was obtained for sub-size tensile specimens of cortical bone.
Abstract: The American Health Level Seven (HL7) Reference Information Model (RIM) consists of six back-bone classes that have different specialized attributes. Furthermore, for the purpose of enforcing the semantic expression, there are some specific mandatory vocabulary domains have been defined for representing the content values of some attributes. In the light of the fact that it is a duplicated effort on spending a lot of time and human cost to develop and modify Clinical Information Systems (CIS) for most hospitals due to the variety of workflows. This study attempts to design and develop sharing RIM-based components of the CIS for the different business processes. Therefore, the CIS contains data of a consistent format and type. The programmers can do transactions with the RIM-based clinical repository by the sharing RIM-based components. And when developing functions of the CIS, the sharing components also can be adopted in the system. These components not only satisfy physicians- needs in using a CIS but also reduce the time of developing new components of a system. All in all, this study provides a new viewpoint that integrating the data and functions with the business processes, it is an easy and flexible approach to build a new CIS.
Abstract: Magnesium alloy has been widely investigated as
biodegradable cardiovascular stent and bone implant. Its application
for biodegradable esophageal stenting remains unexplored. This
paper reports the biodegradation behaviors of AZ31 magnesium alloy
in artificial saliva and various types of beverage in vitro. Results
show that the magnesium ion release rate of AZ31 in artificial saliva
for a stent (2cm diameter, 10cm length at 50% stent surface
coverage) is 43 times lower than the daily allowance of human body
magnesium intakes. The degradation rates of AZ31 in different
beverages could also be significantly different. These results suggest
that the esophagus in nature is a less aggressive chemical
environment for degradation of magnesium alloys. The significant
difference in degradation rates of AZ31 in different beverages opens
new opportunities for development of degradation controllable
esophageal stent through customizing ingested beverages.
Abstract: A considerable amount of energy is consumed during
transmission and reception of messages in a wireless mesh network
(WMN). Reducing per-node transmission power would greatly
increase the network lifetime via power conservation in addition to
increasing the network capacity via better spatial bandwidth reuse. In
this work, the problem of topology control in a hybrid WMN of
heterogeneous wireless devices with varying maximum transmission
ranges is considered. A localized distributed topology control
algorithm is presented which calculates the optimal transmission
power so that (1) network connectivity is maintained (2) node
transmission power is reduced to cover only the nearest neighbours
(3) networks lifetime is extended. Simulations and analysis of results
are carried out in the NS-2 environment to demonstrate the
correctness and effectiveness of the proposed algorithm.
Abstract: Supplementation of palm vitamin E has been reported
to prevent loss of bone density in ovariectomised female rats. The
mechanism by which palm vitamin E exerts these effects is still
unknown. We hypothesized that palm vitamin E may act by
preventing the protein expression changes. Two dimensional poly
acyrilamide gel electrophoresis (2-D PAGE) and PD Quest software
genomic solutions Investigator (proteomics) was used to analyze the
differential protein expression profile in femoral and humeri bones
harvested from three groups of rats; sham-operated rats (SO),
ovariectomised rats (Ovx) and ovariectomised rats supplemented for
2 months with palm vitamin E. The results showed that there were
over 300 valued spot on each of the groups PVE and OVX as
compared to about 200 in SO. Comparison between the differential
protein expression between OVX and PVE groups showed that ten
spots were down –regulated in OVX but up-regulated in PVE. The
ten differential spots were separately named P1-P10. The
identification and understanding of the pathway of the differential
protein expression among the groups is ongoing and may account for
the molecular mechanism through which palm vitamin E exert its
anti-osteoporotic effect.
Abstract: “Dengue" is an African word meaning “bone
breaking" because it causes severe joint and muscle pain that feels
like bones are breaking. It is an infectious disease mainly transmitted
by female mosquito, Aedes aegypti, and causes four serotypes of
dengue viruses. In recent years, a dramatic increase in the dengue
fever confirmed cases around the equator-s belt has been reported.
Several conventional indices have been designed so far to monitor the
transmitting vector populations known as House Index (HI),
Container Index (CI), Breteau Index (BI). However, none of them
describes the adult mosquito population size which is important to
direct and guide comprehensive control strategy operations since
number of infected people has a direct relationship with the vector
density. Therefore, it is crucial to know the population size of the
transmitting vector in order to design a suitable and effective control
program. In this context, a study is carried out to report a new
statistical index, ABURAS Index, using Poisson distribution based
on the collection of vector population in Jeddah Governorate, Saudi Arabia.
Abstract: This study aimed to evaluate the muscularity and tissue composition of 24 legs of Ile de France lambs. They were fed with diets containing “in nature" or hydrolyzed sugarcane with 0.6% of calcium oxide in aerobic and anaerobic environments. Animals entered the trial at 15 and were slaughtered at 32 kg of body weight. The leg tissue composition, as well as muscularity (0.47), muscle:bone (6.66) and muscle:fat (4.25) were not affected (P>0.05) by treatments. The proportions found were: 67.62% for muscle, 17.52% for bone and 10.15% for fat. In relation to lambs fed with “in nature" sugarcane, hydrolyzed sugarcane with calcium oxide in aerobic and anaerobic environments did not affect muscularity and leg tissue composition of lambs.
Abstract: Fundamental sensor-motor couplings form the backbone
of most mobile robot control tasks, and often need to be implemented
fast, efficiently and nevertheless reliably. Machine learning
techniques are therefore often used to obtain the desired sensor-motor
competences.
In this paper we present an alternative to established machine
learning methods such as artificial neural networks, that is very fast,
easy to implement, and has the distinct advantage that it generates
transparent, analysable sensor-motor couplings: system identification
through nonlinear polynomial mapping.
This work, which is part of the RobotMODIC project at the
universities of Essex and Sheffield, aims to develop a theoretical understanding
of the interaction between the robot and its environment.
One of the purposes of this research is to enable the principled design
of robot control programs.
As a first step towards this aim we model the behaviour of the
robot, as this emerges from its interaction with the environment, with
the NARMAX modelling method (Nonlinear, Auto-Regressive, Moving
Average models with eXogenous inputs). This method produces
explicit polynomial functions that can be subsequently analysed using
established mathematical methods.
In this paper we demonstrate the fidelity of the obtained NARMAX
models in the challenging task of robot route learning; we present a
set of experiments in which a Magellan Pro mobile robot was taught
to follow four different routes, always using the same mechanism to
obtain the required control law.
Abstract: In this work, the primary compressive strength
components of human femur trabecular bone are qualitatively
assessed using image processing and wavelet analysis. The Primary
Compressive (PC) component in planar radiographic femur trabecular
images (N=50) is delineated by semi-automatic image processing
procedure. Auto threshold binarization algorithm is employed to
recognize the presence of mineralization in the digitized images. The
qualitative parameters such as apparent mineralization and total area
associated with the PC region are derived for normal and abnormal
images.The two-dimensional discrete wavelet transforms are utilized
to obtain appropriate features that quantify texture changes in medical
images .The normal and abnormal samples of the human femur are
comprehensively analyzed using Harr wavelet.The six statistical
parameters such as mean, median, mode, standard deviation, mean
absolute deviation and median absolute deviation are derived at level
4 decomposition for both approximation and horizontal wavelet
coefficients. The correlation coefficient of various wavelet derived
parameters with normal and abnormal for both approximated and
horizontal coefficients are estimated. It is seen that in almost all cases
the abnormal show higher degree of correlation than normals. Further
the parameters derived from approximation coefficient show more
correlation than those derived from the horizontal coefficients. The
parameters mean and median computed at the output of level 4 Harr
wavelet channel was found to be a useful predictor to delineate the
normal and the abnormal groups.
Abstract: This paper presents an indirect adaptive stabilization
scheme for first-order continuous-time systems under saturated input
which is described by a sigmoidal function. The singularities are
avoided through a modification scheme for the estimated plant
parameter vector so that its associated Sylvester matrix is guaranteed
to be non-singular and then the estimated plant model is controllable.
The modification mechanism involves the use of a hysteresis
switching function. An alternative hybrid scheme, whose estimated
parameters are updated at sampling instants is also given to solve a
similar adaptive stabilization problem. Such a scheme also uses
hysteresis switching for modification of the parameter estimates so as
to ensure the controllability of the estimated plant model.
Abstract: Postmenopausal osteoporosis is a disorder
characterized by the progressive bone loss induced by estrogen
deficiency in postmenopausal women. This imbalance affects
calcium–phosphate metabolism and results in secondary
hyperparathyroidism. Purariae Radix (PR), the root of P. lobata
(Wild.) Ohwi, is one of the earliest medicinal herbs employed in
ancient China. PR contains a high quantity of isoflavones and their
glycosides, which are regarded as phytoestrogen. Few investigations
of PR are related to its osteoprotective effects. The present study is
designed to administer PR water extract to ovariectomized (OVX)
female rats, for the investigation of its possibly protective actions on
bone and to delineate the potential mechanisms involved. Our results
demonstrated that long-term treatment of PR could not significantly
improve bone properties, whereas it greatly ameliorated the condition
of secondary hyperparathyroidism induced by ovariectomy in those
animals. PR might be useful as alternative regimen for protecting
against postmenopausal bone loss.
Abstract: Ultrasound is useful in demonstrating bone mineral
density of regenerating osseous tissue as well as structural alterations.
A proposed ultrasound method, which included ultrasonography and
acoustic parameters measurement, was employed to evaluate its
efficacy in monitoring the bone callus changes in a rabbit tibial
distraction osteogenesis (DO) model.
The findings demonstrated that ultrasonographic images depicted
characteristic changes of the bone callus, typical of histology findings,
during the distraction phase. Follow-up acoustic parameters
measurement of the bone callus, including speed of sound, reflection
and attenuation, showed significant linear changes over time during
the distraction phase. The acoustic parameters obtained during the
distraction phase also showed moderate to strong correlation with
consolidated bone callus density and micro-architecture measured by
micro-computed tomography at the end of the consolidation phase.
The results support the preferred use of ultrasound imaging in the
early monitoring of bone callus changes during DO treatment.
Abstract: The overlay approach has been widely used by many service providers for Traffic Engineering (TE) in large Internet backbones. In the overlay approach, logical connections are set up between edge nodes to form a full mesh virtual network on top of the physical topology. IP routing is then run over the virtual network. Traffic engineering objectives are achieved through carefully routing logical connections over the physical links. Although the overlay approach has been implemented in many operational networks, it has a number of well-known scaling issues. This paper proposes a new approach to achieve traffic engineering without full-mesh overlaying with the help of integrated approach and equal subset split method. Traffic engineering needs to determine the optimal routing of traffic over the existing network infrastructure by efficiently allocating resource in order to optimize traffic performance on an IP network. Even though constraint-based routing [1] of Multi-Protocol Label Switching (MPLS) is developed to address this need, since it is not widely tested or debugged, Internet Service Providers (ISPs) resort to TE methods under Open Shortest Path First (OSPF), which is the most commonly used intra-domain routing protocol. Determining OSPF link weights for optimal network performance is an NP-hard problem. As it is not possible to solve this problem, we present a subset split method to improve the efficiency and performance by minimizing the maximum link utilization in the network via a small number of link weight modifications. The results of this method are compared against results of MPLS architecture [9] and other heuristic methods.
Abstract: True integration of multimedia services over wired or
wireless networks increase the productivity and effectiveness in
today-s networks. IP Multimedia Subsystems are Next Generation
Network architecture to provide the multimedia services over fixed
or mobile networks. This paper proposes an extended SIP-based QoS
Management architecture for IMS services over underlying IP access
networks. To guarantee the end-to-end QoS for IMS services in
interconnection backbone, SIP based proxy Modules are introduced
to support the QoS provisioning and to reduce the handoff disruption
time over IP access networks. In our approach these SIP Modules
implement the combination of Diffserv and MPLS QoS mechanisms
to assure the guaranteed QoS for real-time multimedia services. To
guarantee QoS over access networks, SIP Modules make QoS
resource reservations in advance to provide best QoS to IMS users
over heterogeneous networks. To obtain more reliable multimedia
services, our approach allows the use of SCTP protocol over SIP
instead of UDP due to its multi-streaming feature. This architecture
enables QoS provisioning for IMS roaming users to differentiate IMS
network from other common IP networks for transmission of realtime
multimedia services. To validate our approach simulation
models are developed on short scale basis. The results show that our
approach yields comparable performance for efficient delivery of
IMS services over heterogeneous IP access networks.
Abstract: Dispersions of casein micelles (CM) were studied at a
constant protein concentration of 5 wt % in high NaCl environment
ranging from 0% to 12% by Dynamic light scattering (DLS) and
Fourier Transform Infrared (FTIR). The rehydration profiles obtained
were interpreted in term of wetting, swelling and dispersion stages by
using a turbidity method. Two behaviours were observed depending
on the salt concentration. The first behaviour (low salt concentration)
presents a typical rehydration profile with a significant change
between 3 and 6% NaCl indicating quick wetting, swelling and long
dispersion stage. On the opposite, the dispersion stage of the second
behaviour (high salt concentration) was significantly shortened
indicating a strong modification of the protein backbone. A salt
increase result to a destabilization of the micelle and the formation of
mini-micelles more or less aggregated indicating an average micelles
size ranging from 100 to 200 nm. For the first time, the estimations
of secondary structural elements (irregular, ß-sheet, α-helix and turn)
by the Amide III assignments were correlated with results from
Amide I.
Abstract: The design of an active leg orthosis for tumble
protection is proposed in this paper. The orthosis would be applied to
assist elders or invalids in rebalancing while they fall unexpectedly.
We observe the regain balance motion of healthy and youthful people,
and find the difference to elders or invalids. First, the physical model
of leg would be established, and we consider the leg motions are
achieve through four joints (phalanx stem, ankle, knee, and hip joint)
and five links (phalanges, talus, tibia, femur, and hip bone). To
formulate the dynamic equations, the coordinates which can clearly
describe the position in 3D space are first defined accordance with the
human movement of leg, and the kinematics and dynamics of the leg
movement can be formulated based on the robotics. For the purpose,
assisting elders and invalids in avoiding tumble, the posture variation
of unbalance and regaining balance motion are recorded by the
motion-capture image system, and the trajectory is taken as the desire
one. Then we calculate the force and moment of each joint based on
the leg motion model through programming MATLAB code. The
results would be primary information of the active leg orthosis design
for tumble protection.
Abstract: An implant elicits a biological response in the
surrounding tissue which determines the acceptance and long-term
function of the implant. Dental implants have become one of the
main therapy methods in clinic after teeth lose. A successful implant
is in contact with bone and soft tissue represent by fibroblasts. In our
study we focused on the interaction between six different chemically
and physically modified titanium implants (Tis-MALP, Tis-O, Tis-
OA, Tis-OPAAE, Tis-OZ, Tis-OPAE) with alveolar fibroblasts as
well as with five type of microorganisms (S. epidermis, S.mutans, S.
gordonii, S. intermedius, C.albicans). The analysis of microorganism
adhesion was determined by CFU (colony forming unite) and biofilm
formation. The presence of α3β1 and vinculin expression on alveolar
fibroblasts was demonstrated using phospho specific cell based
ELISA (PACE). Alveolar fibroblasts have the highest expression of
these proteins on Tis-OPAAE and Tis-OPAE. It corresponds with
results from bacterial adhesion and biofilm formation and it was
related to the lowest production of collagen I by alveolar fibroblasts
on Tis-OPAAE titanium disc.
Abstract: This study aimed to present the mechanical
performance evaluation of the dynamic hip screw (DHS) for
trochanteric fracture by means of finite element method. The
analyses were performed based on stainless steel and titanium
implant material definitions at various stages of bone healing and
including implant removal. The assessment of the mechanical
performance used two parameters, von Mises stress to evaluate the
strength of bone and implant and elastic strain to evaluate fracture
stability. The results show several critical aspects of dynamic hip
screw for trochanteric fracture stabilization. In the initial stage of
bone healing process, partial weight bearing should be applied to
avoid the implant failure. In the late stage of bone healing, stainless
steel implant should be removed.
Abstract: Participation in sporting activities can lead to injury.
Sport injuries have been widely studied in many sports including the
more extreme categories of aquatic board sports. Kitesurfing is a
relatively new water surface action sport, and has not yet been
widely studied in terms of injuries and stress on the body. The aim of
this study was to get information about which injuries that are most
common among kitesurfing participants, where they occur, and their
causes. Injuries were studied using an international open web
questionnaire (n=206).
The results showed that many respondents reported injuries, in
total 251 injuries to knee (24%), ankle (17%), trunk (16%) and
shoulders (10%), often sustained while doing jumps and tricks
(40%). Among the reported injuries were joint injuries (n=101),
muscle/tendon damages (n=47), wounds and cuts (n=36) and bone
fractures (n=28). Also environmental factors and equipment can
influence the risk of injury, or the extent of injury in a hazardous
situation. Conclusively, the information from this retrospective study
supports earlier studies in terms of prevalence and site of injuries.
Suggestively, this information should be used for to build a
foundation of knowledge about the sport for development of
applications for physical training and product development.
Abstract: Bone marrow-derived stem cells have been widely
studied as an alternative source of stem cells. Mesenchymal stem
cells (MSCs) were mostly investigated and studies showed MSCs can
promote neurogenesis. Little is known about the non-mesenchymal
mononuclear cell fraction, which contains both hematopoietic and
nonhematopoietic cells, including monocytes and endothelial
progenitor cells. This study focused on unfractionated bone marrow
mononuclear cells (BMMCs), which remained 72 h after MSCs were
adhered to the culture plates. We showed that BMMC-conditioned
medium promoted morphological changes of human SH-SY5Y
neuroblastoma cells from an epithelial-like phenotype towards a
neuron-like phenotype as indicated by an increase in neurite
outgrowth, like those observed in retinoic acid (RA)-treated cells.
The result could be explained by the effects of trophic factors
released from BMMCs, as shown in the RT-PCR results that
BMMCs expressed nerve growth factor (NGF), brain-derived
neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF).
Similar results on the cell proliferation rate were also observed
between RA-treated cells and cells cultured in BMMC-conditioned
medium, suggesting that cells creased proliferating and differentiated
into a neuronal phenotype. Using real-time RT-PCR, a significantly
increased expression of tyrosine hydroxylase (TH) mRNA in SHSY5Y
cells indicated that BMMC-conditioned medium induced
catecholaminergic identities in differentiated SH-SY5Y cells.