Abstract: Ultrasound is useful in demonstrating bone mineral
density of regenerating osseous tissue as well as structural alterations.
A proposed ultrasound method, which included ultrasonography and
acoustic parameters measurement, was employed to evaluate its
efficacy in monitoring the bone callus changes in a rabbit tibial
distraction osteogenesis (DO) model.
The findings demonstrated that ultrasonographic images depicted
characteristic changes of the bone callus, typical of histology findings,
during the distraction phase. Follow-up acoustic parameters
measurement of the bone callus, including speed of sound, reflection
and attenuation, showed significant linear changes over time during
the distraction phase. The acoustic parameters obtained during the
distraction phase also showed moderate to strong correlation with
consolidated bone callus density and micro-architecture measured by
micro-computed tomography at the end of the consolidation phase.
The results support the preferred use of ultrasound imaging in the
early monitoring of bone callus changes during DO treatment.