Abstract: Pain management is a question of quality of life and
an indicator for nursing quality. Chronic pain which is predominant
in oncology and palliative nursing situations is perceived today as a
multifactorial, individual emotional experience with specific
characteristics including the sociocultural dimension when dealing
with migrant patients. This dimension of chronic pain is of major
importance in professional nursing of migrant patients in hospices or
palliative care units. Objectives of the study are: 1. To find out more
about the sociocultural views on pain and nursing care, on customs
and nursing practices connected with pain of both Turkish Muslim
and German Christian women, 2. To improve individual and family
oriented nursing practice with view to sociocultural needs of patients
in severe pain in palliative care. In a qualitative-explorative comparative study 4 groups of women,
Turkish Muslims immigrants (4 from the first generation, 5 from the
second generation) and German Christian women of two generations
(5 of each age group) of the same age groups as the Turkish women
and with similar educational backgrounds were interviewed (semistructured
ethnographic interviews using Spradley, 1979) on their
perceptions and experiences of pain and nursing care within their
families. For both target groups the presentation will demonstrate the
following results in detail: Utterance of pain as well as “private” and
“public” pain vary within different societies and cultures. Permitted
forms of pain utterance are learned in childhood and determine
attitudes and expectations in adulthood. Language, especially when
metaphors and symbols are used, plays a major role for
misunderstandings. The sociocultural context of illness may include
specific beliefs that are important to the patients and yet seem more
than far-fetched from a biomedical perspective. Pain can be an
influential factor in family relationships where respect or hierarchies
do not allow the direct utterance of individual needs. Specific
resources are often, although not exclusively, linked to religious
convictions and are significantly helpful in reducing pain. The discussion will evaluate the results of the study with view to
the relevant literature and present nursing interventions and
instruments beyond medication that are helpful when dealing with
patients from various socio-cultural backgrounds in painful end-oflife
situations.
Abstract: The rheological response of blends obtained from
quaternized polysulfone and polyvinyl alcohol in N-methyl-2-
pyrrolidone as against structural peculiarity of polymers from the
blend, composition of polymer mixtures, as well as the types of
interactions were investigated. Results show that the variation of
polyvinyl alcohol composition in the studied system determines
changes of the rheological properties, suggesting that the PVA acts as
a plasticizer. Consequently, rheological behavior of complex system,
described by the nonlinear flow curve, indicates the impact of
polyvinil alcohol content to polysulfone solution, in order to facilitate
the subsequently preparation of bioactive membranes.
Abstract: In this paper, the secure BioSemantic Scheme is
presented to bridge biological/biomedical research problems and
computational solutions via semantic computing. Due to the diversity
of problems in various research fields, the semantic capability
description language (SCDL) plays and important role as a common
language and generic form for problem formalization. SCDL is
expected the essential for future semantic and logical computing in
Biosemantic field. We show several example to Biomedical problems
in this paper. Moreover, in the coming age of cloud computing, the
security problem is considered to be crucial issue and we presented a
practical scheme to cope with this problem.
Abstract: The MEMS pressure sensor has been introduced and
presented in this paper. The types of pressure sensor and its theory of
operation are also included. The latest MEMS technology, the
fabrication processes of pressure sensor are explored and discussed.
Besides, various device applications of pressure sensor such as tire
pressure-monitoring system, diesel particulate filter and others are
explained. Due to further miniaturization of the device nowadays, the
pressure sensor with nanotechnology (NEMS) is also reviewed. The
NEMS pressure sensor is expected to have better performance as well
as lower in its cost. It has gained an excellent popularity in many
applications.
Abstract: The future and the development of science is therefore
seen in interdisciplinary areas such as biomedical engineering. Selfassembled
structures, similar to stem cell niches would inhibit fast
division process and subsequently capture the stem cells from the
blood flow. By means of surface topography and the stiffness as well
as microstructure progenitor cells should be differentiated towards
the formation of endothelial cells monolayer which effectively will
inhibit activation of the coagulation cascade. The idea of the material
surface development met the interest of the clinical institutions,
which support the development of science in this area and are waiting
for scientific solutions that could contribute to the development of
heart assist systems. This would improve the efficiency of the
treatment of patients with myocardial failure, supported with artificial
heart assist systems. Innovative materials would enable the redesign,
in the post project activity, construction of ventricular heart assist.
Abstract: Optical biosensors have become a powerful detection
and analysis tool for wide-ranging applications in biomedical research,
pharmaceuticals and environmental monitoring. This study carried out
the computational fluid dynamics (CFD)-based simulations to explore
the dispersion phenomenon in the micro channel of an optical
biosensor. The predicted time sequences of concentration contours
were utilized to better understand the dispersion development occurred
in different geometric shapes of micro channels. The simulation results
showed the surface concentrations at the sensing probe (with the best
performance of a grating coupler) in respect of time to appraise the
dispersion effect and therefore identify the design configurations
resulting in minimum dispersion.
Abstract: In this paper, we used data mining to extract
biomedical knowledge. In general, complex biomedical data
collected in studies of populations are treated by statistical methods,
although they are robust, they are not sufficient in themselves to
harness the potential wealth of data. For that you used in step two
learning algorithms: the Decision Trees and Support Vector Machine
(SVM). These supervised classification methods are used to make the
diagnosis of thyroid disease. In this context, we propose to promote
the study and use of symbolic data mining techniques.
Abstract: Diminished antioxidant defense or increased
production of reactive oxygen species in the biological system can
result in oxidative stress which may lead to various
neurodegenerative diseases including Alzheimer’s disease (AD).
Microglial activation also contributes to the progression of AD by
producing several proinflammatory cytokines, nitric oxide (NO) and
prostaglandin E2 (PGE2). Oxidative stress and inflammation have
been reported to be possible pathophysiological mechanisms
underlying AD. In addition, the cholinergic hypothesis postulates that
memory impairment in patient with AD is also associated with the
deficit of cholinergic function in the brain. Although a number of
drugs have been approved for the treatment of AD, most of these
synthetic drugs have diverse side effects and yield relatively modest
benefits. Marine algae have great potential in pharmaceutical and
biomedical applications as they are valuable sources of bioactive
properties such as anticoagulation, antimicrobial, antioxidative,
anticancer and anti-inflammatory. Hence, this study aimed to provide
an overview of the properties of Malaysian seaweeds (Padina
australis, Sargassum polycystum and Caulerpa racemosa) in
inhibiting oxidative stress, neuroinflammation and cholinesterase
enzymes. These seaweeds significantly exhibited potent DPPH and
moderate superoxide anion radical scavenging ability (P
Abstract: Ti6Al4V alloy is highly used in the automotive and
aerospace industry due to its good machining characteristics. Micro
EDM drilling is commonly used to drill micro hole on extremely hard
material with very high depth to diameter ratio. In this study, the
parameters of micro-electrical discharge machining (EDM) in drilling
of Ti6Al4V alloy is optimized for higher machining accuracy with
less hole-dilation and hole taper ratio. The micro-EDM machining
parameters includes, peak current and pulse on time. Fuzzy analysis
was developed to evaluate the machining accuracy. The analysis
shows that hole-dilation and hole-taper ratio are increased with the
increasing of peak current and pulse on time. However, the surface
quality deteriorates as the peak current and pulse on time increase.
The combination that gives the optimum result for hole dilation is
medium peak current and short pulse on time. Meanwhile, the
optimum result for hole taper ratio is low peak current and short pulse
on time.
Abstract: Biometallic materials are the most important materials for use in biomedical applications especially in manufacturing a variety of biological artificial replacements in a modern worlds, e.g. hip, knee or shoulder joints, due to their advanced characteristics. Titanium (Ti) and its alloys are used extensively in biomedical applications based on their high specific strength and excellent corrosion resistance. Beta-Ti alloys containing completely biocompatible elements are exceptionally prospective materials for manufacturing of bioimplants. They have superior mechanical, chemical and electrochemical properties for use as biomaterials. These biomaterials have the ability to introduce the most important property of biochemical compatibility which is low elastic modulus. This review examines current information on the recent developments in alloying elements leading to improvements of beta Ti alloys for use as biomaterials. Moreover, this paper focuses mainly on the evolution, evaluation and development of the modulus of elasticity as an effective factor on the performance of beta alloys.
Abstract: Advances in the field of image processing envision a
new era of evaluation techniques and application of procedures in
various different fields. One such field being considered is the
biomedical field for prognosis as well as diagnosis of diseases. This
plethora of methods though provides a wide range of options to select
from, it also proves confusion in selecting the apt process and also in
finding which one is more suitable. Our objective is to use a series of
techniques on bone scans, so as to detect the occurrence of
rheumatoid arthritis (RA) as accurately as possible. Amongst other
techniques existing in the field our proposed system tends to be more
effective as it depends on new methodologies that have been proved
to be better and more consistent than others. Computer aided
diagnosis will provide more accurate and infallible rate of
consistency that will help to improve the efficiency of the system.
The image first undergoes histogram smoothing and specification,
morphing operation, boundary detection by edge following algorithm
and finally image subtraction to determine the presence of
rheumatoid arthritis in a more efficient and effective way. Using preprocessing
noises are removed from images and using segmentation,
region of interest is found and Histogram smoothing is applied for a
specific portion of the images. Gray level co-occurrence matrix
(GLCM) features like Mean, Median, Energy, Correlation, Bone
Mineral Density (BMD) and etc. After finding all the features it
stores in the database. This dataset is trained with inflamed and noninflamed
values and with the help of neural network all the new
images are checked properly for their status and Rough set is
implemented for further reduction.
Abstract: Search is the most obvious application of information
retrieval. The variety of widely obtainable biomedical data is
enormous and is expanding fast. This expansion makes the existing
techniques are not enough to extract the most interesting patterns
from the collection as per the user requirement. Recent researches are
concentrating more on semantic based searching than the traditional
term based searches. Algorithms for semantic searches are
implemented based on the relations exist between the words of the
documents. Ontologies are used as domain knowledge for identifying
the semantic relations as well as to structure the data for effective
information retrieval. Annotation of data with concepts of ontology is
one of the wide-ranging practices for clustering the documents. In
this paper, indexing based on concept and annotation are proposed
for clustering the biomedical documents. Fuzzy c-means (FCM)
clustering algorithm is used to cluster the documents. The
performances of the proposed methods are analyzed with traditional
term based clustering for PubMed articles in five different diseases
communities. The experimental results show that the proposed
methods outperform the term based fuzzy clustering.
Abstract: This research presents the design, fabrication and application of a flavor sensor for an integrated electronic tongue and electronic nose that can allow rapid characterization of multi-component mixtures in a solution. The odor gas and liquid are separated using hydrophobic porous membrane in micro fluidic channel. The sensor uses an array composed of microbeads in micromachined cavities localized on silicon wafer. Sensing occurs via colorimetric and fluorescence changes to receptors and indicator molecules that are attached to termination sites on the polymeric microbeads. As a result, the sensor array system enables simultaneous and near-real-time analyses using small samples and reagent volumes with the capacity to incorporate significant redundancies. One of the key parts of the system is a passive pump driven only by capillary force. The hydrophilic surface of the fluidic structure draws the sample into the sensor array without any moving mechanical parts. Since there is no moving mechanical component in the structure, the size of the fluidic structure can be compact and the fabrication becomes simple when compared to the device including active microfluidic components. These factors should make the proposed system inexpensive to mass-produce, portable and compatible with biomedical applications.
Abstract: One of the main biomedical problem lies in detecting dependencies in semi structured data. Solution includes biomedical portal and algorithms (integral rating health criteria, multidimensional data visualization methods). Biomedical portal allows to process diagnostic and research data in parallel mode using Microsoft System Center 2012, Windows HPC Server cloud technologies. Service does not allow user to see internal calculations instead it provides practical interface. When data is sent for processing user may track status of task and will achieve results as soon as computation is completed. Service includes own algorithms and allows diagnosing and predicating medical cases. Approved methods are based on complex system entropy methods, algorithms for determining the energy patterns of development and trajectory models of biological systems and logical–probabilistic approach with the blurring of images.
Abstract: Protein kinases participate in a myriad of cellular
processes of major biomedical interest. The in vivo substrate
specificity of these enzymes is a process determined by several
factors, and despite several years of research on the topic, is still
far from being totally understood. In the present work, we have
quantified the contributions to the kinase substrate specificity of
i) the phosphorylation sites and their surrounding residues in the
sequence and of ii) the association of kinases to adaptor or scaffold
proteins. We have used position-specific scoring matrices (PSSMs),
to represent the stretches of sequences phosphorylated by 93 families
of kinases. We have found negative correlations between the number
of sequences from which a PSSM is generated and the statistical
significance and the performance of that PSSM. Using a subset
of 22 statistically significant PSSMs, we have identified specificity
determinant residues (SDRs) for 86% of the corresponding kinase
families. Our results suggest that different SDRs can function as
positive or negative elements of substrate recognition by the different
families of kinases. Additionally, we have found that human proteins
with known function as adaptors or scaffolds (kAS) tend to interact
with a significantly large fraction of the substrates of the kinases to
which they associate. Based on this characteristic we have identified
a set of 279 potential adaptors/scaffolds (pAS) for human kinases,
which is enriched in Pfam domains and functional terms tightly
related to the proposed function. Moreover, our results show that
for 74.6% of the kinase–pAS association found, the pAS colocalize
with the substrates of the kinases they are associated to. Finally, we
have found evidence suggesting that the association of kinases to
adaptors and scaffolds, may contribute significantly to diminish the
in vivo substrate crossed-specificity of protein kinases. In general, our
results indicate the relevance of several SDRs for both the positive
and negative selection of phosphorylation sites by kinase families and
also suggest that the association of kinases to pAS proteins may be
an important factor for the localization of the enzymes with their set
of substrates.
Abstract: The negative Poisson’s ratios can be described in terms of models based on the geometry of the system and the way this geometry changes due to applied loads. As the Poisson’s ratio does not depend on scale hence deformation can take place at the nano to macro level the only requirement is the right combination of the geometry. Our thrust in this paper is to combine our knowledge of tailored enhanced mechanical properties of the materials having negative Poisson’s ratio with the micromachining and electrospining technology to develop a novel stent carrying a drug delivery system. Therefore, the objective of this paper includes (i) fabrication of a micromachined metal sheet tailored with structure having negative Poisson’s ratio through rotating solid squares geometry using femtosecond laser ablation; (ii) rolling fabricated structure and welding to make a tubular structure (iii) wrapping it with nanofibers of biocompatible polymer PCL (polycaprolactone) for drug delivery (iv) analysis of the functional and mechanical performance of fabricated structure analytically and experimentally. Further, as the applications concerned, tubular structures have potential in biomedical for example hollow tubes called stents are placed inside to provide mechanical support to a damaged artery or diseased region and to open a blocked esophagus thus allowing feeding capacity and improving quality of life.
Abstract: The development of an low cost acquisition system of S-EMG signals which are reliable, comfortable for the user and with high mobility shows to be a relevant proposition in modern biomedical engineering scenario. In the study, the sampling capacity of the Arduino microcontroller Atmel Atmega328 with an A / D converter with 10-bit resolution and its reconstructing capability of a signal of surface electromyography is analyzed. An electronic circuit to capture the signal through two differential channels was designed, signals from Biceps Brachialis of a healthy man of 21 years was acquired to test the system prototype. ARV, MDF, MNF and RMS estimators were used to compare de acquired signals with physiological values. The Arduino was configured with a sampling frequency of 1.5kHz for each channel, and the tests with the circuit designed offered a SNR of 20.57dB.
Abstract: This paper deals with the modified wireless power transmission system for biomedical implanted devices. The system consists of efficient class-E power amplifier and inductive power links based on spiral circular transmitter and receiver coils. The model of the class-E power amplifier operated with 13.56 MHz is designed, discussed and analyzed in which it is achieved 87.2% of efficiency. The inductive coupling method is used to achieve link efficiency up to 73% depending on the electronic remote system resistance. The improved system powered with 3.3 DC supply and the voltage across the transmitter side is 40 V whereas, cross the receiver side is 12 V which is rectified to meet the implanted micro-system circuit requirements. The system designed and simulated by NI MULTISIM 11.02.
Abstract: —‘MEDICINE’ is a new project funded under the EC Horizon 2020 Marie-Sklodowska Curie Actions, to determine concepts of health and healing from a culturally specific indigenous context, using a framework of interdisciplinary methods which integrates archaeological-historical, ethnographic and modern health sciences approaches. The study will generate new theoretical and methodological approaches to model how peoples survive and adapt their traditional belief systems in a context of alien cultural impacts. In the immediate wake of the conquest of Peru by invading Spanish armies and ideology, native Andeans responded by forming the Taki Onkoy millenarian movement, which rejected European philosophical and ontological teachings, claiming “you make us sick”. The study explores how people’s experience of their world and their health beliefs within it, is fundamentally shaped by their inherent beliefs about the nature of being and identity in relation to the wider cosmos. Cultural and health belief systems and related rituals or behaviors sustain a people’s sense of identity, wellbeing and integrity. In the event of dislocation and persecution these may change into devolved forms, which eventually inter-relate with ‘modern’ biomedical systems of health in as yet unidentified ways. The development of new conceptual frameworks that model this process will greatly expand our understanding of how people survive and adapt in response to cultural trauma. It will also demonstrate the continuing role, relevance and use of TM in present-day indigenous communities. Studies will first be made of relevant pre-Colombian material culture, and then of early colonial period ethnohistorical texts which document the health beliefs and ritual practices still employed by indigenous Andean societies at the advent of the 17th century Jesuit campaigns of persecution - ‘Extirpación de las Idolatrías’. Core beliefs drawn from these baseline studies will then be used to construct a questionnaire about current health beliefs and practices to be taken into the study population of indigenous Quechua peoples in the northern Andean region of Ecuador. Their current systems of knowledge and medicine have evolved within complex historical contexts of both the conquest by invading Inca armies in the late 15th century, followed a generation later by Spain, into new forms. A new model will be developed of contemporary Andean concepts of health, illness and healing demonstrating the way these have changed through time. With this, a ‘policy tool’ will be constructed as a bridhging facility into contemporary global scenarios relevant to other Indigenous, First Nations, and migrant peoples to provide a means through which their traditional health beliefs and current needs may be more appropriately understood and met. This paper presents findings from the first analytical phases of the work based upon the study of the literature and the archaeological records. The study offers a novel perspective and methods in the development policies sensitive to indigenous and minority people’s health needs.
Abstract: Chitosan is a derivative of chitin, a compound usually
isolated from the shells of some crustaceans such as crab, lobster and
shrimp. It has biocompatible, biodegradable, and antimicrobial
properties. To use these properties of chitosan in biomedical fields,
chitosan films (1%, 2%, 3% and 4%) were prepared by using l%
lactic acid as solvent. The effects of chitosan films on tensile
strength, elongation at break, degree of swelling, thickness,
morphology, allergic and irritation reactions and antibacterial
property were evaluated. Staphylococcus aureus and Escherichia coli
were used as tested microorganisms. In vivo wound healing activities
of chitosan films were investigated using mice model. As results,
Chitosan films have similar appearance and good swelling properties
and 4% chitosan film showed the better swelling activity and the
greatest elongation ratio than the other chitosan films. They also
showed their good activity of wound healing in mice model.
Moreover, the results showed that the films did not produce any
unwilling symptoms (allergy or irritation). In conclusion, it is evident
that the chitosan film has the potentiality to use as wound healing
biofilms in the biomedical fields.