Abstract: There is a growing interest in the use of ultrasonic speckle tracking for biomedical image formation of tissue deformation. Speckle tracking is angle independent and has an ability to differentiate soft tissue into benign and malignant regions. In this paper a simulation model for dynamic ultrasound scatterer is presented. The model composes Field-II ultrasonic scatterers and FEM (ANSYS-11) nodes as a regional tissue deformation. A performance evaluation is presented on axial displacement and strain fields estimation of a uniformly elastic model, using speckle tracking based 1D cross-correlation of optimally segmented pre and post-deformation frames. Optimum correlation window length is investigated in terms of highest signal-to-noise ratio (SNR) for a selected region of interest of a smoothed displacement field. Finally, gradient based strain field of both smoothed and non-smoothed displacement fields are compared. Simulation results from the model are shown to compare favorably with FEM results.
Abstract: Discrete wavelet transform (DWT) has been widely adopted in biomedical signal processing for denoising, compression
and so on. Choosing a suitable decomposition level (DL) in DWT is of paramount importance to its performance. In this paper, we propose to exploit sparseness of the transformed signals to determine the appropriate DL. Simulation results have shown that the sparseness of transformed signals after DWT increases with the increasing DLs. Additional Monte-Carlo simulation results have verified the effectiveness of sparseness measure in determining the DL.
Abstract: In biomedical implant field, a new formula is given
for the study of Radio Frequency power attenuation by simultaneous
effects of side and angular misalignment of the supply/data transfer
coils. A confrontation with the practical measurements done into a
Faraday cage, allowed a checking of the obtained theoretical results.
The DC supply systems without material connection and the data
transmitters used in the case of biomedical implants, can be well
dimensioned by taking into account the possibility of power
attenuation by misalignment of transfer coils
Abstract: This paper presents an algorithm for reconstructing phase and magnitude responses of the impulse response when only the output data are available. The system is driven by a zero-mean independent identically distributed (i.i.d) non-Gaussian sequence that is not observed. The additive noise is assumed to be Gaussian. This is an important and essential problem in many practical applications of various science and engineering areas such as biomedical, seismic, and speech processing signals. The method is based on evaluating the bicepstrum of the third-order statistics of the observed output data. Simulations results are presented that demonstrate the performance of this method.
Abstract: An early and accurate detection of Alzheimer's disease (AD) is an important stage in the treatment of individuals suffering from AD. We present an approach based on the use of structural magnetic resonance imaging (sMRI) phase images to distinguish between normal controls (NC), mild cognitive impairment (MCI) and AD patients with clinical dementia rating (CDR) of 1. Independent component analysis (ICA) technique is used for extracting useful features which form the inputs to the support vector machines (SVM), K nearest neighbour (kNN) and multilayer artificial neural network (ANN) classifiers to discriminate between the three classes. The obtained results are encouraging in terms of classification accuracy and effectively ascertain the usefulness of phase images for the classification of different stages of Alzheimer-s disease.
Abstract: This paper presents a novel method for inferring the
odor based on neural activities observed from rats- main olfactory
bulbs. Multi-channel extra-cellular single unit recordings were done
by micro-wire electrodes (tungsten, 50μm, 32 channels) implanted in
the mitral/tufted cell layers of the main olfactory bulb of anesthetized
rats to obtain neural responses to various odors. Neural response
as a key feature was measured by substraction of neural firing rate
before stimulus from after. For odor inference, we have developed a
decoding method based on the maximum likelihood (ML) estimation.
The results have shown that the average decoding accuracy is about
100.0%, 96.0%, 84.0%, and 100.0% with four rats, respectively. This
work has profound implications for a novel brain-machine interface
system for odor inference.
Abstract: Determining depth of anesthesia is a challenging problem
in the context of biomedical signal processing. Various methods
have been suggested to determine a quantitative index as depth of
anesthesia, but most of these methods suffer from high sensitivity
during the surgery. A novel method based on energy scattering of
samples in the wavelet domain is suggested to represent the basic
content of electroencephalogram (EEG) signal. In this method, first
EEG signal is decomposed into different sub-bands, then samples
are squared and energy of samples sequence is constructed through
each scale and time, which is normalized and finally entropy of the
resulted sequences is suggested as a reliable index. Empirical Results
showed that applying the proposed method to the EEG signals can
classify the awake, moderate and deep anesthesia states similar to
BIS.
Abstract: In many ways, biomedical analysis is analogous to possibilistic reasoning. In spite of that, there are hardly any applications of possibility theory in biology or medicine. The aim of this work is to demonstrate the use of possibility theory in an epidemiological study. In the paper, we build the possibility distribution for the controlled bloodstream concentrations of any physiologically active substance through few approximate considerations. This possibility distribution is tested later against the empirical histograms obtained from the panel study of the eight different physiologically active substances in 417 individuals.
Abstract: Corrugated wire mesh laminates (CWML) are a class
of engineered open cell structures that have potential for applications
in many areas including aerospace and biomedical engineering. Two
different methods of fabricating corrugated wire mesh laminates from
stainless steel, one using a high temperature Lithobraze alloy and the
other using a low temperature Eutectic solder for joining the
corrugated wire meshes are described herein. Their implementation is
demonstrated by manufacturing CWML samples of 304 and 316
stainless steel (SST). It is seen that due to the facility of employing
wire meshes of different densities and wire diameters, it is possible to
create CWML laminates with a wide range of effective densities. The
fabricated laminates are tested under uniaxial compression. The
variation of the compressive yield strength with relative density of the
CWML is compared to the theory developed by Gibson and Ashby for
open cell structures [22]. It is shown that the compressive strength of
the corrugated wire mesh laminates can be described using the same
equations by using an appropriate value for the linear coefficient in the
Gibson-Ashby model.
Abstract: The amount and heterogeneity of data in biomedical research, notably in interdisciplinary research, requires new methods for the collection, presentation and analysis of information. Important data from laboratory experiments as well as patient trials are available but come out of distributed resources. The Charite Medical School in Berlin has established together with the German Research Foundation (DFG) a new information service center for kidney diseases and transplantation (Open European Nephrology Science Centre - OpEN.SC). The system is based on a service-oriented architecture (SOA) with main and auxiliary modules arranged in four layers. To improve the reuse and efficient arrangement of the services the functionalities are described as business processes using the standardised Business Process Execution Language (BPEL).
Abstract: Classifying biomedical literature is a difficult and
challenging task, especially when a large number of biomedical
articles should be organized into a hierarchical structure. In this paper,
we present an approach for classifying a collection of biomedical text
abstracts downloaded from Medline database with the help of
ontology alignment. To accomplish our goal, we construct two types
of hierarchies, the OHSUMED disease hierarchy and the Medline
abstract disease hierarchies from the OHSUMED dataset and the
Medline abstracts, respectively. Then, we enrich the OHSUMED
disease hierarchy before adapting it to ontology alignment process for
finding probable concepts or categories. Subsequently, we compute
the cosine similarity between the vector in probable concepts (in the
“enriched" OHSUMED disease hierarchy) and the vector in Medline
abstract disease hierarchies. Finally, we assign category to the new
Medline abstracts based on the similarity score. The results obtained
from the experiments show the performance of our proposed approach
for hierarchical classification is slightly better than the performance of
the multi-class flat classification.
Abstract: In the last decade, carbohydrates have attracted great
attention as renewable resources for the chemical industry.
Carbohydrates are abundantly found in nature in the form of
monomers, oligomers and polymers, or as components of
biopolymers and other naturally occurring substances. As natural
products, they play important roles in conferring certain physical,
chemical, and biological properties to their carrier molecules.The
synthesis of this particular carbohydrate glycomonomer is part of our
work to obtain biodegradable polymers. Our current paper describes
the synthesis and characterization of a novel carbohydrate
glycomonomer starting from D-glucose, in several synthesis steps,
that involve the protection/deprotection of the D-glucose ring via
acetylation, tritylation, then selective deprotection of the aromaticaliphatic
protective group, in order to obtain 1,2,3,4-tetra-O-acetyl-
6-O-allyl-β-D-glucopyranose. The glycomonomer was then obtained
by the allylation in drastic conditions of 1,2,3,4-tetra-O-acetyl-6-Oallyl-
β-D-glucopyranose with allylic alcohol in the presence of
stannic chloride, in methylene chloride, at room temperature. The
proposed structure of the glycomonomer, 2,3,4-tri-O-acetyl-1,6-di-
O-allyl-β-D-glucopyranose, was confirmed by FTIR, NMR and
HPLC-MS spectrometry. This glycomonomer will be further
submitted to copolymerization with certain acrylic or methacrylic
monomers in order to obtain competitive plastic materials for
applications in the biomedical field.
Abstract: In a transcutanious inductive coupling of a biomedical
implant, a new formula is given for the study of the Radio Frequency
power attenuation by the biological tissue. The loss of the signal
power is related to its interaction with the biological tissue and the
composition of this one. A confrontation with the practical
measurements done with a synthetic muscle into a Faraday cage,
allowed a checking of the obtained theoretical results. The
supply/data transfer systems used in the case of biomedical implants,
can be well dimensioned by taking in account this type of power
attenuation.
Abstract: The myoelectric signal (MES) is one of the Biosignals
utilized in helping humans to control equipments. Recent approaches
in MES classification to control prosthetic devices employing pattern
recognition techniques revealed two problems, first, the classification
performance of the system starts degrading when the number of
motion classes to be classified increases, second, in order to solve the
first problem, additional complicated methods were utilized which
increase the computational cost of a multifunction myoelectric
control system. In an effort to solve these problems and to achieve a
feasible design for real time implementation with high overall
accuracy, this paper presents a new method for feature extraction in
MES recognition systems. The method works by extracting features
using Wavelet Packet Transform (WPT) applied on the MES from
multiple channels, and then employs Fuzzy c-means (FCM)
algorithm to generate a measure that judges on features suitability for
classification. Finally, Principle Component Analysis (PCA) is
utilized to reduce the size of the data before computing the
classification accuracy with a multilayer perceptron neural network.
The proposed system produces powerful classification results (99%
accuracy) by using only a small portion of the original feature set.
Abstract: Medical applications are among the most impactful
areas of microrobotics. The ultimate goal of medical microrobots is
to reach currently inaccessible areas of the human body and carry out
a host of complex operations such as minimally invasive surgery
(MIS), highly localized drug delivery, and screening for diseases at
their very early stages. Miniature, safe and efficient propulsion
systems hold the key to maturing this technology but they pose
significant challenges. A new type of propulsion developed recently,
uses multi-flagella architecture inspired by the motility mechanism of
prokaryotic microorganisms. There is a lack of efficient methods for
designing this type of propulsion system. The goal of this paper is to
overcome the lack and this way, a numerical strategy is proposed to
design multi-flagella propulsion systems. The strategy is based on the
implementation of the regularized stokeslet and rotlet theory, RFT
theory and new approach of “local corrected velocity". The effects of
shape parameters and angular velocities of each flagellum on overall
flow field and on the robot net forces and moments are considered.
Then a multi-layer perceptron artificial neural network is designed
and employed to adjust the angular velocities of the motors for
propulsion control. The proposed method applied successfully on a
sample configuration and useful demonstrative results is obtained.
Abstract: EEG signal is one of the oldest measures of brain
activity that has been used vastly for clinical diagnoses and
biomedical researches. However, EEG signals are highly
contaminated with various artifacts, both from the subject and from
equipment interferences. Among these various kinds of artifacts,
ocular noise is the most important one. Since many applications such
as BCI require online and real-time processing of EEG signal, it is
ideal if the removal of artifacts is performed in an online fashion.
Recently, some methods for online ocular artifact removing have
been proposed. One of these methods is ARMAX modeling of EEG
signal. This method assumes that the recorded EEG signal is a
combination of EOG artifacts and the background EEG. Then the
background EEG is estimated via estimation of ARMAX parameters.
The other recently proposed method is based on adaptive filtering.
This method uses EOG signal as the reference input and subtracts
EOG artifacts from recorded EEG signals. In this paper we
investigate the efficiency of each method for removing of EOG
artifacts. A comparison is made between these two methods. Our
undertaken conclusion from this comparison is that adaptive filtering
method has better results compared with the results achieved by
ARMAX modeling.
Abstract: This paper explores the scalability issues associated
with solving the Named Entity Recognition (NER) problem using
Support Vector Machines (SVM) and high-dimensional features. The
performance results of a set of experiments conducted using binary
and multi-class SVM with increasing training data sizes are
examined. The NER domain chosen for these experiments is the
biomedical publications domain, especially selected due to its
importance and inherent challenges. A simple machine learning
approach is used that eliminates prior language knowledge such as
part-of-speech or noun phrase tagging thereby allowing for its
applicability across languages. No domain-specific knowledge is
included. The accuracy measures achieved are comparable to those
obtained using more complex approaches, which constitutes a
motivation to investigate ways to improve the scalability of multiclass
SVM in order to make the solution more practical and useable.
Improving training time of multi-class SVM would make support
vector machines a more viable and practical machine learning
solution for real-world problems with large datasets. An initial
prototype results in great improvement of the training time at the
expense of memory requirements.
Abstract: The aim of this contribution is to present a new
approach in modeling the electrical activity of the human heart. A
recurrent artificial neural network is being used in order to exhibit a
subset of the dynamics of the electrical behavior of the human heart.
The proposed model can also be used, when integrated, as a
diagnostic tool of the human heart system.
What makes this approach unique is the fact that every model is
being developed from physiological measurements of an individual.
This kind of approach is very difficult to apply successfully in many
modeling problems, because of the complexity and entropy of the
free variables describing the complex system. Differences between
the modeled variables and the variables of an individual, measured at
specific moments, can be used for diagnostic purposes. The sensor
fusion used in order to optimize the utilization of biomedical sensors
is another point that this paper focuses on. Sensor fusion has been
known for its advantages in applications such as control and
diagnostics of mechanical and chemical processes.
Abstract: Alzheimer is known as the loss of mental functions
such as thinking, memory, and reasoning that is severe enough to
interfere with a person's daily functioning. The appearance of
Alzheimer Disease symptoms (AD) are resulted based on which part
of the brain has a variety of infection or damage. In this case, the
MRI is the best biomedical instrumentation can be ever used to
discover the AD existence. Therefore, this paper proposed a fusion
method to distinguish between the normal and (AD) MRIs. In this
combined method around 27 MRIs collected from Jordanian
Hospitals are analyzed based on the use of Low pass -morphological
filters to get the extracted statistical outputs through intensity
histogram to be employed by the descriptive box plot. Also, the
artificial neural network (ANN) is applied to test the performance of
this approach. Finally, the obtained result of t-test with confidence
accuracy (95%) has compared with classification accuracy of ANN
(100 %). The robust of the developed method can be considered
effectively to diagnose and determine the type of AD image.
Abstract: This paper presents the design of a low power second-order continuous-time sigma-delta modulator for low power
applications. The loop filter of this modulator has been implemented based on the nonlinear transconductance-capacitor (Gm-C) by employing current-mode technique. The nonlinear transconductance uses floating gate MOS (FG-MOS) transistors that operate in weak inversion region. The proposed modulator features low power consumption (