Predicting Protein-Protein Interactions from Protein Sequences Using Phylogenetic Profiles

In this study, a high accuracy protein-protein interaction prediction method is developed. The importance of the proposed method is that it only uses sequence information of proteins while predicting interaction. The method extracts phylogenetic profiles of proteins by using their sequence information. Combining the phylogenetic profiles of two proteins by checking existence of homologs in different species and fitting this combined profile into a statistical model, it is possible to make predictions about the interaction status of two proteins. For this purpose, we apply a collection of pattern recognition techniques on the dataset of combined phylogenetic profiles of protein pairs. Support Vector Machines, Feature Extraction using ReliefF, Naive Bayes Classification, K-Nearest Neighborhood Classification, Decision Trees, and Random Forest Classification are the methods we applied for finding the classification method that best predicts the interaction status of protein pairs. Random Forest Classification outperformed all other methods with a prediction accuracy of 76.93%

On Strong(Weak) Domination in Fuzzy Graphs

Let G be a fuzzy graph. Then D Ôèå V is said to be a strong (weak) fuzzy dominating set of G if every vertex v ∈ V -D is strongly (weakly) dominated by some vertex u in D. We denote a strong (weak) fuzzy dominating set by sfd-set (wfd-set). The minimum scalar cardinality of a sfd-set (wfd-set) is called the strong (weak) fuzzy domination number of G and it is denoted by γsf (G)γwf (G). In this paper we introduce the concept of strong (weak) domination in fuzzy graphs and obtain some interesting results for this new parameter in fuzzy graphs.

A New IT-Convergence Service Design Framework

In many countries, digital city or ubiquitous city (u-City) projects have been initiated to provide digitalized economic environments to cities. Recently in Korea, Kangwon Province has started the u-Kangwon project to boost local economy with digitalized tourism services. We analyze the limitations of the ubiquitous IT approach through the u-Kangwon case. We have found that travelers are more interested in quality over speed in access of information. For improved service quality, we are looking to develop an IT-convergence service design framework (ISDF). The ISDF is based on the service engineering technique and composed of three parts: Service Design, Service Simulation, and the Service Platform.

Restoration of Biological Function of Degraded Soil via Chemical Method

The studies concerned an effect of six variants of ion exchange substrate (nutrient carriers with a different potential impact on pH of soil solution) on vegetation of orchard grass during two different periods (42 and 84 days). In the pot experiment plants were grown on sand (model of degraded soil) and six mixtures of sand and 2% (v/v) additions of particular variants of ion exchange substrate (with pH ranged from 5.5 to 8.0). The study results showed that the addition of the substrate at pH=6.5 caused the highest increase in plant yield after shorter vegetation period whereas the addition of the substrate at pH=5.5 increased dry stem and root biomass of orchard grass after longer vegetation period. Thus, the ion exchange substrate at pH=6.5 can be recommended for restoration of exhausted soils when shorter vegetation period is planned; the ion exchange substrate at pH=5.5 can be used for the same purpose when longer periods of vegetative growth are considered.

Discovery of Quantified Hierarchical Production Rules from Large Set of Discovered Rules

Automated discovery of Rule is, due to its applicability, one of the most fundamental and important method in KDD. It has been an active research area in the recent past. Hierarchical representation allows us to easily manage the complexity of knowledge, to view the knowledge at different levels of details, and to focus our attention on the interesting aspects only. One of such efficient and easy to understand systems is Hierarchical Production rule (HPRs) system. A HPR, a standard production rule augmented with generality and specificity information, is of the following form: Decision If < condition> Generality Specificity . HPRs systems are capable of handling taxonomical structures inherent in the knowledge about the real world. This paper focuses on the issue of mining Quantified rules with crisp hierarchical structure using Genetic Programming (GP) approach to knowledge discovery. The post-processing scheme presented in this work uses Quantified production rules as initial individuals of GP and discovers hierarchical structure. In proposed approach rules are quantified by using Dempster Shafer theory. Suitable genetic operators are proposed for the suggested encoding. Based on the Subsumption Matrix(SM), an appropriate fitness function is suggested. Finally, Quantified Hierarchical Production Rules (HPRs) are generated from the discovered hierarchy, using Dempster Shafer theory. Experimental results are presented to demonstrate the performance of the proposed algorithm.

An EEG Case Study of Arithmetical Reasoning by Four Individuals Varying in Imagery and Mathematical Ability: Implications for Mathematics Education

The main issue of interest here is whether individuals who differ in arithmetical reasoning ability and levels of imagery ability display different brain activity during the conduct of mental arithmetical reasoning tasks. This was a case study of four participants who represented four extreme combinations of Maths –Imagery abilities: ie., low-low, high-high, high-low, low-high respectively. As the Ps performed a series of 60 arithmetical reasoning tasks, 128-channel EEG recordings were taken and the pre-response interval subsequently analysed using EGI GeosourceTM software. The P who was high in both imagery and maths ability showed peak activity prior to response in BA7 (superior parietal cortex) but other Ps did not show peak activity in this region. The results are considered in terms of the diverse routes that may be employed by individuals during the conduct of arithmetical reasoning tasks and the possible implications of this for mathematics education.

Image Restoration in Non-Linear Filtering Domain using MDB approach

This paper proposes a new technique based on nonlinear Minmax Detector Based (MDB) filter for image restoration. The aim of image enhancement is to reconstruct the true image from the corrupted image. The process of image acquisition frequently leads to degradation and the quality of the digitized image becomes inferior to the original image. Image degradation can be due to the addition of different types of noise in the original image. Image noise can be modeled of many types and impulse noise is one of them. Impulse noise generates pixels with gray value not consistent with their local neighborhood. It appears as a sprinkle of both light and dark or only light spots in the image. Filtering is a technique for enhancing the image. Linear filter is the filtering in which the value of an output pixel is a linear combination of neighborhood values, which can produce blur in the image. Thus a variety of smoothing techniques have been developed that are non linear. Median filter is the one of the most popular non-linear filter. When considering a small neighborhood it is highly efficient but for large window and in case of high noise it gives rise to more blurring to image. The Centre Weighted Mean (CWM) filter has got a better average performance over the median filter. However the original pixel corrupted and noise reduction is substantial under high noise condition. Hence this technique has also blurring affect on the image. To illustrate the superiority of the proposed approach, the proposed new scheme has been simulated along with the standard ones and various restored performance measures have been compared.

Constraint Based Frequent Pattern Mining Technique for Solving GCS Problem

Generalized Center String (GCS) problem are generalized from Common Approximate Substring problem and Common substring problems. GCS are known to be NP-hard allowing the problems lies in the explosion of potential candidates. Finding longest center string without concerning the sequence that may not contain any motifs is not known in advance in any particular biological gene process. GCS solved by frequent pattern-mining techniques and known to be fixed parameter tractable based on the fixed input sequence length and symbol set size. Efficient method known as Bpriori algorithms can solve GCS with reasonable time/space complexities. Bpriori 2 and Bpriori 3-2 algorithm are been proposed of any length and any positions of all their instances in input sequences. In this paper, we reduced the time/space complexity of Bpriori algorithm by Constrained Based Frequent Pattern mining (CBFP) technique which integrates the idea of Constraint Based Mining and FP-tree mining. CBFP mining technique solves the GCS problem works for all center string of any length, but also for the positions of all their mutated copies of input sequence. CBFP mining technique construct TRIE like with FP tree to represent the mutated copies of center string of any length, along with constraints to restraint growth of the consensus tree. The complexity analysis for Constrained Based FP mining technique and Bpriori algorithm is done based on the worst case and average case approach. Algorithm's correctness compared with the Bpriori algorithm using artificial data is shown.

Phenolic Content and Antioxidant Activity Determination in Broccoli and Lamb’s Lettuce

Broccoli has been widely recognized as a wealthy vegetable which contains multiple nutrients with potent anti-cancer properties. Lamb’s lettuce has been used as food for many centuries but only recently became commercially available and literature is therefore exiguous concerning these vegetables. The aim of this work was to evaluate the influence of the extraction conditions on the yield of phenolic compounds and the corresponding antioxidant capacity of broccoli and lamb’s lettuce. The results indicate that lamb’s lettuce, compared to broccoli, contains simultaneously a large amount of total polyphenols as well as high antioxidant activity. It is clearly demonstrated that extraction solvent significantly influences the antioxidant activity. Methanol is the solvent that can globally maximize the antioxidant extraction yield. The results presented herein prove lamb’s lettuce as a very interesting source of polyphenols, and thus a potential health-promoting food.

The Effect of Multi-Layer Bandage on the Interface Pressure Applied by Compression Bandages

Medical compression bandages are widely used in the treatment of chronic venous disorder. In order to design effective compression bandages, researchers have attempted to describe the interface pressure applied by multi-layer bandages using mathematical models. This paper reports on the work carried out to compare and validate the mathematical models used to describe the interface pressure applied by multi-layer bandages. Both analytical and experimental results showed that using simple multiplication of a number of bandage layers with the pressure applied by one layer of bandage or ignoring the increase in the limb radius due to former layers of bandage will result in overestimating the pressure. Experimental results showed that the mathematical models, which take into consideration the increase in the limb radius due to former bandage layers, are more accurate than the one which does not.

Experimental Validation of Treatment Planning for Multiple Radiotherapy Fields by EDR2 Film Dosimeter

To investigate the applicability of the EDR-2 film for clinical radiation dosimetry, percentage depth-doses, profiles and distributions in open and dynamically wedged fields were measured using film and compared with data from a Treatment Planning system.The validity of the EDR2 film to measure dose in a plane parallel to the beam was tested by irradiating 10 cm×10 cm and 4 cm×4 cm fields from a Siemens, primus linac with a 6MV beam and a source-to-surface distance of 100 cm. The film was placed Horizontally between solid water phantom blocks and marked with pin holes at a depth of 10 cm from the incident beam surface. The film measurement results, in absolute dose, were compared with ion chamber measurements using a Welhoffer scanning water tank system and Treatment Planning system. Our results indicate a maximum underestimate of calculated dose of 8 % with Treatment Planning system.

Instructional Design Using the Virtual Ecological Pond for Science Education in Elementary Schools

Ecological ponds can be a good teaching tool for science teachers, but they must be built and maintained properly to provide students with a safe and suitable learning environment. Hence, many schools do not have the ability to build an ecological pond. This study used virtual reality technology to develop a webbased virtual ecological pond. Supported by situated learning theory and the instructional design of “Aquatic Life" learning unit, elementary school students can actively explore in the virtual ecological pond to observe aquatic animals and plants and learn about the concept of ecological conservation. A teaching experiment was conducted to investigate the learning effectiveness and practicability of this instructional design, and the results showed that students improved a great deal in learning about aquatic life. They found the virtual ecological pond interesting, easy to operate and helpful to understanding the aquatic ecological system. Therefore, it is useful in elementary science education.

Renewal of The Swedish Million Dwelling Program, the Public Housing Company and the Local Community, Hindrances and Mutual Aid

Public housing is a vital factor in community development. Successful city, housing and eco system regeneration design is essential in providing positive community development. This concerns work places, nice dwellings, providing premises for child care, care of the elderly, providing qualitative premises for different kinds of commercial service, providing a nice built environment and housing areas and not the least activating tenants. The public housing companies give value to society by stimulating people, renovating socially and economically sustainable as well as being partners to local business and authorities. By their activities the housing companies contribute to sustainable local and regional growth and the identity and reputation of cities. A Social, Economic and Ecological Reputation Effect (SEERE) model for actions to promote housing and community reputation is presented. The model emphasizes regenerative actions to restore natural eco systems as part of housing renewal strategies and to strengthen municipality reputation.

Effect of the Internet on Social Capital

Internet access is a vital part of the modern world and an important tool in the education of our children. It is present in schools, homes and even shopping malls. Mastering the use of the internet is likely to be an important skill for those entering the job markets of the future. An internet user can be anyone he or she wants to be in an online chat room, or play thrilling and challenging games against other players from all corners of the globe. It seems at present time (or near future) for many people relationships in the real world may be neglected as those in the virtual world increase in importance. Internet is provided a fast mode of transportation caused freedom from family bonds and mixing with different cultures and new communities. This research is an attempt to study effect of Internet on Social capital. For this purpose a survey technique on the sample size amounted 168 students of Payame Noor University of Kermanshah city in country of Iran were considered. Degree of social capital is moderate. With the help of the Multi-variable Regression, variables of Iranian message attractive, Interest to internet with effect of positive and variable Creating a cordial atmosphere with negative effect be significant.

A High Standard Isolated Insolated Photovoltaic Egyptian Safari Rest Red Sea Area

Where renewable energy sources, solar, hydro, wind are available the remote communities and businesses can be provided with the most reliable and affordable source of electrical energy. This paper presents a model of safari rest contains all the necessary services for the interested tourists who visit the safari Sinai desert. The PV energy system provides the rural energy needs of remote communities. A photovoltaic renewable energy system is designed to feed the global Ac and Dc electrical required load of this safari rest . The benefits of photovoltaic renewable energy at rural applications are its versatility and convenience. This model of safari rest must be taken in consideration by Egyptian Government as it will provide the tourism plane by new interested tourism field which put a big spot on Red sea area: El Ghordaka.

Worker Behavior Interpretation for Flexible Production

This paper addresses the problem of recognizing and interpreting the behavior of human workers in industrial environments for the purpose of integrating humans in software controlled manufacturing environments. In this work we propose a generic concept in order to derive solutions for task-related manual production applications. Thus, we are able to use a versatile concept providing flexible components and being less restricted to a specific problem or application. We instantiate our concept in a spot welding scenario in which the behavior of a human worker is interpreted when performing a welding task with a hand welding gun. We acquire signals from inertial sensors, video cameras and triggers and recognize atomic actions by using pose data from a marker based video tracking system and movement data from inertial sensors. Recognized atomic actions are analyzed on a higher evaluation level by a finite state machine.

Fatigue Life Consumption for Turbine Blades-Vanes Accelerated by Erosion-Contour Modification

A new mechanism responsible for structural life consumption due to resonant fatigue in turbine blades, or vanes, is presented and explained. A rotating blade or vane in a gas turbine can change its contour due to erosion and/or material build up, in any of these instances, the surface pressure distribution occurring on the suction and pressure sides of blades-vanes can suffer substantial modification of their pressure and temperatures envelopes and flow characteristics. Meanwhile, the relative rotation between the blade and duct vane while the pressurized gas flows and the consequent wake crossings, will induce a fluctuating thrust force or lift that will excite the blade. An actual totally used up set of vane-blade components in a HP turbine power stage in a gas turbine is analyzed. The blade suffered some material erosion mostly at the trailing edge provoking a peculiar surface pressure envelope which evolved as the relative position between the vane and the blade passed in front of each other. Interestingly preliminary modal analysis for this eroded blade indicates several natural frequencies within the aeromechanic power spectrum, moreover, the highest frequency component is 94% of one natural frequency indicating near resonant condition. Independently of other simultaneously occurring fatigue cycles (such as thermal, centrifugal stresses).

Redefining Field Experiences: Virtual Environments in Teacher Education

The explosion of interest in online gaming and virtual worlds is leading many universities to investigate possible educational applications of the new environments. In this paper we explore the possibilities of 3D online worlds for teacher education, particularly the field experience component. Drawing upon two pedagogical examples, we suggest that virtual simulations may, with certain limitations, create safe spaces that allow preservice teachers to adopt alternate identities and interact safely with the “other." In so doing they may become aware of the constructed nature of social categories and gain the essential pedagogical skill of perspective-taking. We suggest that, ultimately, the ability to be the principal creators of themselves in virtual environments can increase their ability to do the same in the real world.

Visfatin and Apelin Are New Interrelated Adipokines Playing Role in the Pathogenesis of Type 2 Diabetes Mellitus Associated Coronary Artery Disease in Postmenopausal Women

Visfatin and apelin are two new adipokines that recently gained a special interest in diabetes research. This study was conducted to study the interplay between these two adipokines and their correlation with other inflammatory and biochemical parameters in type 2 diabetic (T2D) postmenopausal women with CAD. Visfatin and apelin were measured by enzyme-linked immunoassay (ELISA). Visfatin was found to be significantly higher in the following groups: T2D patients without CAD, non-obese and obese T2D patients with CAD when compared to control group. Apelin was found to be significantly lower in non-obese and obese T2D patients with CAD when compared to control group. Visfatin and apelin were found to be significantly associated with each other and with other biochemical parameters. The current study provides evidence for the interplay between visfatin and apelin through the inflammatory milieu characteristic of T2D and their possible role in the pathogenesis of CAD complication of T2D. 

Experimental Determination of Large Strain Localization in Cut Steel Chips

Metal cutting is a severe plastic deformation process involving large strains, high strain rates, and high temperatures. Conventional analysis of the chip formation process is based on bulk material deformation disregarding the inhomogeneous nature of the material microstructure. A series of orthogonal cutting tests of AISI 1045 and 1144 steel were conducted which yielded similar process characteristics and chip formations. With similar shear angles and cut chip thicknesses, shear strains for both chips were found to range from 2.0 up to 2.8. The manganese-sulfide (MnS) precipitate in the 1144 steel has a very distinct and uniform shape which allows for comparison before and after chip formation. From close observations of MnS precipitates in the cut chips it is shown that the conventional approach underestimates plastic strains in metal cutting. Experimental findings revealed local shear strains around a value of 6. These findings and their implications are presented and discussed.