Abstract: In this study, a high accuracy protein-protein interaction
prediction method is developed. The importance of the proposed
method is that it only uses sequence information of proteins while
predicting interaction. The method extracts phylogenetic profiles of
proteins by using their sequence information. Combining the phylogenetic
profiles of two proteins by checking existence of homologs
in different species and fitting this combined profile into a statistical
model, it is possible to make predictions about the interaction status
of two proteins.
For this purpose, we apply a collection of pattern recognition
techniques on the dataset of combined phylogenetic profiles of protein
pairs. Support Vector Machines, Feature Extraction using ReliefF,
Naive Bayes Classification, K-Nearest Neighborhood Classification,
Decision Trees, and Random Forest Classification are the methods
we applied for finding the classification method that best predicts
the interaction status of protein pairs. Random Forest Classification
outperformed all other methods with a prediction accuracy of 76.93%