Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: Two-phase frictional pressure drop data were
obtained for condensation of carbon dioxide in single horizontal
micro tube of inner diameter ranged from 0.6 mm up to 1.6 mm over
mass flow rates from 2.5*10-5 to 17*10-5 kg/s and vapor qualities
from 0.0 to 1.0. The inlet condensing pressure is changed from 33.5
to 45 bars. The saturation temperature ranged from -1.5 oC up to 10
oC. These data have then been compared against three (two-phase)
frictional pressure drop prediction methods. The first method is by
Muller-Steinhagen and Heck (Muller-Steinhagen H, Heck K. A
simple friction pressure drop correlation for two-phase flow in pipes.
Chem. Eng. Process 1986;20:297–308) and that by Gronnerud R.
Investigation of liquid hold-up, flow-resistance and heat transfer in
circulation type evaporators, part IV: two-phase flow resistance in
boiling refrigerants, Annexe 1972. Then the method used by
FriedelL. Improved friction pressures drop in horizontal and vertical
two-phase pipe flow. European Two-Phase Flow Group Meeting,
Paper E2; 1979 June, Ispra, Italy. The methods are used by M.B Ould
Didi et al (2001) “Prediction of two-phase pressure gradients of
refrigerant in horizontal tubes". Int.J.of Refrigeration 25(2002) 935-
947. The best available method for annular flow was that of Muller-
Steinhagen and Heck. It was observed that the peak in the two-phase
frictional pressure gradient is at high vapor qualities.
Abstract: In this study, communities of ammonia-oxidizing
archaea (AOA) and ammonia-oxidizing bacteria (AOB) in nitrifying
activated sludge (NAS) prepared by enriching sludge from a
municipal wastewater treatment plant in three continuous-flow
reactors receiving an inorganic medium containing different
ammonium concentrations of 2, 10, and 30 mM NH4
+-N (NAS2,
NAS10, and NAS30, respectively) were investigated using molecular
analysis. Results suggested that almost all AOA clones from NAS2,
NAS10, and NAS30 fell into the same AOA cluster and AOA
communities in NAS2 and NAS10 were more diverse than those of
NAS30. In contrast to AOA, AOB communities obviously shifted
from the seed sludge to enriched NASs and in each enriched NAS,
communities of AOB varied particularly. The seed sludge contained
members of N. communis cluster and N. oligotropha cluster. After it
was enriched under various ammonium loads, members of N.
communis cluster disappeared from all enriched NASs. AOB with
high affinity to ammonia presented in NAS 2, AOB with low affinity
to ammonia presented in NAS 30, and both types of AOB survived in
NAS 10. These demonstrated that ammonium load significantly
influenced AOB communities, but not AOA communities in enriched
NASs.
Abstract: Three similar negative differential resistance (NDR)
profiles with both high peak to valley current density ratio (PVCDR)
value and high peak current density (PCD) value in unity resonant
tunneling electronic circuit (RTEC) element is developed in this paper.
The PCD values and valley current density (VCD) values of the three
NDR curves are all about 3.5 A and 0.8 A, respectively. All PV values
of NDR curves are 0.40 V, 0.82 V, and 1.35 V, respectively. The VV
values are 0.61 V, 1.07 V, and 1.69 V, respectively. All PVCDR
values reach about 4.4 in three NDR curves. The PCD value of 3.5 A
in triple PVCDR RTEC element is better than other resonant
tunneling devices (RTD) elements. The high PVCDR value is
concluded the lower VCD value about 0.8 A. The low VCD value is
achieved by suitable selection of resistors in triple PVCDR RTEC
element. The low PV value less than 1.35 V possesses low power
dispersion in triple PVCDR RTEC element. The designed multiple
value logical level (MVLL) system using triple PVCDR RTEC
element provides equidistant logical level. The logical levels of
MVLL system are about 0.2 V, 0.8 V, 1.5 V, and 2.2 V from low
voltage to high voltage and then 2.2 V, 1.3 V, 0.8 V, and 0.2 V from
high voltage back to low voltage in half cycle of sinusoid wave. The
output level of four levels MVLL system is represented in 0.3 V, 1.1 V,
1.7 V, and 2.6 V, which satisfies the NMP condition of traditional
two-bit system. The remarkable logical characteristic of improved
MVLL system with paralleled capacitor are with four significant
stable logical levels about 220 mV, 223 mV, 228 mV, and 230 mV.
The stability and articulation of logical levels of improved MVLL
system are outstanding. The average holding time of improved MVLL
system is approximately 0.14 μs. The holding time of improved
MVLL system is fourfold than of basic MVLL system. The function of
additional capacitor in the improved MVLL system is successfully
discovered.
Abstract: Assessment for image quality traditionally needs its
original image as a reference. The conventional method for assessment
like Mean Square Error (MSE) or Peak Signal to Noise Ratio (PSNR)
is invalid when there is no reference. In this paper, we present a new
No-Reference (NR) assessment of image quality using blur and noise.
The recent camera applications provide high quality images by help of
digital Image Signal Processor (ISP). Since the images taken by the
high performance of digital camera have few blocking and ringing
artifacts, we only focus on the blur and noise for predicting the
objective image quality. The experimental results show that the
proposed assessment method gives high correlation with subjective
Difference Mean Opinion Score (DMOS). Furthermore, the proposed
method provides very low computational load in spatial domain and
similar extraction of characteristics to human perceptional assessment.
Abstract: Neoclassical and functionalist explanations of self
organization in multiagent systems have been criticized on several accounts including unrealistic explication of overadapted agents and
failure to resolve problems of externality. The paper outlines a more
elaborate and dynamic model that is capable of resolving these dilemmas. An illustrative example where behavioral diversity is
cobred in a repeated nonzero sum task via evolutionary computing is
presented.
Abstract: A study of the H-beam's nanosize structure phase
states after thermomechanical strengthening was carried out by TEM.
The following processes were analyzed. 1. The dispersing of the
cementite plates by cutting them by moving dislocations. 2. The
dissolution of cementite plates and repeated precipitation of the
cementite particles on the dislocations, the boundaries, subgrains and
grains. 3. The decay of solid solution of carbon in the α-iron after
"self-tempering" of martensite. 4. The final transformation of the
retained austenite in beinite with α-iron particles and cementite
formation. 5. The implementation of the diffusion mechanism of γ ⇒
α transformation.
Abstract: In the meat processing industry the substitution of
meat with non-meat ingredients is considered an important strategy
for reducing overall production costs. The main purpose of the
current research was to evaluate differences in physical-chemical
composition of cooked sausage with different legumes additions.
Peas (Pisum sativum), beans (Phaseolus vulgaris) and lentil (Lens
culinaris) were used in preparation of sausages. The legumes at
proportion of 20% of the total weight of meat were added in
sausages. The whole ingredients were mixed, filled into casing,
compressed, cooked and cooled. After storage the samples were
sensory evaluated. The sensory evaluation was carried out using the
nine point hedonic scale and line scale. Sausages without legumes
flour was used as control sample. The main conclusion of the current
research the legumes flour can be successfully used for cooked
sausages production.
Abstract: According to the European laws, there is the
possibility of reusing the washing wastes for the environmental
requalification of quarry lakes. The paper deals with the
hydrogeological aspects involved in this possibility, as the
introduction of finest wastes in the quarry lakes can generate
alterations of the hydrogeological setting of the area, and problems
for the future accessibility of the zone. To evaluate the
hydrogeological compatibility of the washing wastes reuse in quarry
lakes a groundwater numerical model was carried out, pointing out
both the hydrogeological feasibility of this intervention and some
guide lines for its optimization, in terms of inflow point with regard
the groundwater flow direction and loss of volume in the quarry lake.
Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: The aim of the present study was to investigate the
chemical and biological properties of local cowpea seed protein
cultivated in Gizan region. The results showed that the cowpea and
its products contain high level of protein (22.9-77.6%), high
carbohydrates (9.4-64.3%) and low fats (0.1-0.3%). The trypsin and
chymotrypsin activities were found to be 32.2 and 15.2 units,
respectively. These activities were not affected in both defatted and
protein concentrate whereas they were significantly reduced in
isolated protein and cooked samples. The phytate content of cooked
and concentrated cowpea samples varied from 0.25% -0.32%,
respectively. Tannin content was found to be 0.4% and 0.23% for
cooked and raw samples, respectively. The in vitro protein
digestibility was very high in cowpea seeds (75.04-78.76%). The
biological evaluation using rats showed that the group fed with
animal feed containing casein gain more weight than those fed with
that containing cowpea. However, the group fed with cooked cowpea
gain more weight than those fed with uncooked cowpea. On the
other hand, in vivo digestion showed high value (98.33%) among the
group consumed casein compared to other groups those consumed
cowpea contains feed. This could be attributed to low antinutritional
factors in casein contains feed compared to those of cowpea contains
feed because cooking significantly increased the digestion rate
(80.8% to 83.5%) of cowpea contains feed. Furthermore, the
biological evaluation was high (91.67%) of casein containing feed
compared to that of cowpea containing feed (80.83%-87.5%). The
net protein utilization (NPU) was higher (89.67%) in the group fed
with casein containing feed than that of cowpea containing feed
(56.33%-69.67%).
Abstract: Enzymatic hydrolysis of starch from natural sources
finds potential application in commercial production of alcoholic
beverage and bioethanol. In this study the effect of starch
concentration, temperature, time and enzyme concentration were
studied and optimized for hydrolysis of Potato starch powder (of
mesh 80/120) into glucose syrup by immobilized (using Sodium
arginate) α-amylase using central composite design. The
experimental result on enzymatic hydrolysis of Potato starch was
subjected to multiple linear regression analysis using MINITAB 14
software. Positive linear effect of starch concentration, enzyme
concentration and time was observed on hydrolysis of Potato starch
by α-amylase. The statistical significance of the model was validated
by F-test for analysis of variance (p ≤ 0.01). The optimum value of
starch concentration, enzyme concentration, temperature, time and
were found to be 6% (w/v), 2% (w/v), 40°C and 80min respectively.
The maximum glucose yield at optimum condition was 2.34 mg/mL.
Abstract: Organizational communication is an administrative
function crucial especially for executives in the implementation of
organizational and administrative functions. Executives spend a
significant part of their time on communicative activities. Doing his or her daily routine, arranging meeting schedules, speaking on the telephone, reading or replying to business correspondence, or
fulfilling the control functions within the organization, an executive typically engages in communication processes.
Efficient communication is the principal device for the adequate implementation of administrative and organizational activities. For
this purpose, management needs to specify the kind of
communication system to be set up and the kind of communication
devices to be used. Communication is vital for any organization.
In conventional offices, communication takes place within the hierarchical pyramid called the organizational structure, and is known as formal or informal communication. Formal communication
is the type that works in specified structures within the organizational rules and towards the organizational goals. Informal communication, on the other hand, is the unofficial type taking place among staff as
face-to-face or telephone interaction.
Communication in virtual as well as conventional offices is
essential for obtaining the right information in administrative
activities and decision-making. Virtual communication technologies
increase the efficiency of communication especially in virtual teams.
Group communication is strengthened through an inter-group central
channel. Further, ease of information transmission makes it possible
to reach the information at the source, allowing efficient and correct decisions. Virtual offices can present as a whole the elements of information which conventional offices produce in different
environments.
At present, virtual work has become a reality with its pros and
cons, and will probably spread very rapidly in coming years, in line
with the growth in information technologies.
Abstract: In the present study, the rate of NOx emission in a
combustion chamber working in conventional combustion and High
Temperature Air Combustion (HiTAC) system are examined using
CFD modeling. The effect of peak temperature, combustion air
temperature and oxygen concentration on NOx emission rate was
undertaken. Results show that in a fixed oxygen concentration,
increasing the preheated air temperature will increase the peak
temperature and NOx emission rate. In addition, it was observed that
the reduction of the oxygen concentration in the fixed preheated air
temperature decreases the peak temperature and NOx emission rate.
On the other hand, the results show that increase of preheated air
temperature at various oxygen concentrations increases the NOx
emission rate. However, the rate of increase in HiTAC conditions is
quite lower than the conventional combustion. The modeling results
show that the NOx emission rate in HiTAC combustion is 133% less
than that of the conventional combustion.
Abstract: Rice husk is a lignocellulosic source that can be
converted to ethanol. Three hundreds grams of rice husk was mixed
with 1 L of 0.18 N sulfuric acid solutions then was heated in an
autoclave. The reaction was expected to be at constant temperature
(isothermal), but before that temperature was achieved, reaction has
occurred. The first liquid sample was taken at temperature of 140 0C
and repeated every 5 minute interval. So the data obtained are in the
regions of non-isothermal and isothermal. It was observed that the
degradation has significant effects on the ethanol production. The
kinetic constants can be expressed by Arrhenius equation with the
frequency factors for hydrolysis and sugar degradation of 1.58 x 105
1/min and 2.29 x 108 L/mole/min, respectively, while the activation
energies are 64,350 J/mole and 76,571 J/mole. The highest ethanol
concentration from fermentation is 1.13% v/v, attained at 220 0C.
Abstract: Signalized intersections on high-volume arterials are
often congested during peak hours, causing a decrease in through
movement efficiency on the arterial. Much of the vehicle delay
incurred at conventional intersections is caused by high left-turn
demand. Unconventional intersection designs attempt to reduce
intersection delay and travel time by rerouting left-turns away from
the main intersection and replacing it with right-turn followed by Uturn.
The proposed new type of U-turn intersection is geometrically
designed with a raised island which provides a protected U-turn
movement. In this study several scenarios based on different
distances between U-turn and main intersection, traffic volume of
major/minor approaches and percentage of left-turn volumes were
simulated by use of AIMSUN, a type of traffic microsimulation
software. Subsequently some models are proposed in order to
compute travel time of each movement. Eventually by correlating
these equations to some in-field collected data of some implemented
U-turn facilities, the reliability of the proposed models are approved.
With these models it would be possible to calculate travel time of
each movement under any kind of geometric and traffic condition. By
comparing travel time of a conventional signalized intersection with
U-turn intersection travel time, it would be possible to decide on
converting signalized intersections into this new kind of U-turn
facility or not. However comparison of travel time is not part of the
scope of this research. In this paper only travel time of this innovative
U-turn facility would be predicted. According to some before and
after study about the traffic performance of some executed U-turn
facilities, it is found that commonly, this new type of U-turn facility
produces lower travel time. Thus, evaluation of using this type of
unconventional intersection should be seriously considered.
Abstract: In this paper, the authors examine whether or not there Institute for Information and Communications Policy shows are differences of Japanese Internet users awareness to information security based on individual attributes by using analysis of variance based on non-parametric method. As a result, generally speaking, it is found that Japanese Internet users' awareness to information security is different by individual attributes. Especially, the authors verify that the users who received the information security education would have rather higher recognition concerning countermeasures than other users including self-educated users. It is suggested that the information security education should be enhanced so that the users may appropriately take the information security countermeasures. In addition, the information security policy such as carrying out "e- net caravan" and "information security seminars" are effective in improving the users' awareness on the information security in Japan.
Abstract: The research is to minimize environmental damage
pertinent to maritime activities about the operation of lighter boat
anchorage and its tugboat. The guidance on upgrading current
harbor service and infrastructure has been provided to Kho Sichang
Municpality. This will involve a study of the maritime logistics of
the water area under jurisdiction of the Sichang island Municipality
and possible recommendations may involve charging taxes,
regulations and fees. With implementing these recommendations will
help in protection of the marine environment and in increasing
operator functionality. Additionally, our recommendation is to
generate a consistent revenue stream to the municipality. The action
items contained in this research are feasible and effective, the success
of these initiatives are heavily dependent upon successful promotion
and enforcement. Promoting new rules and regulations effectively
and peacefully can be done through theories and techniques used in
the psychology of persuasion. In order to assure compliance with the
regulations, the municipality must maintain stringent patrols and
fines for violators. In order to become success, the Municipality
must preserve a consistent, transparent and significant enforcement
system. Considering potential opportunities outside of the current
state of the municipality, the authors recommend that Koh Sichang be
given additional jurisdiction to capture value from the master vessels,
as well as to confront the more significant environmental challenges
these vessels pose. Finally, the authors recommend that the Port of
Koh Sichang Island obtain a free port status in order to increase
economic viability and overall sustainability.
Abstract: Semiconductor nanomaterials like TiO2 nanoparticles
(TiO2-NPs) approximately less than 100 nm in diameter have become
a new generation of advanced materials due to their novel and
interesting optical, dielectric, and photo-catalytic properties. With the
increasing use of NPs in commerce, to date few studies have
investigated the toxicological and environmental effects of NPs.
Motivated by the importance of TiO2-NPs that may contribute to the
cancer research field especially from the treatment prospective
together with the fractal analysis technique, we have investigated the
effect of TiO2-NPs on colony morphology in the dark condition
using fractal dimension as a key morphological characterization
parameter. The aim of this work is mainly to investigate the cytotoxic
effects of TiO2-NPs in the dark on the growth of human cervical
carcinoma (HeLa) cell colonies from morphological aspect. The in
vitro studies were carried out together with the image processing
technique and fractal analysis. It was found that, these colonies were
abnormal in shape and size. Moreover, the size of the control
colonies appeared to be larger than those of the treated group. The
mean Df +/- SEM of the colonies in untreated cultures was
1.085±0.019, N= 25, while that of the cultures treated with TiO2-NPs
was 1.287±0.045. It was found that the circularity of the control
group (0.401±0.071) is higher than that of the treated group
(0.103±0.042). The same tendency was found in the diameter
parameters which are 1161.30±219.56 μm and 852.28±206.50 μm
for the control and treated group respectively. Possible explanation of
the results was discussed, though more works need to be done in
terms of the for mechanism aspects. Finally, our results indicate that
fractal dimension can serve as a useful feature, by itself or in
conjunction with other shape features, in the classification of cancer
colonies.
Abstract: The supply chains (SCs) have to appeal to new management paradigms to improve their ability to respond rapidly and cost effectively to unpredictable changes in markets and increasing levels of environmental turbulence, both in terms of volume and variety. In this highly demanded context, the Agile paradigm provides the capabilities to SC quickly adapt to changes in the market requirements. The purpose of this paper is to suggest an Agile Index to assess the agility of the automotive companies and corresponding SCs. The proposed integrated assessment model incorporates Agile practices weighted according to their importance to the automotive SC competitiveness and obtained from the Delphi technique.