Abstract: Calcium [Ca2+] dynamics is studied as a potential form
of neuron excitability that can control many irregular processes like
metabolism, secretion etc. Ca2+ ion enters presynaptic terminal and
increases the synaptic strength and thus triggers the neurotransmitter
release. The modeling and analysis of calcium dynamics in neuron
cell becomes necessary for deeper understanding of the processes
involved. A mathematical model has been developed for cylindrical
shaped neuron cell by incorporating physiological parameters like
buffer, diffusion coefficient, and association rate. Appropriate initial
and boundary conditions have been framed. The closed form solution
has been developed in terms of modified Bessel function. A computer
program has been developed in MATLAB 7.11 for the whole
approach.
Abstract: Mathematical and computational modeling of calcium
signalling in nerve cells has produced considerable insights into how
the cells contracts with other cells under the variation of biophysical
and physiological parameters. The modeling of calcium signaling in
astrocytes has become more sophisticated. The modeling effort has
provided insight to understand the cell contraction. Main objective
of this work is to study the effect of voltage gated (Operated)
calcium channel (VOC) on calcium profile in the form of advection
diffusion equation. A mathematical model is developed in the form
of advection diffusion equation for the calcium profile. The model
incorporates the important physiological parameter like diffusion
coefficient etc. Appropriate boundary conditions have been framed.
Finite volume method is employed to solve the problem. A program
has been developed using in MATLAB 7.5 for the entire problem
and simulated on an AMD-Turion 32-bite machine to compute the
numerical results.
Abstract: Complex assemblies of interacting proteins carry out
most of the interesting jobs in a cell, such as metabolism, DNA
synthesis, mitosis and cell division. These physiological properties
play out as a subtle molecular dance, choreographed by underlying
regulatory networks that control the activities of cyclin-dependent
kinases (CDK). The network can be modeled by a set of nonlinear
differential equations and its behavior predicted by numerical
simulation. In this paper, an innovative approach has been proposed
that uses genetic algorithms to mine a set of behavior data output by
a biological system in order to determine the kinetic parameters of
the system. In our approach, the machine learning method is
integrated with the framework of existent biological information in a
wiring diagram so that its findings are expressed in a form of system
dynamic behavior. By numerical simulations it has been illustrated
that the model is consistent with experiments and successfully shown
that such application of genetic algorithms will highly improve the
performance of mathematical model of the cell division cycle to
simulate such a complicated bio-system.
Abstract: Medical image modalities such as computed
tomography (CT), magnetic resonance imaging (MRI), ultrasound
(US), X-ray are adapted to diagnose disease. These modalities
provide flexible means of reviewing anatomical cross-sections and
physiological state in different parts of the human body. The raw
medical images have a huge file size and need large storage
requirements. So it should be such a way to reduce the size of those
image files to be valid for telemedicine applications. Thus the image
compression is a key factor to reduce the bit rate for transmission or
storage while maintaining an acceptable reproduction quality, but it is
natural to rise the question of how much an image can be compressed
and still preserve sufficient information for a given clinical
application. Many techniques for achieving data compression have
been introduced. In this study, three different MRI modalities which
are Brain, Spine and Knee have been compressed and reconstructed
using wavelet transform. Subjective and objective evaluation has
been done to investigate the clinical information quality of the
compressed images. For the objective evaluation, the results show
that the PSNR which indicates the quality of the reconstructed image
is ranging from (21.95 dB to 30.80 dB, 27.25 dB to 35.75 dB, and
26.93 dB to 34.93 dB) for Brain, Spine, and Knee respectively. For
the subjective evaluation test, the results show that the compression
ratio of 40:1 was acceptable for brain image, whereas for spine and
knee images 50:1 was acceptable.
Abstract: Computer modeling has played a unique role in
understanding electrocardiography. Modeling and simulating cardiac
action potential propagation is suitable for studying normal and
pathological cardiac activation. This paper presents a 2-D Cellular
Automata model for simulating action potential propagation in
cardiac tissue. We demonstrate a novel algorithm in order to use
minimum neighbors. This algorithm uses the summation of the
excitability attributes of excited neighboring cells. We try to
eliminate flat edges in the result patterns by inserting probability to
the model. We also preserve the real shape of action potential by
using linear curve fitting of one well known electrophysiological
model.
Abstract: The aim of this contribution is to present a new
approach in modeling the electrical activity of the human heart. A
recurrent artificial neural network is being used in order to exhibit a
subset of the dynamics of the electrical behavior of the human heart.
The proposed model can also be used, when integrated, as a
diagnostic tool of the human heart system.
What makes this approach unique is the fact that every model is
being developed from physiological measurements of an individual.
This kind of approach is very difficult to apply successfully in many
modeling problems, because of the complexity and entropy of the
free variables describing the complex system. Differences between
the modeled variables and the variables of an individual, measured at
specific moments, can be used for diagnostic purposes. The sensor
fusion used in order to optimize the utilization of biomedical sensors
is another point that this paper focuses on. Sensor fusion has been
known for its advantages in applications such as control and
diagnostics of mechanical and chemical processes.
Abstract: The influences of pulsed electric fields on early
physiological development in Arabidopsis thaliana were studied.
Inside a 4-mm electroporation cuvette, pre-germination seeds were
subjected to high-intensity, nanosecond electrical pulses generated
using laboratory-assembled pulsed electric field system. The field
strength was varied from 5 to 20 kV.cm-1 and the pulse width and the
pulse number were maintained at 10 ns and 100, respectively,
corresponding to the specific treatment energy from 300 J.kg-1 to 4.5
kJ.kg-1. Statistical analyses on the average leaf area 5 and 15 days
following pulsed electric field treatment showed that the effects
appear significant the second week after treatments with a maximum
increase of 80% compared to the control (P < 0.01).
Abstract: An inflation–extension test with human vena cava
inferior was performed with the aim to fit a material model. The vein
was modeled as a thick–walled tube loaded by internal pressure and
axial force. The material was assumed to be an incompressible
hyperelastic fiber reinforced continuum. Fibers are supposed to be
arranged in two families of anti–symmetric helices. Considered
anisotropy corresponds to local orthotropy. Used strain energy
density function was based on a concept of limiting strain
extensibility. The pressurization was comprised by four pre–cycles
under physiological venous loading (0 – 4kPa) and four cycles under
nonphysiological loading (0 – 21kPa). Each overloading cycle was
performed with different value of axial weight. Overloading data
were used in regression analysis to fit material model. Considered
model did not fit experimental data so good. Especially predictions
of axial force failed. It was hypothesized that due to
nonphysiological values of loading pressure and different values of
axial weight the material was not preconditioned enough and some
damage occurred inside the wall. A limiting fiber extensibility
parameter Jm was assumed to be in relation to supposed damage.
Each of overloading cycles was fitted separately with different values
of Jm. Other parameters were held the same. This approach turned out
to be successful. Variable value of Jm can describe changes in the
axial force – axial stretch response and satisfy pressure – radius
dependence simultaneously.
Abstract: Regular physical activity contributes positively to physiological and psychological health. This study aimed to identify exercise behavior changes, self efficacy and decisional balance in nursing and midwifery students. This was a cross-sectional study carried out in Iran.300undergraduate nursing and midwifery students participated in this study. Data were collected using a questionnaire including demographic information, exercise stages of change, exercise self efficacy and pros and cons exercise decisional balance. The analysis was performed using the SPSS.A p-value of less than 0.05 was considered as statistically significant.
Abstract: An attempt has been made to develop a
seminumerical model to study temperature variations in dermal
layers of human limbs. The model has been developed for two
dimensional steady state case. The human limb has been assumed to
have elliptical cross section. The dermal region has been divided
into three natural layers namely epidermis, dermis and subdermal
tissues. The model incorporates the effect of important physiological
parameters like blood mass flow rate, metabolic heat generation, and
thermal conductivity of the tissues. The outer surface of the limb is
exposed to the environment and it is assumed that heat loss takes
place at the outer surface by conduction, convection, radiation, and
evaporation. The temperature of inner core of the limb also varies at
the lower atmospheric temperature. Appropriate boundary conditions
have been framed based on the physical conditions of the problem.
Cubic splines approach has been employed along radial direction and
Fourier series along angular direction to obtain the solution. The
numerical results have been computed for different values of
eccentricity resembling with the elliptic cross section of the human
limbs. The numerical results have been used to obtain the
temperature profile and to study the relationships among the various
physiological parameters.
Abstract: Globin superfamily proteins including myoglobin and
hemoglobin, have welcome new members recently, namely,
cytoglobin, neuroglobin and globin X, though their physiological
functions are still to be addressed. Fish are the excellent models for the
study of these globins, but their characteristics have not yet been
discussed to date. In the present study, attempts have been made to
characterize their structural uniqueness by making use of proteomics
approach. This is the first comparative study on the characterization of
globin superfamily proteins from fish.
Abstract: Recently, the health of retired National Football
League players, particularly lineman has been investigated. A
number of studies have reported increased cardiometabolic risk,
premature cardiovascular disease and incidence of type 2 diabetes.
Rugby union players have somatotypes very similar to National
Football League players which suggests that rugby players may have
similar health risks. The International Golden Oldies World Rugby
Festival (GORF) provided a unique opportunity to investigate the
demographics of veteran rugby players. METHODOLOGIES: A
cross-sectional, observational study was completed using an online
web-based questionnaire that consisted of medical history and
physiological measures. Data analysis was completed using a one
sample t-test (50yrs) and Chi-square test. RESULTS:
A total of 216 veteran rugby competitors (response rate = 6.8%)
representing 10 countries, aged 35-72 yrs (mean 51.2, S.D. ±8.0),
participated in the online survey. As a group, the incidence of current
smokers was low at 8.8% (avg 72.4 cigs/wk) whilst the percentage
consuming alcohol was high (93.1% (avg 11.2 drinks/wk).
Competitors reported the following top six chronic
diseases/disorders; hypertension (18.6%), arthritis (OA/RA, 11.5%),
asthma (9.3%), hyperlipidemia (8.2%), diabetes (all types, 7.5%) and
gout (6%), there were significant differences between groups with
regard to cancer (all types) and migraines. When compared to the
Australian general population (Australian Bureau of Statistics data,
n=18,000), GORF competitors had a significantly lower incidence of
anxiety (p
Abstract: Five original strains of entomopathogenic bacteria
with insecticidal activity against mosquito larvae of the genera Aedes,
Culex and Anopheles have been isolated from natural conditions in
Armenia and characterized. According to morphological,
physiological and biochemical parameters, all isolates were identified
as Bacillus thuringiensis spp. israelensis (Bti). High larvicidal
activity has been showed by three strains Bti. These strains can be
recommended for industrial production of bacterial preparations.
Abstract: The influence of physical (external added weight) and
neurophysiological (fatigue) factors on static and dynamic balance in
sport related activities was typified statically by the Romberg test
(one foot flat, eyes open) and dynamically by jumping and hopping
in both horizontal and vertical directions. Twenty healthy males were
participated in this study. In Static condition, added weight increased
body-s inertia and therefore decreased body sway in AP direction
though not significantly. Dynamically, added weight significantly
increased body sway in both ML and AP directions, indicating
instability, and the use of the counter rotating segments mechanism to
maintain balance was demonstrated. Fatigue on the other hand
significantly increased body sway during static balance as a
neurophysiological adaptation primarily to the inverted pendulum
mechanism. Dynamically, fatigue significantly increased body sway
in both ML and AP directions again indicating instability but with a
greater use of counter rotating segments mechanism. Differential
adaptations for each of the two balance mechanisms (inverted
pendulum and counter rotating segments) were found between one
foot flat and two feet flat dynamic conditions, as participants relied
more heavily on the first in the one foot flat conditions and relied
more on the second in the two feet flat conditions.
Abstract: This study retrospectively investigated the significance of whole body CT (WCT) for patients with sepsis. A medical chart review was retrospectively performed for all patients with systemic inflammatory response syndrome that were treated initially between April 2011 and March 2012. The subjects were divided into a WCT group that underwent WCT on arrival and a control group. Results of this study suggested that WCT for sepsis was useful for elderly patients whose chief complaint or physiological findings could not suggest the anatomical site of infection, to determine the infectious focus and indications/method for surgery, to diagnose the basic diseases associated with opportunistic infections and to evaluate complicated diseases
Abstract: Shadoo protein (Sho) was described in 2003 as the newest member of Prion protein superfamily [1]. Sho has similar structural motifs like prion protein (PrP) that is known for its central role in transmissible spongiform enchephalopathies. Although a great number of functions have been proposed, the exact physiological function of PrP is not known yet. Investigation of the function and localization of Sho may help us to understand the function of the Prion protein superfamily. Analyzing the subcellular localization of YFP-tagged forms of Sho, we detected the protein in the plasma membrane and in the nucleus of various cell lines. To reveal the localization of the endogenous protein we generated antibodies against Shadoo as well as employed commercially available anti-Shadoo antibodies: i) EG62 anti-mouse Shadoo antibody generated by Eurogentec Ltd.; ii) S-12 anti-human Shadoo antibody by Santa Cruz Biotechnology Inc.; iii) R-12 anti-mouse Shadoo antibody by Santa Cruz Biotechnology Inc.; iv) SPRN antibody against human Shadoo by Abgent Inc. We carried out immunocytochemistry on non-transfected HeLa, Zpl 2-1, Zw 3-5, GT1-1, GT1-7 and SHSY5Y cells as well as on YFP-Sho, Sho-YFP, and YFP-GPI transfected HeLa cells. Their specificity (in antibody-peptide competition assay) and co-localization (with the YFP signal) were assessed.
Abstract: This experiment was carried out to study the effect of
AMF, drought stress and phosphorus on physiological growth indices of basil at Iran using by a split-plot design with three replications.
The main-plot factor included: two levels of irrigation regimes (control=no drought stress and irrigation after 80 evaporation=
drought stress condition) while the sub-plot factors included
phosphorus (0, 35 and 70 kg/ha) and application and non-application of Glomus fasciculatum. The results showed that total dry matter
(TDM), life area index (LAI), relative growth rate (RGR) and crop growth rate (CGR) were all highly significantly different among the
phosphorus, whereas drought stress had effect of practical
significance on TDM, LAI, RGR and CGR. The results also showed that the highest TDM, LAI, RGR and CGR were obtained from
application of Glomus fasciculatum under no-drought condition.
Abstract: En bloc assumes modeling all phases of the orthostatic test with the only one mathematical model, which allows the complex parametric view of orthostatic response. The work presents the implementation of a mathematical model for processing of the measurements of systolic, diastolic blood pressure and heart rate performed on volunteers during orthostatic test. The original assumption of model hypothesis that every postural change means only one Stressor, did not complying with the measurements of physiological circulation factor-time profiles. Results of the identification support the hypothesis that second postural change of orthostatic test causes induced Stressors, with the observation of a physiological regulation mechanism. Maximal demonstrations are on the heart rate and diastolic blood pressure-time profile, minimal are for the measurements of the systolic blood pressure. Presented study gives a new view on orthostatic test with impact on clinical practice.
Abstract: Ventilation is a fundamental requirement for
occupant health and indoor air quality in buildings. Natural
ventilation can be used as a design strategy in free-running
buildings to:
• Renew indoor air with fresh outside air and lower room
temperatures at times when the outdoor air is cooler.
• Promote air flow to cool down the building structure
(structural cooling).
• Promote occupant physiological cooling processes
(comfort cooling).
This paper focuses on ways in which ventilation can
provide the mechanism for heat dissipation and cooling of the
building structure..It also discusses use of ventilation as a
means of increasing air movement to improve comfort when
indoor air temperatures are too high. The main influencing
factors and design considerations and quantitative guidelines
to help meet the design objectives are also discussed.
Abstract: RoboCup Rescue simulation as a large-scale Multi
agent system (MAS) is one of the challenging environments for
keeping coordination between agents to achieve the objectives
despite sensing and communication limitations. The dynamicity of
the environment and intensive dependency between actions of
different kinds of agents make the problem more complex. This point
encouraged us to use learning-based methods to adapt our decision
making to different situations. Our approach is utilizing
reinforcement leaning. Using learning in rescue simulation is one of
the current ways which has been the subject of several researches in
recent years. In this paper we present an innovative learning method
implemented for Police Force (PF) Agent. This method can cope
with the main difficulties that exist in other learning approaches.
Different methods used in the literature have been examined. Their
drawbacks and possible improvements have led us to the method
proposed in this paper which is fast and accurate. The Brain
Emotional Learning Based Intelligent Controller (BELBIC) is our
solution for learning in this environment. BELBIC is a
physiologically motivated approach based on a computational model
of amygdale and limbic system. The paper presents the results
obtained by the proposed approach, showing the power of BELBIC
as a decision making tool in complex and dynamic situation.