Abstract: Calcium [Ca2+] is an important second messenger
which plays an important role in signal transduction. There are
several parameters that affect its concentration profile like buffer
source etc. The effect of stationary immobile buffer on Ca2+
concentration has been incorporated which is a very important
parameter needed to be taken into account in order to make the
model more realistic. Interdependence of all the important parameters
like diffusion coefficient and influx over [Ca2+] profile has been
studied. Model is developed in the form of advection diffusion
equation together with buffer concentration. A program has been
developed using finite volume method for the entire problem and
simulated on an AMD-Turion 32-bit machine to compute the
numerical results.
Abstract: Calcium [Ca2+] dynamics is studied as a potential form
of neuron excitability that can control many irregular processes like
metabolism, secretion etc. Ca2+ ion enters presynaptic terminal and
increases the synaptic strength and thus triggers the neurotransmitter
release. The modeling and analysis of calcium dynamics in neuron
cell becomes necessary for deeper understanding of the processes
involved. A mathematical model has been developed for cylindrical
shaped neuron cell by incorporating physiological parameters like
buffer, diffusion coefficient, and association rate. Appropriate initial
and boundary conditions have been framed. The closed form solution
has been developed in terms of modified Bessel function. A computer
program has been developed in MATLAB 7.11 for the whole
approach.
Abstract: Mathematical and computational modeling of calcium
signalling in nerve cells has produced considerable insights into how
the cells contracts with other cells under the variation of biophysical
and physiological parameters. The modeling of calcium signaling in
astrocytes has become more sophisticated. The modeling effort has
provided insight to understand the cell contraction. Main objective
of this work is to study the effect of voltage gated (Operated)
calcium channel (VOC) on calcium profile in the form of advection
diffusion equation. A mathematical model is developed in the form
of advection diffusion equation for the calcium profile. The model
incorporates the important physiological parameter like diffusion
coefficient etc. Appropriate boundary conditions have been framed.
Finite volume method is employed to solve the problem. A program
has been developed using in MATLAB 7.5 for the entire problem
and simulated on an AMD-Turion 32-bite machine to compute the
numerical results.
Abstract: An attempt has been made to develop a
seminumerical model to study temperature variations in dermal
layers of human limbs. The model has been developed for two
dimensional steady state case. The human limb has been assumed to
have elliptical cross section. The dermal region has been divided
into three natural layers namely epidermis, dermis and subdermal
tissues. The model incorporates the effect of important physiological
parameters like blood mass flow rate, metabolic heat generation, and
thermal conductivity of the tissues. The outer surface of the limb is
exposed to the environment and it is assumed that heat loss takes
place at the outer surface by conduction, convection, radiation, and
evaporation. The temperature of inner core of the limb also varies at
the lower atmospheric temperature. Appropriate boundary conditions
have been framed based on the physical conditions of the problem.
Cubic splines approach has been employed along radial direction and
Fourier series along angular direction to obtain the solution. The
numerical results have been computed for different values of
eccentricity resembling with the elliptic cross section of the human
limbs. The numerical results have been used to obtain the
temperature profile and to study the relationships among the various
physiological parameters.