Abstract: Computer modeling has played a unique role in
understanding electrocardiography. Modeling and simulating cardiac
action potential propagation is suitable for studying normal and
pathological cardiac activation. This paper presents a 2-D Cellular
Automata model for simulating action potential propagation in
cardiac tissue. We demonstrate a novel algorithm in order to use
minimum neighbors. This algorithm uses the summation of the
excitability attributes of excited neighboring cells. We try to
eliminate flat edges in the result patterns by inserting probability to
the model. We also preserve the real shape of action potential by
using linear curve fitting of one well known electrophysiological
model.
Abstract: Ventricular fibrillation is a very important health
problem as is the cause of most of the sudden deaths in the world.
Waves of electrical activity are sent by the SA node, propagate
through the cardiac tissue and activate the mechanisms of cell
contraction, and therefore are responsible to pump blood to the body
harmonically. A spiral wave is an abnormal auto sustainable wave
that is responsible of certain types of arrhythmias. When these waves
break up, give rise to the fibrillation regime, in which there is a
complete loss in the coordination of the contraction of the heart
muscle. Interaction of spiral waves and obstacles is also of great
importance as it is believed that the attachment of a spiral wave to an
obstacle can provide with a transition of two different arrhythmias.
An obstacle can be partially excitable or non excitable. In this talk,
we present a numerical study of the interaction of meandering spiral
waves with partially and non excitable obstacles and focus on the
problem where the obstacle plays a fundamental role in the switch
between different spiral regimes, which represent different
arrhythmic regimes. Particularly, we study the phenomenon of
destabilization of spiral waves due to the presence of obstacles, a
phenomenon not completely understood (This work will appear as a
Chapter in a Book named Cardiac Arrhytmias by INTECH under the
name "Spiral Waves, Obstacles and Cardiac Arrhythmias", ISBN
979-953-307-050-5.).