Abstract: An attempt has been made to develop a
seminumerical model to study temperature variations in dermal
layers of human limbs. The model has been developed for two
dimensional steady state case. The human limb has been assumed to
have elliptical cross section. The dermal region has been divided
into three natural layers namely epidermis, dermis and subdermal
tissues. The model incorporates the effect of important physiological
parameters like blood mass flow rate, metabolic heat generation, and
thermal conductivity of the tissues. The outer surface of the limb is
exposed to the environment and it is assumed that heat loss takes
place at the outer surface by conduction, convection, radiation, and
evaporation. The temperature of inner core of the limb also varies at
the lower atmospheric temperature. Appropriate boundary conditions
have been framed based on the physical conditions of the problem.
Cubic splines approach has been employed along radial direction and
Fourier series along angular direction to obtain the solution. The
numerical results have been computed for different values of
eccentricity resembling with the elliptic cross section of the human
limbs. The numerical results have been used to obtain the
temperature profile and to study the relationships among the various
physiological parameters.
Abstract: Calcium is very important for communication among
the neurons. It is vital in a number of cell processes such as secretion,
cell movement, cell differentiation. To reduce the system of reactiondiffusion
equations of [Ca2+] into a single equation, two theories
have been proposed one is excess buffer approximation (EBA) other
is rapid buffer approximation (RBA). The RBA is more realistic than
the EBA as it considers both the mobile and stationary endogenous
buffers. It is valid near the mouth of the channel. In this work we have
studied the effects of different types of buffers on calcium diffusion
under RBA. The novel thing studied is the effect of sodium ions on
calcium diffusion. The model has been made realistic by considering
factors such as variable [Ca2+], [Na+] sources, sodium-calcium
exchange protein(NCX), Sarcolemmal Calcium ATPase pump. The
proposed mathematical leads to a system of partial differential equations
which has been solved numerically to study the relationships
between different parameters such as buffer concentration, buffer
disassociation rate, calcium permeability. We have used Forward
Time Centred Space (FTCS) approach to solve the system of partial
differential equations.