Abstract: Batch production plants provide a wide range of
scheduling problems. In pharmaceutical industries a batch process
is usually described by a recipe, consisting of an ordering of tasks
to produce the desired product. In this research work we focused
on pharmaceutical production processes requiring the culture of
a microorganism population (i.e. bacteria, yeasts or antibiotics).
Several sources of uncertainty may influence the yield of the culture
processes, including (i) low performance and quality of the cultured
microorganism population or (ii) microbial contamination. For
these reasons, robustness is a valuable property for the considered
application context. In particular, a robust schedule will not collapse
immediately when a cell of microorganisms has to be thrown away
due to a microbial contamination. Indeed, a robust schedule should
change locally in small proportions and the overall performance
measure (i.e. makespan, lateness) should change a little if at all.
In this research work we formulated a constraint programming
optimization (COP) model for the robust planning of antibiotics
production. We developed a discrete-time model with a multi-criteria
objective, ordering the different criteria and performing a
lexicographic optimization. A feasible solution of the proposed
COP model is a schedule of a given set of tasks onto available
resources. The schedule has to satisfy tasks precedence constraints,
resource capacity constraints and time constraints. In particular
time constraints model tasks duedates and resource availability
time windows constraints. To improve the schedule robustness, we
modeled the concept of (a, b) super-solutions, where (a, b) are input
parameters of the COP model. An (a, b) super-solution is one in
which if a variables (i.e. the completion times of a culture tasks)
lose their values (i.e. cultures are contaminated), the solution can be
repaired by assigning these variables values with a new values (i.e.
the completion times of a backup culture tasks) and at most b other
variables (i.e. delaying the completion of at most b other tasks).
The efficiency and applicability of the proposed model is
demonstrated by solving instances taken from a real-life
pharmaceutical company. Computational results showed that
the determined super-solutions are near-optimal.
Abstract: An investigation has been presented to analyze the
effect of internal heat source on the onset of Hadley-Prats flow in
a horizontal fluid saturated porous medium. We examine a better
understanding of the combined influence of the heat source and mass
flow effect by using linear stability analysis. The resultant eigenvalue
problem is solved by using shooting and Runga-Kutta methods for
evaluate critical thermal Rayleigh number with respect to various
flow governing parameters. It is identified that the flow is switch from
stabilizing to destabilizing as the horizontal thermal Rayleigh number
is enhanced. The heat source and mass flow increases resulting a
stronger destabilizing effect.
Abstract: The nickel-manganese (Ni-Mn) alloy coating prepared
from DC electrodeposition process in sulphamate bath was studied.
The effects of process parameters, such as current density and
electrolyte composition, on the cathodic current efficiency,
microstructure, internal stress and mechanical properties were
investigated. Because of its crucial effect on the application to the
electroforming of microelectronic components, the development of
low internal stress coating with high leveling power was emphasized.
It was found that both the coating’s manganese content and the
cathodic current efficiency increased with the raise in current density.
In addition, the internal stress of the deposited coating showed
compressive nature at low current densities while changed to tensile
one at higher current densities. Moreover, the metallographic
observation, X-ray diffraction measurement, and polarization curve
measurement were conducted. It was found that the Ni-Mn coating
consisted of nano-sized columnar grains and the maximum hardness of
the coating was associated with (111) preferred orientation in the
microstructure. The grain size was refined along with the increase in
the manganese content of the coating, which accordingly, raised its
hardness and resistance to annealing softening. In summary, the
Ni-Mn coating prepared at lower current density of 1-2 A/dm2 had low
internal stress, high leveling power, and better corrosion resistance.
Abstract: The global demand for long-tailed macaques for
medical experimentation has continued to increase. Fulfillment of
Indonesian export demands has been mostly from natural habitats,
based on a harvesting quota. This quota has been determined
according to the total catch for a given year, and not based on
consideration of any demographic parameters or physical
environmental factors with regard to the animal; hence threatening
the sustainability of the various populations. It is therefore necessary
to formulate a method for calculating a sustainable harvesting quota,
based on population parameters in natural habitats. Considering the
possibility of variations in habitat characteristics and population
parameters, a time series observation of demographic and
physical/biotic parameters, in various habitats, was performed on 13
groups of long-tailed macaques, distributed throughout the West
Java, Lampung and Yogyakarta areas of Indonesia. These provinces
were selected for comparison of the influence of human/tourism
activities. Data on population parameters that was collected included
data on life expectancy according to age class, numbers of
individuals by sex and age class, and ‘ratio of infants to reproductive
females’. The estimation of population growth was based on a
population dynamic growth model: the Leslie matrix. The harvesting
quota was calculated as being the difference between the actual
population size and the MVP (minimum viable population) for each
sex and age class. Observation indicated that there were variations within group size
(24–106 individuals), gender (sex) ratio (1:1 to 1:1.3), life expectancy
value (0.30 to 0.93), and ‘ratio of infants to reproductive females’
(0.23 to 1.56). Results of subsequent calculations showed that
sustainable harvesting quotas for each studied group of long-tailed
macaques, ranged from 29 to 110 individuals. An estimation model
of the MVP for each age class was formulated as Log Y = 0.315 +
0.884 Log Ni (number of individual on ith age class). This study also
found that life expectancy for the juvenile age class was affected by
the humidity under tree stands, and dietary plants’ density at sapling,
pole and tree stages (equation: Y=2.296 – 1.535 RH + 0.002 Kpcg –
0.002 Ktg – 0.001 Kphn, R2 = 89.6% with a significance value of
0.001). By contrast, for the sub-adult-adult age class, life expectancy
was significantly affected by slope (equation: Y=0.377 = 0.012 Kml,
R2 = 50.4%, with significance level of 0.007). The infant-toreproductive-
female ratio was affected by humidity under tree stands,
and dietary plant density at sapling and pole stages (equation: Y = -
1.432 + 2.172 RH – 0.004 Kpcg + 0.003 Ktg, R2 = 82.0% with
significance level of 0.001). This research confirmed the importance
of population parameters in determining the minimum viable
population, and that MVP varied according to habitat characteristics
(especially food availability). It would be difficult therefore, to
formulate a general mathematical equation model for determining a
harvesting quota for the species as a whole.
Abstract: Sewer deposits have been identified as a major cause
of dysfunctions in combined sewer systems regarding sewer
management, which induces different negative consequents resulting
in poor hydraulic conveyance, environmental damages as well as
worker’s health. In order to overcome the problematics of
sedimentation, flushing has been considered as the most operative
and cost-effective way to minimize the sediments impacts and
prevent such challenges. Flushing, by prompting turbulent wave
effects, can modify the bed form depending on the hydraulic
properties and geometrical characteristics of the conduit. So far, the
dynamics of the bed-load during high-flow events in combined sewer
systems as a complex environment is not well understood, mostly due
to lack of measuring devices capable to work in the “hostile” in
combined sewer system correctly. In this regards, a one-episode
flushing issue from an opening gate valve with weir function was
carried out in a trunk sewer in Paris to understand its cleansing
efficiency on the sediments (thickness: 0-30 cm). During more than
1h of flushing within 5 m distance in downstream of this flushing
device, a maximum flowrate and a maximum level of water have
been recorded at 5 m in downstream of the gate as 4.1 m3/s and 2.1
m respectively. This paper is aimed to evaluate the efficiency of this
type of gate for around 1.1 km (from the point -50 m to +1050 m in
downstream from the gate) by (i) determining bed grain-size
distribution and sediments evolution through the sewer channel, as
well as their organic matter content, and (ii) identifying sections that
exhibit more changes in their texture after the flush. For the first one,
two series of sampling were taken from the sewer length and then
analyzed in laboratory, one before flushing and second after, at same
points among the sewer channel. Hence, a non-intrusive sampling
instrument has undertaken to extract the sediments smaller than the
fine gravels. The comparison between sediments texture after the
flush operation and the initial state, revealed the most modified zones
by the flush effect, regarding the sewer invert slope and hydraulic
parameters in the zone up to 400 m from the gate. At this distance,
despite the increase of sediment grain-size rages, D50 (median grainsize)
varies between 0.6 mm and 1.1 mm compared to 0.8 mm and 10
mm before and after flushing, respectively. Overall, regarding the
sewer channel invert slope, results indicate that grains smaller than
sands (< 2 mm) are more transported to downstream along about 400
m from the gate: in average 69% before against 38% after the flush
with more dispersion of grain-sizes distributions. Furthermore, high
effect of the channel bed irregularities on the bed material evolution
has been observed after the flush.
Abstract: This study aims to investigate the mixing behaviors of
deionized (DI) water and carboxymethyl cellulose (CMC) solutions in
C-shaped serpentine micromixers over a wide range of flow
conditions. The flow of CMC solutions exhibits shear-thinning
behaviors. Numerical simulations are performed to investigate the
effects of the mean flow speed, fluid properties and geometry
parameters on flow and mixing in the micromixers with the serpentine
channel of the same overall channel length. From the results, we can
find the following trends. When convection dominates fluid mixing,
the curvature-induced vortices enhance fluid mixing effectively. The
mixing efficiency of a micromixer consisting of semicircular C-shaped
repeating units with a smaller centerline radius is better than that of a
micromixer consisting of major segment repeating units with a larger
centerline radius. The viscosity of DI water is less than the overall
average apparent viscosity of CMC solutions, and so the effect of
curvature-induced vortices on fluid mixing in DI water is larger than
that in CMC solutions for the cases with the same mean flow speed.
Abstract: Speaker Identification (SI) is the task of establishing
identity of an individual based on his/her voice characteristics. The SI
task is typically achieved by two-stage signal processing: training and
testing. The training process calculates speaker specific feature
parameters from the speech and generates speaker models
accordingly. In the testing phase, speech samples from unknown
speakers are compared with the models and classified. Even though
performance of speaker identification systems has improved due to
recent advances in speech processing techniques, there is still need of
improvement. In this paper, a Closed-Set Tex-Independent Speaker
Identification System (CISI) based on a Multiple Classifier System
(MCS) is proposed, using Mel Frequency Cepstrum Coefficient
(MFCC) as feature extraction and suitable combination of vector
quantization (VQ) and Gaussian Mixture Model (GMM) together
with Expectation Maximization algorithm (EM) for speaker
modeling. The use of Voice Activity Detector (VAD) with a hybrid
approach based on Short Time Energy (STE) and Statistical
Modeling of Background Noise in the pre-processing step of the
feature extraction yields a better and more robust automatic speaker
identification system. Also investigation of Linde-Buzo-Gray (LBG)
clustering algorithm for initialization of GMM, for estimating the
underlying parameters, in the EM step improved the convergence rate
and systems performance. It also uses relative index as confidence
measures in case of contradiction in identification process by GMM
and VQ as well. Simulation results carried out on voxforge.org
speech database using MATLAB highlight the efficacy of the
proposed method compared to earlier work.
Abstract: In this paper, we report the development of the device
for diagnostics of cardiovascular system state and associated
automated workstation for large-scale medical measurement data
collection and analysis. It was shown that optimal design for the
monitoring device is wristband as it represents engineering trade-off
between accuracy and usability. Monitoring device is based on the
infrared reflective photoplethysmographic sensor, which allows
collecting multiple physiological parameters, such as heart rate and
pulsing wave characteristics. Developed device uses BLE interface
for medical and supplementary data transmission to the coupled
mobile phone, which processes it and send it to the doctor's
automated workstation. Results of this experimental model
approbation confirmed the applicability of the proposed approach.
Abstract: This research presents the main ideas to implement an
intelligent system composed by communicating wireless sensors
measuring environmental data linked to drought indicators (such as
air temperature, soil moisture , etc...). On the other hand, the setting
up of a spatio temporal database communicating with a Web mapping
application for a monitoring in real time in activity 24:00 /day, 7
days/week is proposed to allow the screening of the drought
parameters time evolution and their extraction. Thus this system
helps detecting surfaces touched by the phenomenon of drought.
Spatio-temporal conceptual models seek to answer the users who
need to manage soil water content for irrigating or fertilizing or other
activities pursuing crop yield augmentation. Effectively, spatiotemporal
conceptual models enable users to obtain a diagram of
readable and easy data to apprehend. Based on socio-economic
information, it helps identifying people impacted by the phenomena
with the corresponding severity especially that this information is
accessible by farmers and stakeholders themselves. The study will be
applied in Siliana watershed Northern Tunisia.
Abstract: Industries produce millions of cubic meters of effluent
every year and the wastewater produced may be released into the
surrounding water bodies, treated on-site or at municipal treatment
plants. The determination of organic matter in the wastewater
generated is very important to avoid any negative effect on the
aquatic ecosystem. The scope of the present work is to assess the
physicochemical composition of the wastewater produced from one
of the brewery industry in South Africa. This is to estimate the
environmental impact of its discharge into the receiving water bodies
or the municipal treatment plant. The parameters monitored for the
quantitative analysis of brewery wastewater include biological
oxygen demand (BOD5), chemical oxygen demand (COD), total
suspended solids, volatile suspended solids, ammonia, total oxidized
nitrogen, nitrate, nitrite, phosphorus and alkalinity content. In
average, the COD concentration of the brewery effluent was 5340.97
mg/l with average pH values of 4.0 to 6.7. The BOD5 and the solids
content of the wastewater from the brewery industry were high. This
means that the effluent is very rich in organic content and its
discharge into the water bodies or the municipal treatment plant could
cause environmental pollution or damage the treatment plant. In
addition, there were variations in the wastewater composition
throughout the monitoring period. This might be as a result of
different activities that take place during the production process, as
well as the effects of peak period of beer production on the water
usage.
Abstract: The influence of physicochemical water quality
parameters on the abundance and diversity of caddisfly larvae was
studied in seven sampling stations in Mae Tao and Mae Ku
watersheds, Mae Sot District, Tak Province, northern Thailand. The
streams: MK2 and MK8 as reference site, and impacted streams
(MT1-MT5) were sampled bi-monthly during July 2011 to May
2012. A total of 4,584 individual of caddisfly larvae belonging to 10
family and 17 genera were found. The larvae of family
Hydropsychidae were the most abundance, followed by
Philopotamidae, Odontoceridae, and Leptoceridae, respectively. The
genus Cheumatopsyche, Hydropsyche, and Chimarra were the most
abundance genera in this study. Results of CCA ordination showed
the total dissolved solids, sulfate, water temperature, dissolved
oxygen and pH were the most important physicochemical factors to
affect distribution of caddisflies communities. Changes in the
caddisfly fauna may indicate changes in physicochemical factors
owing to agricultural pollution, urbanization, or other human
activities. Results revealed that the order Trichoptera, identified to
species or genus, can be potentially used to assess environmental
water quality status in freshwater ecosystems.
Abstract: The phytotoxicity of heavy metals can be expressed
on roots and visible part of plants and is characterized by molecular
and metabolic answers at various levels of organization of the whole
plant. The present study was undertaken on two varieties of broad
bean Vicia faba (Sidi Aïch and Super Aguadulce). The device was
mounted on a substrate prepared by mixing sand, soil and compost,
the substrate was artificially contaminated with three doses of lead
nitrate [Pb(NO3)2] 0, 500 and 1000 ppm. Our objective is to follow
the behavior of plant opposite the stress by evaluating the
physiological parameters. The results reveal a reduction in the
parameters of the productivity (chlorophyll and proteins production)
with an increase in the osmoregulators (soluble sugars and
proline).These results show that the production of broad bean is
strongly modified by the disturbance of its internal physiology under
lead exposure.
Abstract: The microstrip antennas area has seen some inventive
work in recent years and is now one of the most dynamic fields of
antenna theory. A novel and simple wideband monopole antenna is
presented printed on a single dielectric substrate which is fed by a 50
ohm microstrip line having a low-profile antenna structure with two
parallel s-shaped meandered line of same size. This antenna is fed by
a coaxial feeding tube. In this research, S–form microstrip patch antenna is designed from
measuring the prototypes of the proposed antenna one available
bands with 10db return loss bandwidths of about GPS application
(GPS L2 1490 MHz) and covering the 1400 to 1580 MHz frequency
band at 1.5 GHz, the simulated results for main parameters such as
return loss, impedance bandwidth, radiation patterns, and gains are
also discussed herein. The modeling study shows that such antennas,
in simplicity design and supply, can satisfy GPS application. Two
parallel slots are incorporated to disturb the surface flow path,
introducing local inductive effect. This antenna is fed by a coaxial
feeding tube.
Abstract: In this study, a multi objective optimization for end
milling of Al 6061 alloy has been presented to provide better
surface quality and higher Material Removal Rate (MRR). The input
parameters considered for the analysis are spindle speed, depth of cut
and feed. The experiments were planned as per Taguchis design of
experiment, with L27 orthogonal array. The Grey Relational Analysis
(GRA) has been used for transforming multiple quality responses
into a single response and the weights of the each performance
characteristics are determined by employing the Principal Component
Analysis (PCA), so that their relative importance can be properly and
objectively described. The results reveal that Taguchi based G-PCA
can effectively acquire the optimal combination of cutting parameters.
Abstract: Liquid-Liquid Equilibrium (LLE) data are measured
for the ternary mixtures of water + 1-butanol + butyl acetate and
quaternary mixtures of water + 1-butanol + butyl acetate + glycerol at
atmospheric pressure at 313.15 K. In addition, isothermal
vapor–liquid–liquid equilibrium (VLLE) data are determined
experimentally at 333.15 K. The region of heterogeneity is found to
increase as the hydrophilic agent (glycerol) is introduced into the
aqueous mixtures. The experimental data are correlated with the
NRTL model. The predicted results from the solution model with the
model parameters determined from the constituent binaries are also
compared with the experimental values.
Abstract: In the present study, the properties of Al-Al2O3
nanocomposite hollow sphere structures were investigated. For this
reason, the Al-based nanocomposite hollow spheres with different
amounts of nano-alumina reinforcement (0-10wt %) and different
ratio of thickness to diameter (t/D: 0.06-0.3) were prepared via a
powder metallurgy method. Then, the effect of mentioned parameters
was studied on physical and quasi static mechanical properties of
their related prepared structures (open/closed cell) such as density,
hardness, strength, and energy absorption. It was found that, as the
t/D ratio increases the relative density, compressive strength and
energy absorption increase. The highest values of strength and energy
absorption were obtained from the specimen with 5 wt. % of
nanoparticle reinforcement, t/D of 0.3 (t=1 mm, D=400μm) as 22.88
MPa and 13.24 MJ/m3, respectively. The moderate specific strength
of prepared composites in the present study showed the good
consistency with the properties of others low carbon steel composite
with similar structure.
Abstract: In this paper, analysis of an infinite beam resting on
multilayer tensionless extensible geosynthetic reinforced granular
fill-poor soil system overlying soft soil strata under moving load with
constant velocity is presented. The beam is subjected to a
concentrated load moving with constant velocity. The upper
reinforced granular bed is modeled by a rough membrane embedded
in Pasternak shear layer overlying a series of compressible nonlinear
winkler springs representing the underlying the very poor soil. The
multilayer tensionless extensible geosynthetic layer has been
assumed to deform such that at interface the geosynthetic and the soil
have some deformation. Nonlinear behaviour of granular fill and the
very poor soil has been considered in the analysis by means of
hyperbolic constitutive relationships. Governing differential
equations of the soil foundation system have been obtained and
solved with the help of appropriate boundary conditions. The solution
has been obtained by employing finite difference method by means of
Gauss-Siedal iterative scheme. Detailed parametric study has been
conducted to study the influence of various parameters on the
response of soil–foundation system under consideration by means of
deflection and bending moment in the beam and tension mobilized in
the geosynthetic layer. These parameters include magnitude of
applied load, velocity of load, damping, ultimate resistance of poor
soil and granular fill layer. Range of values of parameters has been
considered as per Indian Railway conditions. This study clearly
observed that the comparisons of multilayer tensionless extensible
geosynthetic reinforcement with poor foundation soil and magnitude
of applied load, relative compressibility of granular fill and ultimate
resistance of poor soil has significant influence on the response of
soil–foundation system.
Abstract: Propagation of arbitrary amplitude nonlinear Alfven
waves has been investigated in low but finite β electron-positron-ion
plasma including full ion dynamics. Using Sagdeev pseudopotential
method an energy integral equation has been derived. The Sagdeev
potential has been calculated for different plasma parameters and it
has been shown that inclusion of ion parallel motion along the
magnetic field changes the nature of slow shear Alfven wave solitons
from dip type to hump type. The effects of positron concentration,
plasma-β and obliqueness of the wave propagation on the solitary
wave structure have also been examined.
Abstract: Singular value decomposition based optimisation of
geometric design parameters of a 5-speed gearbox is studied. During
the optimisation, a four-degree-of freedom torsional vibration model
of the pinion gear-wheel gear system is obtained and the minimum
singular value of the transfer matrix is considered as the objective
functions. The computational cost of the associated singular value
problems is quite low for the objective function, because it is only
necessary to compute the largest and smallest singular values (μmax
and μmin) that can be achieved by using selective eigenvalue solvers;
the other singular values are not needed. The design parameters are
optimised under several constraints that include bending stress,
contact stress and constant distance between gear centres. Thus, by
optimising the geometric parameters of the gearbox such as, the
module, number of teeth and face width it is possible to obtain a
light-weight-gearbox structure. It is concluded that the all optimised
geometric design parameters also satisfy all constraints.
Abstract: Spacer grid assembly supporting the nuclear fuel rods
is an important concern in the design of structural components of a
Pressurized Water Reactor (PWR). The spacer grid is composed by
springs and dimples which are formed from a strip sheet by means of
blanking and stamping processes. In this paper, the blanking process
and tooling parameters are evaluated by means of a 2D plane-strain
finite element model in order to evaluate the punch load and quality
of the sheared edges of Inconel 718 strips used for nuclear spacer
grids. A 3D finite element model is also proposed to predict the
tooling loads resulting from the stamping process of a preformed
Inconel 718 strip and to analyse the residual stress effects upon the
spring and dimple design geometries of a nuclear spacer grid.