Abstract: Batch production plants provide a wide range of
scheduling problems. In pharmaceutical industries a batch process
is usually described by a recipe, consisting of an ordering of tasks
to produce the desired product. In this research work we focused
on pharmaceutical production processes requiring the culture of
a microorganism population (i.e. bacteria, yeasts or antibiotics).
Several sources of uncertainty may influence the yield of the culture
processes, including (i) low performance and quality of the cultured
microorganism population or (ii) microbial contamination. For
these reasons, robustness is a valuable property for the considered
application context. In particular, a robust schedule will not collapse
immediately when a cell of microorganisms has to be thrown away
due to a microbial contamination. Indeed, a robust schedule should
change locally in small proportions and the overall performance
measure (i.e. makespan, lateness) should change a little if at all.
In this research work we formulated a constraint programming
optimization (COP) model for the robust planning of antibiotics
production. We developed a discrete-time model with a multi-criteria
objective, ordering the different criteria and performing a
lexicographic optimization. A feasible solution of the proposed
COP model is a schedule of a given set of tasks onto available
resources. The schedule has to satisfy tasks precedence constraints,
resource capacity constraints and time constraints. In particular
time constraints model tasks duedates and resource availability
time windows constraints. To improve the schedule robustness, we
modeled the concept of (a, b) super-solutions, where (a, b) are input
parameters of the COP model. An (a, b) super-solution is one in
which if a variables (i.e. the completion times of a culture tasks)
lose their values (i.e. cultures are contaminated), the solution can be
repaired by assigning these variables values with a new values (i.e.
the completion times of a backup culture tasks) and at most b other
variables (i.e. delaying the completion of at most b other tasks).
The efficiency and applicability of the proposed model is
demonstrated by solving instances taken from a real-life
pharmaceutical company. Computational results showed that
the determined super-solutions are near-optimal.
Abstract: In this article, we deal with a variant of the classical
course timetabling problem that has a practical application in many
areas of education. In particular, in this paper we are interested in
high schools remedial courses. The purpose of such courses is to
provide under-prepared students with the skills necessary to succeed
in their studies. In particular, a student might be under prepared in
an entire course, or only in a part of it. The limited availability
of funds, as well as the limited amount of time and teachers at
disposal, often requires schools to choose which courses and/or which
teaching units to activate. Thus, schools need to model the training
offer and the related timetabling, with the goal of ensuring the
highest possible teaching quality, by meeting the above-mentioned
financial, time and resources constraints. Moreover, there are some
prerequisites between the teaching units that must be satisfied. We
first present a Mixed-Integer Programming (MIP) model to solve
this problem to optimality. However, the presence of many peculiar
constraints contributes inevitably in increasing the complexity of
the mathematical model. Thus, solving it through a general-purpose
solver may be performed for small instances only, while solving
real-life-sized instances of such model requires specific techniques
or heuristic approaches. For this purpose, we also propose a heuristic
approach, in which we make use of a fast constructive procedure
to obtain a feasible solution. To assess our exact and heuristic
approaches we perform extensive computational results on both
real-life instances (obtained from a high school in Lecce, Italy) and
randomly generated instances. Our tests show that the MIP model is
never solved to optimality, with an average optimality gap of 57%.
On the other hand, the heuristic algorithm is much faster (in about the
50% of the considered instances it converges in approximately half of
the time limit) and in many cases allows achieving an improvement
on the objective function value obtained by the MIP model. Such an
improvement ranges between 18% and 66%.