Abstract: The mathematical modeling of different biological
processes is usually used to predict or assess behavior of systems in
which these processes take place. This study deals with mathematical
and computer modeling of bi-substrate enzymatic reactions with
ping-pong mechanism, which play an important role in different
biochemical pathways. Besides that, three models of competitive
inhibition were designed using different software packages. The main
objective of this study is to represent the results from in silico
investigation of bi-substrate enzymatic reactions with ordered pingpong
mechanism in the presence of competitive inhibitors, as well as
to describe in details the inhibition effects. The simulation of the
models with certain kinetic parameters allowed investigating the
behavior of reactions as well as determined some interesting aspects
concerning influence of different cases of competitive inhibition.
Simultaneous presence of two inhibitors, competitive to the S1 and S2
substrates have been studied. Moreover, we have found the pattern of
simultaneous influence of both inhibitors.
Abstract: This research presents a fuzzy multi-objective model
for a machine selection problem in a flexible manufacturing system
of a tire company. Two main objectives are minimization of an
average machine error and minimization of the total setup time.
Conventionally, the working team uses trial and error in selecting a
pressing machine for each task due to the complexity and constraints
of the problem. So, both objectives may not satisfy. Moreover, trial
and error takes a lot of time to get the final decision. Therefore, in
this research preemptive fuzzy goal programming model is developed
for solving this multi-objective problem. The proposed model can
obtain the appropriate results that the Decision Making (DM) is
satisfied for both objectives. Besides, alternative choice can be easily
generated by varying the satisfaction level. Additionally, decision
time can be reduced by using the model, which includes all
constraints of the system to generate the solutions. A numerical
example is also illustrated to show the effectiveness of the proposed
model.
Abstract: There exists an injective, information-preserving function
that maps a semantic network (i.e a directed labeled network)
to a directed network (i.e. a directed unlabeled network). The edge
label in the semantic network is represented as a topological feature
of the directed network. Also, there exists an injective function that
maps a directed network to an undirected network (i.e. an undirected
unlabeled network). The edge directionality in the directed network
is represented as a topological feature of the undirected network.
Through function composition, there exists an injective function that
maps a semantic network to an undirected network. Thus, aside from
space constraints, the semantic network construct does not have any
modeling functionality that is not possible with either a directed
or undirected network representation. Two proofs of this idea will
be presented. The first is a proof of the aforementioned function
composition concept. The second is a simpler proof involving an
undirected binary encoding of a semantic network.
Abstract: This paper proposes, for the first time, how the
challenges facing the guard-band designs including the margin
assist-circuits scheme for the screening-test in the coming process
generations should be addressed. The increased screening error
impacts are discussed based on the proposed statistical analysis
models. It has been shown that the yield-loss caused by the
misjudgment on the screening test would become 5-orders of
magnitude larger than that for the conventional one when the
amplitude of random telegraph noise (RTN) caused variations
approaches to that of random dopant fluctuation. Three fitting methods
to approximate the RTN caused complex Gamma mixtures
distributions by the simple Gaussian mixtures model (GMM) are
proposed and compared. It has been verified that the proposed
methods can reduce the error of the fail-bit predictions by 4-orders of
magnitude.
Abstract: This paper presents work characterizing finite element
performance boundaries within which live, interactive finite element
modeling is feasible on current and emerging systems. These results
are based on wide-ranging tests performed using a prototype finite
element program implemented specifically for this study, thereby enabling
the unified investigation of numerous direct and iterative solver
strategies and implementations in a variety of modeling contexts.
The results are intended to be useful for researchers interested in
interactive analysis by providing baseline performance estimates, to
give guidance in matching solution strategies to problem domains,
and to spur further work addressing the challenge of extending the
present boundaries.
Abstract: The purpose of this study was to investigate the
relationship between parent involvement and preschool disabled
children’s development. Parents of 3 year old disabled children
(N=440) and 5 year old disabled children (N=937) participating in the
Special Needs Education Longitudinal Study were interviewed or
answered the web design questionnaire about their actions in parenting
their disabled children. These children’s developments were also
evaluated by their teachers. Data were analyzed using Structural
Equation Modeling. Results were showed by tables and figures. Based
on the results, the researcher made some suggestions for future studies.
Abstract: Rutting is one of the major load-related distresses in airport flexible pavements. Rutting in paving materials develop gradually with an increasing number of load applications, usually appearing as longitudinal depressions in the wheel paths and it may be accompanied by small upheavals to the sides. Significant research has been conducted to determine the factors which affect rutting and how they can be controlled. Using the experimental design concepts, a series of tests can be conducted while varying levels of different parameters, which could be the cause for rutting in airport flexible pavements. If proper experimental design is done, the results obtained from these tests can give a better insight into the causes of rutting and the presence of interactions and synergisms among the system variables which have influence on rutting. Although traditionally, laboratory experiments are conducted in a controlled fashion to understand the statistical interaction of variables in such situations, this study is an attempt to identify the critical system variables influencing airport flexible pavement rut depth from a statistical DoE perspective using real field data from a full-scale test facility. The test results do strongly indicate that the response (rut depth) has too much noise in it and it would not allow determination of a good model. From a statistical DoE perspective, two major changes proposed for this experiment are: (1) actual replication of the tests is definitely required, (2) nuisance variables need to be identified and blocked properly. Further investigation is necessary to determine possible sources of noise in the experiment.
Abstract: Arsenic in the sediments of the ash lagoons of the coal-fired power plant in Pagbilao, Quezon Province in the Philippines was sequentially extracted to determine its potential for leaching to the groundwater and the adjacent marine environment. Results show that 89% of the As is bound to the quasi-crystalline Fe/Mn oxides and hydroxide matrix in the sediments, whereas, the adsorbed and exchangeable As hosted by the clay minerals, representing those that are easiest to release from the sediment matrix, is below 10% of the acid leachable As. These As in these sediment matrices represent the possible maximum amount of As that can be released and supplied to the groundwater and the adjacent marine environment. Of the 89% reducible As, up to 4% is associated with the easily reducible variety, whereas, the rest is more strongly bonded by the moderately reducible variety. Based on the long-term As content of the lagoon water, the average desorption rate of As is calculated to be very low -- 0.3-0.5% on the average and 0.6% on the maximum. This indicates that As is well-fixed by its sediment matrices in the ash lagoon, attenuating the influx of As into the adjacent groundwater and marine environments.
Abstract: This paper presents the application of discrete-time
variable structure control with sliding mode based on the 'reaching
law' method for robust control of a 'simple inverted pendulum on
moving cart' - a standard nonlinear benchmark system. The
controllers designed using the above techniques are completely
insensitive to parametric uncertainty and external disturbance. The
controller design is carried out using pole placement technique to find
state feedback gain matrix , which decides the dynamic behavior
of the system during sliding mode. This is followed by feedback gain
realization using the control law which is synthesized from 'Gao-s
reaching law'. The model of a single inverted pendulum and the
discrete variable structure control controller are developed, simulated
in MATLAB-SIMULINK and results are presented. The response of
this simulation is compared with that of the discrete linear quadratic
regulator (DLQR) and the advantages of sliding mode controller over
DLQR are also presented
Abstract: During the last decade ultrafine grained (UFG) and nano-structured (NS) materials have experienced a rapid development. In this research work finite element analysis has been carried out to investigate the plastic strain distribution in equal channel angular process (ECAP). The magnitudes of Standard deviation (S. D.) and inhomogeneity index (Ci) were compared for different ECAP passes. Verification of a three-dimensional finite element model was performed with experimental tests. Finally the mechanical property including impact energy of ultrafine grained pure commercially pure Aluminum produced by severe plastic deformation method has been examined. For this aim, equal channel angular pressing die with the channel angle, outer corner angle and channel diameter of 90°, 20° and 20mm had been designed and manufactured. Commercial pure Aluminum billets were ECAPed up to four passes by route BC at the ambient temperature. The results indicated that there is a great improvement at the hardness measurement, yield strength and ultimate tensile strength after ECAP process. It is found that the magnitudes of HV reach 67HV from 21HV after the final stage of process. Also, about 330% and 285% enhancement at the YS and UTS values have been obtained after the fourth pass as compared to the as-received conditions, respectively. On the other hand, the elongation to failure and impact energy have been reduced by 23% and 50% after imposing four passes of ECAP process, respectively.
Abstract: The aim of this investigation is to study the
performance of the new generation of the PVD coated grade and to
map the influence of cutting conditions on the tool life in milling of
ADI (Austempered Ductile Iron). The results show that chipping is
the main wear mechanism which determines the tool life in dry
condition and notch wear in wet condition for this application. This
due to the different stress mechanisms and preexisting cracks in the
coating. The wear development shows clearly that the new PVD
coating (C20) has the best ability to delay the chipping growth. It
was also found that a high content of Al in the new coating (C20)
was especially favorable compared to a TiAlN multilayer with lower
Al content (C30) or CVD coating. This is due to fine grains and low
compressive stress level in the coating which increase the coating
ability to withstand the mechanical and thermal impact. It was also
found that the use of coolant decreases the tool life with 70-80%
compare to dry milling.
Abstract: The purpose of this paper is to summarize the
following protection of scouring countermeasures by using
Bentonite-Enhanced Sand (BES) mixtures. The concept of
underground improvement is being used in this study to reduce the
void of the sand. The sand bentonite mixture was used to bond the
ground soil conditions surrounding the pile of integral bridge. The
right composition of sand bentonite mixture was proposed based on
previous findings. The swelling effect of bentonite also was
investigated to ensure there is no adverse impact to the structure of
the integral bridge. ScourScour, another name for severe erosion,
occurs when the erosive capacity of water resulting from natural and
manmade events exceeds the ability of earth materials to resist its
effects. According to AASHTO LRFD Specifications (Section
C3.7.5), scour is the most common reason for the collapse of
highway bridges in the United States
Abstract: The agricultural organic farming is different from
conventional farming in a way that is aimed at providing a balanced
and constructive action in agricultural systems. With the increase in
intensive agriculture, undesirable changes were being observed in
ecosystems with irreparable damage being caused to the natural
equilibrium. This is the reason for the increasing interest in organic
farming as an environment friendly agricultural production method.
In the present work three red fruits produced in organic farming were
analyzed, namely raspberry, gooseberry and blueberry. The samples
were harvested in a local farm when at plain maturation. The results
obtained allowed to conclude that the blueberry contained higher
amounts of phenolic compounds, total tannins and total anthocyanins
than raspberry and gooseberry. Furthermore, the HPLC analysis
allowed to identify monomeric anthocyanins and phenolic acids in
the three fruits studied.
Abstract: Aeration by a plunging water jet is an energetically attractive way to effect oxygen-transfer than conventional oxygenation systems. In the present study, a new type of conical shaped plunging aeration device is fabricated to generate hollow inclined ined plunging jets (jet plunge angle of π/3 ) to investigate its oxygen transfer capacity. The results suggest that the volumetric oxygen-transfer coefficient and oxygen-transfer efficiency of the conical plunging jet aerator are competitive with other types of aeration systems. Relationships of volumetric oxygen-transfer coefficient with jet power per unit volume and jet parameters are also proposed. The suggested relationships predict the volumetric oxygentransfer coefficient within a scatter of ± 15% . Further, the application of Support Vector Machines on the experimental data revealed its utility in the prediction of volumetric oxygen-transfer coefficient and development of conical plunging jet aerators.
Abstract: We describe a novel method for removing noise (in wavelet domain) of unknown variance from microarrays. The method is based on the following procedure: We apply 1) Bidimentional Discrete Wavelet Transform (DWT-2D) to the Noisy Microarray, 2) scaling and rounding to the coefficients of the highest subbands (to obtain integer and positive coefficients), 3) bit-slicing to the new highest subbands (to obtain bit-planes), 4) then we apply the Systholic Boolean Orthonormalizer Network (SBON) to the input bit-plane set and we obtain two orthonormal otput bit-plane sets (in a Boolean sense), we project a set on the other one, by means of an AND operation, and then, 5) we apply re-assembling, and, 6) rescaling. Finally, 7) we apply Inverse DWT-2D and reconstruct a microarray from the modified wavelet coefficients. Denoising results compare favorably to the most of methods in use at the moment.
Abstract: We have modeled the effect of a graded band gap
window on the performance of a single junction AlxGa1-xAs/GaAs
solar cell. First, we study the electrical characteristics of a single
junction AlxGa1-xAs/GaAs solar cell, by employing an optimized
structure for this solar cell, we show that grading the band gap of the
window can increase the conversion efficiency of the solar cell by
about 1.5%, and can also improve the quantum efficiency of the solar
cell especially at shorter wavelengths.
Abstract: Ambient hydrolysis products in moist air and
hydrolysis kinetics in argon with humidity of RH1.5% for
polycrystalline LiH powders and sintered bulks were investigated by
X-ray diffraction, Raman spectroscopy and gravimetry. The results
showed that the hydrolysis products made up a layered structure of
LiOH•H2O/LiOH/Li2O from surface of the sample to inside. In low
humid argon atmosphere, the primary hydrolysis product was Li2O
rather than LiOH. The hydrolysis kinetic curves of LiH bulks present a
paralinear shape, which could be explained by the “Layer Diffusion
Control" model. While a three-stage hydrolysis kinetic profile was
observed for LiH powders under the same experimental conditions.
The first two sections were similar to that of the bulk samples, and the
third section also presents a linear reaction kinetics but with a smaller
reaction rate compared to the second section because of a larger
exothermic effect for the hydrolysis reaction of LiH powder.
Abstract: Wireless capsule endoscopy provides real-time images in the digestive tract. Capsule images are usually low resolution and are diverse images due to travel through various regions of human body. Color information has been a primary reference in predicting abnormalities such as bleeding. Often color is not sufficient for this purpose. In this study, we took morphological shapes into account as additional, but important criterion. First, we processed gastric images in order to indentify various objects in the image. Then, we analyzed color information in the object. In this way, we could remove unnecessary information and increase the accuracy. Compared to our previous investigations, we could handle images of various degrees of brightness and improve our diagnostic algorithm.
Abstract: MicroRNAs are an important class of gene expression
regulators that are involved in many biological processes including
embryogenesis. miR-125b is a conserved microRNA that is enriched
in the nervous system. We have previously reported the function of
miR-125b in neuronal differentiation of human cell lines. We also
discovered the function of miR-125b in regulating p53 in human and
zebrafish. Here we further characterize the brain defects in zebrafish
embryos injected with morpholinos against miR-125b. Our data
confirm the essential role of miR-125b in brain morphogenesis
particularly in maintaining the balance between proliferation, cell
death and differentiation. We identified lunatic fringe (lfng) as an
additional target of miR-125b in human and zebrafish and suggest
that lfng may mediate the function of miR-125b in neurogenesis.
Together, this report reveals new insights into the function of miR-
125b during neural development of zebrafish.
Abstract: The paper deals with the analysis of the dynamic
response of footbridges under human - induced dynamic loads.
This is a frequently occurring and often dominant load for
footbridges as it stems from the very purpose of a footbridge - to
convey pedestrian. Due to the emergence of new materials and
advanced engineering technology, slender footbridges are
increasingly becoming popular to satisfy the modern transportation
needs and the aesthetical requirements of the society. These
structures however are always lively with low stiffness, low mass,
low damping and low natural frequencies. As a consequence, they are
prone to vibration induced by human activities and can suffer severe
vibration serviceability problems, particularly in the lateral direction.
Pedestrian bridges are designed according to first and second limit
states, these are the criteria involved in response to static design load.
However, it is necessary to assess the dynamic response of bridge
design load on pedestrians and assess it impact on the comfort of the
user movement. Usually the load is considered a person or a small
group which can be assumed in perfect motion synchronization.
Already one person or small group can excite significant vibration of
the deck. In order to calculate the dynamic response to the movement
of people, designer needs available and suitable computational model
and criteria. For the calculation program ANSYS based on finite
element method was used.