Abstract: Chikungunya virus (CHICKV) is an arboviruses belonging to family Tagoviridae and is transmitted to human through by mosquito (Aedes aegypti and Aedes albopictus) bite. A large outbreak of chikungunya has been reported in India between 2006 and 2007, along with several other countries from South-East Asia and for the first time in Europe. It was for the first time that the CHICKV outbreak has been reported with mortality from Reunion Island and increased mortality from Asian countries. CHICKV affects all age groups, and currently there are no specific drugs or vaccine to cure the disease. The need of antiviral agents for the treatment of CHICKV infection and the success of virtual screening against many therapeutically valuable targets led us to carry out the structure based drug design against Chikungunya nSP2 protease (PDB: 3TRK). Highthroughput virtual screening of publicly available databases, ZINC12 and BindingDB, has been carried out using the Openeye tools and Schrodinger LLC software packages. Openeye Filter program has been used to filter the database and the filtered outputs were docked using HTVS protocol implemented in GLIDE package of Schrodinger LLC. The top HITS were further used for enriching the similar molecules from the database through vROCS; a shape based screening protocol implemented in Openeye. The approach adopted has provided different scaffolds as HITS against CHICKV protease. Three scaffolds: Indole, Pyrazole and Sulphone derivatives were selected based on the docking score and synthetic feasibility. Derivatives of Pyrazole were synthesized and submitted for antiviral screening against CHICKV.
Abstract: Pre-germinated parboiled brown rice or Khao hang (in Thai) is paddy which undergoing the processes of soaking, steaming, drying and dehusking to obtain the edible form for consumption. The objectives of this research were to study the kinetic of pre-germinated parboiled brown rice drying using fluidization technique and to study the properties of pre-germinated parboiled brown rice after drying. The dryings were performed at the different temperatures of 110, 120 and 130 oC at the bed depth of 2 cm with the air velocity of 1.98 m/s. The results found that the higher drying temperature led to the faster moisture reduction. After drying until the moisture content of pre-germinated parboiled brown rice was lower than 14%wet basis, samples were taken to determine various qualities such as percentage of head rice and L* a* b* color values. The shade drying was used as a control. The results found that the higher drying temperature resulted in the decrease of head rice percentage. For the color assessment, the trend of L* and a* values was increased with the drying temperature, while the b* value was not significantly difference (p › 0.05) by drying temperatures. However, the b value of drying by fluidized bed dryer was higher than the control.
Abstract: Lately management strategy that put Industrial Design (ID) in its core is recognized more important, as technology and price alone cannot differentiate a product. The needs to shorten the time to develop a product also shorten the development period of ID, and it necessitates the ID process management. This research analyzes the status of integration process of ID and Engineering Design (ED) of office equipment that requires the collaboration of ID and ED to clarify the issues for the efficiency of the development and to propose solutions.
Abstract: With the advance of multimedia and diagnostic
images technologies, the number of radiographic images is increasing
constantly. The medical field demands sophisticated systems for
search and retrieval of the produced multimedia document. This
paper presents an ongoing research that focuses on the semantic
content of radiographic image documents to facilitate semantic-based
radiographic image indexing and a retrieval system. The proposed
model would divide a radiographic image document, based on its
semantic content, and would be converted into a logical structure or
a semantic structure. The logical structure represents the overall
organization of information. The semantic structure, which is bound
to logical structure, is composed of semantic objects with
interrelationships in the various spaces in the radiographic image.
Abstract: Today-s healthcare industries had become more
patient-centric than profession-centric, from which the issues of quality of healthcare and the patient safety are the major concerns in the modern healthcare facilities. An unplanned extubation (UE) may
be detrimental to the patient-s life, and thus is one of the major indexes
of patient safety and healthcare quality. A high UE rate not only
defeated the healthcare quality as well as the patient safety policy but
also the nurses- morality, and job satisfaction. The UE problem in a psychiatric hospital is unique and may be a tough challenge for the
healthcare professionals for the patients were mostly lacking communication capabilities. We reported with this essay a particular
project that was organized to reduce the UE rate from the current 2.3%
to a lower and satisfactory level in the long-term care units of a psychiatric hospital. The project was conducted between March 1st,
2011 and August 31st, 2011. Based on the error information gathered
from varied units of the hospital, the team analyzed the root causes
with possible solutions proposed to the meetings. Four solutions were
then concluded with consensus and launched to the units in question.
The UE rate was now reduced to a level of 0.17%. Experience from
this project, the procedure and the tools adopted would be good reference to other hospitals.
Abstract: A numerical study of flow in a horizontally channel
partially filled with a porous screen with non-uniform inlet has been
performed by lattice Boltzmann method (LBM). The flow in porous
layer has been simulated by the Brinkman-Forchheimer model.
Numerical solutions have been obtained for variable porosity models
and the effects of Darcy number and porosity have been studied in
detail. It is found that the flow stabilization is reliant on the Darcy
number. Also the results show that the stabilization of flow field and
heat transfer is depended to Darcy number. Distribution of stream
field becomes more stable by decreasing Darcy number. Results
illustrate that the effect of variable porosity is significant just in the
region of the solid boundary. In addition, difference between constant
and variable porosity models is decreased by decreasing the Darcy
number.
Abstract: The Helmholtz equation often arises in the study of physical problems involving partial differential equation. Many researchers have proposed numerous methods to find the analytic or approximate solutions for the proposed problems. In this work, the exact analytical solutions of the Helmholtz equation in spherical polar coordinates are presented using the Nikiforov-Uvarov (NU) method. It is found that the solution of the angular eigenfunction can be expressed by the associated-Legendre polynomial and radial eigenfunctions are obtained in terms of the Laguerre polynomials. The special case for k=0, which corresponds to the Laplace equation is also presented.
Abstract: Until recently, researchers have developed various
tools and methodologies for effective clinical decision-making.
Among those decisions, chest pain diseases have been one of
important diagnostic issues especially in an emergency department. To
improve the ability of physicians in diagnosis, many researchers have
developed diagnosis intelligence by using machine learning and data
mining. However, most of the conventional methodologies have been
generally based on a single classifier for disease classification and
prediction, which shows moderate performance. This study utilizes an
ensemble strategy to combine multiple different classifiers to help
physicians diagnose chest pain diseases more accurately than ever.
Specifically the ensemble strategy is applied by using the integration
of decision trees, neural networks, and support vector machines. The
ensemble models are applied to real-world emergency data. This study
shows that the performance of the ensemble models is superior to each
of single classifiers.
Abstract: This paper To get the angle value with a MEMS rate
gyroscope in some specific field, the usual method is to make an
integral operation to the rate output, which will lead the error
cumulating effect. So the rate gyro is not suitable. MEMS rate
integrating gyroscope (MRIG) will solve this problem. A DSP system
has been developed to implement the control arithmetic. The system
can measure the angle of rotation directly by the control loops that
make the sensor work in whole-angle mode. Modeling the system with
MATLAB, desirable results of angle outputs are got, which prove the
feasibility of the control arithmetic.
Abstract: In this paper as showed a non-invasive 3D eye tracker
for optometry clinical applications. Measurements of biomechanical
variables in clinical practice have many font of errors associated with
traditional procedments such cover test (CT), near point of
accommodation (NPC), eye ductions (ED), eye vergences (EG) and,
eye versions (ES). Ocular motility should always be tested but all
evaluations have a subjective interpretations by practitioners, the
results is based in clinical experiences, repeatability and accuracy
don-t exist. Optometric-lab is a tool with 3 (tree) analogical video
cameras triggered and synchronized in one acquisition board AD.
The variables globe rotation angle and velocity can be quantified.
Data record frequency was performed with 27Hz, camera calibration
was performed in a know volume and image radial distortion
adjustments.
Abstract: This paper investigates the problem of tracking spa¬tiotemporal changes of a satellite image through the use of Knowledge Discovery in Database (KDD). The purpose of this study is to help a given user effectively discover interesting knowledge and then build prediction and decision models. Unfortunately, the KDD process for spatiotemporal data is always marked by several types of imperfections. In our paper, we take these imperfections into consideration in order to provide more accurate decisions. To achieve this objective, different KDD methods are used to discover knowledge in satellite image databases. Each method presents a different point of view of spatiotemporal evolution of a query model (which represents an extracted object from a satellite image). In order to combine these methods, we use the evidence fusion theory which considerably improves the spatiotemporal knowledge discovery process and increases our belief in the spatiotemporal model change. Experimental results of satellite images representing the region of Auckland in New Zealand depict the improvement in the overall change detection as compared to using classical methods.
Abstract: In this study, ZnO nano rods and ZnO ultrafine particles were synthesized by Gel-casting method. The synthesized ZnO powder has a hexagonal zincite structure. The ZnO aggregates with rod-like morphology are typically 1.4 μm in length and 120 nm in diameter, which consist of many small nanocrystals with diameters of 10 nm. Longer wires connected by many hexahedral ZnO nanocrystals were obtained after calcinations at the temperature over 600° C.The crystalline structures and morphologies of the powder have been characterized by X-ray diffraction(XRD) and Scaning electron microscopy (SEM).The result shows that the different preparation conditions such as concentration H2O, calcinations time and calcinations temperature have a lot of influences upon the properties of nano ZnO powders, an increase in the temperature of the calcinations results in an increase of the grain size and also the increase of the calcinations time in high temperature makes the size of the grains bigger. The existences of extra watter prevent nano grains from improving like rod morphology. We have obtained the smallest grain size of ZnO powder by controlling the process conditions. Finally In a suitable condition, a novel nanostructure, namely bi-rod-like ZnO nano rods was found which is different from known ZnO nanostructures.
Abstract: Alkali Activated Slag Concrete (AASC) mixes are manufactured by activating ground granulated blast furnace slag (GGBFS) using sodium hydroxide and sodium silicate solutions. The aim of the present experimental research was to investigate the effect of increasing the dosages of sodium oxide (Na2O, in the range of 4 to 8%) and the activator modulus (Ms) (i.e. the SiO2/Na2O ratio, in the range of 0.5 to 1.5) of the alkaline solutions, on the workability and strength characteristics of self-cured (air-cured) alkali activated Indian slag concrete mixes. Further the split tensile and flexure strengths for optimal mixes were studied for each dosage of Na2O.It is observed that increase in Na2O concentration increases the compressive, split-tensile and flexural strengths, both at the early and later-ages, while increase in Ms, decreases the workability of the mixes. An optimal Ms of 1.25 is found at various Na2O dosages. No significant differences in the strength performances were observed between AASCs manufactured with alkali solutions prepared using either of potable and de-ionized water.
Abstract: Occurrences of spurious crests on the troughs of large,
relatively steep second-order Stokes waves are anomalous and not an
inherent characteristic of real waves. Here, the effects of such
occurrences on the statistics described by the standard second-order
stochastic model are examined theoretically and by way of
simulations. Theoretical results and simulations indicate that when
spurious occurrences are sufficiently large, the standard model leads
to physically unrealistic surface features and inaccuracies in the
statistics of various surface features, in particular, the troughs and
thus zero-crossing heights of large waves. Whereas inaccuracies can
be fairly noticeable for long-crested waves in both deep and
shallower depths, they tend to become relatively insignificant in
directional waves.
Abstract: DC-DC converters are widely used in regulated switched mode power supplies and in DC motor drive applications. There are several sources of unwanted nonlinearity in practical power converters. In addition, their operation is characterized by switching that gives birth to a variety of nonlinear dynamics. DC-DC buck and boost converters controlled by pulse-width modulation (PWM) have been simulated. The voltage waveforms and attractors obtained from the circuit simulation have been studied. With the onset of instability, the phenomenon of subharmonic oscillations, quasi-periodicity, bifurcations, and chaos have been observed. This paper is mainly motivated by potential contributions of chaos theory in the design, analysis and control of power converters, in particular and power electronics circuits, in general.
Abstract: The dynamics of the Autonomous Underwater
Vehicles (AUVs) are highly nonlinear and time varying and the hydrodynamic coefficients of vehicles are difficult to estimate
accurately because of the variations of these coefficients with
different navigation conditions and external disturbances. This study presents the on-line system identification of AUV dynamics to obtain
the coupled nonlinear dynamic model of AUV as a black box. This black box has an input-output relationship based upon on-line
adaptive fuzzy model and adaptive neural fuzzy network (ANFN)
model techniques to overcome the uncertain external disturbance and
the difficulties of modelling the hydrodynamic forces of the AUVs instead of using the mathematical model with hydrodynamic parameters estimation. The models- parameters are adapted according
to the back propagation algorithm based upon the error between the
identified model and the actual output of the plant. The proposed
ANFN model adopts a functional link neural network (FLNN) as the
consequent part of the fuzzy rules. Thus, the consequent part of the
ANFN model is a nonlinear combination of input variables. Fuzzy
control system is applied to guide and control the AUV using both
adaptive models and mathematical model. Simulation results show
the superiority of the proposed adaptive neural fuzzy network
(ANFN) model in tracking of the behavior of the AUV accurately
even in the presence of noise and disturbance.
Abstract: This paper presents an adaptive nonlinear position
controller with velocity constraint, capable of combining the
input-output linearization technique and Lyapunov stability theory.
Based on the Lyapunov stability theory, the adaptation law of the
proposed controller is derived along with the verification of the overall
system-s stability. Computer simulation results demonstrate that the
proposed controller is robust and it can ensure transient stability of
BLDCM, under the occurrence of a large sudden fault.
Abstract: As the Internet technology has developed rapidly, the
number of identities (IDs) managed by each individual person has
increased and various ID management technologies have been
developed to assist users. However, most of these technologies are
vulnerable to the existing hacking methods such as phishing attacks
and key-logging. If the administrator-s password is exposed, an
attacker can access the entire contents of the stolen user-s data files in
other devices. To solve these problems, we propose here a new ID
management scheme based on a Single Password Protocol. The paper
presents the details of the new scheme as well as a formal analysis of
the method using BAN Logic.
Abstract: Financial forecasting using machine learning techniques has received great efforts in the last decide . In this ongoing work, we show how machine learning of graphical models will be able to infer a visualized causal interactions between different banks in the Saudi equities market. One important discovery from such learned causal graphs is how companies influence each other and to what extend. In this work, a set of graphical models named Gaussian graphical models with developed ensemble penalized feature selection methods that combine ; filtering method, wrapper method and a regularizer will be shown. A comparison between these different developed ensemble combinations will also be shown. The best ensemble method will be used to infer the causal relationships between banks in Saudi equities market.
Abstract: In rotating machinery one of the critical components
that is prone to premature failure is the rolling bearing.
Consequently, early warning of an imminent bearing failure is much
critical to the safety and reliability of any high speed rotating
machines. This study is concerned with the application of Recurrence
Quantification Analysis (RQA) in fault detection of rolling element
bearings in rotating machinery. Based on the results from this study it
is reported that the RQA variable, percent determinism, is sensitive
to the type of fault investigated and therefore can provide useful
information on bearing damage in rolling element bearings.