Abstract: By means of Mawhin’s continuation theorem, we study a kind of third-order p-Laplacian functional differential equation with distributed delay in the form: ϕp(x (t)) = g t, 0 −τ x(t + s) dα(s) + e(t), some criteria to guarantee the existence of periodic solutions are obtained.
Abstract: The small interfering RNA (siRNA) alters the
regulatory role of mRNA during gene expression by translational
inhibition. Recent studies show that upregulation of mRNA because
serious diseases like cancer. So designing effective siRNA with good
knockdown effects plays an important role in gene silencing. Various
siRNA design tools had been developed earlier. In this work, we are
trying to analyze the existing good scoring second generation siRNA
predicting tools and to optimize the efficiency of siRNA prediction
by designing a computational model using Artificial Neural Network
and whole stacking energy (%G), which may help in gene silencing
and drug design in cancer therapy. Our model is trained and tested
against a large data set of siRNA sequences. Validation of our results
is done by finding correlation coefficient of experimental versus
observed inhibition efficacy of siRNA. We achieved a correlation
coefficient of 0.727 in our previous computational model and we
could improve the correlation coefficient up to 0.753 when the
threshold of whole tacking energy is greater than or equal to -32.5
kcal/mol.
Abstract: Unsteady natural convection and heat transfer in a square cavity partially filled with porous media using a thermal
non-equilibrium model is studied in this paper. The left vertical wall is
maintained at a constant hot temperature Th and the right vertical wall
is maintained at a constant cold temperature Tc, while the horizontal
walls are adiabatic. The governing equations are obtained by applying
the Darcy model and Boussinesq approximation. COMSOL’s finite
element method is used to solve the non-dimensional governing
equations together with specified boundary conditions. The governing
parameters of this study are the Rayleigh number (Ra = 10^5, and Ra = 10^6 ), Darcy namber (Da = 10^−2, and Da = 10^−3),
the modified thermal conductivity ratio (10^−1 ≤ γ ≤ 10^4), the inter-phase heat transfer coefficien (10^−1 ≤ H ≤ 10^3) and the
time dependent (0.001 ≤ τ ≤ 0.2). The results presented for
values of the governing parameters in terms of streamlines in both
fluid/porous-layer, isotherms of fluid in fluid/porous-layer, isotherms
of solid in porous layer, and average Nusselt number.
Abstract: A new and cost effective robotic device was designed
for remote tele surgery using dual tone multi frequency technology
(DTMF). Tele system with Dual Tone Multiple Frequency has a large
capability in sending and receiving of data in hardware and software.
The robot consists of DC motors for arm movements and it is
controlled manually through a mobile phone through DTMF
Technology. The system enables the surgeon from base station to
send commands through mobile phone to the patient’s robotic system
which includes two robotic arms that translate the input into actual
instrument manipulation. A mobile phone attached to the
microcontroller 8051 which can activate robot through relays. The
Remote robot-assisted tele surgery eliminates geographic constraints
for getting surgical expertise where it is needed and allows an expert
surgeon to teach or proctor the performance of surgical technique by
real-time intervention.
Abstract: The thermal expansion behaviour of silicon carbide
(SCS-2) fibre reinforced 6061 aluminium matrix composite subjected
to the influenced thermal mechanical cycling (TMC) process were
investigated. The thermal stress has important effect on the
longitudinal thermal expansion coefficient of the composites. The
present paper used experimental data of the thermal expansion
behaviour of a SiC/Al composite for temperatures up to 370°C, in
which their data was used for carrying out modelling of theoretical
predictions.
Abstract: In this paper, Land Marks for Unique Addressing( LMUA) algorithm is develped to generate unique ID for each and every node which leads to the formation of overlapping/Non overlapping clusters based on unique ID. To overcome the draw back of the developed LMUA algorithm, the concept of clustering is introduced. Based on the clustering concept a Land Marks for Unique Addressing and Clustering(LMUAC) Algorithm is developed to construct strictly non-overlapping clusters and classify those nodes in to Cluster Heads, Member Nodes, Gate way nodes and generating the Hierarchical code for the cluster heads to operate in the level one hierarchy for wireless communication switching. The expansion of the existing network can be performed or not without modifying the cost of adding the clusterhead is shown. The developed algorithm shows one way of efficiently constructing the
Abstract: Through the course of this paper we define Locationbased
Intelligence (LBI) which is outgrowing from process of
amalgamation of geolocation and Business Intelligence.
Amalgamating geolocation with traditional Business Intelligence (BI)
results in a new dimension of BI named Location-based Intelligence.
LBI is defined as leveraging unified location information for business
intelligence. Collectively, enterprises can transform location data into
business intelligence applications that will benefit all aspects of the
enterprise. Expectations from this new dimension of business
intelligence are great and its future is obviously bright.
Abstract: The antimicrobial, antiplasmid and cytotoxic activities of marine algae Halimeda opuntia and Sarconema filiforme were investigated. Antimicrobial bioassay against some human pathogenic bacteria and yeast were conducted using disc diffusion method. Halimeda extract exhibited antibacterial activity against six species of microrganisms, with significant inhibition against Staphylococcus aureus. While Sarconema extract was better potent as antifungal against Candida albicans. Comparative antibacterial studies showed that Halimeda extract showed equivalent or better activity as compared with commercial antibiotic when tested against Staphylococcus aureus. Further tests conducted using dilution method showed both extracts as having bacteriostatic mode of action against the tested microorganisms. Methanol extract of two species showed significant cytotoxicity (LC50
Abstract: To determine the presence and location of faults in a transmission by the adaptation of protective distance relay based on the measurement of fixed settings as line impedance is achieved by several different techniques. Moreover, a fast, accurate and robust technique for real-time purposes is required for the modern power systems. The appliance of radial basis function neural network in transmission line protection is demonstrated in this paper. The method applies the power system via voltage and current signals to learn the hidden relationship presented in the input patterns. It is experiential that the proposed technique is competent to identify the particular fault direction more speedily. System simulations studied show that the proposed approach is able to distinguish the direction of a fault on a transmission line swiftly and correctly, therefore suitable for the real-time purposes.
Abstract: In order to obtain an accurate result of the heat transfer
of the rib in the internal cooling Rectangular channel, using separation
of variables, analytical solutions of three dimensional steady-state heat
conduction in rectangular ribs are given by solving three dimensional
steady-state function of the rectangular ribs. Therefore, we can get
solution of three dimensional temperature field in the rib. Based on the
solution, we can get how the Bi number affected on heat transfer.
Furthermore, comparisons of the analytical and numerical results
indicate agreement on temperature field in the rib.
Abstract: Distributed denial-of-service (DDoS) attacks pose a
serious threat to network security. There have been a lot of
methodologies and tools devised to detect DDoS attacks and reduce
the damage they cause. Still, most of the methods cannot
simultaneously achieve (1) efficient detection with a small number of
false alarms and (2) real-time transfer of packets. Here, we introduce
a method for proactive detection of DDoS attacks, by classifying the
network status, to be utilized in the detection stage of the proposed
anti-DDoS framework. Initially, we analyse the DDoS architecture
and obtain details of its phases. Then, we investigate the procedures
of DDoS attacks and select variables based on these features. Finally,
we apply the k-nearest neighbour (k-NN) method to classify the
network status into each phase of DDoS attack. The simulation result
showed that each phase of the attack scenario is classified well and
we could detect DDoS attack in the early stage.
Abstract: This paper investigates the performance of Multiple- Input Multiple-Output (MIMO) feedback system combined with Orthogonal Frequency Division Multiplexing (OFDM). Two types of codebook based channel feedback techniques are used in this work. The first feedback technique uses a combination of both the long-term and short-term channel state information (CSI) at the transmitter, whereas the second technique uses only the short term CSI. The long-term and short-term CSI at the transmitter is used for efficient channel utilization. OFDM is a powerful technique employed in communication systems suffering from frequency selectivity. Combined with multiple antennas at the transmitter and receiver, OFDM proves to be robust against delay spread. Moreover, it leads to significant data rates with improved bit error performance over links having only a single antenna at both the transmitter and receiver. The effectiveness of these techniques has been demonstrated through the simulation of a MIMO-OFDM feedback system. The results have been evaluated for 4x4 MIMO channels. Simulation results indicate the benefits of the MIMO-OFDM channel feedback system over the one without incorporating OFDM. Performance gain of about 3 dB is observed for MIMO-OFDM feedback system as compared to the one without employing OFDM. Hence MIMO-OFDM becomes an attractive approach for future high speed wireless communication systems.
Abstract: The accelerated growth in aircraft industries desire
effectual schemes, programs, innovative designs of advanced systems
and facilities to accomplish the augmenting need for home-free air
transportation. In this paper, a contemporary conceptual design of a
cambered airfoil has been proposed in order to providing augmented
effective lift force relative to the airplane, and to eliminating
drawbacks and limitations of an airfoil in a commercial airplane by
using a kind of smart materials. This invention of an unsymmetrical
airfoil structure utilizes the amplified air momentum around the
airfoil and increased camber length to providing improved aircraft
performance and assist to enhancing the reliability of the aircraft
components. Moreover, this conjectured design helps to reducing
airplane weight and total drag.
Abstract: The objective of the present paper is a numerical
analysis of the flow forces acting on spool surfaces of a pressure
regulated valve. The transient, compressible and turbulent flow
structures inside the valve are simulated using ANSYS FLUENT
coupled with a special UDF. Here, valve inlet pressure is varied in a
stepwise manner. For every value of inlet pressure, transient analysis
leads to a quasi-static flow through the valve. Spool forces are
calculated based on different pressures at inlet. From this information
of spool forces, pressure characteristic of the passive control circuit
has been derived.
Abstract: The incorporation of computational fluid dynamics in the design of modern hydraulic turbines appears to be necessary in order to improve their efficiency and cost-effectiveness beyond the traditional design practices. A numerical optimization methodology is developed and applied in the present work to a Turgo water turbine. The fluid is simulated by a Lagrangian mesh-free approach that can provide detailed information on the energy transfer and enhance the understanding of the complex, unsteady flow field, at very small computing cost. The runner blades are initially shaped according to hydrodynamics theory, and parameterized using Bezier polynomials and interpolation techniques. The use of a limited number of free design variables allows for various modifications of the standard blade shape, while stochastic optimization using evolutionary algorithms is implemented to find the best blade that maximizes the attainable hydraulic efficiency of the runner. The obtained optimal runner design achieves considerably higher efficiency than the standard one, and its numerically predicted performance is comparable to a real Turgo turbine, verifying the reliability and the prospects of the new methodology.
Abstract: Reduction of Single Input Single Output (SISO) continuous systems into Reduced Order Model (ROM), using a conventional and an evolutionary technique is presented in this paper. In the conventional technique, the mixed advantages of Mihailov stability criterion and continued fraction expansions (CFE) technique is employed where the reduced denominator polynomial is derived using Mihailov stability criterion and the numerator is obtained by matching the quotients of the Cauer second form of Continued fraction expansions. In the evolutionary technique method Particle Swarm Optimization (PSO) is employed to reduce the higher order model. PSO method is based on the minimization of the Integral Squared Error (ISE) between the transient responses of original higher order model and the reduced order model pertaining to a unit step input. Both the methods are illustrated through numerical example.
Abstract: In this paper we present simulation results for the
application of a bandwidth efficient algorithm (mapping algorithm)
to an image transmission system. This system considers three
different real valued transforms to generate energy compact
coefficients. First results are presented for gray scale and color image
transmission in the absence of noise. It is seen that the system
performs its best when discrete cosine transform is used. Also the
performance of the system is dominated more by the size of the
transform block rather than the number of coefficients transmitted or
the number of bits used to represent each coefficient. Similar results
are obtained in the presence of additive white Gaussian noise. The
varying values of the bit error rate have very little or no impact on
the performance of the algorithm. Optimum results are obtained for
the system considering 8x8 transform block and by transmitting 15
coefficients from each block using 8 bits.
Abstract: Fractional Fourier Transform is a powerful tool,
which is a generalization of the classical Fourier Transform. This
paper provides a mathematical relation relating the span in Fractional
Fourier domain with the amplitude and phase functions of the signal,
which is further used to study the variation of quality factor with
different values of the transform order. It is seen that with the
increase in the number of transients in the signal, the deviation of
average Fractional Fourier span from the frequency bandwidth
increases. Also, with the increase in the transient nature of the signal,
the optimum value of transform order can be estimated based on the
quality factor variation, and this value is found to be very close to
that for which one can obtain the most compact representation. With
the entire mathematical analysis and experimentation, we consolidate
the fact that Fractional Fourier Transform gives more optimal
representations for a number of transform orders than Fourier
transform.
Abstract: 17α-ethinylestradiol (EE2) is a recalcitrant micropollutant which is found in small amounts in municipal wastewater. But these small amounts still adversely affect for the reproductive function of aquatic organisms. Evidence in the past suggested that full-scale WWTPs equipped with nitrification process enhanced the removal of EE2 in the municipal wastewater. EE2 has been proven to be able to be transformed by ammonia oxidizing bacteria (AOB) via co-metabolism. This research aims to clarify the EE2 degradation pattern by different consortium of ammonia oxidizing microorganism (AOM) including AOA (ammonia oxidizing archaea) and investigate contribution between the existing ammonia monooxygenase (AMO) and new synthesized AOM. The result showed that AOA or AOB of N. oligotropha cluster in enriched nitrifying activated sludge (NAS) from 2mM and 5mM, commonly found in municipal WWTPs, could degrade EE2 in wastewater via co-metabolism. Moreover, the investigation of the contribution between the existing ammonia monooxygenase (AMO) and new synthesized AOM demonstrated that the new synthesized AMO enzyme may perform ammonia oxidation rather than the existing AMO enzyme or the existing AMO enzyme may has a small amount to oxidize ammonia.
Abstract: Sensitive and predictive DILI (Drug Induced Liver
Injury) biomarkers are needed in drug R&D to improve early
detection of hepatotoxicity. The discovery of DILI biomarkers that
demonstrate the predictive power to identify individuals at risk to
DILI would represent a major advance in the development of
personalized healthcare approaches. In this healthy volunteer
acetaminophen study (4g/day for 7 days, with 3 monitored nontreatment
days before and 4 after), 450 serum samples from 32
subjects were analyzed using protein profiling by antibody
suspension bead arrays. Multiparallel protein profiles were generated
using a DILI target protein array with 300 antibodies, where the
antibodies were selected based on previous literature findings of
putative DILI biomarkers and a screening process using pre dose
samples from the same cohort. Of the 32 subjects, 16 were found to
develop an elevated ALT value (2Xbaseline, responders). Using the
plasma profiling approach together with multivariate statistical
analysis some novel findings linked to lipid metabolism were found
and more important, endogenous protein profiles in baseline samples
(prior to treatment) with predictive power for ALT elevations were
identified.