Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: Semiconductor nanomaterials like TiO2 nanoparticles
(TiO2-NPs) approximately less than 100 nm in diameter have become
a new generation of advanced materials due to their novel and
interesting optical, dielectric, and photo-catalytic properties. With the
increasing use of NPs in commerce, to date few studies have
investigated the toxicological and environmental effects of NPs.
Motivated by the importance of TiO2-NPs that may contribute to the
cancer research field especially from the treatment prospective
together with the fractal analysis technique, we have investigated the
effect of TiO2-NPs on colony morphology in the dark condition
using fractal dimension as a key morphological characterization
parameter. The aim of this work is mainly to investigate the cytotoxic
effects of TiO2-NPs in the dark on the growth of human cervical
carcinoma (HeLa) cell colonies from morphological aspect. The in
vitro studies were carried out together with the image processing
technique and fractal analysis. It was found that, these colonies were
abnormal in shape and size. Moreover, the size of the control
colonies appeared to be larger than those of the treated group. The
mean Df +/- SEM of the colonies in untreated cultures was
1.085±0.019, N= 25, while that of the cultures treated with TiO2-NPs
was 1.287±0.045. It was found that the circularity of the control
group (0.401±0.071) is higher than that of the treated group
(0.103±0.042). The same tendency was found in the diameter
parameters which are 1161.30±219.56 μm and 852.28±206.50 μm
for the control and treated group respectively. Possible explanation of
the results was discussed, though more works need to be done in
terms of the for mechanism aspects. Finally, our results indicate that
fractal dimension can serve as a useful feature, by itself or in
conjunction with other shape features, in the classification of cancer
colonies.
Abstract: The purpose of this research was to study five vital
factors related to employees’ job performance. A total of 250
respondents were sampled from employees who worked at a public
warehouse organization, Bangkok, Thailand. Samples were divided
into two groups according to their work experience. The average
working experience was about 9 years for group one and 28 years for
group two. A questionnaire was utilized as a tool to collect data.
Statistics utilized in this research included frequency, percentage,
mean, standard deviation, t-test analysis, one way ANOVA, and
Pearson Product-moment correlation coefficient. Data were analyzed
by using Statistical Package for the Social Sciences. The findings
disclosed that the majority of respondents were female between 23-
31 years old, single, and hold an undergraduate degree. The average
income of respondents was less than 30,900 baht. The findings also
revealed that the factors of organization chart awareness, job process
and technology, internal environment, employee loyalty, and policy
and management were ranked as medium level. The hypotheses
testing revealed that difference in gender, age, and position had
differences in terms of the awareness of organization chart, job
process and technology, internal environment, employee loyalty, and
policy and management in the same direction with low level.
Abstract: The main emphasis of metallurgists has been to process the materials to obtain the balanced mechanical properties for the given application. One of the processing routes to alter the properties is heat treatment. Nearly 90% of the structural applications are related to the medium carbon an alloyed steels and hence are regarded as structural steels. The major requirement in the conventional steel is to improve workability, toughness, hardness and grain refinement. In this view, it is proposed to study the mechanical and tribological properties of unalloyed structural (AISI 1140) steel with different thermal (heat) treatments like annealing, normalizing, tempering and hardening and compared with as brought (cold worked) specimen. All heat treatments are carried out in atmospheric condition. Hardening treatment improves hardness of the material, a marginal decrease in hardness value with improved ductility is observed in tempering. Annealing and normalizing improve ductility of the specimen. Normalized specimen shows ultimate ductility. Hardened specimen shows highest wear resistance in the initial period of slide wear where as above 25KM of sliding distance, as brought steel dominates the hardened specimen. Both mild and severe wear regions are observed. Microstructural analysis shows the existence of pearlitic structure in normalized specimen, lath martensitic structure in hardened, pearlitic, ferritic structure in annealed specimen.
Abstract: The paper shows some ability to manage two-phase
flows arising from the use of unsteady effects. In one case, we
consider the condition of fragmentation of the interface between the
two components leads to the intensification of mixing. The problem
is solved when the temporal and linear scale are small for the
appearance of the developed mixing layer. Showing that exist such
conditions for unsteady flow velocity at the surface of the channel,
which will lead to the creation and fragmentation of vortices at Re
numbers of order unity. Also showing that the Re is not a criterion of
similarity for this type of flows, but we can introduce a criterion that
depends on both the Re, and the frequency splitting of the vortices. It
turned out that feature of this situation is that streamlines behave
stable, and if we analyze the behavior of the interface between the
components it satisfies all the properties of unstable flows. The other
problem we consider the behavior of solid impurities in the extensive
system of channels. Simulated unsteady periodic flow modeled
breaths. Consider the behavior of the particles along the trajectories.
It is shown that, depending on the mass and diameter of the particles,
they can be collected in a caustic on the channel walls, stop in a
certain place or fly back. Of interest is the distribution of particle
velocity in frequency. It turned out that by choosing a behavior of the
velocity field of the carrier gas can affect the trajectory of individual
particles including force them to fly back.
Abstract: The objective of this research was to study the factors
related to the satisfaction of consumers who purchased a Toyota
SUV Fortuner. This paper was a survey data which collected 400
samples from 65 car dealerships. The survey was conducted mainly
in Bangkok, Thailand. The statistics utilized in this paper included
percentage, mean, standard deviation and Pearson Product-Moment.
The findings revealed that the majority of respondent were male with
an undergraduate degree, married and live together. The average
income of the respondents was between 20,001 - 30,000 baht. Most
of them worked for private companies. Most of them had a family
with the average of 4 members. The hypotheses testing revealed that
the factors of marketing mix in terms of product (ability, gas
mileage, and safety) were related to overall satisfaction at the
medium level. However, the findings also revealed that the factors of
marketing mix in terms of product (image), price, and promotion, and
service center were related to the overall satisfaction at the low level.
Abstract: The problem of frequent pattern discovery is defined
as the process of searching for patterns such as sets of features or items that appear in data frequently. Finding such frequent patterns
has become an important data mining task because it reveals associations, correlations, and many other interesting relationships
hidden in a database. Most of the proposed frequent pattern mining
algorithms have been implemented with imperative programming
languages. Such paradigm is inefficient when set of patterns is large
and the frequent pattern is long. We suggest a high-level declarative
style of programming apply to the problem of frequent pattern
discovery. We consider two languages: Haskell and Prolog. Our
intuitive idea is that the problem of finding frequent patterns should
be efficiently and concisely implemented via a declarative paradigm
since pattern matching is a fundamental feature supported by most
functional languages and Prolog. Our frequent pattern mining
implementation using the Haskell and Prolog languages confirms our
hypothesis about conciseness of the program. The comparative
performance studies on line-of-code, speed and memory usage of
declarative versus imperative programming have been reported in the
paper.
Abstract: Nowadays, computer worms, viruses and Trojan horse
become popular, and they are collectively called malware. Those
malware just spoiled computers by deleting or rewriting important
files a decade ago. However, recent malware seems to be born to earn
money. Some of malware work for collecting personal information so
that malicious people can find secret information such as password for
online banking, evidence for a scandal or contact address which relates
with the target. Moreover, relation between money and malware
becomes more complex. Many kinds of malware bear bots to get
springboards. Meanwhile, for ordinary internet users,
countermeasures against malware come up against a blank wall.
Pattern matching becomes too much waste of computer resources,
since matching tools have to deal with a lot of patterns derived from
subspecies. Virus making tools can automatically bear subspecies of
malware. Moreover, metamorphic and polymorphic malware are no
longer special. Recently there appears malware checking sites that
check contents in place of users' PC. However, there appears a new
type of malicious sites that avoids check by malware checking sites. In
this paper, existing protocols and methods related with the web are
reconsidered in terms of protection from current attacks, and new
protocol and method are indicated for the purpose of security of the
web.
Abstract: Experimental investigations were made on the instability of supercritical kerosene flowing in active cooling channels. Two approaches were used to control the pressure in the channel. One is the back-pressure valve while the other is the venturi. In both conditions, a kind of low-frequency oscillation of pressure and temperature is observed. And the oscillation periods are calculated. By comparison with the flow time, it is concluded that the instability occurred in active cooling channels is probably one kind of density wave instability. And its period has no relationship with the cooling channel geometry, nor the pressure, but only depends on the flow time of kerosene in active cooling channels. When the mass flow rate, density and pressure drop couple with each other, the density wave instability will appear.
Abstract: Open and distance learning is a fairly new concept in
Malawi. The major public provider, the Malawi College of Distance
Education, rolled out its activities only about 40 years ago. Over the
years, the demand for distance education has tremendously increased.
The present government has displayed positive political will to uplift
ODL as outlined in the Malawi Growth and Development Strategy as
well as the National Education Sector Plan. A growing national
interest in education coupled with political stability and a booming
ICT industry also raise hope for success. However, a fragile economy
with a GNI per capita of -US$ 200 over the last decade, poor public
funding, erratic power supply and lack of expertise put strain on
efforts towards the promotion of ODL initiatives. Despite the
challenges, the nation appears determined to go flat out and explore
all possible avenues that could revolutionise education access and
equity through ODL.
Abstract: One astonishing capability of humans is to recognize thousands of different objects visually, and to learn the semantic association between those objects and words referring to them. This work is an attempt to build a computational model of such capacity,simulating the process by which infants learn how to recognize objects and words through exposure to visual stimuli and vocal sounds.One of the main fact shaping the brain of a newborn is that lights and colors come from entities of the world. Gradually the visual system learn which light sensations belong to same entities, despite large changes in appearance. This experience is common between humans and several other mammals, like non-human primates. But humans only can recognize a huge variety of objects, most manufactured by himself, and make use of sounds to identify and categorize them. The aim of this model is to reproduce these processes in a biologically plausible way, by reconstructing the essential hierarchy of cortical circuits on the visual and auditory neural paths.
Abstract: Increasing use of cell phone as a medium of human interaction is playing a vital role in solving riddles of crime as well. A young girl went missing from her home late in the evening in the month of August, 2008 when her enraged relatives and villagers physically assaulted and chased her fiancée who often frequented her home. Two years later, her mother lodged a complaint against the relatives and the villagers alleging that after abduction her daughter was either sold or killed as she had failed to trace her. On investigation, a rusted cell phone with partial visible IMEI number, clothes, bangles, human skeleton etc. recovered from abandoned well in the month of May, 2011 were examined in the lab. All hopes pinned on identity of cell phone, for only linking evidence to fix the scene of occurrence supported by call detail record (CDR) and to dispel doubts about mode of sudden disappearance or death as DNA technology did not help in establishing identity of the deceased. The conventional scientific methods were used without success and international mobile equipment identification number of the cell phone could be generated by using statistical analysis followed by online verification.
Abstract: The influences of pulsed electric fields on early
physiological development in Arabidopsis thaliana were studied.
Inside a 4-mm electroporation cuvette, pre-germination seeds were
subjected to high-intensity, nanosecond electrical pulses generated
using laboratory-assembled pulsed electric field system. The field
strength was varied from 5 to 20 kV.cm-1 and the pulse width and the
pulse number were maintained at 10 ns and 100, respectively,
corresponding to the specific treatment energy from 300 J.kg-1 to 4.5
kJ.kg-1. Statistical analyses on the average leaf area 5 and 15 days
following pulsed electric field treatment showed that the effects
appear significant the second week after treatments with a maximum
increase of 80% compared to the control (P < 0.01).
Abstract: Having considered tactile sensing and palpation of a
surgeon in order to detect kidney stone during open surgery; we
present the 2D model of nephrolithiasis (two dimensional model of
kidney containing a simulated stone). The effects of stone existence
that appear on the surface of kidney (because of exerting mechanical
load) are determined. Using Finite element method, it is illustrated
that the created stress patterns on the surface of kidney and stress
graphs not only show existence of stone inside kidney, but also show
its exact location.
Abstract: Technological innovation capability (TIC) is
defined as a comprehensive set of characteristics of a firm that
facilities and supports its technological innovation strategies.
An audit to evaluate the TICs of a firm may trigger
improvement in its future practices. Such an audit can be used
by the firm for self assessment or third-party independent
assessment to identify problems of its capability status. This
paper attempts to develop such an auditing framework that
can help to determine the subtle links between innovation
capabilities and business performance; and to enable the
auditor to determine whether good practice is in place. The
seven TICs in this study include learning, R&D, resources
allocation, manufacturing, marketing, organization and
strategic planning capabilities. Empirical data was acquired
through a survey study of 200 manufacturing firms in the
Hong Kong/Pearl River Delta (HK/PRD) region. Structural
equation modelling was employed to examine the
relationships among TICs and various performance indicators:
sales performance, innovation performance, product
performance, and sales growth. The results revealed that
different TICs have different impacts on different
performance measures. Organization capability was found to
have the most influential impact. Hong Kong manufacturers
are now facing the challenge of high-mix-low-volume
customer orders. In order to cope with this change, good
capability in organizing different activities among various
departments is critical to the success of a company.
Abstract: The current of professional bicycle pedal-s
manufacturing model mostly used casting, forging, die-casting
processing methods, so the paper used 7075 aluminum alloy which is
to produce the bicycle parts most commonly, and employs the
rigid-plastic finite element (FE) DEFORMTM 3D software to simulate
and to analyze the professional bicycle pedal design. First we use Solid
works 2010 3D graphics software to design the professional bicycle
pedal of the mold and appearance, then import finite element (FE)
DEFORMTM 3D software for analysis. The paper used rigid-plastic
model analytical methods, and assuming mode to be rigid body. A
series of simulation analyses in which the variables depend on
different temperature of forging billet, friction factors, forging speed,
mold temperature are reveal to effective stress, effective strain, damage
and die radial load distribution for forging bicycle pedal. The analysis
results hope to provide professional bicycle pedal forming mold
references to identified whether suit with the finite element results for
high-strength design suitability of aluminum alloy.
Abstract: Direct numerical simulation (DNS) is used to study the evolution of a boundary layer that was laminar initially followed by separation and then reattachment owing to generation of turbulence. This creates a closed region of recirculation, known as the laminar-separation bubble. The present simulation emulates the flow environment encountered in a modern LP turbine blade, where a laminar separation bubble may occur on the suction surface. The unsteady, incompressible three-dimensional (3-D) Navier-Stokes (NS) equations have been solved over a flat plate in the Cartesian coordinates. The adverse pressure gradient, which causes the flow to separate, is created by a boundary condition. The separated shear layer undergoes transition through appearance of ╬ø vortices, stretching of these create longitudinal streaks. Breakdown of the streaks into small and irregular structures makes the flow turbulent downstream.
Abstract: The acoustic and articulatory properties of fricative speech sounds are being studied using magnetic resonance imaging (MRI) and acoustic recordings from a single subject. Area functions were derived from a complete set of axial and coronal MR slices using two different methods: the Mermelstein technique and the Blum transform. Area functions derived from the two techniques were shown to differ significantly in some cases. Such differences will lead to different acoustic predictions and it is important to know which is the more accurate. The vocal tract acoustic transfer function (VTTF) was derived from these area functions for each fricative and compared with measured speech signals for the same fricative and same subject. The VTTFs for /f/ in two vowel contexts and the corresponding acoustic spectra are derived here; the Blum transform appears to show a better match between prediction and measurement than the Mermelstein technique.
Abstract: The electrochemical coagulation of a kaolin
suspension was investigated at the currents of 0.06, 0.12, 0.22, 0.44,
0.85 A (corresponding to 0.68, 1.36, 2.50, 5.00, 9.66 mA·cm-2,
respectively) for the contact time of 5, 10, 20, 30, and 50 min. The
TSS removal efficiency at currents of 0.06 A, 0.12 A and 0.22 A
increased with the amount of iron generated by the sacrificial anode,
while the removal efficiencies did not increase proportionally with
the amount of iron generated at the currents of 0.44 and 0.85 A,
where electroflotation was clearly observed. Zeta potential
measurement illustrated the presence of the highly positive charged
particles created by sorption of highly charged polymeric metal
hydroxyl species onto the negative surface charged kaolin particles at
both low and high applied currents. The disappearance of the
individual peaks after certain contact times indicated the attraction
between these positive and negative charged particles causing
agglomeration. It was concluded that charge neutralization of the
individual species was not the only mechanism operating in the
electrocoagulation process at any current level, but electrostatic
attraction was likely to co-operate or mainly operate.
Abstract: This paper proposes a novel methodology for enabling
debugging and tracing of production web applications without
affecting its normal flow and functionality. This method of debugging
enables developers and maintenance engineers to replace a set of
existing resources such as images, server side scripts, cascading
style sheets with another set of resources per web session. The new
resources will only be active in the debug session and other sessions
will not be affected. This methodology will help developers in tracing
defects, especially those that appear only in production environments
and in exploring the behaviour of the system. A realization of the
proposed methodology has been implemented in Java.