Abstract: P16/INK4A is tumor suppressor protein that plays a critical role in cell cycle regulation. Loss of P16 protein expression has been implicated in pathogenesis of many cancers, including lymphoma. Therefore, we sought to investigate if loss of P16 protein expression is associated with lymphoma and/or any specific lymphoma subtypes (Hodgkin-s lymphoma (HL) and nonHodgkin-s lymphoma (NHL)). Fifty-five lymphoma cases consisted of 30 cases of HL and 25 cases of NHL, with an age range of 3 to 78 years, were examined for loss of P16 by immunohistochemical technique using a specific antibody reacting against P16. In total, P16 loss was seen in 33% of all lymphoma cases. P16 loss was identified in 47.7% of HL cases. In contrast, only 16% of NHL showed loss of P16. Loss of P16 was seen in 67% of HL patients with 50 years of age or older, whereas P16 loss was found in only 42% of HL patients with less than 50 years of age. P16 loss in HL is somewhat higher in male (55%) than in female (30%). In subtypes of HL, P16 loss was found exclusively in all cases of lymphocyte depletion, lymphocyte predominance and unclassified cases, whereas P16 loss was seen in 39% of mixed cellularity and 29% of nodular sclerosis cases. In low grade NHL patients, P16 loss was seen in approximately one-third of cases, whereas no or very rare of P16 loss was found in intermediate and high grade cases. P16 loss did not show any correlation with age or gender of NHL patients. In conclusion, the high rate of P16 loss seen in our study suggests that loss of P16 expression plays a critical role in the pathogenesis of lymphoma, particularly with HL.
Abstract: Nonlinear solitary structures of electron plasma waves
have been investigated by using nonlinear quantum fluid equations for electrons with an arbitrary temperature. It is shown that the electron degeneracy parameter has significant effects on the linear and nonlinear properties of electron plasma waves. Depending on its
value both compressive and rarefactive solitons can be excited in the model plasma under consideration.
Abstract: Work-life balance has been acknowledged and
promoted for the sake of employee retention. It is essential for a
manager to realize the human resources situation within a company to
help employees work happily and perform at their best. This paper
suggests knowledge management and critical thinking are useful to
motivate employees to think about their work-life balance. A
qualitative case study is presented, which aimed to discover the
meaning of work-life balance-s meaning from the perspective of Thai
knowledge workers and how it affects their decision-making towards
work resignation. Results found three types of work-life balance
dimensions; a work- life balance including a workplace and a private
life setting, an organizational working life balance only, and a worklife
balance only in a private life setting. These aspects all influenced
the decision-making of the employees. Factors within a theme of an
organizational work-life balance were involved with systematic
administration, fair treatment, employee recognition, challenging
assignments to gain working experience, assignment engagement,
teamwork, relationship with superiors, and working environment,
while factors concerning private life settings were about personal
demands such as an increasing their salary or starting their own
business.
Abstract: The recent trend in field oriented control (FOC) is towards the use of sensorless techniques that avoid the use of speed sensor and flux sensor. Sensors are replaced by estimators or observers to minimise the cost and increase the reliability. In this paper an anlyse of perfomance of a MRAS used in sensorless control of induction motors and sensitvity to machine parameters change are studied.
Abstract: In this article the influence of higher frequency effects
in addition to a special damper design on the electrical behavior of a
synchronous generator main exciter machine is investigated. On the
one hand these machines are often highly stressed by harmonics from
the bridge rectifier thus facing additional eddy current losses. On the
other hand the switching may cause the excitation of dangerous
voltage peaks in resonant circuits formed by the diodes of the
rectifier and the commutation reactance of the machine. Therefore
modern rotating exciters are treated like synchronous generators
usually modeled with a second order equivalent circuit. Hence the
well known Standstill Frequency Response Test (SSFR) method is
applied to a test machine in order to determine parameters for the
simulation. With these results it is clearly shown that higher
frequencies have a strong impact on the conventional equivalent
circuit model. Because of increasing field displacement effects in the
stranded armature winding the sub-transient reactance is even smaller
than the armature leakage at high frequencies. As a matter of fact this
prevents the algorithm to find an equivalent scheme. This issue is
finally solved using Laplace transfer functions fully describing the
transient behavior at the model ports.
Abstract: In this paper, a technique is proposed to implement
an artificial voltage-controlled capacitance or inductance which can
replace the well-known varactor diode in many applications. The
technique is based on injecting the current of a voltage-controlled
current source onto a fixed capacitor or inductor. Then, by controlling
the transconductance of the current source by an external bias voltage,
a voltage-controlled capacitive or inductive reactance is obtained.
The proposed voltage-controlled reactance devices can be designed
to work anywhere in the frequency spectrum. Practical circuits for the
proposed voltage-controlled reactances are suggested and simulated.
Abstract: Permeability reduction induced by asphaltene
precipitation during gas injection is one of the serious problems in
the oil industry. This problem can lead to formation damage and
decrease the oil production rate. In this work, Malaysian light oil
sample has been used to investigate the effect CO2 injection and
Water Alternating Gas (WAG) injection on permeability reduction.
In this work, dynamic core flooding experiments were conducted to
study the effect of CO2 and WAG injection on the amount of
asphaltene precipitated. Core properties after displacement were
inspected for any permeability reduction to study the effect of
asphaltene precipitation on rock properties.
The results showed that WAG injection gave less asphaltene
precipitation and formation damage compared to CO2 injection. The
study suggested that WAG injection can be one of the important
factors of managing asphaltene precipitation.
Abstract: Recent research on seeds of bio-diesel plants like
Jatropha curcas, constituting 40-50% bio-crude oil indicates its
potential as one of the most promising alternatives to conventional
sources of energy. Also, limited studies on utilization of de-oiled cake
have revealed that Jatropha bio-waste has good potential to be used as
organic fertilizers produced via aerobic and anaerobic treatment.
However, their commercial exploitation has not yet been possible. The
present study aims at developing appropriate bio-processes and
formulations utilizing Jatropha seed cake as organic fertilizer, for
improving the growth of Polianthes tuberose L. (Tuberose). Pot
experiments were carried out by growing tuberose plants on soil
treated with composted formulations of Jatropha de-oiled cake, Farm
Yard Manure (FYM) and inorganic fertilizers were also blended in
soil. The treatment was carried out through soil amendment as well as
foliar spray. The growth and morphological parameters were
monitored for entire crop cycle.
The growth Length and number of leaves, spike length, rachis
length, number of bulb per plant and earliness of sprouting of bulb and
yield enhancement were comparable to that achieved under inorganic
fertilizer. Furthermore, performance of inorganic fertilizer also showed
an improvement when blended with composted bio-waste. These
findings would open new avenues for Jatropha based bio-wastes to be
composted and used as organic fertilizers for commercial floriculture.
Abstract: Cosmic showers, from their places of origin in space,
after entering earth generate secondary particles called Extensive Air
Shower (EAS). Detection and analysis of EAS and similar High
Energy Particle Showers involve a plethora of experimental setups
with certain constraints for which soft-computational tools like
Artificial Neural Network (ANN)s can be adopted. The optimality
of ANN classifiers can be enhanced further by the use of Multiple
Classifier System (MCS) and certain data - dimension reduction
techniques. This work describes the performance of certain data
dimension reduction techniques like Principal Component Analysis
(PCA), Independent Component Analysis (ICA) and Self Organizing
Map (SOM) approximators for application with an MCS formed
using Multi Layer Perceptron (MLP), Recurrent Neural Network
(RNN) and Probabilistic Neural Network (PNN). The data inputs are
obtained from an array of detectors placed in a circular arrangement
resembling a practical detector grid which have a higher dimension
and greater correlation among themselves. The PCA, ICA and SOM
blocks reduce the correlation and generate a form suitable for real
time practical applications for prediction of primary energy and
location of EAS from density values captured using detectors in a
circular grid.
Abstract: Previous studies on political budget cycles (PBCs)
implicitly assume the executive has full discretion power over fiscal
policy, neglecting the role of checks and balances of the legislature.
This paper goes beyond traditional PBCs models and sheds light on
the case study of Japan, South Korea, and Taiwan over the 1988-2007
periods. Based on the results, we find no evidence of electoral impacts
on the public expenditures in South Korean and Taiwan's
congressional elections. We also noted that PBCs are found on
Taiwan-s government expenditures during our sample periods.
Furthermore, the results also show that Japan-s legislature has a
significant checks and balances on government-s expenditures.
However, empirical results show that the legislature veto player in
Taiwan neither has effect on the reduction of public expenditures, nor
has the moderating effect over Taiwan-s political budget cycles, albeit
that they are statistically insignificant.We suggest that the existence of
PBCs in Taiwan is due to a weaker systemof checks and balances. Our
conjecture is that Taiwan either has no legislative veto player or has
observed low compliance to the law during the time period examined
in our study.
Abstract: Both the minimum energy consumption and
smoothness, which is quantified as a function of jerk, are generally
needed in many dynamic systems such as the automobile and the
pick-and-place robot manipulator that handles fragile equipments.
Nevertheless, many researchers come up with either solely
concerning on the minimum energy consumption or minimum jerk
trajectory. This research paper proposes a simple yet very interesting
relationship between the minimum direct and indirect jerks
approaches in designing the time-dependent system yielding an
alternative optimal solution. Extremal solutions for the cost functions
of direct and indirect jerks are found using the dynamic optimization
methods together with the numerical approximation. This is to allow
us to simulate and compare visually and statistically the time history
of control inputs employed by minimum direct and indirect jerk
designs. By considering minimum indirect jerk problem, the
numerical solution becomes much easier and yields to the similar
results as minimum direct jerk problem.
Abstract: One of the robust fault detection filter (RFDF)
designing method is based on sliding-mode theory. The main purpose
of our study is to introduce an innovative simplified reference
residual model generator to formulate the RFDF as a sliding-mode
observer without any manipulation package or transformation matrix,
through which the generated residual signals can be evaluated. So the
proposed design is more explicit and requires less design parameters
in comparison with approaches requiring changing coordinates. To
the best author's knowledge, this is the first time that the sliding
mode technique is applied to detect actuator and sensor faults in a
real boiler. The designing procedure is proposed in a drum boiler in
Synvendska Kraft AB Plant in Malmo, Sweden as a multivariable
and strongly coupled system. It is demonstrated that both sensor and
actuator faults can robustly be detected. Also sensor faults can be
diagnosed and isolated through this method.
Abstract: In this paper, an analytical approach is used to study the coupled lateral-torsional vibrations of laminated composite beam. It is known that in such structures due to the fibers orientation in various layers, any lateral displacement will produce a twisting moment. This phenomenon is modeled by the bending-twisting material coupling rigidity and its main feature is the coupling of lateral and torsional vibrations. In addition to the material coupling, the effects of shear deformation and rotary inertia are taken into account in the definition of the potential and kinetic energies. Then, the governing differential equations are derived using the Hamilton-s principle and the mathematical model matches the Timoshenko beam model when neglecting the effect of bending-twisting rigidity. The equations of motion which form a system of three coupled PDEs are solved analytically to study the free vibrations of the beam in lateral and rotational modes due to the bending, as well as the torsional mode caused by twisting. The analytic solution is carried out in three steps: 1) assuming synchronous motion for the kinematic variables which are the lateral, rotational and torsional displacements, 2) solving the ensuing eigenvalue problem which contains three coupled second order ODEs and 3) imposing different boundary conditions related to combinations of simply, clamped and free end conditions. The resulting natural frequencies and mode shapes are compared with similar results in the literature and good agreement is achieved.
Abstract: Cry j 1 is a causative substance of Japanese cedar
pollinosis, and it may deteriorate by Cry j 1 invasion to a lower
respiratory tract. We observed airborne particles containing Cry j 1 by
an immunofluorescence technique using a fluorescence microscope,
and we clarified that Cry j 1 exist as aggregates of airborne fine
particles (< 1.1 μm) in the urban atmosphere. Airborne Cry j 1 may
react with air pollutants and be denature to a substance deteriorated
Japanese cedar pollinosis. Therefore, we applied a sodium dodecyl
sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) to evaluate a
Cry j 1 reacted with various air pollutants by liquid phase reaction,
and calculated kinetics constants of Cry j 1 extracted from pollens
collected in various sites and airborne fine particles containing Cry j
1 by using a surface plasmon resonance (SPR) method. As a result, it
is suggested that Cry j 1 may be denatured by air pollutants during
the transportation to the urban atmosphere.
Abstract: In order to maximize efficiency of an information management platform and to assist in decision making, the collection, storage and analysis of performance-relevant data has become of fundamental importance. This paper addresses the merits and drawbacks provided by the OLAP paradigm for efficiently navigating large volumes of performance measurement data hierarchically. The system managers or database administrators navigate through adequately (re)structured measurement data aiming to detect performance bottlenecks, identify causes for performance problems or assessing the impact of configuration changes on the system and its representative metrics. Of particular importance is finding the root cause of an imminent problem, threatening availability and performance of an information system. Leveraging OLAP techniques, in contrast to traditional static reporting, this is supposed to be accomplished within moderate amount of time and little processing complexity. It is shown how OLAP techniques can help improve understandability and manageability of measurement data and, hence, improve the whole Performance Analysis process.
Abstract: This paper presents the doping profile measurement
and characterization technique for the pocket implanted nano scale
n-MOSFET. Scanning capacitance microscopy and atomic force
microscopy have been used to image the extent of lateral dopant
diffusion in MOS structures. The data are capacitance vs. voltage
measurements made on a nano scale device. The technique is nondestructive
when imaging uncleaved samples. Experimental data from
the published literature are presented here on actual, cleaved device
structures which clearly indicate the two-dimensional dopant profile
in terms of a spatially varying modulated capacitance signal. Firstorder
deconvolution indicates the technique has much promise for
the quantitative characterization of lateral dopant profiles. The pocket
profile is modeled assuming the linear pocket profiles at the source
and drain edges. From the model, the effective doping concentration
is found to use in modeling and simulation results of the various
parameters of the pocket implanted nano scale n-MOSFET. The
potential of the technique to characterize important device related
phenomena on a local scale is also discussed.
Abstract: This paper presents a new adaptive DMC controller
that improves the controller performance in case of plant-model
mismatch. The new controller monitors the plant measured output,
compares it with the model output and calculates weights applied to
the controller move. Simulations show that the new controller can
help improve control performance and avoid instability in case of
severe model mismatches.
Abstract: We demonstrate the synthesis of intermediary views
within a sequence of color encoded, materials discriminating, X-ray
images that exhibit animated depth in a visual display. During the
image acquisition process, the requirement for a linear X-ray detector
array is replaced by synthetic image. Scale Invariant Feature
Transform, SIFT, in combination with material segmented morphing
is employed to produce synthetic imagery. A quantitative analysis of
the feature matching performance of the SIFT is presented along with
a comparative study of the synthetic imagery. We show that the total
number of matches produced by SIFT reduces as the angular
separation between the generating views increases. This effect is
accompanied by an increase in the total number of synthetic pixel
errors. The trends observed are obtained from 15 different luggage
items. This programme of research is in collaboration with the UK
Home Office and the US Dept. of Homeland Security.
Abstract: This paper deals with the application of artificial
neural network (ANN) and fuzzy based Adaptive Neuro Fuzzy
Inference System(ANFIS) approach to Load Frequency Control
(LFC) of multi unequal area hydro-thermal interconnected power
system. The proposed ANFIS controller combines the advantages of
fuzzy controller as well as quick response and adaptability nature of
ANN. Area-1 and area-2 consists of thermal reheat power plant
whereas area-3 and area-4 consists of hydro power plant with electric
governor. Performance evaluation is carried out by using intelligent
controller like ANFIS, ANN and Fuzzy controllers and conventional
PI and PID control approaches. To enhance the performance of
intelligent and conventional controller sliding surface is included.
The performances of the controllers are simulated using
MATLAB/SIMULINK package. A comparison of ANFIS, ANN,
Fuzzy, PI and PID based approaches shows the superiority of
proposed ANFIS over ANN & fuzzy, PI and PID controller for 1%
step load variation.
Abstract: Atherosclerosis was identified as a chronic inflammatory process resulting from interactions between plasma lipoproteins, cellular components (monocyte, macrophages, T lymphocytes, endothelial cells and smooth muscle cells) and the extracellular matrix of the arterial wall. Several types of genes were known to express during formation of atherosclerosis. This study is carried out to identify unknown differentially expressed gene (DEG) in atherogenesis. Rabbit’s aorta tissues were stained by H&E for histomorphology. GeneFishing™ PCR analysis was performed from total RNA extracted from the aorta tissues. The DNA fragment from DEG was cloned, sequenced and validated by Real-time PCR. Histomorphology showed intimal thickening in the aorta. DEG detected from ACP-41 was identified as cathepsin B gene and showed upregulation at week-8 and week-12 of atherogenesis. Therefore, ACP-based GeneFishing™ PCR facilitated identification of cathepsin B gene which was differentially expressed during development of atherosclerosis.