Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: In the upstream we place a piece of ring and rotate
it with 83Hz, 166Hz, 333Hz,and 666H to find the effect of the
periodic distortion.In the experiment this type of the perturbation
will not allow since the mechanical failure of any parts of the
equipment in the upstream will destroy the blade system. This type of
study will be only possible by CFD. We use two pumps NS32
(ENSAM) and three blades pump (Tamagawa Univ). The benchmark
computations were performed without perturbation parts, and confirm
the computational results well agreement in head-flow rate. We
obtained the pressure fluctuation growth rate that is representing the
global instability of the turbo-system. The fluctuating torque
components were 0.01Nm(5000rpm), 0.1Nm(10000rmp),
0.04Nm(20000rmp), 0.15Nm( 40000rmp) respectively. Only for
10000rpm(166Hz) the output toque was random, and it implies that it
creates unsteady flow by separations on the blades, and will reduce the
pressure loss significantly
Abstract: Since the beginning of human history, human
activities have caused many changes in the environment. Today, a
particular attention should be paid to gaining knowledge about water
quality of wetlands which are pristine natural environments rich in
genetic reserves. If qualitative conditions of industrial areas (in terms
of both physicochemical and biological conditions) are not addressed
properly, they could cause disruption in natural ecosystems,
especially in rivers. With regards to the quality of water resources,
determination of pollutant sources plays a pivotal role in engineering
projects as well as designing water quality control systems. Thus,
using different methods such as flow duration curves, dischargepollution
load model and frequency analysis by HYFA software
package, risk of various industrial pollutants in international and
ecologically important Gavkhoni wetland is analyzed. In this study, a
station located at Varzaneh City is used as the last station on
Zayanderud River, from where the river water is discharged into the
wetland. Results showed that elements- concentrations often
exceeded the allowed level and river water can endanger regional
ecosystem. In addition, if the river discharge is managed on Q25
basis, this basis can lower concentrations of elements, keeping them
within the normal level.
Abstract: Reinforced concrete crash barriers used in road traffic
must meet a number of criteria. Crash barriers are laid lengthwise,
one behind another, and joined using specially designed steel locks.
While developing BSV reinforced concrete crash barriers (type
ŽPSV), experiments and calculations aimed to optimize the shape of
a newly designed lock and the reinforcement quantity and
distribution in a crash barrier were carried out. The tension carrying
capacity of two parallelly joined locks was solved experimentally.
Based on the performed experiments, adjustments of nonlinear
properties of steel were performed in the calculations. The obtained
results served as a basis to optimize the lock design using a
computational model that takes into account the plastic behaviour of
steel and the influence of the surrounding concrete [6]. The response
to the vehicle impact has been analyzed using a specially elaborated
complex computational model, comprising both the nonlinear model
of the damping wall or crash barrier and the detailed model of the
vehicle [7].
Abstract: A different concept for designing and detailing of
reinforced concrete precast frame structures is analyzed in this paper.
The new detailing of the joints derives from the special hybrid
moment frame joints. The special reinforcements of this alternative
detailing, named modified special hybrid joint, are bondless with
respect to both column and beams. Full scale tests were performed on
a plan model, which represents a part of 5 story structure, cropped in
the middle of the beams and columns spans. Theoretical approach
was developed, based on testing results on twice repaired model,
subjected to lateral seismic type loading. Discussion regarding the
modified special hybrid joint behavior and further on widening
research needed concludes the presentation.
Abstract: This paper deals with the evaluation of flow properties
of polymeric matrix with natural animal fillers. Technical university
of Liberec cooperates on the long-term development of “green
materials“ that should replace conventionally used materials
(especially in automotive industry). Natural fibres (of animal and
plant origin) from all over the world are collected and adapted
(drying, cutting etc.) for extrusion processing. Inside the extruder
these natural additives are blended with polymeric (synthetic and
biodegradable - PLA) matrix and created compound is subsequently
cut for pellets in the wet way. These green materials with unique
recipes are then studied and their mechanical, physical and
processing properties are determined. The main goal of this research
is to develop new ecological materials very similar to unfilled
polymers. In this article the rheological behaviour of chosen natural
animal fibres is introduced considering their shape and surface that
were observed with use of SEM microscopy.
Abstract: Through a proper analysis of residual strain and stress
distributions obtained at the surface of high speed milled specimens
of AA 6082–T6 aluminium alloy, the performance of an improved
indentation method is evaluated. This method integrates a special
device of indentation to a universal measuring machine. The
mentioned device allows introducing elongated indents allowing to
diminish the absolute error of measurement. It must be noted that the
present method offers the great advantage of avoiding both the
specific equipment and highly qualified personnel, and their inherent
high costs. In this work, the cutting tool geometry and high speed
parameters are selected to introduce reduced plastic damage.
Through the variation of the depth of cut, the stability of the shapes
adopted by the residual strain and stress distributions is evaluated.
The results show that the strain and stress distributions remain
unchanged, compressive and small. Moreover, these distributions
reveal a similar asymmetry when the gradients corresponding to
conventional and climb cutting zones are compared.
Abstract: This research aimed to study on the potential of
recycling organic waste in Suan Sunandha Rajabhat University as
compost. In doing so, the composition of solid waste generated in the
campus was investigated while physical and chemical properties of
organic waste were analyzed in order to evaluate the portion of waste
suitable for recycling as compost. As a result of the study, it was
found that (1) the amount of organic waste was averaged at 299.8
kg/day in which mixed food wastes had the highest amount of 191.9
kg/day followed by mixed leave & yard wastes and mixed fruit &
vegetable wastes at the amount of 66.3 and 41.6 kg/day respectively;
(2) physical and chemical properties of organic waste in terms of
moisture content was between 69.54 to 78.15%, major elements for
plant as N, P and K were 0.14 to 0.17%, 0.46 to 0.52% and 0.16 to
0.18% respectively, and carbon/nitrogen ratio (C/N) was about 15:1
to 17.5:1; (3) recycling organic waste as compost was designed by
aerobic decomposition using mixed food wastes : mixed leave & yard
wastes : mixed fruit & vegetable wastes at the portion of 3:2:1 by
weight in accordance with the potential of their amounts and their
physical and chemical properties.
Abstract: Yogurt is a coagulated milk product obtained from
the lactic acid fermentation by the action of Lactobacillus
bulgaricus and Streptococcus thermophilus. The additions of fruits
into milk may enhance the taste and the therapeutical values of milk
products. However fruits also may change the fermentation
behaviour. In this present study, the changes in physicochemical, the
peptide concentration, total phenolics content and the antioxidant
potential of yogurt upon the addition of Hylocereus polyrhizus and
Hylocereus undatus (white and red dragon fruit) were investigated.
Fruits enriched yogurt (10%, 20%, 30% w/w) were prepared and the
pH, TTA, syneresis measurement, peptide concentration, total
phenolics content and DPPH antioxidant inhibition percentage were
determined. Milk fermentation rate was enhanced in red dragon fruit
yogurt for all doses (-0.3606 - -0.4126 pH/h) while only white
dragon fruit yogurt with 20% and 30% (w/w) composition showed
increment in fermentation rate (-0.3471 - -0.3609 pH/h) compared to
plain yogurt (-0.3369pH/h). All dragon fruit enriched yogurts
generally showed lower pH readings (pH 3.95 - 4.03) compared to
plain yogurt (pH 4.05). Both fruit yogurts showed a higher lactic
acid percentage (1.14-1.23%) compared to plain yogurt (1.08%).
Significantly higher syneresis percentage (57.19 - 70.32%)
compared to plain yogurt (52.93%) were seen in all fruit enriched
yogurts. The antioxidant activity of plain yogurt (19.16%) was
enhanced by the presence of white and red dragon fruit (24.97-
45.74%). All fruit enriched yogurt showed an increment in total
phenolic content (36.44 - 64.43mg/ml) compared to plain yogurt
(20.25mg/ml). However, the addition of white and red dragon fruit
did not enhance the proteolysis of milk during fermentation.
Therefore, it could be concluded that the addition of white and red
dragon fruit into yogurt enhanced the milk fermentation rate, lactic
acid content, syneresis percentage, antioxidant activity, and total
phenolics content in yogurt.
Abstract: This paper deals with the problem of thermal and
mechanical shocks, which rising during operation, mostly at
interrupted cut. Here will be solved their impact on the cutting edge
tool life, the impact of coating technology on resistance to shocks
and experimental determination of tool life in heating flame.
Resistance of removable cutting edges against thermal and
mechanical shock is an important indicator of quality as well as its
abrasion resistance. Breach of the edge or its crumble may occur due
to cyclic loading. We can observe it not only during the interrupted
cutting (milling, turning areas abandoned hole or slot), but also in
continuous cutting. This is due to the volatility of cutting force on
cutting. Frequency of the volatility in this case depends on the type
of rising chips (chip size element). For difficult-to-machine materials
such as austenitic steel particularly happened at higher cutting speeds
for the localization of plastic deformation in the shear plane and for
the inception of separate elements substantially continuous chips.
This leads to variations of cutting forces substantially greater than for
other types of steel.
Abstract: Energy consumption is one of the indices in
determining the levels of development of a nation. Therefore,
availability of energy supply to all sectors of life in any country is
crucial for its development. These exists shortage of all kinds of
energy, particularly electricity which is badly needed for economic
development. Electricity from the sun which is quite abundant in
most of the developing countries is used in rural areas to meet basic
electricity needs of a rural community. Today-s electricity supply in
Myanmar is generated by fuel generators and hydroelectric power
plants. However, far-flung areas which are away from National Grids
cannot enjoy the electricity generated by these sources. Since
Myanmar is a land of plentiful sunshine, especially in central and
southern regions of the country, the first form of energy- solar energy
could hopefully become the final solution to its energy supply
problem. The direct conversion of solar energy into electricity using
photovoltaic system has been receiving intensive installation not only
in developed countries but also in developing countries. It is mainly
intended to present solar energy potential and application in
Myanmar. It is also wanted to get the benefits of using solar energy
for people in remote areas which are not yet connected to the national
grids because of the high price of fossil fuel.
Abstract: Caching was suggested as a solution for reducing bandwidth utilization and minimizing query latency in mobile environments. Over the years, different caching approaches have been proposed, some relying on the server to broadcast reports periodically informing of the updated data while others allowed the clients to request for the data whenever needed. Until recently a hybrid cache consistency scheme Scalable Asynchronous Cache Consistency Scheme SACCS was proposed, which combined the two different approaches benefits- and is proved to be more efficient and scalable. Nevertheless, caching has its limitations too, due to the limited cache size and the limited bandwidth, which makes the implementation of cache replacement strategy an important aspect for improving the cache consistency algorithms. In this thesis, we proposed a new cache replacement strategy, the Least Unified Value strategy (LUV) to replace the Least Recently Used (LRU) that SACCS was based on. This paper studies the advantages and the drawbacks of the new proposed strategy, comparing it with different categories of cache replacement strategies.
Abstract: Offset Double-Disk Opener (DDO) is a popular
furrow opener in conservation tillage. It has some limitations such as
negative suction to penetrate in the soil, hair pinning and mixing seed
and fertilizer in the slot. Because of importance of separation of seed
and fertilizer in the slot, by adding two horizontal mini disks to DDO
a modified opener was made (MDO) which placed the fertilizer
between and under two rows of seed. To consider performance of
novel opener an indoor comparison test between DDO and MDO was
performed at soil bin. The experiment was conducted with three
working speeds (3, 6 and 8 km h-1), two bulk densities of soil (1.1
and 1.4 Mg m-3) and two levels of residues (1 and 2 ton ha-1). The
experimental design consisted in a (3×2×2) complete randomized
factorial with three replicates for each test. Moisture of seed furrow,
separation of seed and fertilizer, hair pinning and resultant forces
acting on the openers were used as assessing indexes. There was no
significant difference between soil moisture content in slots created
by DDO and MDO at 0-4 cm depth, but at 4-8 cm the in the slot
created by MDO moisture content was higher about 9%. Horizontal
force for both openers increased with increasing speed and soil bulk
density. Vertical force for DDO was negative so it needed additional
weight for penetrating in the soil, but vertical force for MDO was
positive and, which can solve the challenge of penetration in the soil
in DDO. In soft soil with heavy residues some trash was pushed by
DDO into seed furrow (hair pinning) but at MDO seed were placed at
clean groove. Lateral and vertical separation of seed and fertilizer
was performed effectively by MDO (4.5 and 5 cm, respectively)
while DDO put seed and fertilizer close to each other. Overall, the
Modified Offset Double-disks (MDO) had better performance. So by
adapting this opener with no-tillage drillers it would possible to have
higher yield in conservation tillage where the most appropriate
opener is disk type.
Abstract: Domain-specific languages describe specific solutions to problems in the application domain. Traditionally they form a solution composing black-box abstractions together. This, usually, involves non-deep transformations over the target model. In this paper we argue that it is potentially powerful to operate with grey-box abstractions to build a domain-specific software system. We present parametric code templates as grey-box abstractions and conceptual tools to encapsulate and manipulate these templates. Manipulations introduce template-s merging routines and can be defined in a generic way. This involves reasoning mechanisms at the code templates level. We introduce the concept of Neurath Modelling Language (NML) that operates with parametric code templates and specifies a visualisation mapping mechanism for target models. Finally we provide an example of calculating a domain-specific software system with predefined NML elements.
Abstract: This paper introduces a framework that aims to
support the design and development of mobile services. The
traditional innovation process and its supporting instruments in form
of creativity tools, acceptance research and user-generated content
analysis are screened for potentials for improvement. The result is a
reshaped innovation process where acceptance research and usergenerated
content analysis are fully integrated within a creativity
tool. Advantages of this method are the enhancement of design
relevant information for developers and designers and the possibility
to forecast market success.
Abstract: Ten percent of the population will develop plantar
fasciitis (PF) during their lifetime. Two million people are treated
yearly accounting for 11-15% of visits to medical professionals.
Treatment ranges from conservative to surgical intervention. The
purpose of this study was to assess the effects of extracorporeal
shockwave therapy (ECSWT) on heel pain, function, range of motion
(ROM), and strength in patients with PF. One hundred subjects were
treated with ECSWT and measures were taken before and three
months after treatment. There was significant differences in visual
analog scale scores for pain at rest (p=0.0001); after activity (p=
0.0001) and; overall improvement (p=0.0001). There was also
significant improvement in Lower Extremity Functional Scale scores
(p=0.0001); ankle plantarflexion (p=0.0001), dorsiflexion (p=0.001),
and eversion (p=0.017),and first metatarsophalangeal joint flexion
(p=0.002) and extension (p=0.003) ROM. ECSWT is an effective
treatment improving heel pain, function and ROM in patients with
PF.
Abstract: In this study, communities of ammonia-oxidizing
archaea (AOA) and ammonia-oxidizing bacteria (AOB) in nitrifying
activated sludge (NAS) prepared by enriching sludge from a
municipal wastewater treatment plant in three continuous-flow
reactors receiving an inorganic medium containing different
ammonium concentrations of 2, 10, and 30 mM NH4
+-N (NAS2,
NAS10, and NAS30, respectively) were investigated using molecular
analysis. Results suggested that almost all AOA clones from NAS2,
NAS10, and NAS30 fell into the same AOA cluster and AOA
communities in NAS2 and NAS10 were more diverse than those of
NAS30. In contrast to AOA, AOB communities obviously shifted
from the seed sludge to enriched NASs and in each enriched NAS,
communities of AOB varied particularly. The seed sludge contained
members of N. communis cluster and N. oligotropha cluster. After it
was enriched under various ammonium loads, members of N.
communis cluster disappeared from all enriched NASs. AOB with
high affinity to ammonia presented in NAS 2, AOB with low affinity
to ammonia presented in NAS 30, and both types of AOB survived in
NAS 10. These demonstrated that ammonium load significantly
influenced AOB communities, but not AOA communities in enriched
NASs.
Abstract: This paper presents an overview of the Ocean wave kinetic energy harvesting system. Energy harvesting is a concept by which energy is captured, stored, and utilized using various sources by employing interfaces, storage devices, and other units. Ocean wave energy harvesting in which the kinetic and potential energy contained in the natural oscillations of Ocean waves are converted into electric power. The kinetic energy harvesting system could be used for a number of areas. The main applications that we have discussed in this paper are to how generate the energy from Ocean wave energy (kinetic energy) to electric energy that is to eliminate the requirement for continual battery replacement.
Abstract: For a long time as a result of accommodating car
traffic, planning ideologies in the past put a low priority on public
space, pedestrianism and the role of city space as a meeting place for
urban dwellers. In addition, according to authors such as Jan Gehl,
market forces and changing architectural perceptions began to shift
the focus of planning practice from the integration of public space in
various pockets around the contemporary city to individual buildings.
Eventually, these buildings have become increasingly more isolated
and introverted and have turned their backs to the realm of the public
space adjoining them. As a result of this practice, the traditional
function of public space as a social forum for city dwellers has in
many cases been reduced or even phased out. Author Jane Jacobs
published her seminal book “The Death and Life of Great American
Cities" more than fifty years ago, but her observations and
predictions at the time still ring true today, where she pointed out
how the dramatic increase in car traffic and its accommodation by the
urban planning ideology that was brought about by the Modern
movement has prompted a separation of the uses of the city. At the
same time it emphasizes free standing buildings that threaten urban
space and city life and result in underutilized and lifeless urban cores.
In this discussion context, the aim of this paper is to showcase a
reversal of just such a situation in the case of the Dasoupolis
neighborhood in Strovolos, Cyprus, where enlightened urban design
practice has see the reclamation of pedestrian space in a car
dominated area.
Abstract: For Seismic design, it is important to estimate,
maximum lateral displacement (inelastic displacement) of the
structures due to sever earthquakes for several reasons. Seismic
design provisions estimate the maximum roof and storey drifts
occurring in major earthquakes by amplifying the drifts of the
structures obtained by elastic analysis subjected to seismic design
load, with a coefficient named “displacement amplification factor"
which is greater than one. Here, this coefficient depends on various
parameters, such as ductility and overstrength factors. The present
research aims to evaluate the value of the displacement amplification
factor in seismic design codes and then tries to propose a value to
estimate the maximum lateral structural displacement from sever
earthquakes, without using non-linear analysis. In seismic codes,
since the displacement amplification is related to “force reduction
factor" hence; this aspect has been accepted in the current study.
Meanwhile, two methodologies are applied to evaluate the value of
displacement amplification factor and its relation with the force
reduction factor. In the first methodology, which is applied for all
structures, the ratio of displacement amplification and force reduction
factors is determined directly. Whereas, in the second methodology
that is applicable just for R/C moment resisting frame, the ratio is
obtained by calculating both factors, separately. The acquired results
of these methodologies are alike and estimate the ratio of two factors
from 1 to 1.2. The results indicate that the ratio of the displacement
amplification factor and the force reduction factor differs to those
proposed by seismic provisions such as NEHRP, IBC and Iranian
seismic code (standard no. 2800).