Abstract: F-actin fibrils are the cytoskeleton of osteocytes. They react in a dynamic manner to mechanical loading, and strength and
reposition their efforts to reinforce the cells structure. We hypothesize that f-actin is temporarly disrupted after loading and repolymerizes
in a new orientation to oppose the applied load. In vitro studies are conducted to determine f-actin disruption after varying mechanical stimulus parameters that are known to affect bone
formation. Results indicate that the f-actin cytoskeleton is disrupted in vitro as a function of applied mechanical stimulus parameters and
that the f-actin bundles reassemble after loading induced disruption
within 3 minutes after cessation of loading. The disruption of the factin
cytoskeleton depends on the magnitude of stretch, the numbers
of loading cycles, frequency, the insertion of rest between loading
cycles and extracellular calcium. In vivo studies also demonstrate
disruption of the f-actin cytoskeleton in cells embedded in the bone
matrix immediately after mechanical loading. These studies suggest
that adaptation of the f-actin fiber bundles of the cytoskeleton in
response to applied loads occurs by disruption and subsequent repolymerization.
Abstract: Engineered nanoparticles’ usage rapidly increased in
various applications in the last decade due to their unusual properties.
However, there is an ever increasing concern to understand their
toxicological effect in human health. Particularly, metal and metal
oxide nanoparticles have been used in various sectors including
biomedical, food and agriculture. But their impact on human health is
yet to be fully understood. In this present investigation, we assessed
the toxic effect of engineered nanoparticles (ENPs) including Ag,
MgO and Co3O4 nanoparticles (NPs) on human mesenchymal stem
cells (hMSC) adopting cell viability and cellular morphological
changes as tools The results suggested that silver NPs are more toxic
than MgO and Co3O4NPs. The ENPs induced cytotoxicity and
nuclear morphological changes in hMSC depending on dose. The cell
viability decreases with increase in concentration of ENPs. The
cellular morphology studies revealed that ENPs damaged the cells.
These preliminary findings have implications for the use of these
nanoparticles in food industry with systematic regulations.
Abstract: Most, if not all, public hospitals in Thailand have encountered a common problem regarding the increasing demand for medical services. The increasing number of patients causes so much strain on the hospital-s services, over-crowded, overloaded working hours, staff fatigue, medical error and long waiting time. This research studied the characteristics of operational processes of the medical care services at the medicine department in a large public university hospital. The research focuses on details regarding methods, procedures, processes, resources, and time management in overall processes. The simulation model is used as a tool to analyze the impact of various improvement strategies.
Abstract: Analytical seismic response of multi-story building
supported on base isolation system is investigated under real
earthquake motion. The superstructure is idealized as a shear type
flexible building with lateral degree-of-freedom at each floor. The
force-deformation behaviour of the isolation system is modelled by
the bi-linear behaviour which can be effectively used to model all
isolation systems in practice. The governing equations of motion of
the isolated structural system are derived. The response of the system
is obtained numerically by step-by-method under three real recorded
earthquake motions and pulse motions associated in the near-fault
earthquake motion. The variation of the top floor acceleration, interstory
drift, base shear and bearing displacement of the isolated
building is studied under different initial stiffness of the bi-linear
isolation system. It was observed that the high initial stiffness of the
isolation system excites higher modes in base-isolated structure and
generate floor accelerations and story drift. Such behaviour of the
base-isolated building especially supported on sliding type of
isolation systems can be detrimental to sensitive equipment installed
in the building. On the other hand, the bearing displacement and base
shear found to reduce marginally with the increase of the initial
stiffness of the initial stiffness of the isolation system. Further, the
above behaviour of the base-isolated building was observed for
different parameters of the bearing (i.e. post-yield stiffness and
characteristic strength) and earthquake motions (i.e. real time history
as well as pulse type motion).
Abstract: The present energy situation and the concerns
about global warming has stimulated active research interest
in non-petroleum, carbon free compounds and non-polluting
fuels, particularly for transportation, power generation, and
agricultural sectors. Environmental concerns and limited
amount of petroleum fuels have caused interests in the
development of alternative fuels for internal combustion (IC)
engines. The petroleum crude reserves however, are declining
and consumption of transport fuels particularly in the
developing countries is increasing at high rates. Severe
shortage of liquid fuels derived from petroleum may be faced
in the second half of this century. Recently more and more
stringent environmental regulations being enacted in the USA
and Europe have led to the research and development
activities on clean alternative fuels. Among the gaseous fuels
hydrogen is considered to be one of the clean alternative fuel.
Hydrogen is an interesting candidate for future internal
combustion engine based power trains. In this experimental
investigation, the performance and combustion analysis were
carried out on a direct injection (DI) diesel engine using
hydrogen with diesel following the TMI(Time Manifold
Injection) technique at different injection timings of 10
degree,45 degree and 80 degree ATDC using an electronic
control unit (ECU) and injection durations were controlled.
Further, the tests have been carried out at a constant speed of
1500rpm at different load conditions and it can be observed
that brake thermal efficiency increases with increase in load
conditions with a maximum gain of 15% at full load
conditions during all injection strategies of hydrogen. It was
also observed that with the increase in hydrogen energy share
BSEC started reducing and it reduced to a maximum of 9% as
compared to baseline diesel at 10deg ATDC injection during
maximum injection proving the exceptional combustion
properties of hydrogen.
Abstract: Carboneous catalytical methane decomposition is an
attractive process because it produces two valuable products:
hydrogen and carbon. Furthermore, this reaction does not emit any
green house or hazardous gases. In the present study, experiments
were conducted in a thermo gravimetric analyzer using Fluka 05120
as carboneous catalyst to analyze its effectiveness in methane
decomposition. Various temperatures and methane partial pressures
were chosen and carbon mass gain was observed as a function of
time. Results are presented in terms of carbon formation rate,
hydrogen production and catalytical activity. It is observed that there
is linearity in carbon deposition amount by time at lower reaction
temperature (780 °C). On the other hand, it is observed that carbon
and hydrogen formation rates are increased with increasing
temperature. Finally, we observed that the carbon formation rate is
highest at 950 °C within the range of temperatures studied.
Abstract: This paper is a continuation of our interest in the influence of temperature on specific retention volumes and the resulting infinite dilution activity coefficients. This has a direct effect in the design of absorption and stripping columns for the abatement of volatile organic compounds. The interaction of 13 volatile organic compounds (VOCs) with polydimethylsiloxane (PDMS) at varying temperatures was studied by gas liquid chromatography (GLC). Infinite dilution activity coefficients and specific retention volumes obtained in this study were found to be in agreement with those obtained from static headspace and group contribution methods by the authors as well as literature values for similar systems. Temperature variation also allows for transport calculations for different seasons. The results of this work confirm that PDMS is well suited for the scrubbing of VOCs from waste gas streams. Plots of specific retention volumes against temperature gave linear van-t Hoff plots.
Abstract: Certain tRNA synthetases have developed highly accurate molecular machinery to discriminate their cognate amino acids. Those aaRSs achieve their goal via editing reaction in the Connective Polypeptide 1 (CP1). Recently mutagenesis studies have revealed the critical importance of residues in the CP1 domain for editing activity and X-ray structures have shown binding mode of noncognate amino acids in the editing domain. To pursue molecular mechanism for amino acid discrimination, molecular modeling studies were performed. Our results suggest that aaRS bind the noncognate amino acid more tightly than the cognate one. Finally, by comparing binding conformations of the amino acids in three systems, the amino acid binding mode was elucidated and a discrimination mechanism proposed. The results strongly reveal that the conserved threonines are responsible for amino acid discrimination. This is achieved through side chain interactions between T252 and T247/T248 as well as between those threonines and the incoming amino acids.
Abstract: This paper mainly studies the analyses of parameters
in the intersection collision avoidance (ICA) system based on the radar
sensors. The parameters include the positioning errors, the repeat
period of the radar sensor, the conditions of potential collisions of two
cross-path vehicles, etc. The analyses of the parameters can provide
the requirements, limitations, or specifications of this ICA system. In
these analyses, the positioning errors will be increased as the measured
vehicle approach the intersection. In addition, it is not necessary to
implement the radar sensor in higher position since the positioning
sensitivities become serious as the height of the radar sensor increases.
A concept of the safety buffer distances for front and rear of the
measured vehicle is also proposed. The conditions for potential
collisions of two cross-path vehicles are also presented to facilitate the
computation algorithm.
Abstract: Organizational culture fosters innovation, and
innovation is the main engine to be sustained within the uncertainty
market. Like other countries, the construction industry significantly
contributes to the economy, society and technology of Malaysia, yet,
innovation is still considered slow compared to other industries such
as manufacturing. Given the important role of an architect as the key
player and the contributor of new ideas in the construction industry,
there is a call to identify the issue and improve the current situation
by focusing on the architectural firms. In addition, the existing
studies tend to focus only on a few dimensions of organizational
culture and very few studies consider whether innovation is being
generated or adopted. Hence, the present research tends to fill in the
gap by identifying the organizational cultures that foster or hinder
innovation generation and/or innovation adoption, and propose a
model of organizational culture and innovation generation and/or
adoption.
Abstract: An Artificial Neural Network based modeling
technique has been used to study the influence of different
combinations of meteorological parameters on evaporation from a
reservoir. The data set used is taken from an earlier reported study.
Several input combination were tried so as to find out the importance
of different input parameters in predicting the evaporation. The
prediction accuracy of Artificial Neural Network has also been
compared with the accuracy of linear regression for predicting
evaporation. The comparison demonstrated superior performance of
Artificial Neural Network over linear regression approach. The
findings of the study also revealed the requirement of all input
parameters considered together, instead of individual parameters
taken one at a time as reported in earlier studies, in predicting the
evaporation. The highest correlation coefficient (0.960) along with
lowest root mean square error (0.865) was obtained with the input
combination of air temperature, wind speed, sunshine hours and
mean relative humidity. A graph between the actual and predicted
values of evaporation suggests that most of the values lie within a
scatter of ±15% with all input parameters. The findings of this study
suggest the usefulness of ANN technique in predicting the
evaporation losses from reservoirs.
Abstract: An economic operation scheduling problem of a
hydro-thermal power generation system has been properly solved by
the proposed multipath adaptive tabu search algorithm (MATS). Four
reservoirs with their own hydro plants and another one thermal plant
are integrated to be a studied system used to formulate the objective
function under complicated constraints, eg water managements,
power balance and thermal generator limits. MATS with four subsearch
units (ATSs) and two stages of discarding mechanism (DM),
has been setting and trying to solve the problem through 25 trials
under function evaluation criterion. It is shown that MATS can
provide superior results with respect to single ATS and other
previous methods, genetic algorithms (GA) and differential evolution
(DE).
Abstract: Intelligent deep-drawing is an instrumental research field in sheet metal forming. A set of 28 different experimental data have been employed in this paper, investigating the roles of die radius, punch radius, friction coefficients and drawing ratios for axisymmetric workpieces deep drawing. This paper focuses an evolutionary neural network, specifically, error back propagation in collaboration with genetic algorithm. The neural network encompasses a number of different functional nodes defined through the established principles. The input parameters, i.e., punch radii, die radii, friction coefficients and drawing ratios are set to the network; thereafter, the material outputs at two critical points are accurately calculated. The output of the network is used to establish the best parameters leading to the most uniform thickness in the product via the genetic algorithm. This research achieved satisfactory results based on demonstration of neural networks.
Abstract: In parallel, broadcasting has changed rapidly with the
changing of the world at the same area. Broadcasting is also
influenced and reshaped in terms of the emergence of new
communication technologies. These developments have resulted a lot
of economic and social consequences. The most important
consequences of these results are those of the powers of the
governments to control over the means of communication and control
mechanisms related to the descriptions of the new issues. For this
purpose, autonomous and independent regulatory bodies have been
established by the state. One of these regulatory bodies is the Radio
and Television Supreme Council, which to be established in 1994,
with the Code no 3984. Today’s Radio and Television Supreme
Council which is responsible for the regulation of the radio and
television broadcasts all across Turkey has an important and effective
position as autonomous and independent regulatory body. The Radio
and Television Supreme Council acts as being a remarkable organizer
for a sensitive area of radio and television broadcasting on one hand,
and the area of democratic, liberal and keep in mind the concept of
the public interest by putting certain principles for the functioning of
the Board control, in the context of media policy as one of the central
organs, on the other hand.
In this study, the role of the Radio and Television Supreme
Council is examined in accordance with the Code no 3894 in order to
control over the communication and control mechanisms as well as
the examination of the changes in the duties of the Code No. 6112,
dated 2011.
Abstract: Recently, several designs of single fed circularly
polarized microstrip antennas have been studied. Relatively, a few
designs for achieving circular polarization using triangular microstrip
antenna are available. Typically existing design of single fed
circularly polarized triangular microstrip antennas include the use of
equilateral triangular patch with a slit or a horizontal slot on the patch
or addition a narrow band stub on the edge or a vertex of triangular
patch.
In other word, with using a narrow band tune stub on middle of an
edge of triangle causes of facility to compensate the possible
fabrication error and substrate materials with easier adjusting the
tuner stub length. Even though disadvantages of this method is very
long of stub (approximate 1/3 length of triangle edge). In this paper,
instead of narrow band stub, a wide band stub has been applied,
therefore the length of stub by this method has been decreased
around 1/10 edge of triangle in addition changing the aperture angle
of stub, provides more facility for designing and producing circular
polarization wave.
Abstract: Simultaneous recovery of copper and DCA from
simulated MEUF concentrated stream was investigated. Effects of
surfactant (DCA) and metal (copper) concentrations, surfactant to
metal molar ratio (S/M ratio), electroplating voltage, EDTA
concentration, solution pH, and salt concentration on metal recovery
and current efficiency were studied. Electric voltage of -0.5 V was
shown to be optimum operation condition in terms of Cu recovery,
current efficiency, and surfactant recovery. Increasing Cu recovery and
current efficiency were observed with increases of Cu concentration
while keeping concentration of DCA constant. However, increasing
both Cu and DCA concentration while keeping S/M ratio constant at
2.5 showed detrimental effect on Cu recovery at DCA concentration
higher than 15 mM. Cu recovery decreases with increasing pH while
current efficiency showed an opposite trend. It is believed that
conductivity is the main cause for discrepancy of Cu recovery and
current efficiency observed at different pH. Finally, it was shown that
EDTA had adverse effect on both Cu recovery and current efficiency
while addition of NaCl salt had negative impact on current efficiency
at concentration higher than 8000 mg/L.
Abstract: Global Software Development (GSD) projects are
passing through different boundaries of a company, country and even
in other continents where time zone differs between both sites.
Beside many benefits of such development, research declared plenty
of negative impacts on these GSD projects. It is important to
understand problems which may lie during the execution of GSD
project with different time zones. This research project discussed and
provided different issues related to time delays in GSD projects. In
this paper, authors investigated some of the time delay factors which
usually lie in GSD projects with different time zones. This
investigation is done through systematic review of literature.
Furthermore, the practices to overcome these delay factors which
have already been reported in literature and GSD organizations are
also explored through literature survey and case studies.
Abstract: Faced with social and health system capacity
constraints and rising and changing demand for welfare services,
governments and welfare providers are increasingly relying on
innovation to help support and enhance services. However, the
evidence reported by several studies indicates that the realization of
that potential is not an easy task. Innovations can be deemed
inherently complex to implement and operate, because many of them
involve a combination of technological and organizational renewal
within an environment featuring a diversity of stakeholders. Many
public welfare service innovations are markedly systemic in their
nature, which means that they emerge from, and must address, the
complex interplay between political, administrative, technological,
institutional and legal issues. This paper suggests that stakeholders
dealing with systemic innovation in welfare services must deal with
ambiguous and incomplete information in circumstances of
uncertainty. Employing a literature review methodology and case
study, this paper identifies, categorizes and discusses different
aspects of the uncertainty of systemic innovation in public welfare
services, and argues that uncertainty can be classified into eight
categories: technological uncertainty, market uncertainty,
regulatory/institutional uncertainty, social/political uncertainty,
acceptance/legitimacy uncertainty, managerial uncertainty, timing
uncertainty and consequence uncertainty.
Abstract: Hydrogen is an important chemical in many industries
and it is expected to become one of the major fuels for energy
generation in the future. Unfortunately, hydrogen does not exist in its
elemental form in nature and therefore has to be produced from
hydrocarbons, hydrogen-containing compounds or water.
Above its critical point (374.8oC and 22.1MPa), water has lower
density and viscosity, and a higher heat capacity than those of
ambient water. Mass transfer in supercritical water (SCW) is
enhanced due to its increased diffusivity and transport ability. The
reduced dielectric constant makes supercritical water a better solvent
for organic compounds and gases. Hence, due to the aforementioned
desirable properties, there is a growing interest toward studies
regarding the gasification of organic matter containing biomass or
model biomass solutions in supercritical water.
In this study, hydrogen and biofuel production by the catalytic
gasification of 2-Propanol in supercritical conditions of water was
investigated. Pt/Al2O3and Ni/Al2O3were the catalysts used in the
gasification reactions. All of the experiments were performed under a
constant pressure of 25MPa. The effects of five reaction temperatures
(400, 450, 500, 550 and 600°C) and five reaction times (10, 15, 20,
25 and 30 s) on the gasification yield and flammable component
content were investigated.
Abstract: Water hyacinth has been used in aquatic systems for
wastewater purification in many years worldwide. The role of water
hyacinth (Eichhornia crassipes) species in polishing nitrate and
phosphorus concentration from municipal wastewater treatment plant
effluent by phytoremediation method was evaluated. The objective
of this project is to determine the removal efficiency of water
hyacinth in polishing nitrate and phosphorus, as well as chemical
oxygen demand (COD) and ammonia. Water hyacinth is considered
as the most efficient aquatic plant used in removing vast range of
pollutants such as organic matters, nutrients and heavy metals. Water
hyacinth, also referred as macrophytes, were cultivated in the
treatment house in a reactor tank of approximately 90(L) x 40(W) x
25(H) in dimension and built with three compartments. Three water
hyacinths were placed in each compartments and water sample in
each compartment were collected in every two days. The plant
observation was conducted by weight measurement, plant uptake and
new young shoot development. Water hyacinth effectively removed
approximately 49% of COD, 81% of ammonia, 67% of phosphorus
and 92% of nitrate. It also showed significant growth rate at starting
from day 6 with 0.33 shoot/day and they kept developing up to 0.38
shoot/day at the end of day 24. From the studies conducted, it was
proved that water hyacinth is capable of polishing the effluent of
municipal wastewater which contains undesirable amount of nitrate
and phosphorus concentration.