Abstract: Doxorubicin, also known as Adriamycin, is an
anthracycline class of drug used in cancer chemotherapy. It is used in
the treatment of non-Hodgkin’s lymphoma, multiple myeloma, acute
leukemia, breast cancer, lung cancer, endometrium cancer and ovary
cancers. It functions via intercalating DNA and ultimately killing
cancer cells. The major side effects of doxorubicin are hair loss,
myelosuppression, nausea & vomiting, oesophagitis, diarrhea, heart
damage and liver dysfunction. The minor modifications in the
structure of compound exhibit large variation in the biological
activity, has prompted us to carry out the synthesis of sulfonamide
derivatives. Sulfonamide is an important feature with broad spectrum
of biological activity such as antiviral, antifungal, diuretics, antiinflammatory,
antibacterial and anticancer activities. Structure of the
synthesized compound N-(1-methyl-2-oxo-2-N-methyl anilinoethyl)
benzene sulfonamide confirmed by proton nuclear magnetic
resonance (1H NMR),13C NMR, Mass and FTIR spectroscopic tools
to assure the position of all protons and hence stereochemistry of the
molecule. Further we have reported the binding potential of
synthesized sulfonamide analogues in comparison to doxorubicin
drug using Auto Dock 4.2 software. Computational binding energy
(B.E.) and inhibitory constant (Ki) has been evaluated for the
synthesized compound in comparison of doxorubicin against Poly
(dA-dT).Poly (dA-dT) and Poly (dG-dC).Poly (dG-dC) sequences.
The in vitro cytotoxic study against human breast cancer cell lines
confirms the better anticancer activity of the synthesized compound
over currently in use anticancer drug doxorubicin. The IC50 value of
the synthesized compound is 7.12 μM whereas for doxorubicin is 7.2
μM.
Abstract: A quartz crystal microbalance (QCM) nanosensor was developed to detect lysozyme enzyme by functionalizing its gold surface with the attachment of poly(methacroyl-L-phenylalanine) (PMAPA) nanoparticles. PMAPA was chosen as a hydrophobic matrix. The hydrophobic nanoparticles were synthesized by micro-emulsion polymerization method. Hydrophobic QCM nanosensor was tested for real time detection of lysozyme enzyme from aqueous solution. The kinetic and affinity studies were determined by using lysozyme solutions with different concentrations. The responses related with mass (Δm) and frequency (Δf) shifts were used to evaluate adsorption properties.
Abstract: The aim of research was to define the relations
between volatile compounds, some parameters (pH, titratable acidity
(TA), total soluble solid (TSS), lactic acid bacteria count) and
consumer preference of commercial fermented milks. These relations
tend to be used for controlling and developing new fermented milk
product. Three leading commercial brands of fermented milks in
Thailand were evaluated by consumers (n=71) using hedonic scale
for four attributes (sweetness, sourness, flavour, and overall liking),
volatile compounds using headspace-solid phase microextraction
(HS-SPME) GC-MS, pH, TA, TSS and LAB count. Then the
relations were analyzed by principal component analysis (PCA). The
PCA data showed that all of four attributes liking scores were related
to each other. They were also related to TA, TSS and volatile
compounds. The related volatile compounds were mainly on
fermented produced compounds including acetic acid, furanmethanol,
furfural, octanoic acid and the volatiles known as artificial fruit
flavour (beta pinene, limonene, vanillin, and ethyl vanillin). These
compounds were provided the information about flavour addition in
commercial fermented milk in Thailand.
Abstract: The purpose of this presentation is to describe an interdisciplinary teaching program that integrates physical education concepts using a philosophical approach. The presentation includes a review of: a) the philosophy of American education, b) the philosophy of sports and physical education, c) the interdisciplinary physical education program, d) professional development programs, (e) the Success of this physical education program, f) future of physical education. This unique interdisciplinary program has been implemented in an urban school physical education discipline in East Orange, New Jersey for over 10 years.
During the program the students realize that the bodies go through different experiences. The body becomes a place where a child can recognize in an enjoyable way to express and perceive particular feelings or mental states. Children may distinguish themselves to have high abilities in the social or other domains but low abilities in the field of athletics.
The goal of this program for the individuals is to discover new skills, develop and demonstrate age appropriate mastery level at different tasks, therefore the program consists of 9 to 12 sports, including many game. Each successful experience increases the awareness ability. Engaging in sports and physical activities are social movements involving groups of children in situations such as teams, friends, and recreational settings, which serve as a primary socializing agent for teaching interpersonal skills. As a result of this presentation the audience will reflect and explore how to structure a physical education program to integrate interdisciplinary subjects with philosophical concepts.
Abstract: This research aimed to study about motivation for
students of Suan Sunandha Rajabhat University to follow and happily
live according to Sufficiency Economy Philosophy. Having collected
394 questionnaires, the result showed that most students had great
motivation to follow this philosophy at a high level, especially in
terms of righteousness in profession; besides, students’ determination
and intention to apply this philosophy in everyday lives was
impressive though the students’ families were not completely ready.
Each of students, in fact, consulted their families for plans of any
activities without tiredness and discouragement based on the saying,
“Where there’s a will, there’s a way.” On the part of universities life,
students interacted with society and created projects that supported
income to the community including exercises, sports, recreational
activities, and community services.
Abstract: In this paper, we consider the vehicle routing problem
with mixed fleet of conventional and heterogenous electric vehicles
and time dependent charging costs, denoted VRP-HFCC, in which
a set of geographically scattered customers have to be served by a
mixed fleet of vehicles composed of a heterogenous fleet of Electric
Vehicles (EVs), having different battery capacities and operating
costs, and Conventional Vehicles (CVs). We include the possibility
of charging EVs in the available charging stations during the routes
in order to serve all customers. Each charging station offers charging
service with a known technology of chargers and time dependent
charging costs. Charging stations are also subject to operating time
windows constraints. EVs are not necessarily compatible with all
available charging technologies and a partial charging is allowed.
Intermittent charging at the depot is also allowed provided that
constraints related to the electricity grid are satisfied.
The objective is to minimize the number of employed vehicles and
then minimize the total travel and charging costs.
In this study, we present a Mixed Integer Programming Model and
develop a Charging Routing Heuristic and a Local Search Heuristic
based on the Inject-Eject routine with different insertion methods. All
heuristics are tested on real data instances.
Abstract: IEEE 802.16 (WiMAX) aims to present high speed
wireless access to cover wide range coverage. The base station (BS)
and the subscriber station (SS) are the main parts of WiMAX.
WiMAX uses either Point-to-Multipoint (PMP) or mesh topologies.
In the PMP mode, the SSs connect to the BS to gain access to the
network. However, in the mesh mode, the SSs connect to each other
to gain access to the BS.
The main components of QoS management in the 802.16 standard
are the admission control, buffer management and packet scheduling.
In this paper, we use QualNet 5.0.2 to study the performance of
different scheduling schemes, such as WFQ, SCFQ, RR and SP when
the numbers of SSs increase. We find that when the number of SSs
increases, the average jitter and average end-to-end delay is increased
and the throughput is reduced.
Abstract: Since “Hello Kitty” was manufactured in the market in
1974, the manufacturer, Sanrio Co., Ltd. gains high profits not only
Kitty’s products but also Kitty license, which gives us a picture of
Sanrio’s sales strategy in the global market. Kitty’s history, its
products, and Sanrio’s sales strategy are researched in this paper.
Comparing it to American Girl, and focusing on KITTYLAB, a type of
attraction where you can enjoy games with Kitty, and choose its parts
to build your own Kitty, the image of the cultural icon can be altered.
Abstract: It is likely that robots will cross the boundaries of
industry into households over the next decades. With demographic
challenges worldwide, the future ageing populations will require the
introduction of assistive technologies capable of providing, care,
human dignity and quality of life through the aging process. Robotics
technology has a high potential for being used in the areas of social
and healthcare by promoting a wide range of activities such as
entertainment, companionship, supervision or cognitive and physical
assistance. However such close Human Robotics Interaction (HRI)
encompass a rich set of ethical scenarios that need to be addressed
before Socially Assistive Robots (SARs) reach the global markets.
Such interactions with robots may seem a worthy goal for many
technical/financial reasons but inevitably require close attention to
the ethical dimensions of such interactions. This article investigates
the current HRI benchmark of social success. It revises it according
to the ethical principles of beneficence, non-maleficence and justice
aligned with social care ethos. An extension of such benchmark is
proposed based on an empirical study of HRIs conducted with elderly
groups.
Abstract: Fluid viscous damping systems are well suited for
many air vehicles subjected to shock and vibration. These damping
system work with the principle of viscous fluid throttling through the
orifice to create huge pressure difference between compression and
rebound chamber and obtain the required damping force. One
application of such systems is its use in aircraft door system to
counteract the door’s velocity and safely stop it. In exigency
situations like crash or emergency landing where the door doesn’t
open easily, possibly due to unusually tilting of fuselage or some
obstacles or intrusion of debris obstruction to move the parts of the
door, such system can be combined with other systems to provide
needed force to forcefully open the door and also securely stop it
simultaneously within the required time i.e. less than 8 seconds. In
the present study, a hydraulic system called snubber along with other
systems like actuator, gas bottle assembly which together known as
emergency power assist system (EPAS) is designed, built and
experimentally studied to check the magnitude of angular velocity,
damping force and time required to effectively open the door.
Whenever needed, the gas pressure from the bottle is released to
actuate the actuator and at the same time pull the snubber’s piston to
operate the emergency opening of the door. Such EPAS installed in
the suspension arm of the aircraft door is studied explicitly changing
parameters like orifice size, oil level, oil viscosity and bypass valve
gap and its spring of the snubber at varying temperature to generate
the optimum design case. Comparative analysis of the EPAS at
several cases is done and conclusions are made. It is found that
during emergency condition, the system opening time and angular
velocity, when snubber with 0.3mm piston and shaft orifice and
bypass valve gap of 0.5 mm with its original spring is used, shows
significant improvement over the old ones.
Abstract: This research was conducted in the Mae Sot
Watershed where located in the Moei River Basin at the Upper
Salween River Basin in Tak Province, Thailand. The Mae Sot
Municipality is the largest urban area in Tak Province and situated in
the midstream of the Mae Sot Watershed. It usually faces flash flood
problem after heavy rain due to poor flood management has been
reported since economic rapidly bloom up in recent years. Its
catchment can be classified as ungauged basin with lack of rainfall
data and no any stream gaging station was reported. It was attached
by most severely flood events in 2013 as the worst studied case for
all those communities in this municipality. Moreover, other problems
are also faced in this watershed, such shortage water supply for
domestic consumption and agriculture utilizations including a
deterioration of water quality and landslide as well. The research
aimed to increase capability building and strengthening the
participation of those local community leaders and related agencies to
conduct better water management in urban area was started by mean
of the data collection and illustration of the appropriated application
of some short period rainfall forecasting model as they aim for better
flood relief plan and management through the hydrologic model
system and river analysis system programs. The authors intended to
apply the global rainfall data via the integrated data viewer (IDV)
program from the Unidata with the aim for rainfall forecasting in a
short period of 7-10 days in advance during rainy season instead of
real time record. The IDV product can be present in an advance
period of rainfall with time step of 3-6 hours was introduced to the
communities. The result can be used as input data to the hydrologic
modeling system model (HEC-HMS) for synthesizing flood
hydrographs and use for flood forecasting as well. The authors
applied the river analysis system model (HEC-RAS) to present flood
flow behaviors in the reach of the Mae Sot stream via the downtown
of the Mae Sot City as flood extents as the water surface level at
every cross-sectional profiles of the stream. Both models of HMS and
RAS were tested in 2013 with observed rainfall and inflow-outflow
data from the Mae Sot Dam. The result of HMS showed fit to the
observed data at the dam and applied at upstream boundary discharge
to RAS in order to simulate flood extents and tested in the field, and
the result found satisfying. The product of rainfall from IDV was fair
while compared with observed data. However, it is an appropriate
tool to use in the ungauged catchment to use with flood hydrograph
and river analysis models for future efficient flood relief plan and
management.
Abstract: This article discusses issues related to the System of
Innovation: Comparing economies of Brazil and South Africa.
Having as this study aimed at comparing the Innovation System of
the countries mentioned. Then briefly describe the process of Venture
Capital and present the industry innovation in Brazil and South
Africa. The methodological approach described in this article is
descriptive and the approach is qualitative, taking as a basis
secondary data relating to research articles. The main results are
related to the different forms of financing of Venture Capital used by
countries compared, in addition to the training and economic policy.
And finally, it was highlighted the importance of implementation of
policy reforms for the Brazil and Africa in the innovation process.
Abstract: Remote sensing plays a vital role in mapping of
resources and monitoring of environments of the earth. In the present
research study, mapping and monitoring of clay siltations occurred in
the Alkhod Dam of Muscat, Sultanate of Oman are carried out using
low-cost multispectral Landsat and ASTER data. The dam is
constructed across the Wadi Samail catchment for ground water
recharge. The occurrence and spatial distribution of siltations in the
dam are studied with five years of interval from the year 1987 of
construction to 2014. The deposits are mainly due to the clay, sand
and silt occurrences derived from the weathering rocks of ophiolite
sequences occurred in the Wadi Samail catchment. The occurrences
of clays are confirmed by minerals identification using ASTER
VNIR-SWIR spectral bands and Spectral Angle Mapper supervised
image processing method. The presence of clays and their spatial
distribution are verified in the field. The study recommends the
technique and the low-cost satellite data to similar region of the
world.
Abstract: In this article a comparison was made between Cu and
TiO2 supported catalysts on activated carbon for ozone
decomposition reaction. The activated carbon support in the case of
TiO2/AC sample was prepared by physicochemical pyrolysis and for
Cu/AC samples the supports are chemically modified carbons. The
prepared catalysts were synthesized by impregnation method. The
samples were annealed in two different regimes- in air and under
vacuum. To examine adsorption efficiency of the samples BET
method was used. All investigated catalysts supported on chemically
modified carbons have higher specific surface area compared to the
specific surface area of TiO2 supported catalysts, varying in the range
590÷620 m2/g. The method of synthesis of the precursors had
influenced catalytic activity.
Abstract: The objective of this study was to assess whether
living in proximity to a roofing fiber cement factory in southern
Thailand was associated with physical, mental, social, and spiritual
health domains measured in a self-reported health risk assessment
(HRA) questionnaire. A cross-sectional study was conducted among
community members divided into two groups: near population (living
within 0-2km of factory) and far population (living within 2-5km of
factory) (N=198). A greater proportion of those living far from the
factory (65.34%) reported physical health problems than the near
group (51.04%) (p =0.032). This study has demonstrated that the near
population group had higher proportion of participants with positive
ratings on mental assessment (30.34%) and social health impacts
(28.42%) than far population group (10.59% and 16.67%,
respectively) (p
Abstract: Governments collect and produce large amounts of
data. Increasingly, governments worldwide have started to implement
open data initiatives and also launch open data portals to enable the
release of these data in open and reusable formats. Therefore, a large
number of open data repositories, catalogues and portals have been
emerging in the world. The greater availability of interoperable and
linkable open government data catalyzes secondary use of such data,
so they can be used for building useful applications which leverage
their value, allow insight, provide access to government services, and
support transparency. The efficient development of successful open
data portals makes it necessary to evaluate them systematic, in order
to understand them better and assess the various types of value they
generate, and identify the required improvements for increasing this
value. Thus, the attention of this paper is directed particularly to the
field of open data portals. The main aim of this paper is to compare
the selected open data portals on the national level using content
analysis and propose a new evaluation framework, which further
improves the quality of these portals. It also establishes a set of
considerations for involving businesses and citizens to create eservices
and applications that leverage on the datasets available from
these portals.
Abstract: This study investigates the cleaning performance of
high intensity 360 kHz frequency on removal of nano-dimensional
and sub-micron particles from various surfaces, uniformity of the
cleaning tank and run to run variation of cleaning process. The
uniformity of the cleaning tank was measured by two different
methods i.e. 1. ppbTM meter and 2. Liquid Particle Counting (LPC)
technique. The result indicates that the energy was distributed more
uniformly throughout the entire cleaning vessel even at the corners
and edges of the tank when megasonic sweeping technology is
applied. The result also shows that rinsing the parts with 360 kHz
frequency at final rinse gives lower particle counts, hence higher
cleaning efficiency as compared to other frequencies. When
megasonic sweeping technology is applied each piezoelectric
transducers will operate at their optimum resonant frequency and
generates stronger acoustic cavitational force and higher acoustic
streaming velocity. These combined forces are helping to enhance the
particle removal and at the same time improve the overall cleaning
performance. The multiple extractions study was also carried out for
various frequencies to measure the cleaning potential and asymptote
value.
Abstract: Comparisons of financial development across
countries are central to answering many of the questions on factors
leading to economic development. For this reason this study analyzes
the implications of financial system’s development on country’s
economic development. The aim of the article: to analyze the impact
of financial system’s development on economic development. The
following research methods were used: systemic, logical and
comparative analysis of scientific literature, analysis of statistical
data, time series model (Autoregressive Distributed Lag (ARDL)
Model). The empirical results suggest about positive short and long
term effect of stock market development on GDP per capita.
Abstract: Artificial intelligence applications are commonly used
in industry in many fields in parallel with the developments in the
computer technology. In this study, a fire room was prepared for the
resistance of wooden construction elements and with the mechanism
here, the experiments of polished materials were carried out. By
utilizing from the experimental data, an artificial neural network
(ANN) was modelled in order to evaluate the final cross sections of
the wooden samples remaining from the fire. In modelling,
experimental data obtained from the fire room were used. In the
developed system, the first weight of samples (ws-gr), preliminary
cross-section (pcs-mm2), fire time (ft-minute), and fire temperature
(t-oC) as input parameters and final cross-section (fcs-mm2) as output
parameter were taken. When the results obtained from ANN and
experimental data are compared after making statistical analyses, the
data of two groups are determined to be coherent and seen to have no
meaning difference between them. As a result, it is seen that ANN
can be safely used in determining cross sections of wooden materials
after fire and it prevents many disadvantages.
Abstract: Nature is a great source of inspiration for solving
complex problems in networks. It helps to find the optimal solution.
Metaheuristic algorithm is one of the nature-inspired algorithm which
helps in solving routing problem in networks. The dynamic features,
changing of topology frequently and limited bandwidth make the
routing, challenging in MANET. Implementation of appropriate
routing algorithms leads to the efficient transmission of data in
mobile ad hoc networks. The algorithms that are inspired by the
principles of naturally-distributed/collective behavior of social
colonies have shown excellence in dealing with complex
optimization problems. Thus some of the bio-inspired metaheuristic
algorithms help to increase the efficiency of routing in ad hoc
networks. This survey work presents the overview of bio-inspired
metaheuristic algorithms which support the efficiency of routing in
mobile ad hoc networks.