Abstract: It is known that the heart interacts with and adapts to its venous and arterial loading conditions. Various experimental studies and modeling approaches have been developed to investigate the underlying mechanisms. This paper presents a model of the left ventricle derived based on nonlinear stress-length myocardial characteristics integrated over truncated ellipsoidal geometry, and second-order dynamic mechanism for the excitation-contraction coupling system. The results of the model presented here describe the effects of the viscoelastic damping element of the electromechanical coupling system on the hemodynamic response. Different heart rates are considered to study the pacing effects on the performance of the left-ventricle against constant preload and afterload conditions under various damping conditions. The results indicate that the pacing process of the left ventricle has to take into account, among other things, the viscoelastic damping conditions of the myofilament excitation-contraction process. The effects of left ventricular dimensions on the hemdynamic response have been examined. These effects are found to be different at different viscoelastic and pacing conditions.
Abstract: In this paper we present high performance
dynamically allocated multi-queue (DAMQ) buffer schemes for fault
tolerance systems on chip applications that require an interconnection
network. Two virtual channels shared the same buffer space. Fault
tolerant mechanisms for interconnection networks are becoming a
critical design issue for large massively parallel computers. It is also
important to high performance SoCs as the system complexity keeps
increasing rapidly. On the message switching layer, we make
improvement to boost system performance when there are faults
involved in the components communication. The proposed scheme is
when a node or a physical channel is deemed as faulty, the previous
hop node will terminate the buffer occupancy of messages destined
to the failed link. The buffer usage decisions are made at switching
layer without interactions with higher abstract layer, thus buffer
space will be released to messages destined to other healthy nodes
quickly. Therefore, the buffer space will be efficiently used in case
fault occurs at some nodes.
Abstract: Tumour suppressors are key participants in the
prevention of cancer. Regulation of their expression through
miRNAs is important for comprehensive translation inhibition of
tumour suppressors and elucidation of carcinogenesis mechanisms.
We studies the possibility of 1521 miRNAs to bind with 873 mRNAs
of human tumour suppressors using RNAHybrid 2.1 and ERNAhybrid
programmes. Only 978 miRNAs were found to be
translational regulators of 812 mRNAs, and 61 mRNAs did not have
any miRNA binding sites. Additionally, 45.9% of all miRNA binding
sites were located in coding sequences (CDSs), 33.8% were located
in 3' untranslated region (UTR), and 20.3% were located in the
5'UTR. MiRNAs binding with more than 50 target mRNAs and
mRNAs binding with several miRNAs were selected. Hsa-miR-5096
had 15 perfectly complementary binding sites with mRNAs of 14
tumour suppressors. These newly indentified miRNA binding sites
can be used in the development of medicines (anti-sense therapies)
for cancer treatment.
Abstract: We report the results of an lattice Boltzmann
simulation of magnetohydrodynamic damping of sidewall convection
in a rectangular enclosure filled with a porous medium. In particular
we investigate the suppression of convection when a steady magnetic
field is applied in the vertical direction. The left and right vertical
walls of the cavity are kept at constant but different temperatures
while both the top and bottom horizontal walls are insulated. The
effects of the controlling parameters involved in the heat transfer and
hydrodynamic characteristics are studied in detail. The heat and mass
transfer mechanisms and the flow characteristics inside the enclosure
depended strongly on the strength of the magnetic field and Darcy
number. The average Nusselt number decreases with rising values of
the Hartmann number while this increases with increasing values of
the Darcy number.
Abstract: Several different cements have been tested to evaluate
their potential to leach calcium, chromium and aluminum ions in soft
water environment. The research allows comparing some different
cements in order to the potential risk of water contamination. This
can be done only in the same environment. To reach the results in
reasonable short time intervals and to make heavy metals
measurements with high accuracy, demineralized water was used. In
this case the conditions of experiments are far away from the water
supply practice, but short time experiments and measurably high
concentrations of elements in the water solution are an important
advantage. Moreover leaching mechanisms can be recognized, our
experiments reported here refer to this kind of cements evaluation.
Abstract: The velocity of a moving point in a general path is the vector quantity, which has both magnitude and direction. The magnitude or the direction of the velocity vector can change over time as a result of acceleration that the time rate of velocity changes. Acceleration analysis is important because inertial forces and inertial torques are proportional to rectilinear and angular accelerations accordingly. The loads must be determined in advance to ensure that a machine is adequately designed to handle these dynamic loads. For planar motion, the vector direction of acceleration is commonly separated into two elements: tangential and centripetal or radial components of a point on a rotating body. All textbooks in physics, kinematics and dynamics of machinery consider the magnitude of a radial acceleration at condition when a point rotates with a constant angular velocity and it means without acceleration. The magnitude of the tangential acceleration considered on a basis of acceleration for a rotating point. Such condition of presentation of magnitudes for two components of acceleration logically and mathematically is not correct and may cause further confusion in calculation. This paper presents new analytical expressions of the radial and absolute accelerations of a rotating point with acceleration and covers the gap in theoretical study of acceleration analysis.
Abstract: Tacit knowledge has been one of the most discussed
and contradictory concepts in the field of knowledge management
since the mid 1990s. The concept is used relatively vaguely to refer
to any type of information that is difficult to articulate, which has led
to discussions about the original meaning of the concept (adopted
from Polanyi-s philosophy) and the nature of tacit knowing. It is
proposed that the subject should be approached from the perspective
of cognitive science in order to connect tacit knowledge to
empirically studied cognitive phenomena. Some of the most
important examples of tacit knowing presented by Polanyi are
analyzed in order to trace the cognitive mechanisms of tacit knowing
and to promote better understanding of the nature of tacit knowledge.
The cognitive approach to Polanyi-s theory reveals that the
tacit/explicit typology of knowledge often presented in the
knowledge management literature is not only artificial but totally
opposite approach compared to Polanyi-s thinking.
Abstract: Arvia®, a spin-out company of University of Manchester, UK is commercialising a water treatment technology for the removal of low concentrations of organics from water. This technology is based on the adsorption of organics onto graphite based adsorbents coupled with their electrochemical regeneration in a simple electrochemical cell. In this paper, the potential of the process to adsorb microorganisms and electrochemically disinfect them present in water has been demonstrated. Bench scale experiments have indicated that the process of adsorption using graphite adsorbents with electrochemical regeneration can be used for water disinfection effectively. The most likely mechanisms of disinfection of water through this process include direct electrochemical oxidation and electrochemical chlorination.
Abstract: Deaminated lesions were produced via nitrosative oxidation of natural nucleobases; uracul (Ura, U) from cytosine (Cyt, C), hypoxanthine (Hyp, H) from adenine (Ade, A), and xanthine (Xan, X) and oxanine (Oxa, O) from guanine (Gua, G). Such damaged nucleobases may induce mutagenic problems, so that much attentions and efforts have been poured on the revealing of their mechanisms in vivo or in vitro. In this study, we employed these deaminated lesions as useful probes for analysis of DNA-binding/recognizing proteins or enzymes. Since the pyrimidine lesions such as Hyp, Oxa and Xan are employed as analogues of guanine, their comparative uses are informative for analyzing the role of Gua in DNA sequence in DNA-protein interaction. Several DNA oligomers containing such Hyp, Oxa or Xan substituted for Gua were designed to reveal the molecular interaction between DNA and protein. From this approach, we have got useful information to understand the molecular mechanisms of the DNA-recognizing enzymes, which have not ever been observed using conventional DNA oligomer composed of just natural nucleobases.
Abstract: Interactive push VOD system is a new kind of system
that incorporates push technology and interactive technique. It can
push movies to users at high speeds at off-peak hours for optimal
network usage so as to save bandwidth. This paper presents effective
software-based solution for processing mass downstream data at
terminals of interactive push VOD system, where the service can
download movie according to a viewer-s selection. The downstream
data is divided into two catalogs: (1) the carousel data delivered
according to DSM-CC protocol; (2) IP data delivered according to
Euro-DOCSIS protocol. In order to accelerate download speed and
reduce data loss rate at terminals, this software strategy introduces
caching, multi-thread and resuming mechanisms. The experiments
demonstrate advantages of the software-based solution.
Abstract: SQL injection on web applications is a very popular
kind of attack. There are mechanisms such as intrusion detection
systems in order to detect this attack. These strategies often rely on
techniques implemented at high layers of the application but do not
consider the low level of system calls. The problem of only
considering the high level perspective is that an attacker can
circumvent the detection tools using certain techniques such as URL
encoding. One technique currently used for detecting low-level
attacks on privileged processes is the tracing of system calls. System
calls act as a single gate to the Operating System (OS) kernel; they
allow catching the critical data at an appropriate level of detail. Our
basic assumption is that any type of application, be it a system
service, utility program or Web application, “speaks” the language of
system calls when having a conversation with the OS kernel. At this
level we can see the actual attack while it is happening. We conduct
an experiment in order to demonstrate the suitability of system call
analysis for detecting SQL injection. We are able to detect the attack.
Therefore we conclude that system calls are not only powerful in
detecting low-level attacks but that they also enable us to detect highlevel
attacks such as SQL injection.
Abstract: This paper proposes a robot able to climb Columns.
This robot is not dependent on the diameter and material of the
columns. Some climbing robots have been designed up to now but
Koala robot was designed and fabricated for climbing columns
exclusively. Simple kinematics of climbing in the nature inspired us
to design this robot. We used two linear mechanisms to grip the
column. The gripper consists of a DC motor and a power screw
mechanism with a linear bushing as a guide. This mechanism
provides enough force to grip the column. In addition we needed an
actuator for climbing the column; hence, two pneumatic jacks were
used. All the mechanical parts were designed according to the
exerted forces and operational condition. The prototype can be
simply installed and controlled on the column by an inexperienced
operator. This robot is intended for inspection and surveillance of
pipes in oil industries and power poles in electric industries.
Abstract: In recent years, the research in wireless sensor
network has increased steadily, and many studies were focusing on
reducing energy consumption of sensor nodes to extend their lifetimes.
In this paper, the issue of energy consumption is investigated and two
adaptive mechanisms are proposed to extend the network lifetime.
This study uses high-energy-first scheme to determine cluster heads
for data transmission. Thus, energy consumption in each cluster is
balanced and network lifetime can be extended. In addition, this study
uses cluster merging and dynamic routing mechanisms to further
reduce energy consumption during data transmission. The simulation
results show that the proposed method can effectively extend the
lifetime of wireless sensor network, and it is suitable for different base
station locations.
Abstract: The paper is concerned with developing stochastic delay mechanisms for efficient multicast protocols and for smooth mobile handover processes which are capable of preserving a given Quality of Service (QoS). In both applications the participating entities (receiver nodes or subscribers) sample a stochastic timer and generate load after a random delay. In this way, the load on the networking resources is evenly distributed which helps to maintain QoS communication. The optimal timer distributions have been sought in different p.d.f. families (e.g. exponential, power law and radial basis function) and the optimal parameter have been found in a recursive manner. Detailed simulations have demonstrated the improvement in performance both in the case of multicast and mobile handover applications.
Abstract: In cellular networks, limited availability of resources
has to be tapped to its fullest potential. In view of this aspect, a
sophisticated averaging and voting technique has been discussed in
this paper, wherein the radio resources available are utilized to the
fullest value by taking into consideration, several network and radio
parameters which decide on when the handover has to be made and
thereby reducing the load on Base station .The increase in the load
on the Base station might be due to several unnecessary handover
taking place which can be eliminated by making judicious use of the
radio and network parameters.
Abstract: The present work compares the performance of three
turbulence modeling approach (based on the two-equation k -ε
model) in predicting erosive wear in multi-size dense slurry flow
through rotating channel. All three turbulence models include
rotation modification to the production term in the turbulent kineticenergy
equation. The two-phase flow field obtained numerically
using Galerkin finite element methodology relates the local flow
velocity and concentration to the wear rate via a suitable wear model.
The wear models for both sliding wear and impact wear mechanisms
account for the particle size dependence. Results of predicted wear
rates using the three turbulence models are compared for a large
number of cases spanning such operating parameters as rotation rate,
solids concentration, flow rate, particle size distribution and so forth.
The root-mean-square error between FE-generated data and the
correlation between maximum wear rate and the operating
parameters is found less than 2.5% for all the three models.
Abstract: Ventricular fibrillation is a very important health
problem as is the cause of most of the sudden deaths in the world.
Waves of electrical activity are sent by the SA node, propagate
through the cardiac tissue and activate the mechanisms of cell
contraction, and therefore are responsible to pump blood to the body
harmonically. A spiral wave is an abnormal auto sustainable wave
that is responsible of certain types of arrhythmias. When these waves
break up, give rise to the fibrillation regime, in which there is a
complete loss in the coordination of the contraction of the heart
muscle. Interaction of spiral waves and obstacles is also of great
importance as it is believed that the attachment of a spiral wave to an
obstacle can provide with a transition of two different arrhythmias.
An obstacle can be partially excitable or non excitable. In this talk,
we present a numerical study of the interaction of meandering spiral
waves with partially and non excitable obstacles and focus on the
problem where the obstacle plays a fundamental role in the switch
between different spiral regimes, which represent different
arrhythmic regimes. Particularly, we study the phenomenon of
destabilization of spiral waves due to the presence of obstacles, a
phenomenon not completely understood (This work will appear as a
Chapter in a Book named Cardiac Arrhytmias by INTECH under the
name "Spiral Waves, Obstacles and Cardiac Arrhythmias", ISBN
979-953-307-050-5.).
Abstract: Malware is software which was invented and meant for doing harms on computers. Malware is becoming a significant threat in computer network nowadays. Malware attack is not just only involving financial lost but it can also cause fatal errors which may cost lives in some cases. As new Internet Protocol version 6 (IPv6) emerged, many people believe this protocol could solve most malware propagation issues due to its broader addressing scheme. As IPv6 is still new compares to native IPv4, some transition mechanisms have been introduced to promote smoother migration. Unfortunately, these transition mechanisms allow some malwares to propagate its attack from IPv4 to IPv6 network environment. In this paper, a proof of concept shall be presented in order to show that some existing IPv4 malware detection technique need to be improvised in order to detect malware attack in dual-stack network more efficiently. A testbed of dual-stack network environment has been deployed and some genuine malware have been released to observe their behaviors. The results between these different scenarios will be analyzed and discussed further in term of their behaviors and propagation methods. The results show that malware behave differently on IPv6 from the IPv4 network protocol on the dual-stack network environment. A new detection technique is called for in order to cater this problem in the near future.
Abstract: This paper presents ageing experiments controlled by the evolution of junction parameters. The deterioration of the device is related to high injection effects which modified the transport mechanisms in the space charge region of the junction. Physical phenomena linked to the degradation of junction parameters that affect the devices reliability are reported and discussed. We have used the method based on numerical analysis of experimental current-voltage characteristic of the junction, in order to extract the electrical parameters. The simultaneous follow-up of the evolutions of the series resistance and of the transition voltage allow us to introduce a new parameter for reliability evaluation.
Abstract: The paradigm of mobile agent provides a promising technology for the development of distributed and open applications. However, one of the main obstacles to widespread adoption of the mobile agent paradigm seems to be security. This paper treats the security of the mobile agent against malicious host attacks. It describes generic mobile agent protection architecture. The proposed approach is based on the dynamic adaptability and adopts the reflexivity as a model of conception and implantation. In order to protect it against behaviour analysis attempts, the suggested approach supplies the mobile agent with a flexibility faculty allowing it to present an unexpected behaviour. Furthermore, some classical protective mechanisms are used to reinforce the level of security.