Abstract: The plant world is the source of many medicines.
Recently, researchers have estimated that there are approximately
400,000 plant species worldwide, of which about a quarter or a third
have been used by societies for medicinal purposes. The human uses
of plants for thousands of years to treat various ailments, in many
developing countries, much of the population trust in traditional
doctors and their collections of medicinal plants to treat them.
Essential oils have many therapeutic properties. In herbal medicine,
they are used for their antiseptic properties against infectious
diseases of fungal origin, against dermatophytes, those of bacterial
origin. The aim of our study is to determine the antimicrobial effect
of essential oils of the plant Trigonella focnum greacum on some
pathogenic bacteria, it is a medicinal plant used in traditional
therapy. The test adopted is based on the diffusion method on solid
medium (Antibiogram), this method determines the sensitivity or
resistance of a microorganism vis-à-vis the extract studied. Our study
reveals that the essential oil of the plant Trigonella focnum greacum
has a different effect on the resistance of germs. For staphiloccocus
Pseudomonnas aeroginosa and Krebsilla, are moderately sensitive
strains, also Escherichia coli and Candida albicans represents a high
sensitivity. By against Proteus is a strain that represents a weak
sensitivity.
Abstract: Calcium [Ca2+] dynamics is studied as a potential form
of neuron excitability that can control many irregular processes like
metabolism, secretion etc. Ca2+ ion enters presynaptic terminal and
increases the synaptic strength and thus triggers the neurotransmitter
release. The modeling and analysis of calcium dynamics in neuron
cell becomes necessary for deeper understanding of the processes
involved. A mathematical model has been developed for cylindrical
shaped neuron cell by incorporating physiological parameters like
buffer, diffusion coefficient, and association rate. Appropriate initial
and boundary conditions have been framed. The closed form solution
has been developed in terms of modified Bessel function. A computer
program has been developed in MATLAB 7.11 for the whole
approach.
Abstract: Linear cryptanalysis methods are rarely used to improve the security of chaotic stream ciphers. In this paper, we apply linear cryptanalysis to a chaotic stream cipher which was designed by strictly using the basic design criterion of cryptosystem – confusion and diffusion. We show that this well-designed chaos-based stream cipher is still insecure against distinguishing attack. This distinguishing attack promotes the further improvement of the cipher.
Abstract: This paper presents the doping profile measurement
and characterization technique for the pocket implanted nano scale
n-MOSFET. Scanning capacitance microscopy and atomic force
microscopy have been used to image the extent of lateral dopant
diffusion in MOS structures. The data are capacitance vs. voltage
measurements made on a nano scale device. The technique is nondestructive
when imaging uncleaved samples. Experimental data from
the published literature are presented here on actual, cleaved device
structures which clearly indicate the two-dimensional dopant profile
in terms of a spatially varying modulated capacitance signal. Firstorder
deconvolution indicates the technique has much promise for
the quantitative characterization of lateral dopant profiles. The pocket
profile is modeled assuming the linear pocket profiles at the source
and drain edges. From the model, the effective doping concentration
is found to use in modeling and simulation results of the various
parameters of the pocket implanted nano scale n-MOSFET. The
potential of the technique to characterize important device related
phenomena on a local scale is also discussed.
Abstract: To understand working features of a micro combustor,
a computer code has been developed to study combustion of
hydrogen–air mixture in a series of chambers with same shape aspect
ratio but various dimensions from millimeter to micrometer level.
The prepared algorithm and the computer code are capable of
modeling mixture effects in different fluid flows including chemical
reactions, viscous and mass diffusion effects. The effect of various
heat transfer conditions at chamber wall, e.g. adiabatic wall, with
heat loss and heat conduction within the wall, on the combustion is
analyzed. These thermal conditions have strong effects on the
combustion especially when the chamber dimension goes smaller and
the ratio of surface area to volume becomes larger.
Both factors, such as larger heat loss through the chamber wall
and smaller chamber dimension size, may lead to the thermal
quenching of micro-scale combustion. Through such systematic
numerical analysis, a proper operation space for the micro-combustor
is suggested, which may be used as the guideline for microcombustor
design. In addition, the results reported in this paper
illustrate that the numerical simulation can be one of the most
powerful and beneficial tools for the micro-combustor design,
optimization and performance analysis.
Abstract: Human genome is not only the evolutionary
summation of all advantageous events, but also houses lesions of
deleterious foot prints. A single gene mutation sometimes may
express multiple consequences in numerous tissues and a linear
relationship of the genotype and the phenotype may often be obscure.
ß Thalassemia minor, a transfusion independent mild anaemia,
coupled with environment among other factors may articulate into
phenotypic pleotropy with Hypocholesterolemia, Vitamin D
deficiency, Tissue hypoxia, Hyper-parathyroidism and Psychological
alterations. Occurrence of Pancreatic insufficiency, resultant
steatorrhoea, Vitamin-D (25-OH) deficiency (13.86 ngm/ml) with
Hypocholesterolemia (85mg/dl) in a 30 years old male ß Thal-minor
patient (Hemoglobin 11mg/dl with Fetal Hemoglobin 2.10%, Hb A2
4.60% and Hb Adult 84.80% and altered Hemogram) with increased
Para thyroid hormone (62 pg/ml) & moderate Serum Ca+2
(9.5mg/ml) indicate towards a cascade of phenotypic pleotropy
where the ß Thalassemia mutation ,be it in the 5’ cap site of the
mRNA , differential splicing etc in heterozygous state is effecting
several metabolic pathways. Compensatory extramedulary
hematopoiesis may not coped up well with the stressful life style of
the young individual and increased erythropoietic stress with high
demand for cholesterol for RBC membrane synthesis may have
resulted in Hypocholesterolemia.Oxidative stress and tissue hypoxia
may have caused the pancreatic insufficiency, leading to Vitamin D
deficiency. This may in turn have caused the secondary
hyperparathyroidism to sustain serum Calcium level. Irritability and
stress intolerance of the patient was a cumulative effect of the vicious
cycle of metabolic compromises. From these findings we propose
that the metabolic deficiencies in the ß Thalassemia mutations may
be considered as the phenotypic display of the pleotropy to explain
the genetic epidemiology.
According to the recommendations from the NIH Workshop on
Gene-Environment Interplay in Common Complex Diseases: Forging
an Integrative Model, study design of observations should be
informed by gene-environment hypotheses and results of a study
(genetic diseases) should be published to inform future hypotheses.
Variety of approaches is needed to capture data on all possible
aspects, each of which is likely to contribute to the etiology of
disease. Speakers also agreed that there is a need for development of
new statistical methods and measurement tools to appraise
information that may be missed out by conventional method where
large sample size is needed to segregate considerable effect.
A meta analytic cohort study in future may bring about significant
insight on to the title comment.
Abstract: A study of the H-beam's nanosize structure phase
states after thermomechanical strengthening was carried out by TEM.
The following processes were analyzed. 1. The dispersing of the
cementite plates by cutting them by moving dislocations. 2. The
dissolution of cementite plates and repeated precipitation of the
cementite particles on the dislocations, the boundaries, subgrains and
grains. 3. The decay of solid solution of carbon in the α-iron after
"self-tempering" of martensite. 4. The final transformation of the
retained austenite in beinite with α-iron particles and cementite
formation. 5. The implementation of the diffusion mechanism of γ ⇒
α transformation.
Abstract: Lattice Monte Carlo methods are an excellent
choice for the simulation of non-linear thermal diffusion
problems. In this paper, and for the first time, Lattice Monte
Carlo analysis is performed on thermal diffusion combined
with convective heat transfer. Laminar flow of water modeled
as an incompressible fluid inside a copper pipe with a constant
surface temperature is considered. For the simulation of
thermal conduction, the temperature dependence of the
thermal conductivity of the water is accounted for. Using the
novel Lattice Monte Carlo approach, temperature distributions
and energy fluxes are obtained.
Abstract: We report a novel fusion tag for expressing
recombinant proteins in E. coli. The fusion tag is the C-terminus part
of the human GMCSF gene comprising 45 amino acids, which aid in
over expression of otherwise non expressible genes. Expression of
hIFN a2b with this fusion tag also escapes the requirement of rare
codons for expression. This is also a first report of a small fusion tag
of human origin having affinity to heparin sepharose column
facilitating the purification of fusion protein.
Abstract: Mathematical and computational modeling of calcium
signalling in nerve cells has produced considerable insights into how
the cells contracts with other cells under the variation of biophysical
and physiological parameters. The modeling of calcium signaling in
astrocytes has become more sophisticated. The modeling effort has
provided insight to understand the cell contraction. Main objective
of this work is to study the effect of voltage gated (Operated)
calcium channel (VOC) on calcium profile in the form of advection
diffusion equation. A mathematical model is developed in the form
of advection diffusion equation for the calcium profile. The model
incorporates the important physiological parameter like diffusion
coefficient etc. Appropriate boundary conditions have been framed.
Finite volume method is employed to solve the problem. A program
has been developed using in MATLAB 7.5 for the entire problem
and simulated on an AMD-Turion 32-bite machine to compute the
numerical results.
Abstract: Interaction of inorganic water-soluble salts and building stones is studied in the paper. Two types of sandstone and one type of spongillite as representatives of materials used in historical masonry are subjected to experimental testing. Within the performed experiments, measurement of moisture and chloride concentration profiles is done in order to get input data for computational inverse analysis. Using the inverse analysis, moisture diffusivity and chloride diffusion coefficient of investigated materials are accessed. Additionally, the effect of salt presence on water vapor storage is investigated using dynamic vapor sorption device. The obtained data represents valuable information for restoration of historical masonry and give evidence on the performance of studied stones in contact with water soluble salts.
Abstract: Fuller’s earth is a fine-grained, naturally occurring substance that has a substantial ability to adsorb impurities. In the present study Fuller’s earth has been characterized and used for the removal of Pb(II) from aqueous solution. The effect of various physicochemical parameters such as pH, adsorbent dosage and shaking time on adsorption were studied. The result of the equilibrium studies showed that the solution pH was the key factor affecting the adsorption. The optimum pH for adsorption was 5. Kinetics data for the adsorption of Pb(II) was best described by pseudo-second order model. The effective diffusion co-efficient for Pb(II) adsorption was of the order of 10-8 m2/s. The adsorption data for metal adsorption can be well described by Langmuir adsorption isotherm. The maximum uptake of metal was 103.3 mg/g of adsorbent. Mass transfer analysis was also carried out for the adsorption process. The values of mass transfer coefficients obtained from the study indicate that the velocity of the adsorbate transport from bulk to the solid phase was quite fast. The mean sorption energy calculated from Dubinin-Radushkevich isotherm indicated that the metal adsorption process was chemical in nature.
Abstract: Sensor Network are emerging as a new tool for
important application in diverse fields like military surveillance,
habitat monitoring, weather, home electrical appliances and others.
Technically, sensor network nodes are limited in respect to energy
supply, computational capacity and communication bandwidth. In
order to prolong the lifetime of the sensor nodes, designing efficient
routing protocol is very critical. In this paper, we illustrate the
existing routing protocol for wireless sensor network using data
centric approach and present performance analysis of these protocols.
The paper focuses in the performance analysis of specific protocol
namely Directed Diffusion and SPIN. This analysis reveals that the
energy usage is important features which need to be taken into
consideration while designing routing protocol for wireless sensor
network.
Abstract: In this paper we propose a novel approach for ascertaining human identity based on fusion of profile face and gait biometric cues The identification approach based on feature learning in PCA-LDA subspace, and classification using multivariate Bayesian classifiers allows significant improvement in recognition accuracy for low resolution surveillance video scenarios. The experimental evaluation of the proposed identification scheme on a publicly available database [2] showed that the fusion of face and gait cues in joint PCA-LDA space turns out to be a powerful method for capturing the inherent multimodality in walking gait patterns, and at the same time discriminating the person identity..
Abstract: Measuring the complexity of software has been an
insoluble problem in software engineering. Complexity measures can
be used to predict critical information about testability, reliability,
and maintainability of software systems from automatic analysis of
the source code. During the past few years, many complexity
measures have been invented based on the emerging Cognitive
Informatics discipline. These software complexity measures,
including cognitive functional size, lend themselves to the approach
of the total cognitive weights of basic control structures such as loops
and branches. This paper shows that the current existing calculation
method can generate different results that are algebraically
equivalence. However, analysis of the combinatorial meanings of this
calculation method shows significant flaw of the measure, which also
explains why it does not satisfy Weyuker's properties. Based on the
findings, improvement directions, such as measures fusion, and
cumulative variable counting scheme are suggested to enhance the
effectiveness of cognitive complexity measures.
Abstract: The aim of this contribution is to present a new
approach in modeling the electrical activity of the human heart. A
recurrent artificial neural network is being used in order to exhibit a
subset of the dynamics of the electrical behavior of the human heart.
The proposed model can also be used, when integrated, as a
diagnostic tool of the human heart system.
What makes this approach unique is the fact that every model is
being developed from physiological measurements of an individual.
This kind of approach is very difficult to apply successfully in many
modeling problems, because of the complexity and entropy of the
free variables describing the complex system. Differences between
the modeled variables and the variables of an individual, measured at
specific moments, can be used for diagnostic purposes. The sensor
fusion used in order to optimize the utilization of biomedical sensors
is another point that this paper focuses on. Sensor fusion has been
known for its advantages in applications such as control and
diagnostics of mechanical and chemical processes.
Abstract: Photoplethysmography is a simple measurement of the
variation in blood volume in tissue. It detects the pulse signal of heart
beat as well as the low frequency signal of vasoconstriction and
vasodilation. The transmission type measurement is limited to only a
few specific positions for example the index finger that have a short
path length for light. The reflectance type measurement can be
conveniently applied on most parts of the body surface. This study
analyzed the factors that determine the quality of reflectance
photoplethysmograph signal including the emitter-detector distance,
wavelength, light intensity, and optical properties of skin tissue.
Light emitting diodes (LEDs) with four different visible
wavelengths were used as the light emitters. A phototransistor was
used as the light detector. A micro translation stage adjusts the
emitter-detector distance from 2 mm to 15 mm.
The reflective photoplethysmograph signals were measured on
different sites. The optimal emitter-detector distance was chosen to
have a large dynamic range for low frequency drifting without signal
saturation and a high perfusion index. Among these four wavelengths,
a yellowish green (571nm) light with a proper emitter-detection
distance of 2mm is the most suitable for obtaining a steady and reliable
reflectance photoplethysmograph signal
Abstract: A highly optimized implementation of binary mixture
diffusion with no initial bulk velocity on graphics processors is
presented. The lattice Boltzmann model is employed for simulating
the binary diffusion of oxygen and nitrogen into each other with
different initial concentration distributions. Simulations have been
performed using the latest proposed lattice Boltzmann model that
satisfies both the indifferentiability principle and the H-theorem for
multi-component gas mixtures. Contemporary numerical
optimization techniques such as memory alignment and increasing
the multiprocessor occupancy are exploited along with some novel
optimization strategies to enhance the computational performance on
graphics processors using the C for CUDA programming language.
Speedup of more than two orders of magnitude over single-core
processors is achieved on a variety of Graphical Processing Unit
(GPU) devices ranging from conventional graphics cards to
advanced, high-end GPUs, while the numerical results are in
excellent agreement with the available analytical and numerical data
in the literature.
Abstract: This paper presents an approach for repairing word order errors in English text by reordering words in a sentence and choosing the version that maximizes the number of trigram hits according to a language model. A possible way for reordering the words is to use all the permutations. The problem is that for a sentence with length N words the number of all permutations is N!. The novelty of this method concerns the use of an efficient confusion matrix technique for reordering the words. The confusion matrix technique has been designed in order to reduce the search space among permuted sentences. The limitation of search space is succeeded using the statistical inference of N-grams. The results of this technique are very interesting and prove that the number of permuted sentences can be reduced by 98,16%. For experimental purposes a test set of TOEFL sentences was used and the results show that more than 95% can be repaired using the proposed method.
Abstract: The aim of the present study was to evaluate the
mucoadhesion and the release of nicotinamide gel formulations using
in vitro methods. An agar plate technique was used to investigate the
adhesiveness of the gels whereas a diffusion apparatus was employed
to determine the release of nicotinamide from the gels. In this
respect, 10% w/w nicotinamide gels containing bioadhesive
polymers: Carbopol 934P (0.5-2% w/w), hydroxypropylmethyl
cellulose (HPMC) (4-10% w/w), sodium carboxymethyl cellulose
(SCMC) (4-6% w/w) and methylcellulose 4000 (MC) (3-5% w/w)
were prepared. The gel formulations had pH values in the range of
7.14 - 8.17, which were considered appropriate to oral mucosa
application. In general, the rank order of pH values appeared to be
SCMC > MC4000 > HPMC > Carbopol 934P. Types and
concentrations of polymers used somewhat affected the
adhesiveness. It was found that anionic polymers (Carbopol 934 and
SCMC) adhered more firmly to the agar plate than the neutral
polymers (HPMC and MC 4000). The formulation containing 0.5%
Carbopol 934P (F1) showed the highest release rate. With the
exception of the formulation F1, the neutral polymers tended to give
higher relate rates than the anionic polymers. For oral tissue
treatment, the optimum has to be balanced between the residence
time (adhesiveness) of the formulations and the release rate of the
drug. The formulations containing the anionic polymers: Carbopol
934P or SCMC possessed suitable physical properties (appearance,
pH and viscosity). In addition, for anionic polymer formulations,
justifiable mucoadhesive properties and reasonable release rates of
nicotinamide were achieved. Accordingly, these gel formulations
may be applied for the treatment of oral mucosal lesions.