Abstract: In this study, three subtypes of influenza A viruses (pH1N1, H5N1 and H3N2) which naturally infected human were analyzed by bioinformatic approaches to find candidate human cellular miRNAs targeting viral genomes. There were 76 miRNAs targeting influenza A viruses. Among these candidates, 70 miRNAs were subtypes specifically targeting each subtype of influenza A virus including 21 miRNAs targeted subtype H1N1, 27 miRNAs targeted subtype H5N1 and 22 miRNAs targeted subtype H3N2. The remaining 6 miRNAs target on multiple subtypes of influenza A viruses. Uniquely, hsa-miR-3145 is the only one candidate miRNA targeting PB1 gene of all three subtypes. Obviously, most of the candidate miRNAs are targeting on polymerase complex genes (PB2, PB1 and PA) of influenza A viruses. This study predicted potential human miRNAs targeting on different subtypes of influenza A viruses which might be useful for inhibition of viral replication and for better understanding of the interaction between virus and host cell.
Abstract: The use of wind energy for electricity generation is
growing rapidly across the world and in Portugal. However, the
geographical characteristics of the country along with the average
wind regime and with the environmental restrictions imposed to these
projects create limitations to the exploit of the onshore wind
resource. The best onshore wind spots are already committed and the
possibility of offshore wind farms in the Portuguese cost is now
being considered. This paper aims to make a contribution to the
evaluation of offshore wind power projects in Portugal. The technical
restrictions are addressed and the strategic, environmental and
financial interest of the project is analysed from the private company
and public points of view. The results suggest that additional support
schemes are required to ensure private investors interest for these
projects. Assuming an approach of direct substitution of energy
sources for electricity generation, the avoided CO2 equivalent
emissions for an offshore wind power project were quantified. Based
on the conclusions, future research is proposed to address the
environmental and social impacts of these projects.
Abstract: It is claimed that a new style of urban planning and
policy intertwined with ICT is emerging and urban planning and ICT
policy are no longer considered as separate disciplines. The
interactions between electronic spaces and urban spaces are so
complex and uncertain that confront urban planners and policy makers
with great challenges. However, the assumption about the relationship
between ICT and urban planning is mainly based on North American
and European experiences. In the light of empirical evidence from
Taipei City, this paper shows that this new type of urban planning and
policy intertwined with ICT has existed in Asian city for a decade as
well. Based on these results, this paper further reviews how the Taipei
City government implements this new type of urban ICT planning and
the validity and realism of its underlying assumptions. Finally, it also
explores the extent to which urban ICT planning could promote
positive synergies between physical and electronic developments.
Abstract: The seismic vulnerability of an urban area is of a great
deal for local authorities especially those facing earthquakes. So, it is
important to have an efficient tool to assess the vulnerability of
existing buildings. The use of the VIP (Vulnerability Index Program)
and the GIS (Geographic Information System) let us to identify the
most vulnerable districts of an urban area.
The use of the vulnerability index method lets us to assess the
vulnerability of the center town of Blida (Algeria) which is a
historical town and which has grown enormously during the last
decades. In this method, three levels of vulnerability are defined. The
GIS has been used to build a data base in order to perform different
thematic analyses. These analyses show the seismic vulnerability of
Blida.
Abstract: Using bottom-up image processing algorithms to predict human eye fixations and extract the relevant embedded information in images has been widely applied in the design of active machine vision systems. Scene text is an important feature to be extracted, especially in vision-based mobile robot navigation as many potential landmarks such as nameplates and information signs contain text. This paper proposes an edge-based text region extraction algorithm, which is robust with respect to font sizes, styles, color/intensity, orientations, and effects of illumination, reflections, shadows, perspective distortion, and the complexity of image backgrounds. Performance of the proposed algorithm is compared against a number of widely used text localization algorithms and the results show that this method can quickly and effectively localize and extract text regions from real scenes and can be used in mobile robot navigation under an indoor environment to detect text based landmarks.
Abstract: Life is beautiful. But, it is decided by genes, environment and the individual and shattered by the natural and / or the invited problems. Most of the global rural helpless masses are struggling for their survival since; they are neglected in all aspects of life including health. Amidst a countless number of miserable diseases in man, diabetes is becoming a dreaded killer and ramifying the entire globe in a jet speed. Diabetes control continues as a Herculean task to the scientific community and the modern society in the 21st century also. T2DM is not pertaining to any age and it can develop even during the childhood. This multifactorial disease abruptly changes the activities of certain vital biomarkers in the present rural T2DM cases. A remarkable variation in the levels of biomarkers like AST, ALT, GGT, ALP, LDH, HbA1C, C- peptide, fasting sugar, post-prandial sugar, sodium, potassium, BUN, creatinine and insulin show the rampant nature of T2DM in this physically active rural agrarian community.
Abstract: All the geophysical phenomena including river
networks and flow time series are fractal events inherently and fractal
patterns can be investigated through their behaviors. A non-linear
system like a river basin can well be analyzed by a non-linear
measure such as the fractal analysis. A bilateral study is held on the
fractal properties of the river network and the river flow time series.
A moving window technique is utilized to scan the fractal properties
of them. Results depict both events follow the same strategy
regarding to the fractal properties. Both the river network and the
time series fractal dimension tend to saturate in a distinct value.
Abstract: In the traditional concept of product life cycle management, the activities of design, manufacturing, and assembly are performed in a sequential way. The drawback is that the considerations in design may contradict the considerations in manufacturing and assembly. The different designs of components can lead to different assembly sequences. Therefore, in some cases, a good design may result in a high cost in the downstream assembly activities. In this research, an integrated design evaluation and assembly sequence planning model is presented. Given a product requirement, there may be several design alternative cases to design the components for the same product. If a different design case is selected, the assembly sequence for constructing the product can be different. In this paper, first, the designed components are represented by using graph based models. The graph based models are transformed to assembly precedence constraints and assembly costs. A particle swarm optimization (PSO) approach is presented by encoding a particle using a position matrix defined by the design cases and the assembly sequences. The PSO algorithm simultaneously performs design evaluation and assembly sequence planning with an objective of minimizing the total assembly costs. As a result, the design cases and the assembly sequences can both be optimized. The main contribution lies in the new concept of integrated design evaluation and assembly sequence planning model and the new PSO solution method. The test results show that the presented method is feasible and efficient for solving the integrated design evaluation and assembly planning problem. In this paper, an example product is tested and illustrated.
Abstract: M. Kemal Ataturk was a great leader who was fond of art and he had displayed his being fond of art many times. In his speeches and writings you can see that he had showed his approval to art and the importance of artists and art for the society. During the foundation of republic, he also wanted renovation in art as in other fields and ordered many novelties both in art and society. One of the greatest steps in realizing this was to prepare a national Turkish opera. In this study, it was studied how a Turkish opera, Özsoy was prepared in the context of social and political conditions of that time and what kind of processes it passed. As a result, it is seen that there was two main aims for Ataturk with this opera. First, Ataturk wanted to abolish the sectarian conflict between Iran and Turkey going on for centuries. The second and maybe the most important is that he wanted to make a revolution in the field of art and aimed to reach the level of civilized countries.
Abstract: An original Direct Numerical Simulation (DNS) method to tackle the problem of particulate flows at moderate to high concentration and finite Reynolds number is presented. Our method is built on the framework established by Glowinski and his coworkers [1] in the sense that we use their Distributed Lagrange Multiplier/Fictitious Domain (DLM/FD) formulation and their operator-splitting idea but differs in the treatment of particle collisions. The novelty of our contribution relies on replacing the simple artificial repulsive force based collision model usually employed in the literature by an efficient Discrete Element Method (DEM) granular solver. The use of our DEM solver enables us to consider particles of arbitrary shape (at least convex) and to account for actual contacts, in the sense that particles actually touch each other, in contrast with the simple repulsive force based collision model. We recently upgraded our serial code, GRIFF 1 [2], to full MPI capabilities. Our new code, PeliGRIFF 2, is developed under the framework of the full MPI open source platform PELICANS [3]. The new MPI capabilities of PeliGRIFF open new perspectives in the study of particulate flows and significantly increase the number of particles that can be considered in a full DNS approach: O(100000) in 2D and O(10000) in 3D. Results on the 2D/3D sedimentation/fluidization of isometric polygonal/polyedral particles with collisions are presented.
Abstract: Human immunodeficiency virus infection and
acquired immunodeficiency syndrome is a global pandemic with
cases reporting from virtually every country and continues to be a
common infection in developing country like India.
Microalbuminuria is a manifestation of human immunodeficiency
virus associated nephropathy. Therefore, microalbuminuria may be
an early marker of human immunodeficiency virus associated
nephropathy, and screening for its presence may be beneficial. A
strikingly high prevalence of microalbuminuria among human
immunodeficiency virus infected patients has been described in
various studies. Risk factors for clinically significant proteinuria
include African - American race, higher human immunodeficiency
virus ribonucleic acid level and lower CD4 lymphocyte count. The
cardiovascular risk factors of increased systolic blood pressure and
increase fasting blood sugar level are strongly associated with
microalbuminuria in human immunodeficiency virus patient. These
results suggest that microalbuminuria may be a sign of current
endothelial dysfunction and micro-vascular disease and there is
substantial risk of future cardiovascular disease events. Positive
contributing factors include early kidney disease such as human
immunodeficiency virus associated nephropathy, a marker of end
organ damage related to co morbidities of diabetes or hypertension,
or more diffuse endothelial cells dysfunction. Nevertheless after
adjustment for non human immunodeficiency virus factors, human
immunodeficiency virus itself is a major risk factor. The presence of
human immunodeficiency virus infection is independent risk to
develop microalbuminuria in human immunodeficiency virus patient.
Cardiovascular risk factors appeared to be stronger predictors of
microalbuminuria than markers of human immunodeficiency virus
severity person with human immunodeficiency virus infection and
microalbuminuria therefore appear to potentially bear the burden of
two separate damage related to known vascular end organ damage
related to know vascular risk factors, and human immunodeficiency
virus specific processes such as the direct viral infection of kidney
cells.The higher prevalence of microalbuminuria among the human
immunodeficiency virus infected could be harbinger of future
increased risks of both kidney and cardiovascular disease. Further
study defining the prognostic significance of microalbuminuria
among human immunodeficiency virus infected persons will be
essential. Microalbuminuria seems to be a predictor of cardiovascular
disease in diabetic and non diabetic subjects, hence it can also be
used for early detection of micro vascular disease in human
immunodeficiency virus positive patients, thus can help to diagnose
the disease at the earliest.
Abstract: Effective evaluation of software development effort is an important issue during project plan. This study provides a model to predict development effort based on the software size estimated with function points. We generalize the average amount of effort spent on each phase of the development, and give the estimates for the effort used in software building, testing, and implementation. Finally, this paper finds a strong correlation between software defects and software size. As the size of software constantly increases, the quality remains to be a matter which requires major concern.
Abstract: The Information and Communication Technologies
(ICTs), and the Wide World Web (WWW) have fundamentally
altered the practice of teaching and learning world wide. Many
universities, organizations, colleges and schools are trying to apply
the benefits of the emerging ICT. In the early nineties the term
learning object was introduced into the instructional technology
vernacular; the idea being that educational resources could be broken
into modular components for later combination by instructors,
learners, and eventually computes into larger structures that would
support learning [1]. However in many developing countries, the use
of ICT is still in its infancy stage and the concept of learning object
is quite new. This paper outlines the learning object design
considerations for developing countries depending on learning
environment.
Abstract: This article proposes a voltage-mode
multifunction filter using differential voltage current
controllable current conveyor transconductance amplifier
(DV-CCCCTA). The features of the circuit are that: the
quality factor and pole frequency can be tuned independently
via the values of capacitors: the circuit description is very
simple, consisting of merely 1 DV-CCCCTA, and 2
capacitors. Without any component matching conditions, the
proposed circuit is very appropriate to further develop into
an integrated circuit. Additionally, each function response
can be selected by suitably selecting input signals with
digital method. The PSpice simulation results are depicted.
The given results agree well with the theoretical anticipation.
Abstract: Xanthan gum is one of the major commercial
biopolymers. Due to its excellent rheological properties xanthan gum
is used in many applications, mainly in food industry. Commercial
production of xanthan gum uses glucose as the carbon substrate;
consequently the price of xanthan production is high. One of the
ways to decrease xanthan price, is using cheaper substrate like
agricultural wastes. Iran is one of the biggest date producer countries.
However approximately 50% of date production is wasted annually.
The goal of this study is to produce xanthan gum from waste date
using Xanthomonas campestris PTCC1473 by submerged
fermentation. In this study the effect of three variables including
phosphor and nitrogen amount and agitation rate in three levels using
response surface methodology (RSM) has been studied. Results
achieved from statistical analysis Design Expert 7.0.0 software
showed that xanthan increased with increasing level of phosphor.
Low level of nitrogen leaded to higher xanthan production. Xanthan
amount, increasing agitation had positive influence. The statistical
model identified the optimum conditions nitrogen amount=3.15g/l,
phosphor amount=5.03 g/l and agitation=394.8 rpm for xanthan. To
model validation, experiments in optimum conditions for xanthan
gum were carried out. The mean of result for xanthan was 6.72±0.26.
The result was closed to the predicted value by using RSM.
Abstract: Based on an analysis of the current research and application of Road maintenance, geographic information system (WebGIS) and ArcGIS Server, the platform overhead construction for Road maintenance development is studied and the key issues are presented, including the organization and design of spatial data on the basis of the geodatabase technology, middleware technology, tiles cache index technology and dynamic segmentation of WebGIS. Road maintenance geographic information platform is put forward through the researching ideas of analysis of the system design. The design and application of WebGIS system are discussed on the basis of a case study of BaNan district of Chongqing highway maintenance management .The feasibility of the theories and methods are validated through the system.
Abstract: In this research, heat transfer of a poly Ethylene
fluidized bed reactor without reaction were studied experimentally
and computationally at different superficial gas velocities. A multifluid
Eulerian computational model incorporating the kinetic theory
for solid particles was developed and used to simulate the heat
conducting gas–solid flows in a fluidized bed configuration.
Momentum exchange coefficients were evaluated using the Syamlal–
O-Brien drag functions. Temperature distributions of different phases
in the reactor were also computed. Good agreement was found
between the model predictions and the experimentally obtained data
for the bed expansion ratio as well as the qualitative gas–solid flow
patterns. The simulation and experimental results showed that the gas
temperature decreases as it moves upward in the reactor, while the
solid particle temperature increases. Pressure drop and temperature
distribution predicted by the simulations were in good agreement
with the experimental measurements at superficial gas velocities
higher than the minimum fluidization velocity. Also, the predicted
time-average local voidage profiles were in reasonable agreement
with the experimental results. The study showed that the
computational model was capable of predicting the heat transfer and
the hydrodynamic behavior of gas-solid fluidized bed flows with
reasonable accuracy.
Abstract: In this paper, the solubility of CO2 in AMP solution
have been measured at temperature range of ( 293, 303 ,313,323)
K.The amine concentration ranges studied are (2.0, 2.8, and 3.4) M.
A solubility apparatus was used to measure the solubility of CO2 in
AMP solution on samples of flue gases from Thermal and Central
Power Plants of Esfahan Steel Company. The modified Kent
Eisenberg model was used to correlate and predict the vapor-liquid
equilibria of the (CO2 + AMP + H2O) system. The model predicted
results are in good agreement with the experimental vapor-liquid
equilibrium measurements.
Abstract: Interactions among proteins are the basis of various
life events. So, it is important to recognize and research protein
interaction sites. A control set that contains 149 protein molecules
were used here. Then 10 features were extracted and 4 sample sets
that contained 9 sliding windows were made according to features.
These 4 sample sets were calculated by Radial Basis Functional neutral
networks which were optimized by Particle Swarm Optimization
respectively. Then 4 groups of results were obtained. Finally, these 4
groups of results were integrated by decision fusion (DF) and Genetic
Algorithm based Selected Ensemble (GASEN). A better accuracy was
got by DF and GASEN. So, the integrated methods were proved to
be effective.
Abstract: This work is focused on the steady boundary layer flow
near the forward stagnation point of plane and axisymmetric bodies
towards a stretching sheet. The no slip condition on the solid
boundary is replaced by the partial slip condition. The analytical
solutions for the velocity distributions are obtained for the various
values of the ratio of free stream velocity and stretching velocity, slip
parameter, the suction and injection velocity parameter, magnetic
parameter and dimensionality index parameter in the series forms with
the help of homotopy analysis method (HAM). Convergence of the
series is explicitly discussed. Results show that the flow and the skin
friction coefficient depend heavily on the velocity slip factor. In
addition, the effects of all the parameters mentioned above were more
pronounced for plane flows than for axisymmetric flows.