Abstract: Bone growth factors, such as Bone Morphogenic
Protein-2 (BMP-2) have been approved by the FDA to replace grafting for some surgical interventions, but the high dose requirement limits its use in patients. Noggin, an extracellular protein, blocks the effect of BMP-2 by binding to BMP. Preventing
the BMP-2/noggin interaction will help increase the free
concentration of BMP-2 and therefore should enhance its efficacy to
induce bone formation. The work presented here involves
computational design of novel small molecule inhibitory agents of BMP-2/noggin interaction, based on our current understanding of
BMP-2, and its known putative ligands (receptors and antagonists). A
successful acquisition of such an inhibitory agent of BMP-2/noggin interaction would allow clinicians to reduce the dose required of
BMP-2 protein in clinical applications to promote osteogenesis. The
available crystal structures of the BMPs, its receptors, and the binding partner noggin were analyzed to identify the critical residues
involved in their interaction. In presenting this study, LUDI de novo design method was utilized to perform virtual screening of a large
number of compounds from a commercially available library against the binding sites of noggin to identify the lead chemical compounds
that could potentially block BMP-noggin interaction with a high specificity.
Abstract: Increase in using internet makes some problems that
one of them is "internet anxiety". Internet anxiety is a type of anxious
that people may feel during surfing internet or using internet for their
educational purpose, blogging or streaming to digital libraries. The
goal of this study is evaluating of internet anxiety among the
management students. In this research Ealy's internet anxiety
questionnaire, consists of positive and negative items, is completed
by 310 participants. According to the findings, about 64.7% of them
were equal or below to mean anxiety score (50). The distribution of
internet anxiety scores was normal and there was no meaningful
difference between men-s and women's anxiety level in this sample.
Results also showed that there is no meaningful difference of internet
anxiety level between different fields of study in Management. This
evaluation will help managers to perform gap analysis between the
existent level and the desired one. Future work would be providing
techniques for abating human anxiety while using internet via human
computer interaction techniques.
Abstract: Attachment of the circulating monocytes to the
endothelium is the earliest detectable events during formation of
atherosclerosis. The adhesion molecules, chemokines and matrix
proteases genes were identified to be expressed in atherogenesis.
Expressions of these genes may influence structural integrity of the
luminal endothelium. The aim of this study is to relate changes in the
ultrastructural morphology of the aortic luminal surface and gene
expressions of the endothelial surface, chemokine and MMP-12 in
normal and hypercholesterolemic rabbits. Luminal endothelial
surface from rabbit aortic tissue was examined by scanning electron
microscopy (SEM) using low vacuum mode to ascertain
ultrastructural changes in development of atherosclerotic lesion. Gene
expression of adhesion molecules, MCP-1 and MMP-12 were studied
by Real-time PCR. Ultrastructural observations of the aortic luminal
surface exhibited changes from normal regular smooth intact
endothelium to irregular luminal surface including marked globular
appearance and ruptures of the membrane layer. Real-time PCR
demonstrated differentially expressed of studied genes in
atherosclerotic tissues. The appearance of ultrastructural changes in
aortic tissue of hypercholesterolemic rabbits is suggested to have
relation with underlying changes of endothelial surface molecules,
chemokine and MMP-12 gene expressions.
Abstract: The main goal of this paper is to establish a
methodology for testing and optimizing GPRS performance over
Libya GSM network as well as to propose a suitable optimization
technique to improve performance. Some measurements of
download, upload, throughput, round-trip time, reliability, handover,
security enhancement and packet loss over a GPRS access network
were carried out. Measured values are compared to the theoretical
values that could be calculated beforehand. This data should be
processed and delivered by the server across the wireless network to
the client. The client on the fly takes those pieces of the data and
process immediately. Also, we illustrate the results by describing the
main parameters that affect the quality of service. Finally, Libya-s
two mobile operators, Libyana Mobile Phone and Al-Madar al-
Jadeed Company are selected as a case study to validate our
methodology.
Abstract: This paper describes vibration analysis using the finite
element method for a small earphone, especially for the diaphragm
shape with a low-rigidity. The viscoelastic diaphragm is supported by
multiple nonlinear concentrated springs with linear hysteresis
damping. The restoring forces of the nonlinear springs have cubic
nonlinearity. The finite elements for the nonlinear springs with
hysteresis are expressed and are connected to the diaphragm that is
modeled by linear solid finite elements in consideration of a complex
modulus of elasticity. Further, the discretized equations in physical
coordinates are transformed into the nonlinear ordinary coupled
equations using normal coordinates corresponding to the linear natural
modes. We computed the nonlinear stationary and non-stationary
responses due to the internal resonance between modes with large
amplitude in the nonlinear springs and elastic modes in the diaphragm.
The non-stationary motions are confirmed as the chaos due to the
maximum Lyapunov exponents with a positive number. From the time
histories of the deformation distribution in the chaotic vibration, we
identified nonlinear modal couplings.
Abstract: Malaysia is aggressive in promoting the usage of ICT
to its mass population through the support by the government
policies and programs targeting the general population. However,
with the uneven distribution of the basic telecommunication
infrastructure between the urban and rural area, cost for being
“interconnected" that is considered high among the poorer rural
population and the lack of local contents that suit the rural population
needs or lifestyles, it is still a challenge for Malaysia to achieve its
Vision 2020 Agenda moving the nation towards an information
society by the year 2020. Among the existing programs that have
been carried out by the government to encourage the usage of ICT by
the rural population is “Kedaikom", a community telecenter with the
general aim is to engage the community to get exposed and to use the
ICT, encouraging the diffusion of the ICT technology to the rural
population. The research investigated by using a questionnaire
survey of how Kedaikom, as a community telecenter could play a
role in encouraging the rural or underserved community to use the
ICT. The result from the survey has proven that the community
telecenter could bridge the digital divide between the underserved
rural population and the well-accessed urban population in Malaysia.
More of the rural population, especially from the younger generation
and those with higher educational background are using the
community telecenter to be connected to the ICT.
Abstract: A new supported liquid membrane (SLM) system for
the selective transport of VO2
+ ions was prepared in this present
work. The SLM was a thin porous polyvinylidene difluoride
(PVDF) membrane soaked with Di-(2-ethylhexyl) phosphoric acid
(D2EHPA) as mobile carrier in Xylene as organic solvent.
D2EHPA acts as a highly selective carrier for the uphill transport of
VO2
+ ions through the SLM. The transport of VO2
+ ions reached to
64%. In the presence of P2O7-2 ion as suitable masking agent in the
feed solution, the interfering effects of other cations were eliminated.
Abstract: One of object oriented software developing problem
is the difficulty of searching the appropriate and suitable objects for
starting the system. In this work, ontologies appear in the part of
supporting the object discovering in the initial of object oriented
software developing. There are many researches try to demonstrate
that there is a great potential between object model and ontologies.
Constructing ontology from object model is called ontology
engineering can be done; On the other hand, this research is aiming to
support the idea of building object model from ontology is also
promising and practical. Ontology classes are available online in any
specific areas, which can be searched by semantic search engine.
There are also many helping tools to do so; one of them which are
used in this research is Protégé ontology editor and Visual Paradigm.
To put them together give a great outcome. This research will be
shown how it works efficiently with the real case study by using
ontology classes in travel/tourism domain area. It needs to combine
classes, properties, and relationships from more than two ontologies
in order to generate the object model. In this paper presents a simple
methodology framework which explains the process of discovering
objects. The results show that this framework has great value while
there is possible for expansion. Reusing of existing ontologies offers
a much cheaper alternative than building new ones from scratch.
More ontologies are becoming available on the web, and online
ontologies libraries for storing and indexing ontologies are increasing
in number and demand. Semantic and Ontologies search engines have
also started to appear, to facilitate search and retrieval of online
ontologies.
Abstract: Supercritical carbon dioxide (SC-CO2) was used as a
solvent to extract oil from wheat bran. Extractions were carried out in a
semi-batch process at temperatures ranging from 40 to 60ºC and
pressures ranging from 10 to 30 MPa, with a carbon dioxide (CO2)
flow rate of 26.81 g/min. The oil obtained from wheat bran at different
extraction conditions was quantitatively measured to investigate the
solubility of oil in SC-CO2. The solubility of wheat bran oil was found
to be enhanced in high temperature and pressure. The composition of
fatty acids in wheat bran oil was measured by gas chromatography
(GC). Linoleic, palmitic, oleic and γ-linolenic acid were the major
fatty acids of wheat bran oil. Tocopherol contents in oil were analyzed
by high performance liquid chromatography (HPLC). The highest
amount of phenolics and tocopherols (α and β) were found at
temperature of 60ºC and pressure of 30 MPa.
Abstract: This paper presented the technique of robot control by event-related potentials (ERPs) of brain waves. Based on the proposed technique, severe physical disabilities can free browse outside world. A specific component of ERPs, N2P3, was found and used to control the movement of robot and the view of camera on the designed brain-computer interface (BCI). Users only required watching the stimuli of attended button on the BCI, the evoked potentials of brain waves of the target button, N2P3, had the greatest amplitude among all control buttons. An experimental scene had been constructed that the robot required walking to a specific position and move the view of camera to see the instruction of the mission, and then completed the task. Twelve volunteers participated in this experiment, and experimental results showed that the correct rate of BCI control achieved 80% and the average of execution time was 353 seconds for completing the mission. Four main contributions included in this research: (1) find an efficient component of ERPs, N2P3, for BCI control, (2) embed robot's viewpoint image into user interface for robot control, (3) design an experimental scene and conduct the experiment, and (4) evaluate the performance of the proposed system for assessing the practicability.
Abstract: This paper details few mechanical modeling and
design issues of RF MEMS switches. We concentrate on an
electrostatically actuated broad side series switch; surface
micromachined with a crab leg membrane. The same results are
extended to any complex structure. With available experimental data
and fabrication results, we present the variation in dynamic
performance and compliance of the switch with reference to few
design issues, which we find are critical in deciding the dynamic
behavior of the switch, without compromise on the RF
characteristics. The optimization of pull in voltage, transient time and
resonant frequency with regard to these critical design parameters are
also presented.
Abstract: In this study, an experimental investigation was carried
out to fix CO2 into the electronic arc furnace (EAF) reducing slag from
stainless steelmaking process under wet grinding. The slag was ground
by the vibrating ball mill with the CO2 and pure water. The reaction
behavior was monitored with constant pressure method, and the
change of CO2 volume in the experimental system with grinding time
was measured. It was found that the CO2 absorption occurred as soon
as the grinding started. The CO2 absorption under wet grinding was
significantly larger than that under dry grinding. Generally, the
amount of CO2 absorption increased as the amount of water, the
amount of slag, the diameter of alumina ball and the initial pressure of
CO2 increased. However, the initial absorption rate was scarcely
influenced by the experimental conditions except for the initial CO2
pressure. According to this research, the CO2 reacted with the CaO
inside the slag to form CaCO3.
Abstract: Psoriasis is a widespread skin disease affecting up to 2% population with plaque psoriasis accounting to about 80%. It can be identified as a red lesion and for the higher severity the lesion is usually covered with rough scale. Psoriasis Area Severity Index (PASI) scoring is the gold standard method for measuring psoriasis severity. Scaliness is one of PASI parameter that needs to be quantified in PASI scoring. Surface roughness of lesion can be used as a scaliness feature, since existing scale on lesion surface makes the lesion rougher. The dermatologist usually assesses the severity through their tactile sense, therefore direct contact between doctor and patient is required. The problem is the doctor may not assess the lesion objectively. In this paper, a digital image analysis technique is developed to objectively determine the scaliness of the psoriasis lesion and provide the PASI scaliness score. Psoriasis lesion is modelled by a rough surface. The rough surface is created by superimposing a smooth average (curve) surface with a triangular waveform. For roughness determination, a polynomial surface fitting is used to estimate average surface followed by a subtraction between rough and average surface to give elevation surface (surface deviations). Roughness index is calculated by using average roughness equation to the height map matrix. The roughness algorithm has been tested to 444 lesion models. From roughness validation result, only 6 models can not be accepted (percentage error is greater than 10%). These errors occur due the scanned image quality. Roughness algorithm is validated for roughness measurement on abrasive papers at flat surface. The Pearson-s correlation coefficient of grade value (G) of abrasive paper and Ra is -0.9488, its shows there is a strong relation between G and Ra. The algorithm needs to be improved by surface filtering, especially to overcome a problem with noisy data.
Abstract: This paper attempts to identify the significance of
Information and Communications Technology (ICT) and
competitiveness to the profit efficiency of commercial banks in
Malaysia. The profit efficiency of commercial banks in Malaysia, the
dependent variable, was estimated using the Stochastic Frontier
Approach (SFA) on a sample of unbalanced panel data, covering 23
commercial banks, between 1995 to 2007. Based on the empirical
results, ICT was not found to exert a significant impact on profit
efficiency, whereas competitiveness, non ICT stock expenditure and
ownership were significant contributors. On the other hand, the size
of banks was found to have significantly reduced profit efficiency,
opening up for various interpretations of the interrelated role of ICT
and competition.
Abstract: Microorganisms isolated from water and soil of
Kazakhstan to identify potential high-effective producers of the
arachidonic acid, exhibiting a wide range of physiological activity
and having practical applications were screened. Based on the results
of two independent tests (the test on the sensitivity of the growth
processes of microorganisms to acetylsalicylic acid - an irreversible
inhibitor of PGH-synthase involved in the metabolism of arachidonic
acid and its derivatives, the test for inhibition of peroxidase activity
of membrane-bounding fraction of PGH - synthase by acetylsalicylic
acid) were selected microbial cultures which are potential highproducer
of arachidonic acid. They are characterized by a stable
strong growth in the laboratory conditions. Identification of
microorganism cultures based on morphological, physiological,
biochemical and molecular genetic characteristics was performed.
Abstract: This paper focuses on the calibration problem of a
multi-view shooting system designed for the production of 3D
content for auto-stereoscopic visualization. The considered multiview
camera is characterized by coplanar and decentered image
sensors regarding to the corresponding optical axis. Based on the
Faugéras and Toscani-s calibration approach, a calibration method is
herein proposed for the case of multi-view camera with parallel and
decentered image sensors. At first, the geometrical model of the
shooting system is recalled and some industrial prototypes with some
shooting simulations are presented. Next, the development of the
proposed calibration method is detailed. Finally, some simulation
results are presented before ending with some conclusions about this
work.
Abstract: This interdisciplinary study is an investigation to evaluate user-interfaces in business administration. The study is going to be implemented on two computerized business administration systems with two distinctive user-interfaces, so that differences between the two systems can be determined. Both systems, a commercial and a prototype developed for the purpose of this study, deal with ordering of supplies, tendering procedures, issuing purchase orders, controlling the movement of the stocks against their actual balances on the shelves and editing them on their tabulations. In the second suggested system, modern computer graphics and multimedia issues were taken into consideration to cover the drawbacks of the first system. To highlight differences between the two investigated systems regarding some chosen standard quality criteria, the study employs various statistical techniques and methods to evaluate the users- interaction with both systems. The study variables are divided into two divisions: independent representing the interfaces of the two systems, and dependent embracing efficiency, effectiveness, satisfaction, error rate etc.
Abstract: In this work Membrane Distillation is applied to
concentrate orange Juice. Clarified orange juice (11o Brix) obtained
from fresh fruits and a sugar solution was subjected to membrane
distillation. The experiments were performed on a flat sheet module
using orange juice and sucrose solution as feeds. The concentration
of a sucrose solution, used as a model fruit juice and also orange
juice, was carried out in a direct contact membrane distillation using
hydrophobic PTFE membrane of pore size 0.2 μm and porosity 70%.
Surface modification of PTFE membrane has been carried out by
treating membrane with alcohol and water solution to make it
hydrophilic and then hydrophobicity was regained by drying. The
influences of the feed temperature, feed concentration, flow rate,
operating time on the permeate flux were studied for treated and non
treated membrane. In this work treated and non treated membrane
were compared in terms of water flux, Within the tested range, MD
with surface modified membrane the water flux has been
significantly improved by treating the membrane surface.
Abstract: The heterotrophic seedling growth can be defined as a
product of two components: (1) the weight of mobilized seed reserve,
and (2) conversion efficiency of utilized seed reserve to seedling
tissue. The first component can be further divided into (1) initial seed
weight, and (2) the fraction of seed reserve, which is mobilized. The
objective of this study was the identification of the sensitive seedling
growth component(s) in response to drought and salinity stresses.
Two experiments were separately conducted using various salinity
levels (osmotic pressure) of 0, 0.25, 0.50, 0.75, 1, 1.25 and 1.5 MPa
created using NaCl as first experiment and by polyethylene glycol
(drought stress) of 0, 0.2, 0.4, 0.6, 0.8, 1, 1.2 and 1.4 MPa in second
experiment. Seeds of five crops species (Hordeum vulgare, Brassica
napus, Zea mays, Medicago sativa and Medicago scutellata) were
used in each experiment. In both experiments, seedling growth,
fraction of seed reserve utilization and weight of mobilized seed
reserve decreased with increasing drought and salt intensity.
However, drought and salinity stresses had no effect on the
conversion efficiency. It was concluded that the sensitive component
of seedling growth is the weight of mobilized seed reserve.
Abstract: This paper presents the influence of preloading on a)
the contact tractions, b) slip levels and c) stresses at the dovetail
blade-disc interface of an aero-engine through a three-dimensional
(3D) finite element (FE) modeling and analysis. The preloading is
applied by an interference fit at the dovetail interface and the bulk
loading is applied through the rotational speed of rotor. Preloading at
the dovetail interface reduces the peak contact pressure developed
due to bulk loading up to 35%, and reduces the peak contact pressure
and stress difference between top and bottom contact edges.
Increasing the level of preloading reduces the cyclic stress amplitude
at the interface up to certain values of preload and as a consequence,
an improvement in fatigue life could be expected. Fretting damage,
due to vibration and wind milling effect during engine ground
condition, can be minimized by preloading the dovetail interface.