Abstract: Non-viral gene carriers composed of biodegradable
polymers or lipids have been considered as a safer alternative for gene
carriers over viral vectors. We have developed multi-functional
nano-micelles for both drug and gene delivery application.
Polyethyleneimine (PEI) was modified by grafting stearic acid (SA)
and formulated to polymeric micelles (PEI-SA) with positive surface
charge for gene and drug delivery. Our results showed that PEI-SA
micelles provided high siRNA binding efficiency. In addition, siRNA
delivered by PEI-SA carriers also demonstrated significantly high
cellular uptake even in the presence of serum proteins. The
post-transcriptional gene silencing efficiency was greatly improved by
the polyplex formulated by 10k PEI-SA/siRNA. The amphiphilic
structure of PEI-SA micelles provided advantages for multifunctional
tasks; where the hydrophilic shell modified with cationic charges can
electrostatically interact with DNA or siRNA, and the hydrophobic
core can serve as payloads for hydrophobic drugs, making it a
promising multifunctional vehicle for both genetic and chemotherapy
application.
Abstract: In the recent past Learning Classifier Systems have
been successfully used for data mining. Learning Classifier System
(LCS) is basically a machine learning technique which combines
evolutionary computing, reinforcement learning, supervised or
unsupervised learning and heuristics to produce adaptive systems. A
LCS learns by interacting with an environment from which it
receives feedback in the form of numerical reward. Learning is
achieved by trying to maximize the amount of reward received. All
LCSs models more or less, comprise four main components; a finite
population of condition–action rules, called classifiers; the
performance component, which governs the interaction with the
environment; the credit assignment component, which distributes the
reward received from the environment to the classifiers accountable
for the rewards obtained; the discovery component, which is
responsible for discovering better rules and improving existing ones
through a genetic algorithm. The concatenate of the production rules
in the LCS form the genotype, and therefore the GA should operate
on a population of classifier systems. This approach is known as the
'Pittsburgh' Classifier Systems. Other LCS that perform their GA at
the rule level within a population are known as 'Mitchigan' Classifier
Systems. The most predominant representation of the discovered
knowledge is the standard production rules (PRs) in the form of IF P
THEN D. The PRs, however, are unable to handle exceptions and do
not exhibit variable precision. The Censored Production Rules
(CPRs), an extension of PRs, were proposed by Michalski and
Winston that exhibit variable precision and supports an efficient
mechanism for handling exceptions. A CPR is an augmented
production rule of the form: IF P THEN D UNLESS C, where
Censor C is an exception to the rule. Such rules are employed in
situations, in which conditional statement IF P THEN D holds
frequently and the assertion C holds rarely. By using a rule of this
type we are free to ignore the exception conditions, when the
resources needed to establish its presence are tight or there is simply
no information available as to whether it holds or not. Thus, the IF P
THEN D part of CPR expresses important information, while the
UNLESS C part acts only as a switch and changes the polarity of D
to ~D. In this paper Pittsburgh style LCSs approach is used for
automated discovery of CPRs. An appropriate encoding scheme is
suggested to represent a chromosome consisting of fixed size set of
CPRs. Suitable genetic operators are designed for the set of CPRs
and individual CPRs and also appropriate fitness function is proposed
that incorporates basic constraints on CPR. Experimental results are
presented to demonstrate the performance of the proposed learning
classifier system.
Abstract: In this paper, a new time-delay estimation
technique based on the cross IB-energy operator [5] is
introduced. This quadratic energy detector measures how
much a signal is present in another one. The location of the
peak of the energy operator, corresponding to the maximum of
interaction between the two signals, is the estimate of the
delay. The method is a fully data-driven approach. The
discrete version of the continuous-time form of the cross IBenergy
operator, for its implementation, is presented. The
effectiveness of the proposed method is demonstrated on real
underwater acoustic signals arriving from targets and the
results compared to the cross-correlation method.
Abstract: Human identification at a distance has recently gained
growing interest from computer vision researchers. Gait recognition
aims essentially to address this problem by identifying people based
on the way they walk [1]. Gait recognition has 3 steps. The first step
is preprocessing, the second step is feature extraction and the third
one is classification. This paper focuses on the classification step that
is essential to increase the CCR (Correct Classification Rate).
Multilayer Perceptron (MLP) is used in this work. Neural Networks
imitate the human brain to perform intelligent tasks [3].They can
represent complicated relationships between input and output and
acquire knowledge about these relationships directly from the data
[2]. In this paper we apply MLP NN for 11 views in our database and
compare the CCR values for these views. Experiments are performed
with the NLPR databases, and the effectiveness of the proposed
method for gait recognition is demonstrated.
Abstract: 17α-ethynylestradiol (EE2) is a synthetic estrogen
used as a key ingredient in an oral contraceptives pill. EE2 is an
endocrine disrupting compound, high in estrogenic potency.
Although EE2 exhibits low degree of biodegradability with common
microorganisms in wastewater treatment plants (WWTPs), this
compound can be biotransformed by ammonia-oxidizing bacteria
(AOB) via a co-metabolism mechanism in WWTPs. This study
aimed to investigate the effect of real wastewater on
biotransformation of EE2 by AOB. A preliminary experiment on the
effect of nitrite and pH levels on abiotic transformation of EE2
suggested that the abiotic transformation occurred at only pH
Abstract: Dredged sediment (DS) was utilized as source of
silt-clay and organic matter in artificially prepared eelgrass substrates with mountain sand (MS) as the sand media. Addition of DS showed
improved growth of eelgrass in the mixed substrates. Increase in added
DS up to 15% silt-clay showed increased shoot growth but additional
DS in 20% silt-clay mixture didn-t result to further increase in eelgrass
growth. Improved root establishment were also found for plants in pots
with added DS as shown by the increased resistance to uprooting, increased number of rhizome nodes and longer roots. Results demonstrated that addition of DS may be beneficial to eelgrass up to a
certain extent only and too much of it might be harmful to eelgrass plants.
Abstract: The paper deals with the estimation of amplitude and phase of an analogue multi-harmonic band-limited signal from irregularly spaced sampling values. To this end, assuming the signal fundamental frequency is known in advance (i.e., estimated at an independent stage), a complexity-reduced algorithm for signal reconstruction in time domain is proposed. The reduction in complexity is achieved owing to completely new analytical and summarized expressions that enable a quick estimation at a low numerical error. The proposed algorithm for the calculation of the unknown parameters requires O((2M+1)2) flops, while the straightforward solution of the obtained equations takes O((2M+1)3) flops (M is the number of the harmonic components). It is applied in signal reconstruction, spectral estimation, system identification, as well as in other important signal processing problems. The proposed method of processing can be used for precise RMS measurements (for power and energy) of a periodic signal based on the presented signal reconstruction. The paper investigates the errors related to the signal parameter estimation, and there is a computer simulation that demonstrates the accuracy of these algorithms.
Abstract: The purpose of this paper is to solve the problem of protecting aerial lines from high impedance faults (HIFs) in distribution systems. This investigation successfully applies 3I0 zero sequence current to solve HIF problems. The feature extraction system based on discrete wavelet transform (DWT) and the feature identification technique found on statistical confidence are then applied to discriminate effectively between the HIFs and the switch operations. Based on continuous wavelet transform (CWT) pattern recognition of HIFs is proposed, also. Staged fault testing results demonstrate that the proposed wavelet based algorithm is feasible performance well.
Abstract: This study was carried out in Ankara, the capital city of Turkey, in order to determine how people living in the slums of Ankara benefit from educational equality. Within the scope of the research, interviews were made with 64 families whose children have been getting education from the primary schools of these parts and the data of the study was collected by the researcher. The results of the research demonstrate that the children getting education in the slums of Ankara can not experience educational equality and justice. The results of this study show that the opportunities of the schools in the slums of Ankara are very limited, so the individuals in these districts can not equally benefit from the education. The families are aware of the problem they are faced with. KeywordsDiscrimination, inequality, primary education, slums of Turkey.
Abstract: We study dynamic instability in high-rise steel moment
resisting frames (SMRFs) subjected to synthetic long-period ground
motions caused by hypothetical huge subduction earthquakes. Since
long duration as well as long dominant periods is a characteristic of
long-period ground motions, interstory drifts may enter the negative
postyield stiffness range many times when high-rise buildings are
subjected to long-period ground motions. Through the case studies of
9 high-rise SMRFs designed in accordance with the Japanese design
practice in 1980s, we demonstrate that drifting, or accumulation of
interstory drifts in one direction, occurs at the lower stories of the
SMRFs, if their natural periods are close to the dominant periods of the
long-period ground motions. The drifting led to residual interstory
drift ratio over 0.01, or to collapse if the design base shear was small.
Abstract: There have been different approaches to compute the
analytic instantaneous frequency with a variety of background reasoning
and applicability in practice, as well as restrictions. This paper presents an adaptive Fourier decomposition and (α-counting) based
instantaneous frequency computation approach. The adaptive Fourier
decomposition is a recently proposed new signal decomposition
approach. The instantaneous frequency can be computed through the so called mono-components decomposed by it. Due to the fast energy
convergency, the highest frequency of the signal will be discarded by the adaptive Fourier decomposition, which represents the noise of
the signal in most of the situation. A new instantaneous frequency
definition for a large class of so-called simple waves is also proposed
in this paper. Simple wave contains a wide range of signals for which
the concept instantaneous frequency has a perfect physical sense.
The α-counting instantaneous frequency can be used to compute the highest frequency for a signal. Combination of these two approaches one can obtain the IFs of the whole signal. An experiment is demonstrated the computation procedure with promising results.
Abstract: In this study we investigate silica nanoparticle (SiO2- NP) effects on the structure and phase properties of supported lipid monolayers and bilayers, coupling surface pressure measurements, fluorescence microscopy and atomic force microscopy. SiO2-NPs typically in size range of 10nm to 100 nm in diameter are tested. Our results suggest first that lipid molecules organization depends to their nature. Secondly, lipid molecules in the vinicity of big aggregates nanoparticles organize in liquid condensed phase whereas small aggregates are localized in both fluid liquid-expanded (LE) and liquid-condenced (LC). We demonstrated also by atomic force microscopy that by measuring friction forces it is possible to get information as if nanoparticle aggregates are recovered or not by lipid monolayers and bilayers.
Abstract: Buildings and associated construction methods have a significant impact on the environment. As construction activity increases in Kuwait, there is a need to create design and construction strategies which will minimize the environmental impact of new buildings. Green construction is a design philosophy intended to improve the sustainability of construction by the minimization of resource depletion and CO2 emissions throughout the life cycle of buildings. This paper presents and discusses the results of a survey that was conducted in Kuwait, with the objective of investigating the awareness of developers and other stakeholders regarding their understanding and use of green construction strategies. The results of the survey demonstrate that whilst there seems to be a reasonable level of awareness amongst the stakeholders, this awareness is not currently well reflected in the design and construction practices actually being applied. It is therefore concluded is there is a pressing need for intervention from Government in order that the use of sustainable green design and construction strategies becomes the norm in Kuwait.
Abstract: The electromagnetic imaging of inhomogeneous
dielectric cylinders buried in a slab medium by transverse electric
(TE) wave illumination is investigated. Dielectric cylinders of
unknown permittivities are buried in second space and scattered a
group of unrelated waves incident from first space where the scattered
field is recorded. By proper arrangement of the various unrelated
incident fields, the difficulties of ill-posedness and nonlinearity are
circumvented, and the permittivity distribution can be reconstructed
through simple matrix operations. The algorithm is based on the
moment method and the unrelated illumination method. Numerical
results are given to demonstrate the capability of the inverse
algorithm. Good reconstruction is obtained even in the presence of
additive Gaussian random noise in measured data. In addition, the
effect of noise on the reconstruction result is also investigated.
Abstract: In a product development process, understanding the functional behavior of the system, the role of components in achieving functions and failure modes if components/subsystem fails its required function will help develop appropriate design validation and verification program for reliability assessment. The integration of these three issues will help design and reliability engineers in identifying weak spots in design and planning future actions and testing program. This case study demonstrate the advantage of unascertained theory described in the subjective cognition uncertainty, and then applies blind number (BN) theory in describing the uncertainty of the mechanical system failure process and the same time used the same theory in bringing out another mechanical reliability system model. The practical calculations shows the BN Model embodied the characters of simply, small account of calculation but betterforecasting capability, which had the value of macroscopic discussion to some extent.
Abstract: In this paper, we have developed a method to
compute fractal dimension (FD) of discrete time signals, in the
time domain, by modifying the box-counting method. The size
of the box is dependent on the sampling frequency of the
signal. The number of boxes required to completely cover the
signal are obtained at multiple time resolutions. The time
resolutions are made coarse by decimating the signal. The loglog
plot of total number of boxes required to cover the curve
versus size of the box used appears to be a straight line, whose
slope is taken as an estimate of FD of the signal. The results
are provided to demonstrate the performance of the proposed
method using parametric fractal signals. The estimation
accuracy of the method is compared with that of Katz, Sevcik,
and Higuchi methods. In addition, some properties of the FD
are discussed.
Abstract: This paper demonstrates an effort of a serviceoriented
engineering department in improving the sharing and
transfer of knowledge. Although the department consist of only six
employees, but it provides services in various chemical application in
an oil and gas business. The services provided span across Asia
Pacific region mainly Indonesia, Myanmar, Vietnam, Brunei,
Thailand and Singapore. Currently there are no effective tools or
integrated systems that support the sharing or transfer and
maintenance of knowledge so the department has considered
preserving this valuable knowledge by developing a Knowledge
Management System (KMS). This paper presents the development of
a KMS to support the sharing of knowledge in a service-oriented
engineering department of an oil and gas company. The embedded
features in the KMS like blog and forum will encourage iterative
process of knowledge sharing among the employees in the
department. The information and knowledge being shared, discussed
and communicated will be then achieved for future re-use. The re-use
of the knowledge allows the department to reduce redundant efforts
in providing consistent, up-to-date and cost effective of the best
solution to the its clients.
Abstract: This study examines the issue of recommendation
sources from the perspectives of gender and consumers- perceived
risk, and validates a model for the antecedents of consumer online
purchases. The method of obtaining quantitative data was that of the
instrument of a survey questionnaire. Data were collected via
questionnaires from 396 undergraduate students aged 18-24, and a
multiple regression analysis was conducted to identify causal
relationships. Empirical findings established the link between
recommendation sources (word-of-mouth, advertising, and
recommendation systems) and the likelihood of making online
purchases and demonstrated the role of gender and perceived risk as
moderators in this context. The results showed that the effects of
word-of-mouth on online purchase intentions were stronger than those
of advertising and recommendation systems. In addition, female
consumers have less experience with online purchases, so they may be
more likely than males to refer to recommendations during the
decision-making process. The findings of the study will help
marketers to address the recommendation factor which influences
consumers- intention to purchase and to improve firm performances to
meet consumer needs.
Abstract: The purpose of this paper is to elucidate the flow unsteady behavior for moving plug in convergent-divergent variable thrust nozzle. Compressible axisymmetric Navier-Stokes equations are used to study this physical phenomenon. Different velocities are set for plug to investigate the effect of plug movement on flow unsteadiness. Variation of mass flow rate and thrust are compared under two conditions: First, the plug is placed at different positions and flow is simulated to reach the steady state (quasi steady simulation) and second, the plug is moved with assigned velocity and flow simulation is coupled with plug movement (unsteady simulation). If plug speed is high enough and its movement time scale is at the same order of the flow time scale, variation of the mass flow rate and thrust level versus plug position demonstrate a vital discrepancy under the quasi steady and unsteady conditions. This phenomenon should be considered especially from response time viewpoints in thrusters design.
Abstract: The purpose of this paper is to demonstrate the ability
of a genetic programming (GP) algorithm to evolve a team of data
classification models. The GP algorithm used in this work is
“multigene" in nature, i.e. there are multiple tree structures (genes)
that are used to represent team members. Each team member assigns
a data sample to one of a fixed set of output classes. A majority vote,
determined using the mode (highest occurrence) of classes predicted
by the individual genes, is used to determine the final class
prediction. The algorithm is tested on a binary classification problem.
For the case study investigated, compact classification models are
obtained with comparable accuracy to alternative approaches.