Abstract: To ensure targeting of apoferritin nanocarrier with
encapsulated doxorubicin drug, we used a peptide linker based on a
protein G with N-terminus affinity towards Fc region of antibodies.
To connect the peptide to the surface of apoferritin, the C-terminus of
peptide was made of cysteine with affinity to gold. The surface of
apoferritin with encapsulated doxorubicin (APODOX) was coated
either with gold nanoparticles (APODOX-Nano) or gold(III) chloride
hydrate reduced with sodium borohydride (APODOX-HAu). The
reduction with sodium borohydride caused a loss of doxorubicin
fluorescent properties and probably accompanied with the loss of its
biological activity. Fluorescent properties of APODOX-Nano were
similar to the unmodified APODOX; therefore it was more suited for
the intended use. To evaluate the specificity of apoferritin modified
with antibodies, ELISA-like method was used with the surface of
microtitration plate wells coated by the antigen (goat anti-human IgG
antibodies). To these wells, the nanocarrier was applied. APODOX
without the modification showed 5× lower affinity to the antigen than
APODOX-Nano modified gold and targeting antibodies (human IgG
antibodies).
Abstract: Current research is targeting new molecular
mechanisms that underlie non-alcoholic fatty liver disease (NAFLD)
and associated metabolic disorders like non-alcoholic steatohepatitis
(NASH). Forty New Zealand White rabbits have been used and fed a
high protein (HP) and energy diet based on grains and containing
11.76 MJ/kg. Boron added to 3 experimental groups’ drinking waters
(30 mg boron/L) as boron compounds. Biochemical analysis
including boron levels, and nuclear magnetic resonance (NMR) based
metabolomics evaluation, and mRNA expression of peroxisome
proliferator-activated receptor (PPAR) family was performed. LDLcholesterol
concentrations alone were decreased in all the
experimental groups. Boron levels in serum and feces were increased.
Content of acetate was in about 2x higher for anhydrous borax group,
at least 3x higher for boric acid group. PPARα mRNA expression
was significantly decreased in boric acid group. Anhydrous borax
attenuated mRNA levels of PPARγ, which was further suppressed by
boric acid. Boron supplementation decreased the degenerative
alterations in hepatocytes. Except borax group other boron groups did
not have a pronounced change in tubular epithels of kidney. In
conclusion, high protein and energy diet leads hepatocytes’
degenerative changes which can be prevented by boron
supplementation. Boric acid seems to be more effective in this
situation.
Abstract: Image segmentation and edge detection is a fundamental section in image processing. In case of noisy images Edge Detection is very less effective if we use conventional Spatial Filters like Sobel, Prewitt, LOG, Laplacian etc. To overcome this problem we have proposed the use of Stochastic Gradient Mask instead of Spatial Filters for generating gradient images. The present study has shown that the resultant images obtained by applying Stochastic Gradient Masks appear to be much clearer and sharper as per Edge detection is considered.
Abstract: In the present research work we present the optical
emission studies of the Indium (In) – Tin (Sn) plasma produced by
the first (1064 nm) harmonic of an Nd: YAG nanosecond pulsed
laser. The experimentally observed line profiles of neutral Indium (In
I) and Tin (SnI) are used to extract the electron temperature (Te)
using the Boltzmann plot method. Whereas, the electron number
density (Ne) has been determined from the Stark broadening line
profile method. The Te is calculated by varying the distance from the
target surface along the line of propagation of plasma plume and also
by varying the laser irradiance. Beside we have studied the variation
of Ne as a function of laser irradiance as well as its variation with
distance from the target surface.
Abstract: Development of new generation bio-tribological,
multilayer coatings opens an avenue for fabrication of future hightech
functional surfaces. In the presented work, nano-composite,
Cr/CrN+[Cr/ a-C:H implanted by metallic nanocrystals] multilayer
coatings have been developed for surface protection of medical tools.
Thin films were fabricated by a hybrid Pulsed Laser Deposition
technique. Complex microstructure analysis of nanomultilayer
coatings, subjected to mechanical and biological tests, were
performed by means of transmission electron microscopy (TEM).
Microstructure characterization revealed the layered arrangement of
Cr23C6 nanoparticles in multilayer structure. Influence of deposition
conditions on bio-tribological properties of the coatings was studied.
The bio-tests were used as a screening tool for the analyzed
nanomultilayer coatings before they could be deposited on medical
tools. Bio-medical tests were done using fibroblasts. The mechanical
properties of the coatings were investigated by means of a ball-ondisc
mechanical test. The micro hardness was done using Berkovich
indenter. The scratch adhesion test was done using Rockwell
indenter. From the bio-tribological point of view, the optimal
properties had the C106_1 material.
Abstract: In this paper, the dependence of soliton pulses with
respect to phase in a 10Gbps, single channel, dispersion
uncompensated telecommunication system was studied. The
characteristic feature of periodic soliton interaction was noted at the
Interaction point (I=6202.5Km) in one collision length of L=12405.1
Km. The interaction point is located for 10Gbps system with an
initial relative spacing (qo) of soliton as 5.28 using Perturbation
theory. It is shown that, when two in-phase solitons are launched,
they interact at the point I=6202.5 Km, but the interaction could be
restricted with introduction of different phase initially. When the
phase of the input solitons increases, the deviation of soliton pulses at
the ‘I’ also increases. We have successfully demonstrated this effect
in a telecommunication set-up in terms of Quality factor (Q), where
the Q=0 for in-phase soliton. The Q was noted to be 125.9, 38.63,
47.53, 59.60, 161.37, and 78.04 for different phases such as 10o, 20o,
30o, 45o, 60o and 90o degrees respectively at Interaction point (I).
Abstract: Community integration is a construct that an
increasing body of research has shown to have a significant impact
on the wellbeing and recovery of people with psychiatric problems.
However, there are few studies that explore which factors can be
associated and predict community integration. Moreover, community
integration has been mostly studied in minority groups, and current
literature on the definition and manifestation of community
integration in the general population is scarcer. Thus, the current
study aims to characterize community integration and explore
possible predictor variables in a sample of participants with
psychiatric problems (PP, N=183) and a sample of participants from
the general population (GP, N=211).
Results show that people with psychiatric problems present above
average values of community integration, but are significantly lower
than their healthy counterparts. It was also possible to observe that
community integration does not vary in terms of the sociodemographic
characteristics of both groups in this study. Correlation
and multiple regression showed that, among several variables that
literature present as relevant in the community integration process,
only three variables emerged as having the most explanatory value in
community integration of both groups: sense of community, basic
needs satisfaction and submission. These results also shown that
those variables have increased explanatory power in the PP sample,
which leads us to emphasize the need to address this issue in future
studies and increase the understanding of the factors that can be
involved in the promotion of community integration, in order to
devise more effective interventions in this field.
Abstract: The substantial development of the construction
industry has forced the cement industry, its major support, to focus
on achieving maximum productivity to meet the growing demand for
this material. This means that the reliability of a cement production
system needs to be at the highest level that can be achieved by good
maintenance. This paper studies the extent to which the
implementation of RCM is needed as a strategy for increasing the
reliability of the production systems component can be increased,
thus ensuring continuous productivity. In a case study of four Libyan
cement factories, 80 employees were surveyed and 12 top and middle
managers interviewed. It is evident that these factories usually
breakdown more often than once per month which has led to a
decline in productivity. In many times they cannot achieve the
minimum level of production amount. This has resulted from the
poor reliability of their production systems as a result of poor or
insufficient maintenance. It has been found that most of the factories’
employees misunderstand maintenance and its importance. The main
cause of this problem is the lack of qualified and trained staff, but in
addition it has been found that most employees are not found to be
motivated as a result of a lack of management support and interest. In
response to these findings, it has been suggested that the RCM
strategy should be implemented in the four factories. The results
show the importance of the development of maintenance strategies
through the implementation of RCM in these factories. The purpose
of it would be to overcome the problems that could secure the
reliability of the production systems. This study could be a useful
source of information for academic researchers and the industrial
organizations which are still experiencing problems in maintenance
practices.
Abstract: Microbes have been used to solve environmental
problems for many years. The role of microorganism to sequester,
precipitate or alter the oxidation state of various heavy metals has
been extensively studied. Treatment using microorganism interacts
with toxic metal are very diverse. The purpose of this research is to
remove the mercury using Pseudomonas putida (P. putida), pure
culture ATTC 49128 at optimum growth parameters such as
techniques of culture, acclimatization time and speed of incubator
shaker. Thus, in this study, the optimum growth parameters of P.
putida were obtained to achieve the maximum of mercury removal.
Based on the optimum parameters of P. putida for specific growth
rate, the removal of two different mercury concentration, 1 ppm and
4 ppm were studied. From mercury nitrate solution, a mercuryresistant
bacterial strain which is able to reduce from ionic mercury
to metallic mercury was used to reduce ionic mercury. The overall
levels of mercury removal in this study were between 80% and 89%.
The information obtained in this study is of fundamental for
understanding of the survival of P. putida ATTC 49128 in mercury
solution. Thus, microbial mercury removal is a potential
bioremediation for wastewater especially in petrochemical industries
in Malaysia.
Abstract: Five palm oil ether monoesters utilized as novel
biodiesels were synthesized and structurally identified in the paper.
The investigation was made on the effect of ether species on
physicochemical properties of the palm oil ether monoesters. The
results showed that density, kinematic viscosity, smoke point, and
solidifying point increase linearly with their –CH2 group number in
certain relationships. Cetane number is enhanced whereas heat value
decreases linearly with –CH2 group number. In addition, the
influencing regularities of the volumetric content of the palm oil ether
monoesters on the fuel properties were also studied when the ether
monoesters are used as diesel fuel additives.
Abstract: New design of three dimensional (3D) flywheel system
based on gimbal and gyro mechanics is proposed. The 3D flywheel
device utilizes the rotational motion of three spherical shells and the
conservation of angular momentum to achieve planar locomotion.
Actuators mounted to the ring-shape frames are installed within the
system to drive the spherical shells to rotate, for the purpose of steering
and stabilization. Similar to the design of 2D flywheel system, it is
expected that the spherical shells may function like a “flyball” to store
and supply mechanical energy; additionally, in comparison with
typical single-wheel and spherical robots, the 3D flywheel can be used
for developing omnidirectional robotic systems with better mobility.
The Lagrangian method is applied to derive the equation of motion of
the 3D flywheel system, and simulation studies are presented to verify
the proposed design.
Abstract: Pneumatic reactors have been widely employed in various sectors of the chemical industry, especially where are required high heat and mass transfer rates. This study aimed to obtain correlations that allow the prediction of gas hold-up (Ԑ) and volumetric oxygen transfer coefficient (kLa), and compare these values, for three models of pneumatic reactors on two scales utilizing Newtonian fluids. Values of kLa were obtained using the dynamic pressure-step method, while e was used for a new proposed measure. Comparing the three models of reactors studied, it was observed that the mass transfer was superior to draft-tube airlift, reaching e of 0.173 and kLa of 0.00904s-1. All correlations showed good fit to the experimental data (R2≥94%), and comparisons with correlations from the literature demonstrate the need for further similar studies due to shortage of data available, mainly for airlift reactors and high viscosity fluids.
Abstract: The effect of partially substitution of magnetic
impurity Fe for Cu to the magnetic and transport properties in
electron-doped superconducting cuprates of
Eu1.85+yCe0.15-yCu1-yFeyO4+α-δ (ECCFO) with y = 0, 0.010, 0.020, and
0.050 has been studied, in order to investigate the mechanism of
magnetic and transport properties of ECCFO in normal-state.
Magnetic properties are investigated by DC magnetic-susceptibility
measurements that carried out at low temperatures down to 2 K using a
standard SQUID magnetometer in a magnetic field of 5 Oe on field
cooling. Transport properties addressed to electron mobility, are
extracted from radius of electron localization calculated from
temperature dependence of resistivity. For y = 0, temperature
dependence of dc magnetic-susceptibility (χ) indicated the change of
magnetic behavior from paramagnetic to diamagnetic below 15 K.
Above 15 K, all samples show paramagnetic behavior with the values
of magnetic moment in every volume unit increased with increasing y.
Electron mobility decreased with increasing y.
Abstract: Some plants of genus Schinus have been used in the
folk medicine as topical antiseptic, digestive, purgative, diuretic,
analgesic or antidepressant, and also for respiratory and urinary
infections. Chemical composition of essential oils of S. molle and S.
terebinthifolius had been evaluated and presented high variability
according with the part of the plant studied and with the geographic
and climatic regions. The pharmacological properties, namely
antimicrobial, anti-tumoural and anti-inflammatory activities are
conditioned by chemical composition of essential oils. Taking into
account the difficulty to infer the pharmacological properties of
Schinus essential oils without hard experimental approach, this work
will focus on the development of a decision support system, in terms
of its knowledge representation and reasoning procedures, under a
formal framework based on Logic Programming, complemented with
an approach to computing centered on Artificial Neural Networks
and the respective Degree-of-Confidence that one has on such an
occurrence.
Abstract: Any variation in environmental characteristics of
geomorphosites would lead to destabilisation of their geotouristic
values all around the planet. The Urmia lake, with an area of
approximately 5,500 km2 and a catchment area of 51,876 km2, and to
which various reasons over time, especially in the last fifty years
have seen a sharp decline and have decreased by about 93 % in two
recent decades. These variations are not only driving significant
changes in the morphology and ecology of the present lake
landscape, but at the same time are shaping newly formed
morphologies, which vanished some valuable geomorphosites or
develop into smaller geomorphosites with significant value from a
scientific and cultural point of view. This paper analyses and
discusses features and evolution in several representative coastal and
island geomorphosites. For this purpose, a total of 23 geomorphosites
were studied in two data series (1963 and 2015) and the respective
data were compared and analysed. The results showed, the total loss
in geomorphosites area in a half century amounted to a loss of more
than 90% of the valuable geomorphosites. Moreover, the comparison
between the mean yearly value of coastal area lost over the entire
period and the yearly average calculated for the shorter period (1998-
2014) clearly indicates a pattern of acceleration. This acceleration in
the rate of reduction in lake area was seen in most of the southern
half of the lake. In the region as well, the general water-level falling
is not only causing the loss of a significant water resource, which is
followed by major impact on regional ecosystems, but is also driving
the most marked recent (last century) changes in the geotouristic
landscapes. In fact, the disappearance of geomorphosites means the
loss of tourism phenomenon. In this context attention must be paid to
the question of conservation. The action needed to safeguard
geomorphosites includes: 1) Preventive action, 2) Corrective action,
and 3) Sharing knowledge.
Abstract: Electrodeposition is a simple and economic technique
for precision coating of different shaped substrates with pure metal,
alloy or composite films. Dc electrodeposition was used to produce
Cr, Co-Cr and Co-Cr/TiO2 nano-composite coatings from Cr(III)
based electrolytes onto 316L SS substrates. The effects of TiO2 nanoparticles
concentration on co-deposition of these particles along with
Cr content and microhardness of the coatings were investigated.
Morphology of the Cr, Co-Cr and Co-Cr/TiO2 coatings besides their
tribological behavior were studied. The results showed that increment
of TiO2 nanoparticles concentration from 0 to 30 g L-1 in the bath
increased their co-deposition and Cr content of the coatings from 0 to
3.5 wt.% and from 23.7 to 31.2 wt.%, respectively. Microhardness of
Cr coating was about 920 Hv which was higher than Co-Cr and even
Co-Cr/TiO2 films. Microhardness of Co-Cr and Co-Cr/TiO2 coatings
were improved by increasing their Cr and TiO2 content. All the
coatings had nodular morphology and contained microcracks.
Nodules sizes and the number of microcracks in the alloy and
composite coatings were lower than the Cr film. Wear results
revealed that the Co-Cr/TiO2 coating had the lowest wear loss
between all the samples, while the Cr film had the worst wear
resistance.
Abstract: In this paper, a summary of analytical and
experimental studies into the behavior of a new hysteretic damper,
designed for seismic protection of structures is presented. The Multidirectional
Torsional Hysteretic Damper (MRSD) is a patented
invention in which a symmetrical arrangement of identical cylindrical
steel cores is so configured as to yield in torsion while the structure
experiences planar movements due to earthquake shakings. The new
device has certain desirable properties. Notably, it is characterized by
a variable and controllable-via-design post-elastic stiffness. The
mentioned property is a result of MRSD’s kinematic configuration
which produces this geometric hardening, rather than being a
secondary large-displacement effect. Additionally, the new system is
capable of reaching high force and displacement capacities, shows
high levels of damping, and very stable cyclic response. The device
has gone through many stages of design refinement, multiple
prototype verification tests and development of design guide-lines
and computer codes to facilitate its implementation in practice.
Practicality of the new device, as offspring of an academic sphere, is
assured through extensive collaboration with industry in its final
design stages, prototyping and verification test programs.
Abstract: Auditory hallucinations among the most invalidating
and distressing experiences reported by patients diagnosed with
schizophrenia, leading to feelings of powerlessness and helplessness
towards their illness. In more severe cases, these auditory
hallucinations can take the form of commanding voices, which are
often related to high suicidality rates in these patients. Several
authors propose that the meanings attributed to the hallucinatory
experience, rather than characteristics like form and content, can be
determinant in patients’ reactions to hallucinatory activity,
particularly in the case of voice-hearing experiences. In this study, 48
patients diagnosed with paranoid schizophrenia presenting auditory
hallucinations were studied. Multiple regression analyses were
computed to study the influence of several developmental aspects,
such as family and social dynamics, bullying, depression, and sociocognitive
variables on the auditory hallucinations, on patients’
attributions and relationships with their voices, and on the resulting
invalidation of hallucinatory experience. Overall, results showed how
relationships with voices can mirror several aspects of interpersonal
relationship with others, and how self-schemas, depression and actual
social relationships help shaping the voice-hearing experience. Early
experiences of victimization and submission help predict the
attributions of omnipotence of the voices, and increased hostility
from parents seems to increase the malevolence of the voices,
suggesting that socio-cognitive factors can significantly contribute to
the etiology and maintenance of auditory hallucinations. The
understanding of the characteristics of auditory hallucinations and the
relationships patients established with their voices can allow the
development of more promising therapeutic interventions that can be
more effective in decreasing invalidation caused by this devastating
mental illness.
Abstract: The chemical and physical characteristics of rainwater
harvested from a typical rooftop were progressively studied. The
samples of rainwater collected were analyzed for pH, major ion
concentrations, TDS, turbidity, conductivity. All the Physicochemical
constituents fell within the WHO guideline limits at some points as
rainfall progresses except the pH. All the components of rainwater
quality measured during the study showed higher concentrations
during the early stages of rainfall and reduce as time progresses.
There was a downward trend in terms of pH as rain progressed, with
18% of the samples recording pH below the WHO limit of 6.5-8.0. It
was observed that iron concentration was above the WHO threshold
value of 0.3 mg/l on occasions of heavy rains. The results revealed
that most of physicochemical characteristics of rainwater samples
were generally below the WHO threshold, as such, the rainwater
characteristics showed satisfactory conditions in terms of
physicochemical constituents.
Abstract: In order to use bitumen in hot mix asphalt, it must
have specific characteristics. There are some methods to reach these
properties. Using polymer modifiers are one of the methods to
modify the bitumen properties. In this paper the effect of Styrene-
Butadiene-Rubber that is one of the bitumen polymer modifiers on
rheology properties of bitumen is studied. In this regard, the
rheological properties of base bitumen and the modified bitumen with
3, 4, and 5 percent of Styrene-Butadiene-Rubber (SBR) were
analysed. The results show that bitumen modified with 5 percent of
SBR has the best performance than the other samples.