Abstract: Sense-antisense gene pair (SAGP) is a pair of two oppositely transcribed genes sharing a common region on a chromosome. In the mammalian genomes, SAGPs can be organized in more complex sense-antisense gene architectures (CSAGA) in which at least one gene could share loci with two or more antisense partners. Many dozens of CSAGAs can be found in the human genome. However, CSAGAs have not been systematically identified and characterized in context of their role in human diseases including cancers. In this work we characterize the structural-functional properties of a cluster of 5 genes –TMEM97, IFT20, TNFAIP1, POLDIP2 and TMEM199, termed TNFAIP1 / POLDIP2 module. This cluster is organized as CSAGA in cytoband 17q11.2. Affymetrix U133A&B expression data of two large cohorts (410 atients, in total) of breast cancer patients and patient survival data were used. For the both studied cohorts, we demonstrate (i) strong and reproducible transcriptional co-regulatory patterns of genes of TNFAIP1/POLDIP2 module in breast cancer cell subtypes and (ii) significant associations of TNFAIP1/POLDIP2 CSAGA with amplification of the CSAGA region in breast cancer, (ii) cancer aggressiveness (e.g. genetic grades) and (iv) disease free patient-s survival. Moreover, gene pairs of this module demonstrate strong synergetic effect in the prognosis of time of breast cancer relapse. We suggest that TNFAIP1/ POLDIP2 cluster can be considered as a novel type of structural-functional gene modules in the human genome.
Abstract: Turbulence modeling of large-scale flow over a vegetated surface is complex. Such problems involve large scale computational domains, while the characteristics of flow near the surface are also involved. In modeling large scale flow, surface roughness including vegetation is generally taken into account by mean of roughness parameters in the modified law of the wall. However, the turbulence structure within the canopy region cannot be captured with this method, another method which applies source/sink terms to model plant drag can be used. These models have been developed and tested intensively but with a simple surface geometry. This paper aims to compare the use of roughness parameter, and additional source/sink terms in modeling the effect of plant drag on wind flow over a complex vegetated surface. The RNG k-ε turbulence model with the non-equilibrium wall function was tested with both cases. In addition, the k-ω turbulence model, which is claimed to be computationally stable, was also investigated with the source/sink terms. All numerical results were compared to the experimental results obtained at the study site Mason Bay, Stewart Island, New Zealand. In the near-surface region, it is found that the results obtained by using the source/sink term are more accurate than those using roughness parameters. The k-ω turbulence model with source/sink term is more appropriate as it is more accurate and more computationally stable than the RNG k-ε turbulence model. At higher region, there is no significant difference amongst the results obtained from all simulations.
Abstract: This paper examines the readability of the chairman’s narratives, as determined by the Flesch score, of a Malaysian public listed company’s corporate reports from 1962 to 2009. It partially supports earlier studies which demonstrated that corporate reports were difficult to read, and had shown very negligible decrease in difficulty over time. Net profit to sales and readability was significantly positively correlated but number of financial statements was significantly negatively correlated with readability.
Abstract: Recently, majors of doctors are divided into terribly lots of detailed areas. However, it is actually not a rare case that a doctor has a patient who is not in his/her major. He/She must judge an assessment and make a medical treatment plan for this patient. According to our investigation, conventional approaches such as image diagnosis cooperation are insufficient. This paper proposes an 'Assessment / Medical Treatment Plan Consulting System'. We have implemented a pilot system based on our proposition. Its effectiveness is clarified by an evaluation.
Abstract: This paper is a simple and systematic approaches to the design and analysis a pulse width modulation (PWM) based sliding mode controller for buck DC-DC Converters. Various aspects of the design, including the practical problems and the proposed solutions, are detailed. However, these control strategies can't compensate for large load current and input voltage variations. In this paper, a new control strategy by compromising both schemes advantages and avoiding their drawbacks is proposed, analyzed and simulated.
Abstract: In this paper, a method based on Non-Dominated
Sorting Genetic Algorithm (NSGA) has been presented for the Volt /
Var control in power distribution systems with dispersed generation
(DG). Genetic algorithm approach is used due to its broad
applicability, ease of use and high accuracy. The proposed method is
better suited for volt/var control problems. A multi-objective
optimization problem has been formulated for the volt/var control of
the distribution system. The non-dominated sorting genetic algorithm
based method proposed in this paper, alleviates the problem of tuning
the weighting factors required in solving the multi-objective volt/var
control optimization problems. Based on the simulation studies
carried out on the distribution system, the proposed scheme has been
found to be simple, accurate and easy to apply to solve the multiobjective
volt/var control optimization problem of the distribution
system with dispersed generation.
Abstract: This study is aimed to investigate feasibility of the
aerobic biological process to treat oily wastewater from palm oil food
industry. Effect of aeration and sludge concentrations are studied.
Raw sludge and raw wastewater was mixed and acclimatized for five
days in a stirred tank reactor. The aeration rate (no aeration, low;
1.5L/min and high rate; 2L/min) and sludge concentration (3675,
7350, and 11025mg/L of VSS) were varied. Responses of process
were pH, COD, oil and grease, VSS, and PHB content. It was found
that the treatment can remove 85.1 to 97.1 % of COD and remove
12.9 to 54.8% of oil & grease. The PHB yield was found to be within
0.15% to 2.4% as PHB/VSS ratio and 0.01% to 0.12% as PHB/COD
removed. The higher aeration results a high COD removal and oil &
grease removal, while experiment without aeration gives better PHB
yield. Higher sludge concentrations (11025mg/L VSS) give higher
removal of oil & grease while moderate sludge concentration
(7350mg/L VSS) give better result in COD removal. Higher PHB
yield is obtained in low sludge concentration (3675mg/L).
Abstract: Even it has been recognized that Shape Memory
Alloys (SMA) have a significant potential for deployment actuators,
the number of applications of SMA-based actuators to the present
day is still quite small, due to the need of deep understanding of the
thermo-mechanical behavior of SMA, causing an important need for
a mathematical model able to describe all thermo-mechanical
properties of SMA by relatively simple final set of constitutive
equations. SMAs offer attractive potentials such as: reversible strains
of several percent, generation of high recovery stresses and high
power / weight ratios. The paper tries to provide an overview of the
shape memory functions and a presentation of the designed and
developed temperature control system used for a gripper actuated by
two pairs of differential SMA active springs. An experimental setup
was established, using electrical energy for actuator-s springs heating
process. As for holding the temperature of the SMA springs at certain
level for a long time was developed a control system in order to
avoid the active elements overheating.
Abstract: A climate dependent model is proposed to simulate
the population of Aedes aegypti mosquito. In developing the model,
average temperature of Shah Alam, Malaysia was used to determine
the development rate of each stage of the life cycle of mosquito.
Rainfall dependent function was proposed to simulate the hatching
rate of the eggs under several assumptions. The proposed transition
matrix was obtained and used to simulate the population of eggs,
larvae, pupae and adults mosquito. It was found that the peak of
mosquito abundance comes during a relatively dry period following a
heavy rainfall. In addition, lag time between the peaks of mosquito
abundance and dengue fever cases in Shah Alam was estimated.
Abstract: Lignocellulosic materials are considered the most
abundant renewable resource available for the Bioethanol
Production. Water Hyacinth is one of potential raw material of the
world-s worst aquatic plant as a feedstock to produce Bioethanol.
The purposed this research is obtain reduced of matter for
biodegradation lignin in Biological pretreatment with White Rot
Fungi eg. Phanerochaete Chrysosporium using Solid state
Fermentation methods. Phanerochaete Chrysosporium is known to
have the best ability to degraded lignin, but simultaneously it can also
degraded cellulose and hemicelulose. During 8 weeks incubation,
water hyacinth occurred loss of weight reached 34,67%, while loss
of lignin reached 67,21%, loss of cellulose reached 11,01% and loss
of hemicellulose reached 36,56%. The kinetic of losses lignin using
regression linear plot, the results is obtained constant rate (k) of
reduction lignin is -0.1053 and the equation of reduction of lignin
is y = wo - 0, 1.53 x
Abstract: In this paper the complete rotor system including
elastic shaft with distributed mass, allowing for the effects of oil film
in bearings. Also, flexibility of foundation is modeled. As a whole
this article is a relatively complete research in modeling and
vibration analysis of rotor considering gyroscopic effect, damping,
dependency of stiffness and damping coefficients on frequency and
solving the vibration equations including these parameters. On the
basis of finite element method and utilizing four element types
including element of shaft, disk, bearing and foundation and using
MATLAB, a computer program is written. So the responses in
several cases and considering different effects are obtained. Then the
results are compared with each other, with exact solutions and results
of other papers.
Abstract: In this investigation, anatase TiO2 thin films were
grown by radio frequency magnetron sputtering on glass substrates at
a high sputtering pressure and room temperature. The anatase films
were then annealed at 300-600 °C in air for a period of 1 hour. To
examine the structure and morphology of the films, X-ray diffraction
(XRD) and atomic force microscopy (AFM) methods were used
respectively. From X-ray diffraction patterns of the TiO2 films, it was
found that the as-deposited film showed some differences compared
with the annealed films and the intensities of the peaks of the
crystalline phase increased with the increase of annealing
temperature. From AFM images, the distinct variations in the
morphology of the thin films were also observed. The optical
constants were characterized using the transmission spectra of the
films obtained by UV-VIS-IR spectrophotometer. Besides, optical
thickness of the film deposited at room temperature was calculated
and cross-checked by taking a cross-sectional image through SEM.
The optical band gaps were evaluated through Tauc model. It was
observed that TiO2 films produced at room temperatures exhibited
high visible transmittance and transmittance decreased slightly with
the increase of annealing temperatures. The films were found to be
crystalline having anatase phase. The refractive index of the films
was found from 2.31-2.35 in the visible range. The extinction
coefficient was nearly zero in the visible range and was found to
increase with annealing temperature. The allowed indirect optical
band gap of the films was estimated to be in the range from 3.39 to
3.42 eV which showed a small variation. The allowed direct band
gap was found to increase from 3.67 to 3.72 eV. The porosity was
also found to decrease at a higher annealing temperature making the
film compact and dense.
Abstract: In recent years, copulas have become very popular in
financial research and actuarial science as they are more flexible in
modelling the co-movements and relationships of risk factors as compared
to the conventional linear correlation coefficient by Pearson.
However, a precise estimation of the copula parameters is vital in
order to correctly capture the (possibly nonlinear) dependence structure
and joint tail events. In this study, we employ two optimization
heuristics, namely Differential Evolution and Threshold Accepting to
tackle the parameter estimation of multivariate t distribution models
in the EML approach. Since the evolutionary optimizer does not rely
on gradient search, the EML approach can be applied to estimation of
more complicated copula models such as high-dimensional copulas.
Our experimental study shows that the proposed method provides
more robust and more accurate estimates as compared to the IFM
approach.
Abstract: This experiment was conducted in attempt of
improving hydrodynamic efficiency of the propulsion mechanism by
installing a spring to the wing so that the opening angle of the wing in
one stroke can be changed automatically, compared to the existing
method of fixed maximum opening angle in Weis-Fogh type ship
propulsion mechanism. Average thrust coefficient was almost fixed
with all velocity ratio with the prototype, but with the spring type,
thrust coefficient increased sharply as velocity ratio increased.
Average propulsive efficiency was larger with bigger opening angle in
the prototype, but in the spring type, the one with smaller spring
coefficient had larger value. In the range over 1.0 in velocity ratio
where big thrust can be generated, spring type had more than twice of
propulsive efficiency increase compared to the prototype.
Abstract: This paper presents the theoretical investigation of a
slotted patch antenna. The main objective of proposed work is to
obtain a large bandwidth antenna with reduced size. The antenna has
a compact size of 21.1mm x 20.25mm x 8.5mm. Two designs with
minor variation are studied which provide wide impedance
bandwidths of 24.056% and 25.63% respectively with the use of
parasitic elements when excited by a probe feed. The advantages of
this configuration are its compact size and the wide range of
frequencies covered. A parametric study is also conducted to
investigate the characteristics of the antenna under different
conditions. The measured return loss and radiation pattern indicate
the suitability of this design for WLAN applications, namely, Wi-
Max, 802.11a/b/g and ISM bands.
Abstract: The present study was designed to demonstrate the seasonal variations in physico-chemical parameters of fish farm at Govt. Nursery Unit, Muzaffargarh, Department of Fisheries Govt. of Punjab, Pakistan for a period of eight months from January to August 2008. Water samples were collected on fifteen days basis and have been analyzed for estimation of Air temperature, Water temperature, Light penetration, pH, Total dissolved oxygen, Clouds, Carbonates, Bicarbonates, Total carbonates, Total dissolved solids, Chlorides, Calcium and Hardness. Seasonal fluctuations were observed in all the physico-chemical parameters of fish farm. The overall physicochemical parameters of fish pond water remained within the tolerable range throughout the study period.
Abstract: Because of the global warming and the rising sea level, residents living in southwestern coastland, Taiwan are faced with the submerged land and may move to higher elevation area. It is desirable to discuss the key consideration factor for selecting the migration location under five dimensions of ಯ security”, “health”, “convenience”, “comfort” and “socio-economic” based on the document reviews. This paper uses the Structural Equation Modeling (SEM) and the questionnaire survey. The analysis results show that the convenience is the most key factor for residents in Taiwan.
Abstract: In this paper, we present a technical and an economic
assessment of several sources of renewable energy in Saudi Arabia;
mainly solar, wind, hydro and biomass. We analyze the
environmental and climatic conditions in relation to these sources
and give an overview of some of the existing clean energy
technologies. Using standardized cost and efficiency data, we carry
out a cost benefit analysis to understand the economic factors
influencing the sustainability of energy production from renewable
sources in light of the energy cost and demand in the Saudi market.
Finally, we take a look at the Saudi petroleum industry and the
existing sources of conventional energy and assess the potential of
building a successful market for renewable energy under the
constraints imposed by the flow of subsidized cheap oil. We show
that while some renewable energy resources are well suited for
distributed or grid connected generation in the kingdom, their
viability is greatly undercut by the well developed and well
capitalized oil industry.
Abstract: This study experimentally and numerically investigates
motor cooling performance. The motor consists of a centrifugal fan,
two axial fans, a shaft, a stator, a rotor and a heat exchanger with 637
cooling tubes. The pressure rise-flow rate (P-Q) performance curves of
the cooling fans at 1800 rpm are tested using a test apparatus
complying with the Chinese National Standard (CNS) 2726.
Compared with the experimental measurements, the numerical
analysis results show that the P-Q performance curves of the axial fan
and centrifugal fan can be estimated within about 2% and 6%,
respectively. By using the simplified model, setting up the heat
exchanger and stator as porous media, the flow field in the motor is
calculated. By using the results of the flow field near the rotor and
stator, and subjecting the heat generation rate as a boundary condition,
the temperature distributions of the stator and rotor are also calculated.
The simulation results show that the calculated temperature of the
stator winding near the axial fans is lower by about 5% than the
measured value, and the calculated temperature of the stator core
located at the center of the stator is about 1% higher than the measured
value. Besides, discussion is made to improve the motor cooling
performance.
Abstract: Using 1km grid datasets representing monthly mean
precipitation, monthly mean temperature, and dry matter production
(DMP), we considered the regional plant production ability in
Southeast and South Asia, and also employed pixel-by-pixel
correlation analysis to assess the intensity of relation between climate
factors and plant production. While annual DMP in South Asia was
approximately less than 2,000kg, the one in most part of Southeast
Asia exceeded 2,500 - 3,000kg. It suggested that plant production in
Southeast Asia was superior to South Asia, however, Rain-Use
Efficiency (RUE) representing dry matter production per 1mm
precipitation showed that inland of Indochina Peninsula and India
were higher than islands in Southeast Asia. By the results of
correlation analysis between climate factors and DMP, while the area
in most parts of Indochina Peninsula indicated negative correlation
coefficients between DMP and precipitation or temperature, the area
in Malay Peninsula and islands showed negative correlation to
precipitation and positive one to temperature, and most part of India
dominating South Asia showed positive to precipitation and negative
to temperature. In addition, the areas where the correlation coefficients
exceeded |0.8| were regarded as “susceptible" to climate factors, and
the areas smaller than |0.2| were “insusceptible". By following the
discrimination, the map implying expected impacts by climate change
was provided.