Abstract: Bioinformatics and Cheminformatics use computer as disciplines providing tools for acquisition, storage, processing, analysis, integrate data and for the development of potential applications of biological and chemical data. A chemical database is one of the databases that exclusively designed to store chemical information. NMRShiftDB is one of the main databases that used to represent the chemical structures in 2D or 3D structures. SMILES format is one of many ways to write a chemical structure in a linear format. In this study we extracted Antimicrobial Structures in SMILES format from NMRShiftDB and stored it in our Local Data Warehouse with its corresponding information. Additionally, we developed a searching tool that would response to user-s query using the JME Editor tool that allows user to draw or edit molecules and converts the drawn structure into SMILES format. We applied Quick Search algorithm to search for Antimicrobial Structures in our Local Data Ware House.
Abstract: The current trend of increasing quality and demands
of the final product is affected by time analysis of the entire
manufacturing process. The primary requirement of manufacturing is
to produce as many products as soon as possible, at the lowest
possible cost, but of course with the highest quality. Such
requirements may be satisfied only if all the elements entering and
affecting the production cycle are in a fully functional condition.
These elements consist of sensory equipment and intelligent control
elements that are essential for building intelligent manufacturing
systems. The intelligent manufacturing paradigm includes a new
approach to production system structure design. Intelligent behaviors
are based on the monitoring of important parameters of system and
its environment. The flexible reaction to changes. The realization and
utilization of this design paradigm as an "intelligent manufacturing
system" enables the flexible system reaction to production
requirement as soon as environmental changes too. Results of these
flexible reactions are a smaller layout space, be decreasing of
production and investment costs and be increasing of productivity.
Intelligent manufacturing system itself should be a system that can
flexibly respond to changes in entering and exiting the process in
interaction with the surroundings.
Abstract: A Picard-Newton iteration method is studied to accelerate the numerical solution procedure of a class of two-dimensional nonlinear coupled parabolic-hyperbolic system. The Picard-Newton iteration is designed by adding higher-order terms of small quantity to an existing Picard iteration. The discrete functional analysis and inductive hypothesis reasoning techniques are used to overcome difficulties coming from nonlinearity and coupling, and theoretical analysis is made for the convergence and approximation properties of the iteration scheme. The Picard-Newton iteration has a quadratic convergent ratio, and its solution has second order spatial approximation and first order temporal approximation to the exact solution of the original problem. Numerical tests verify the results of the theoretical analysis, and show the Picard-Newton iteration is more efficient than the Picard iteration.
Abstract: Nowadays, a passenger car suspension must has high
performance criteria with light weight, low cost, and low energy
consumption. Pilot controlled proportional valve is designed and
analyzed to get small pressure change rate after blow-off, and to get a
fast response of the damper, a reverse damping mechanism is adapted.
The reverse continuous variable damper is designed as a HS-SH
damper which offers good body control with reduced transferred input
force from the tire, compared with any other type of suspension
system. The damper structure is designed, so that rebound and
compression damping forces can be tuned independently, of which the
variable valve is placed externally. The rate of pressure change with
respect to the flow rate after blow-off becomes smooth when the fixed
orifice size increases, which means that the blow-off slope is
controllable using the fixed orifice size. Damping forces are measured
with the change of the solenoid current at the different piston
velocities to confirm the maximum hysteresis of 20 N, linearity, and
variance of damping force. The damping force variance is wide and
continuous, and is controlled by the spool opening, of which scheme is
usually adapted in proportional valves. The reverse continuous
variable damper developed in this study is expected to be utilized in
the semi-active suspension systems in passenger cars after its
performance and simplicity of the design is confirmed through a real
car test.
Abstract: One of the most growing areas in the embedded community is multimedia devices. Multimedia devices incorporate a number of complicated functions for their operation, like motion estimation. A multitude of different implementations have been proposed to reduce motion estimation complexity, such as spiral search. We have studied the implementations of spiral search and identified areas of improvement. We propose a modified spiral search algorithm, with lower computational complexity compared to the original spiral search. We have implemented our algorithm on an embedded ARM based architecture, with custom memory hierarchy. The resulting system yields energy consumption reduction up to 64% and performance increase up to 77%, with a small penalty of 2.3 dB, in average, of video quality compared with the original spiral search algorithm.
Abstract: This paper compares the recent transformerless ACDC
power converter architectures and provides an assessment of
each. A prototype of one of the transformerless AC-DC converter
architecture is also presented depicting the feasibility of a small form
factor, power supply design. In this paper component selection
guidelines to achieve high efficiency AC-DC power conversion are
also discussed.
Abstract: This research focuses on micro-enterprise of
Malaysian Malays that are involved in very small-scaled business
activities. Among them include food stall and burger stall operators,
night market hawkers, grocery store operators as well as construction
and small service activities works. The study seeks to explore why
some micro-entrepreneurs still lag in entrepreneurship and what
needs to be rectified. This quantitative study is conducted on 173
Malay micro-enterprise owners (MEOs) and 58 Malay failed microenterprise
owners (FMEOs) involved in all range of businesses
throughout the state of Perak, Malaysia. The main aims are to
identify the gaps between the failed micro-enterprise owners
(FMEOs) and existing micro-enterprise owners (MEOs) and the
problems faced among FMEOs. The results reveal that the MEOs had
strong motivations and better marketing approaches as compared to
FMEOs. Furthermore, the FMEOs failed in the business ventures
mainly due to lack of management, sales and marketing skills and
poor competitive abilities to keep up with rivals.
Abstract: Staphylococcus aureus, one of the microflora in a
human external auditory canal (EAC) is frequently exposed to highfrequency
electromagnetic field (HF-EMF) generated by mobile
phones. It is normally non-pathogenic but in certain circumstances, it
can cause infections. This study investigates the changes in the
physiology of S. aureus when exposed to HF-EMF of a mobile
phone. Exponentially grown S. aureus were exposed to two
conditions of EMF irradiation (standby-mode and on-call mode) at
four durations; 15, 30, 45 and 60 min. Changes in the viability and
biofilm production of the S. aureus were compared between the two
conditions of exposure. EMF from the standby-mode has enhanced
the growth of S. aureus but during on-call, the growth was
suppressed. No significant difference in the amount of biofilm
produced in both modes of exposure was observed. Thus, HF-EMF
of mobile phone affects the viability of S. aureus but not its ability to
produce biofilm.
Abstract: The paper shows how the CASMAS modeling language,
and its associated pervasive computing architecture, can be
used to facilitate continuity of care by providing members of patientcentered
communities of care with a support to cooperation and
knowledge sharing through the usage of electronic documents and
digital devices. We consider a scenario of clearly fragmented care to
show how proper mechanisms can be defined to facilitate a better
integration of practices and information across heterogeneous care
networks. The scenario is declined in terms of architectural components
and cooperation-oriented mechanisms that make the support
reactive to the evolution of the context where these communities
operate.
Abstract: Heat pipes are two-phase heat transfer devices with
high effective thermal conductivity. Due to the high heat transport
capacity, heat exchanger with heat pipes has become much smaller
than traditional heat exchangers in handling high heat fluxes. With
the working fluid in a heat pipe, heat can be absorbed on the
evaporator region and transported to the condenser region where the
vapour condenses releasing the heat to the cooling media. Heat pipe
technology has found increasing applications in enhancing the
thermal performance of heat exchangers in microelectranics, energy
saving in HVAC systems for operating rooms,surgery centers, hotels,
cleanrooms etc, temperature regulation systems for the human body
and other industrial sectors. Development activity in heat pipe and
thermosyphon technology in asia in recent years is surveyed. Some
new results obtained in Australia and other countries are also
included.
Abstract: Time interleaved sigma-delta (TIΣΔ) architecture is a
potential candidate for high bandwidth analog to digital converters
(ADC) which remains a bottleneck for software and cognitive radio
receivers. However, the performance of the TIΣΔ architecture is
limited by the unavoidable gain and offset mismatches resulting
from the manufacturing process. This paper presents a novel digital
calibration method to compensate the gain and offset mismatch
effect. The proposed method takes advantage of the reconstruction
digital signal processing on each channel and requires only few logic
components for implementation. The run time calibration is estimated
to 10 and 15 clock cycles for offset cancellation and gain mismatch
calibration respectively.
Abstract: This paper discusses the investigation of a wearable
textile monopole antenna on specific absorption rate (SAR) for bodycentric
wireless communication applications at 2.45 GHz. The
antenna is characterized on a realistic 8 x 8 x 8 mm3 resolution
truncated Hugo body model in CST Microwave Studio software. The
result exhibited that the simulated SAR values were reduced
significantly by 83.5% as the position of textile monopole was
varying between 0 mm and 15 mm away from the human upper arm.
A power absorption reduction of 52.2% was also noticed as the
distance of textile monopole increased.
Abstract: Small-scale RC models of both piles and tunnel ducts
were produced as mockups of reality and loaded under soil
confinement conditionsto investigate the damage evolution of
structural RC interacting with soil. Experimental verifications usinga
3D nonlinear FE analysis program called COM3D, which was
developed at the University of Tokyo, are introduced. This analysis
has been used in practice for seismic performance assessment of
underground ducts and in-ground LNG storage tanks in consideration
of soil-structure interactionunder static and dynamic loading. Varying
modes of failure of RCpilessubjected to different magnitudes of soil
confinement were successfully reproduced in the proposed small-scale
experiments and numerically simulated as well. Analytical simulation
was applied to RC tunnel mockups under a wide variety of depth and
soil confinement conditions, and reasonable matching was confirmed.
Abstract: We report a novel fusion tag for expressing
recombinant proteins in E. coli. The fusion tag is the C-terminus part
of the human GMCSF gene comprising 45 amino acids, which aid in
over expression of otherwise non expressible genes. Expression of
hIFN a2b with this fusion tag also escapes the requirement of rare
codons for expression. This is also a first report of a small fusion tag
of human origin having affinity to heparin sepharose column
facilitating the purification of fusion protein.
Abstract: Computer network courses are essential parts of college computer science curriculum and hands-on networking experience is well recognized as an effective approach to help students understand better about the network concepts, the layered architecture of network protocols, and the dynamics of the networks. However, existing networking labs are usually server-based and relatively cumbersome, which require a certain level of specialty and resource to set up and maintain the lab environment. Many universities/colleges lack the resources and build-ups in this field and have difficulty to provide students with hands-on practice labs. A new affordable and easily-adoptable approach to networking labs is desirable to enhance network teaching and learning. In addition, current network labs are short on providing hands-on practice for modern wireless and mobile network learning. With the prevalence of smart mobile devices, wireless and mobile network are permeating into various aspects of our information society. The emerging and modern mobile technology provides computer science students with more authentic learning experience opportunities especially in network learning. A mobile device based hands-on labware can provide an excellent ‘real world’ authentic learning environment for computer network especially for wireless network study. In this paper, we present our mobile device-based hands-on labware (series of lab module) for computer network learning which is guided by authentic learning principles to immerse students in a real world relevant learning environment. We have been using this labware in teaching computer network, mobile security, and wireless network classes. The student feedback shows that students can learn more when they have hands-on authentic learning experience.
Abstract: Wheat has a bimodal starch granule population and the dependency of the rate of enzymatic hydrolysis on particle size has been investigated. Ungelatinised wheaten starch granules were separated into two populations by sedimentation and decantation. Particle size was analysed by laser diffraction and morphological characteristics were viewed using SEM. The sedimentation technique though lengthy, gave satisfactory separation of the granules. Samples (10μm and original) were digested with a-amylase using a dialysis model. Granules of 10μm (p10μm. Moreover, the digestion rate was dependent on particle size whereby smaller granules produced higher rate of release. The methodology and results reported here can be used as a basis for further evaluations designed to delay the release of glucose during the digestion of native starches.
Abstract: Among many different methods that are used for
optimizing different engineering problems mathematical (numerical)
optimization techniques are very important because they can easily
be used and are consistent with most of engineering problems. Many
studies and researches are done on stability analysis of three
dimensional (3D) slopes and the relating probable slip surfaces and
determination of factors of safety, but in most of them force
equilibrium equations, as in simplified 2D methods, are considered
only in two directions. In other words for decreasing mathematical
calculations and also for simplifying purposes the force equilibrium
equation in 3rd direction is omitted. This point is considered in just a
few numbers of previous studies and most of them have only given a
factor of safety and they haven-t made enough effort to find the most
probable slip surface. In this study shapes of the slip surfaces are
modeled, and safety factors are calculated considering the force
equilibrium equations in all three directions, and also the moment
equilibrium equation is satisfied in the slip direction, and using
nonlinear programming techniques the shape of the most probable
slip surface is determined. The model which is used in this study is a
3D model that is composed of three upper surfaces which can cover
all defined and probable slip surfaces. In this research the meshing
process is done in a way that all elements are prismatic with
quadrilateral cross sections, and the safety factor is defined on this
quadrilateral surface in the base of the element which is a part of the
whole slip surface. The method that is used in this study to find the
most probable slip surface is the non-linear programming method in
which the objective function that must get optimized is the factor of
safety that is a function of the soil properties and the coordinates of
the nodes on the probable slip surface. The main reason for using
non-linear programming method in this research is its quick
convergence to the desired responses. The final results show a good
compatibility with the previously used classical and 2D methods and
also show a reasonable convergence speed.
Abstract: In this paper, algorithms for the automatic localisation
of two anatomical soft tissue landmarks of the head the medial
canthus (inner corner of the eye) and the tragus (a small, pointed,
cartilaginous flap of the ear), in CT images are describet. These
landmarks are to be used as a basis for an automated image-to-patient
registration system we are developing. The landmarks are localised
on a surface model extracted from CT images, based on surface
curvature and a rule based system that incorporates prior knowledge
of the landmark characteristics. The approach was tested on a dataset
of near isotropic CT images of 95 patients. The position of the
automatically localised landmarks was compared to the position of
the manually localised landmarks. The average difference was 1.5
mm and 0.8 mm for the medial canthus and tragus, with a maximum
difference of 4.5 mm and 2.6 mm respectively.The medial canthus
and tragus can be automatically localised in CT images, with
performance comparable to manual localisation
Abstract: Dichotomization of the outcome by a single cut-off point is an important part of various medical studies. Usually the relationship between the resulted dichotomized dependent variable and explanatory variables is analyzed with linear regression, probit regression or logistic regression. However, in many real-life situations, a certain cut-off point dividing the outcome into two groups is unknown and can be specified only approximately, i.e. surrounded by some (small) uncertainty. It means that in order to have any practical meaning the regression model must be robust to this uncertainty. In this paper, we show that neither the beta in the linear regression model, nor its significance level is robust to the small variations in the dichotomization cut-off point. As an alternative robust approach to the problem of uncertain medical categories, we propose to use the linear regression model with the fuzzy membership function as a dependent variable. This fuzzy membership function denotes to what degree the value of the underlying (continuous) outcome falls below or above the dichotomization cut-off point. In the paper, we demonstrate that the linear regression model of the fuzzy dependent variable can be insensitive against the uncertainty in the cut-off point location. In the paper we present the modeling results from the real study of low hemoglobin levels in infants. We systematically test the robustness of the binomial regression model and the linear regression model with the fuzzy dependent variable by changing the boundary for the category Anemia and show that the behavior of the latter model persists over a quite wide interval.
Abstract: A stack with a small critical temperature gradient is
desirable for a standing wave thermoacoustic engine to obtain a low
onset temperature difference (the minimum temperature difference to
start engine-s self-oscillation). The viscous and heat relaxation loss in
the stack determines the critical temperature gradient. In this work, a
dimensionless critical temperature gradient factor is obtained based
on the linear thermoacoustic theory. It is indicated that the
impedance determines the proportion between the viscous loss, heat
relaxation losses and the power production from the heat energy. It
reveals the effects of the channel dimensions, geometrical
configuration and the local acoustic impedance on the critical
temperature gradient in stacks. The numerical analysis shows that
there exists a possible optimum combination of these parameters
which leads to the lowest critical temperature gradient. Furthermore,
several different geometries have been tested and compared
numerically.