Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) method with fluorescent detector (FLD) was developed and optimized for Norfloxacin determination in human plasma. Mobile phase specifications, extraction method and excitation and emission wavelengths were varied for optimization. HPLC system contained a reverse phase C18 (5 μm, 4.6 mm×150 mm) column with FLD operated at excitation 330 nm and emission 440 nm. The optimized mobile phase consisted of 14% acetonitrile in buffer solution. The aqueous phase was prepared by mixing 2g of citric acid, 2g sodium acetate and 1 ml of triethylamine in 1 L of Milli-Q water was run at a flow rate of 1.2 mL/min. The standard curve was linear for the range tested (0.156–20 μg/mL) and the coefficient of determination was 0.9978. Aceclofenac sodium was used as internal standard. A detection limit of 0.078 μg/mL was achieved. Run time was set at 10 minutes because retention time of norfloxacin was 0.99 min. which shows the rapidness of this method of analysis. The present assay showed good accuracy, precision and sensitivity for Norfloxacin determination in human plasma with a new internal standard and can be applied pharmacokinetic evaluation of Norfloxacin tablets after oral administration in human.
Abstract: Over the years, there is a growing trend towards
quality-based specifications in highway construction. In many
Quality Control/Quality Assurance (QC/QA) specifications, the
contractor is primarily responsible for quality control of the process,
whereas the highway agency is responsible for testing the acceptance
of the product. A cooperative investigation was conducted in Illinois
over several years to develop a prototype End-Result Specification
(ERS) for asphalt pavement construction. The final characteristics of
the product are stipulated in the ERS and the contractor is given
considerable freedom in achieving those characteristics. The risk for
the contractor or agency depends on how the acceptance limits and
processes are specified. Stochastic simulation models are very useful
in estimating and analyzing payment risk in ERS systems and these
form an integral part of the Illinois-s prototype ERS system. This
paper describes the development of an innovative methodology to
estimate the variability components in in-situ density, air voids and
asphalt content data from ERS projects. The information gained from
this would be crucial in simulating these ERS projects for estimation
and analysis of payment risks associated with asphalt pavement
construction. However, these methods require at least two parties to
conduct tests on all the split samples obtained according to the
sampling scheme prescribed in present ERS implemented in Illinois.
Abstract: A robust control approach is proposed for a high speed manipulator using a hybrid computed torque control approach in the state space. The high-speed manipulator is driven by permanent magnet dc motors to track a trajectory in the joint space in the presence of disturbances. Tracking problem is analyzed in the state space where the completed models are considered for actuators. The proposed control approach can guarantee the stability and a satisfactory tracking performance. A two-link elbow manipulator driven by electrical actuators is simulated and results are shown to satisfy conditions under technical specifications.
Abstract: In this paper, an optimal design of linear phase digital
high pass finite impulse response (FIR) filter using Particle Swarm
Optimization with Constriction Factor and Inertia Weight Approach
(PSO-CFIWA) has been presented. In the design process, the filter
length, pass band and stop band frequencies, feasible pass band and
stop band ripple sizes are specified. FIR filter design is a multi-modal
optimization problem. The conventional gradient based optimization
techniques are not efficient for digital filter design. Given the filter
specifications to be realized, the PSO-CFIWA algorithm generates a
set of optimal filter coefficients and tries to meet the ideal frequency
response characteristic. In this paper, for the given problem, the
designs of the optimal FIR high pass filters of different orders have
been performed. The simulation results have been compared to those
obtained by the well accepted algorithms such as Parks and
McClellan algorithm (PM), genetic algorithm (GA). The results
justify that the proposed optimal filter design approach using PSOCFIWA
outperforms PM and GA, not only in the accuracy of the
designed filter but also in the convergence speed and solution
quality.
Abstract: Microstrip lines, widely used for good reason, are
broadband in frequency and provide circuits that are compact and
light in weight. They are generally economical to produce since they
are readily adaptable to hybrid and monolithic integrated circuit (IC)
fabrication technologies at RF and microwave frequencies. Although,
the existing EM simulation models used for the synthesis and
analysis of microstrip lines are reasonably accurate, they are
computationally intensive and time consuming. Neural networks
recently gained attention as fast and flexible vehicles to microwave
modeling, simulation and optimization. After learning and
abstracting from microwave data, through a process called training,
neural network models are used during microwave design to provide
instant answers to the task learned.This paper presents simple and
accurate ANN models for the synthesis and analysis of Microstrip
lines to more accurately compute the characteristic parameters and
the physical dimensions respectively for the required design
specifications.
Abstract: An application framework provides a reusable design
and implementation for a family of software systems. Application
developers extend the framework to build their particular
applications using hooks. Hooks are the places identified to show
how to use and customize the framework. Hooks define Framework
Interface Classes (FICs) and their possible specifications, which
helps in building reusable test cases for the implementations of these
classes. In applications developed using gray-box frameworks, FICs
inherit framework classes or use them without inheritance. In this
paper, a test-case generation technique is extended to build test cases
for FICs built for gray-box frameworks. A tool is developed to
automate the introduced technique.
Abstract: This paper proposes a Fuzzy Expert System design to
determine the wearing properties of nitrided and non nitrided steel.
The proposed Fuzzy Expert System approach helps the user and the
manufacturer to forecast the wearing properties of nitrided and non
nitrided steel under specified laboratory conditions. Surfaces of the
engineering components are often nitrided for improving wear,
corosion, fatigue specifications. A major property of nitriding
process is reducing distortion and wearing of the metalic alloys. A
Fuzzy Expert System was developed for determining the wearing and
durability properties of nitrided and non nitrided steels that were
tested under different loads and different sliding speeds in the
laboratory conditions.
Abstract: Carbon steel is used in boilers, pressure vessels, heat
exchangers, piping, structural elements and other moderatetemperature
service systems in which good strength and ductility are
desired. ASME Boiler and Pressure Vessel Code, Section II Part A
(2004) provides specifications of ferrous materials for construction of
pressure equipment, covering wide range of mechanical properties
including high strength materials for power plants application.
However, increased level of springback is one of the major problems
in fabricating components of high strength steel using bending.
Presented work discuss the springback simulations for five different
steels (i.e. SA-36, SA-299, SA-515 grade 70, SA-612 and SA-724
grade B) using finite element analysis of air V-bending. Analytical
springback simulations of hypothetical layered materials are
presented. Result shows that; (i) combination of the material property
parameters controls the springback, (ii) layer of the high ductility
steel on the high strength steel greatly suppresses the springback.
Abstract: This paper studies the optimum design for reducing
optical loss of an 8x8 mechanical type optical switch due to the
temperature change. The 8x8 optical switch is composed of a base, 8
input fibers, 8 output fibers, 3 fixed mirrors and 17 movable mirrors.
First, an innovative switch configuration is proposed with
thermal-compensated design. Most mechanical type optical switches
have a disadvantage that their precision and accuracy are influenced
by the ambient temperature. Therefore, the thermal-compensated
design is to deal with this situation by using materials with different
thermal expansion coefficients (α). Second, a parametric modeling
program is developed to generate solid models for finite element
analysis, and the thermal and structural behaviors of the switch are
analyzed. Finally, an integrated optimum design program, combining
Autodesk Inventor Professional software, finite element analysis
software, and genetic algorithms, is developed for improving the
thermal behaviors that the optical loss of the switch is reduced. By
changing design parameters of the switch in the integrated design
program, the final optimum design that satisfies the design constraints
and specifications can be found.
Abstract: Nowadays due to globalization of economy and
competition environment, innovation and technology plays key role
at creation of wealth and economic growth of countries. In fact
prompt growth of practical and technologic knowledge may results in
social benefits for countries when changes into effective innovation.
Considering the importance of innovation for the development of
countries, this study addresses the radical technological innovation
introduced by nanopapers at different stages of producing paper
including stock preparation, using authorized additives, fillers and
pigments, using retention, calender, stages of producing conductive
paper, porous nanopaper and Layer by layer self-assembly. Research
results show that in coming years the jungle related products will lose
considerable portion of their market share, unless embracing radical
innovation. Although incremental innovations can make this industry
still competitive in mid-term, but to have economic growth and
competitive advantage in long term, radical innovations are
necessary. Radical innovations can lead to new products and
materials which their applications in packaging industry can produce
value added. However application of nanotechnology in this industry
can be costly, it can be done in cooperation with other industries to
make the maximum use of nanotechnology possible. Therefore this
technology can be used in all the production process resulting in the
mass production of simple and flexible papers with low cost and
special properties such as facility at shape, form, easy transportation,
light weight, recovery and recycle marketing abilities, and sealing.
Improving the resistance of the packaging materials without reducing
the performance of packaging materials enhances the quality and the
value added of packaging. Improving the cellulose at nano scale can
have considerable electron optical and magnetic effects leading to
improvement in packaging and value added. Comparing to the
specifications of thermoplastic products and ordinary papers,
nanopapers show much better performance in terms of effective
mechanical indexes such as the modulus of elasticity, tensile strength,
and strain-stress. In densities lower than 640 kgm -3, due to the
network structure of nanofibers and the balanced and randomized
distribution of NFC in flat space, these specifications will even
improve more. For nanopapers, strains are 1,4Gpa, 84Mpa and 17%,
13,3 Gpa, 214Mpa and 10% respectively. In layer by layer self
assembly method (LbL) the tensile strength of nanopaper with Tio3
particles and Sio2 and halloysite clay nanotube are 30,4 ±7.6Nm/g
and 13,6 ±0.8Nm/g and 14±0.3,3Nm/g respectively that fall within
acceptable range of similar samples with virgin fiber. The usage of
improved brightness and porosity index in nanopapers can create
more competitive advantages at packaging industry.
Abstract: This paper discusses a systematic design of a Σ-Δ fractional-N Phase-Locked Loop based on HDL behavioral modeling. The proposed design consists in describing the mixed behavior of this PLL architecture starting from the specifications of each building block. The HDL models of critical PLL blocks have been described in VHDL-AMS to predict the different specifications of the PLL. The effect of different noise sources has been efficiently introduced to study the PLL system performances. The obtained results are compared with transistor-level simulations to validate the effectiveness of the proposed models for wireless applications in the frequency range around 2.45 GHz.
Abstract: Machining is an important manufacturing process used to produce a wide variety of metallic parts. Among various machining processes, turning is one of the most important one which is employed to shape cylindrical parts. In turning, the quality of finished product is measured in terms of surface roughness. In turn, surface quality is determined by machining parameters and tool geometry specifications. The main objective of this study is to simultaneously model and optimize machining parameters and tool geometry in order to improve the surface roughness for AISI1045 steel. Several levels of machining parameters and tool geometry specifications are considered as input parameters. The surface roughness is selected as process output measure of performance. A Taguchi approach is employed to gather experimental data. Then, based on signal-to-noise (S/N) ratio, the best sets of cutting parameters and tool geometry specifications have been determined. Using these parameters values, the surface roughness of AISI1045 steel parts may be minimized. Experimental results are provided to illustrate the effectiveness of the proposed approach.
Abstract: Studying alternative raw materials for biodiesel production is of major importance. The use of mixtures with incorporation of wastes is an environmental friendly alternative and might reduce biodiesel production costs. The objective of the present work was: (i) to study biodiesel production using waste frying oil mixed with pork lard and (ii) to understand how mixture composition influences biodiesel quality. Biodiesel was produced by transesterification and quality was evaluated through determination of several parameters according to EN 14214. The weight fraction of lard in the mixture varied from 0 to 1 in 0.2 intervals. Biodiesel production yields varied from 81.7 to 88.0 (wt%), the lowest yields being the ones obtained using waste frying oil and lard alone as raw materials. The obtained products fulfilled most of the determined quality specifications according to European biodiesel quality standard EN 14214. Minimum purity (96.5 wt%) was closely obtained when waste frying oil was used alone and when 0.2% of lard was incorporated in the raw material (96.3 wt%); however, it ranged from 93.9 to 96.3 (wt%) being always close to the limit. From the evaluation of the influence of mixture composition in biodiesel quality, it was possible to establish a model to be used for predicting some parameters of biodiesel resulting from mixtures of waste frying oil with lard when different lard contents are used.
Abstract: The theatre-auditorium under investigation following
the highly reflective characteristics of materials used in it (marble,
painted wood, smooth plaster, etc), architectural and structural
features of the Protocol and its intended use (very multifunctional:
Auditorium, theatre, cinema, musicals, conference room) from the
analysis of the statement of fact made by the acoustic simulation
software Ramsete and supported by data obtained through a
campaign of acoustic measurements of the state of fact made on the
spot by a Fonomet Svantek model SVAN 957, appears to be
acoustically inadequate. After the completion of the 3D model
according to the specifications necessary software used forecast in
order to be recognized by him, have made three simulations, acoustic
simulation of the state of and acoustic simulation of two design
solutions.
Improved noise characteristics found in the first design solution,
compared to the state in fact consists therefore in lowering
Reverberation Time that you turn most desirable value, while the
Indicators of Clarity, the Baricentric Time, the Lateral Efficiency,
Ratio of Low Tmedia BR and defined the Speech Intelligibility
improved significantly. Improved noise characteristics found instead
in the second design solution, as compared to first design solution, is
finally mostly in a more uniform distribution of Leq and in lowering
Reverberation Time that you turn the optimum values. Indicators of
Clarity, and the Lateral Efficiency improve further but at the expense
of a value slightly worse than the BR. Slightly vary the remaining
indices.
Abstract: Discovery schools in Jordan are connected in one flat
ATM bridge network. All Schools connected to the network will hear
broadcast traffic. High percentage of unwanted traffic such as
broadcast, consumes the bandwidth between schools and QRC.
Routers in QRC have high CPU utilization. The number of
connections on the router is very high, and may exceed recommend
manufacturing specifications. One way to minimize number of
connections to the routers in QRC, and minimize broadcast traffic is
to use PPPoE. In this study, a PPPoE solution has been presented
which shows high performance for the clients when accessing the
school server resources. Despite the large number of the discovery
schools at MoE, the experimental results show that the PPPoE
solution is able to yield a satisfactory performance for each client at
the school and noticeably reduce the traffic broadcast to the QRC.
Abstract: Formal Specification languages are being widely used
for system specification and testing. Highly critical systems such as
real time systems, avionics, and medical systems are represented
using Formal specification languages. Formal specifications based
testing is mostly performed using black box testing approaches thus
testing only the set of inputs and outputs of the system. The formal
specification language such as VDMµ can be used for white box
testing as they provide enough constructs as any other high level
programming language. In this work, we perform data and control
flow analysis of VDMµ class specifications. The proposed work is
discussed with an example of SavingAccount.
Abstract: An application framework provides a reusable design
and implementation for a family of software systems. Application
developers extend the framework to build their particular
applications using hooks. Hooks are the places identified to show
how to use and customize the framework. Hooks define the
Framework Interface Classes (FICs) and the specifications of their
methods. As part of the development life cycle, it is required to test
the implementations of the FICs. Building a testing model to express
the behavior of a class is an essential step for the generation of the
class-based test cases. The testing model has to be consistent with the
specifications provided for the hooks. State-based models consisting
of states and transitions are testing models well suited to objectoriented
software. Typically, hand-construction of a state-based
model of a class behavior is expensive, error-prone, and may result in
constructing an inconsistent model with the specifications of the class
methods, which misleads verification results. In this paper, a
technique is introduced to automatically synthesize a state-based
testing model for FICs using the specifications provided for the
hooks. A tool that supports the proposed technique is introduced.
Abstract: For today-s and future wireless communications applications,
more and more data traffic has to be transmitted with
growing speed and quality demands. The analog front-end of any
mobile device has to cope with very hard specifications regardless
which transmission standard has to be supported. State-of-the-art
analog front-end implementations are reaching the limit of technical
feasibility. For that reason, alternative front-end architectures could
support a continuing development of mobile communications e.g.,
six-port-based front-ends [1], [2].
In this article we propose an analog front-end with high intermediate
frequency and which utilizes additive mixing instead
of multiplicative mixing. The system architecture is presented and
several spurious effects as well as their influence on the system
dimensioning are discussed. Furthermore, several issues concerning
the technical feasibility are provided and some simulation results
are discussed which show the principle functionality of the proposed
superposition heterodyne receiver.
Abstract: It-s known that incorporating prior knowledge into support
vector regression (SVR) can help to improve the approximation
performance. Most of researches are concerned with the incorporation
of knowledge in form of numerical relationships. Little work,
however, has been done to incorporate the prior knowledge on the
structural relationships among the variables (referred as to Structural
Prior Knowledge, SPK). This paper explores the incorporation of SPK
in SVR by constructing appropriate admissible support vector kernel
(SV kernel) based on the properties of reproducing kernel (R.K).
Three-levels specifications of SPK are studies with the corresponding
sub-levels of prior knowledge that can be considered for the method.
These include Hierarchical SPK (HSPK), Interactional SPK (ISPK)
consisting of independence, global and local interaction, Functional
SPK (FSPK) composed of exterior-FSPK and interior-FSPK. A
convenient tool for describing the SPK, namely Description Matrix
of SPK is introduced. Subsequently, a new SVR, namely Motivated
Support Vector Regression (MSVR) whose structure is motivated
in part by SPK, is proposed. Synthetic examples show that it is
possible to incorporate a wide variety of SPK and helpful to improve
the approximation performance in complex cases. The benefits of
MSVR are finally shown on a real-life military application, Air-toground
battle simulation, which shows great potential for MSVR to
the complex military applications.
Abstract: The gel-supported precipitation (GSP) process can be
used to make spherical particles (spherules) of nuclear fuel,
particularly for very high temperature reactors (VHTR) and even for
implementing the process called SPHEREPAC. In these different
cases, the main characteristics are the sphericity of the particles to be
manufactured and the control over their grain size. Nonetheless,
depending on the specifications defined for these spherical particles,
the GSP process has intrinsic limits, particularly when fabricating
very small particles. This paper describes the use of secondary
fragmentation (water, water/PVA and uranyl nitrate) on solid
surfaces under varying temperature and vibration conditions to assess
the relevance of using this new technique to manufacture very small
spherical particles by means of a modified GSP process. The
fragmentation mechanisms are monitored and analysed, before the
trends for its subsequent optimised application are described.