Abstract: With the rapid growth in business size, today-s businesses orient Throughout thirty years local, national and international experience in medicine as a medical student, junior doctor and eventually Consultant and Professor in Anaesthesia, Intensive Care and Pain Management, I note significant generalised dissatisfaction among medical students and doctors regarding their medical education and practice. We repeatedly hear complaints from patients about the dysfunctional health care system they are dealing with and subsequently the poor medical service that they are receiving. Medical students are bombarded with lectures, tutorials, clinical rounds and various exams. Clinicians are weighed down with a never-ending array of competing duties. Patients are extremely unhappy about the long waiting lists, loss of their records and the continuous deterioration of the health care service. This problem has been reported in different countries by several authors [1,2,3]. In a trial to solve this dilemma, a genuine idea has been suggested implementing computer technology in medicine [2,3]. Computers in medicine are a medium of international communication of the revolutionary advances being made in the application of the computer to the fields of bioscience and medicine [4,5]. The awareness about using computers in medicine has recently increased all over the world. In Misr University for Science & Technology (MUST), Egypt, medical students are now given hand-held computers (Laptop) with Internet facility making their medical education accessible, convenient and up to date. However, this trial still needs to be validated. Helping the readers to catch up with the on going fast development in this interesting field, the author has decided to continue reviewing the literature, exploring the state-of-art in computer based medicine and up dating the medical professionals especially the local trainee Doctors in Egypt. In part I of this review article we will give a general background discussing the potential use of computer technology in the various aspects of the medical field including education, research, clinical practice and the health care service given to patients. Hope this will help starting changing the culture, promoting the awareness about the importance of implementing information technology (IT) in medicine, which is a field in which such help is needed. An international collaboration is recommended supporting the emerging countries achieving this target.
Abstract: As a part of routine oesophageal HDR Brachytherapy procedure, treatment planning takes about 45 minutes while patients are under light sedation. Some patients may suffer gagging and/or spasms before the 90-minute brachytherapy procedure complete, and the treatment may need to be aborted. A pre-prepared plan generated before patient’s sedation may reduce the brachytherapy procedure time by 40 minutes. This paper reports rationality and evidence of pre-prepared treatment plans. A retrospective study of 28 patients confirms that pre-prepared plans would be acceptable for all reviewed patients. The rationality is further confirmed by a systemic study with a wide range of applicator curvature and treatment volume. Detailed comparison between CT based treatment plans and pre-prepared plans are discussed. The argument holds for endobronchial HDR brachytherapy too. With the above evidence, pre-prepared plans have been used for all oesophageal and endobronchial HDR brachytherapy cases in our clinic.
Abstract: III-nitride quaternary InxAlyGa1-x-yN alloys have experienced considerable interest as potential materials for optoelectronic applications. Despite these interesting applications and the extensive efforts to understand their fundamental properties, research on its fundamental surface property, i.e., surface phonon polariton (SPP) has not yet been reported. In fact, the SPP properties have been shown to provide application for some photonic devices. Hence, there is an absolute need for thorough studies on the SPP properties of this material. In this work, theoretical study on the SPP modes in InAlGaN quaternary alloys are reported. Attention is focus on the wurtzite (α-) structure InxAlyGa1-x-yN semi-crystal with different In composition, x ranging from 0 to 0.10 and constant Al composition, y = 0.06. The SPP modes are obtained through the theoretical simulation by means of anisotropy model. The characteristics of SP dispersion curves are discussed. Accessible results in terms of the experimental point of view are also given. Finally, the results revealed that the SPP mode of α-InxAlyGa1-x-yN semiconductors exhibits two-mode behavior.
Abstract: Due to their high power-to-weight ratio and low cost, pneumatic actuators are attractive for robotics and automation applications; however, achieving fast and accurate control of their position have been known as a complex control problem. The paper presents a methodology for obtaining controllers that achieve high position accuracy and preserve the closed-loop characteristics over a broad operating range. Experimentation with a number of conventional (or "classical") three-term controllers shows that, as repeated operations accumulate, the characteristics of the pneumatic actuator change requiring frequent re-tuning of the controller parameters (PID gains). Furthermore, three-term controllers are found to perform poorly in recovering the closed-loop system after the application of load or other external disturbances. The key reason for these problems lies in the non-linear exchange of energy inside the cylinder relating, in particular, to the complex friction forces that develop on the piston-wall interface. In order to overcome this problem but still remain within the boundaries of classical control methods, we designed an auto selective classicaql controller so that the system performance would benefit from all three control gains (KP, Kd, Ki) according to system requirements and the characteristics of each type of controller. This challenging experimentation took place for consistent performance in the face of modelling imprecision and disturbances. In the work presented, a selective PID controller is presented for an experimental rig comprising an air cylinder driven by a variable-opening pneumatic valve and equipped with position and pressure sensors. The paper reports on tests carried out to investigate the capability of this specific controller to achieve consistent control performance under, repeated operations and other changes in operating conditions.
Abstract: IETF RFC 2002 originally introduced the wireless
Mobile-IP protocol to support portable IP addresses for mobile
devices that often change their network access points to the Internet.
The inefficiency of this protocol mainly within the handoff
management produces large end-to-end packet delays, during
registration process, and further degrades the system efficiency due to
packet losses between subnets. The criterion to initiate a simple and
fast full-duplex connection between the home agent and foreign
agent, to reduce the roaming duration, is a very important issue to be
considered by a work in this paper. State-transition Petri-Nets of the
modeling scenario-based CIA: communication inter-agents procedure
as an extension to the basic Mobile-IP registration process was
designed and manipulated. The heuristic of configuration file during
practical Setup session for registration parameters, on Cisco platform
Router-1760 using IOS 12.3 (15)T is created. Finally, stand-alone
performance simulations results from Simulink Matlab, within each
subnet and also between subnets, are illustrated for reporting better
end-to-end packet delays. Results verified the effectiveness of our
Mathcad analytical manipulation and experimental implementation. It
showed lower values of end-to-end packet delay for Mobile-IP using
CIA procedure. Furthermore, it reported packets flow between
subnets to improve packet losses between subnets.
Abstract: Carbon tetrachloride (CCl4) is a well-known
hepatotoxin and exposure to this chemical is known to induce
oxidative stress and causes liver injury by the formation of free
radicals. Flacourtia indica commonly known as 'Baichi' has been
reported as an effective remedy for the treatment of a variety of
diseases. The objective of this study was to investigate the
hepatoprotective activity of aqueous extract of leaves of Flacourtia
indica against CCl4 induced hepatotoxicity. Animals were pretreated
with the aqueous extract of Flacourtia indica (250 & 500 mg/kg
body weight) for one week and then challenged with CCl4 (1.5 ml/kg
bw) in olive oil (1:1, v/v) on 7th day. Serum marker enzymes (ALP,
AST, ALT, Total Protein & Total Bilirubin) and TBARS level
(Marker for oxidative stress) were estimated in all the study groups.
Alteration in the levels of biochemical markers of hepatic damage
like AST, ALT, ALP, Total Protein, Total Bilirubin and lipid
peroxides (TBARS) were tested in both CCl4 treated and extract
treated groups. CCl4 has enhanced the AST, ALT, ALP and the
Lipid peroxides (TBARS) in liver. Treatment of aqueous extract of
Flacourtia indica leaves (250 & 500 mg/kg) exhibited a significant
protective effect by altering the serum levels of AST, ALT, ALP,
Total Protein, Total Bilirubin and liver TBARS. These biochemical
observations were supported by histopathological study of liver
sections. From this preliminary study it has been concluded that the
aqueous extract of the leaves of Flacourtia indica protects liver
against oxidative damages and could be used as an effective protector
against CCl4 induced hepatic damage. Our findings suggested that
Flacourtia indica possessed good hepatoprotective activity
Abstract: Recently, nanomaterials are developed in the form of nano-films, nano-crystals and nano-pores. Lanthanide phosphates as a material find extensive application as laser, ceramic, sensor, phosphor, and also in optoelectronics, medical and biological labels, solar cells and light sources. Among the different kinds of rare-earth orthophosphates, yttrium orthophosphate has been shown to be an efficient host lattice for rare earth activator ions, which have become a research focus because of their important role in the field of light display systems, lasers, and optoelectronic devices. It is in this context that the 4fn- « 4fn-1 5d transitions of rare earth in insulating materials, lying in the UV and VUV, are the aim of large number of studies .Though there has been a few reports on Eu3+, Nd3+, Pr3+,Er3+, Ce3+, Tm3+ doped YPO4. The 4fn- « 4fn-1 5d transitions of the rare earth dependent to the host-matrix, several matrices ions were used to study these transitions, in this work we are suggesting to study on a very specific class of inorganic material that are orthophosphate doped with rare earth ions. This study focused on the effect of Ce3+ concentration on the structural and optical properties of Ce3+ doped YPO4 yttrium orthophosphate with powder form prepared by the Sol Gel method.
Abstract: A study was undertaken to assess the potential of an
Algal Turf Scrubber to remove nitrogen from aquaculture effluent to
reduce environmental pollution. High total ammonia nitrogen
concentrations were introduced to an Algal Turf Scrubber developed
under varying hydraulic surface loading rates of African catfish
(Clarius gariepinus) effluent in a recirculating aquaculture system.
Nutrient removal rates were not affected at total suspended solids
concentration of up to 0.04g TSS/l (P > 0.05). Nitrogen removal
rates 0.93-0.99g TAN/m²/d were recorded at very high loading rates
3.76-3.81 g TAN/m²/d. Total ammonia removal showed ½ order
kinetics between 1.6 to 2.3mg/l Total Ammonia Nitrogen
concentrations. Nitrogen removal increased with its loading, which
increased with hydraulic surface loading rate. Total Ammonia
Nitrogen removal by Algal turf scrubber was higher than reported
values for fluidized bed filters and trickling filters. The algal turf
scrubber also effectively removed nitrate thereby reducing the need
for water exchange.
Abstract: There is an urgent need to develop novel
Mycobacterium tuberculosis (Mtb) drugs that are active against drug
resistant bacteria but, more importantly, kill persistent bacteria. Our
study structured based on integrated analysis of metabolic pathways,
small molecule screening and similarity Search in PubChem
Database. Metabolic analysis approaches based on Unified weighted
used for potent target selection. Our results suggest that pantothenate
synthetase (panC) and and 3-methyl-2-oxobutanoate hydroxymethyl
transferase (panB) as a appropriate drug targets. In our study, we
used pantothenate synthetase because of existence inhibitors. We
have reported the discovery of new antitubercular compounds
through ligand based approaches using computational tools.
Abstract: This paper attempts to establish the fact that Multi
State Network Classification is essential for performance
enhancement of Transport protocols over Satellite based Networks. A
model to classify Multi State network condition taking into
consideration both congestion and channel error is evolved. In order
to arrive at such a model an analysis of the impact of congestion and
channel error on RTT values has been carried out using ns2. The
analysis results are also reported in the paper. The inference drawn
from this analysis is used to develop a novel statistical RTT based
model for multi state network classification.
An Adaptive Multi State Proactive Transport Protocol consisting
of Proactive Slow Start, State based Error Recovery, Timeout Action
and Proactive Reduction is proposed which uses the multi state
network state classification model. This paper also confirms through
detail simulation and analysis that a prior knowledge about the
overall characteristics of the network helps in enhancing the
performance of the protocol over satellite channel which is
significantly affected due to channel noise and congestion.
The necessary augmentation of ns2 simulator is done for
simulating the multi state network classification logic. This
simulation has been used in detail evaluation of the protocol under
varied levels of congestion and channel noise. The performance
enhancement of this protocol with reference to established protocols
namely TCP SACK and Vegas has been discussed. The results as
discussed in this paper clearly reveal that the proposed protocol
always outperforms its peers and show a significant improvement in
very high error conditions as envisaged in the design of the protocol.
Abstract: In this paper newly reported Cosh window function is
used in the design of prototype filter for M-channel Near Perfect
Reconstruction (NPR) Cosine Modulated Filter Bank (CMFB). Local
search optimization algorithm is used for minimization of distortion
parameters by optimizing the filter coefficients of prototype filter.
Design examples are presented and comparison has been made with
Kaiser window based filterbank design of recently reported work.
The result shows that the proposed design approach provides lower
distortion parameters and improved far-end suppression than the
Kaiser window based design of recent reported work.
Abstract: A virtual collaborative classroom was created at East Carolina University, using videoconference technology via regular internet to bring students from 18 different countries, 2 at a time, to the ECU classroom in real time to learn about each other-s culture. Students from two countries are partnered one on one, they meet for 4-5 weeks, and submit a joint paper. Then the same process is repeated for two other countries. Lectures and student discussions are managed with pre-determined topics and questions. Classes are conducted in English and reading assignments are placed on the website. Administratively all partners are independent, students pay fees and get credits at their home institution. Familiarity with technology, knowledge in cultural understanding and attitude change were assessed, only attitude changes are reported in this paper. After taking this course, all students stated their comfort level in working with, and their desire to interact with, culturally different others grew stronger and their xenophobia and isolationist attitudes decreased.
Abstract: A number of routing algorithms based on learning
automata technique have been proposed for communication
networks. How ever, there has been little work on the effects of
variation of graph scarcity on the performance of these algorithms. In
this paper, a comprehensive study is launched to investigate the
performance of LASPA, the first learning automata based solution to
the dynamic shortest path routing, across different graph structures
with varying scarcities. The sensitivity of three main performance
parameters of the algorithm, being average number of processed
nodes, scanned edges and average time per update, to variation in
graph scarcity is reported. Simulation results indicate that the LASPA
algorithm can adapt well to the scarcity variation in graph structure
and gives much better outputs than the existing dynamic and fixed
algorithms in terms of performance criteria.
Abstract: Cryptographic protocols are widely used in various
applications to provide secure communications. They are usually
represented as communicating agents that send and receive messages.
These agents use their knowledge to exchange information and
communicate with other agents involved in the protocol. An agent
knowledge can be partitioned into explicit knowledge and procedural
knowledge. The explicit knowledge refers to the set of information
which is either proper to the agent or directly obtained from other
agents through communication. The procedural knowledge relates to
the set of mechanisms used to get new information from what is
already available to the agent.
In this paper, we propose a mathematical framework which specifies
the explicit knowledge of an agent involved in a cryptographic
protocol. Modelling this knowledge is crucial for the specification,
analysis, and implementation of cryptographic protocols. We also,
report on a prototype tool that allows the representation and the
manipulation of the explicit knowledge.
Abstract: The shortest path (SP) problem concerns with finding the shortest path from a specific origin to a specified destination in a given network while minimizing the total cost associated with the path. This problem has widespread applications. Important applications of the SP problem include vehicle routing in transportation systems particularly in the field of in-vehicle Route Guidance System (RGS) and traffic assignment problem (in transportation planning). Well known applications of evolutionary methods like Genetic Algorithms (GA), Ant Colony Optimization, Particle Swarm Optimization (PSO) have come up to solve complex optimization problems to overcome the shortcomings of existing shortest path analysis methods. It has been reported by various researchers that PSO performs better than other evolutionary optimization algorithms in terms of success rate and solution quality. Further Geographic Information Systems (GIS) have emerged as key information systems for geospatial data analysis and visualization. This research paper is focused towards the application of PSO for solving the shortest path problem between multiple points of interest (POI) based on spatial data of Allahabad City and traffic speed data collected using GPS. Geovisualization of results of analysis is carried out in GIS.
Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: Role of acoustic driving pressure on the
translational-radial dynamics of a moving single bubble
sonoluminescence (m-SBSL) has been numerically
investigated. The results indicate that increase in the
amplitude of the driving pressure leads to increase in the
bubble peak temperature. The length and the shape of the
trajectory of the bubble depends on the acoustic pressure and
because of the spatially dependence of the radial dynamics of
the moving bubble, its peak temperature varies during the
acoustical pulses. The results are in good agreement with the
experimental reports on m-SBSL.
Abstract: In recent years, a number of works proposing the
combination of multiple classifiers to produce a single
classification have been reported in remote sensing literature. The
resulting classifier, referred to as an ensemble classifier, is
generally found to be more accurate than any of the individual
classifiers making up the ensemble. As accuracy is the primary
concern, much of the research in the field of land cover
classification is focused on improving classification accuracy. This
study compares the performance of four ensemble approaches
(boosting, bagging, DECORATE and random subspace) with a
univariate decision tree as base classifier. Two training datasets,
one without ant noise and other with 20 percent noise was used to
judge the performance of different ensemble approaches. Results
with noise free data set suggest an improvement of about 4% in
classification accuracy with all ensemble approaches in
comparison to the results provided by univariate decision tree
classifier. Highest classification accuracy of 87.43% was achieved
by boosted decision tree. A comparison of results with noisy data
set suggests that bagging, DECORATE and random subspace
approaches works well with this data whereas the performance of
boosted decision tree degrades and a classification accuracy of
79.7% is achieved which is even lower than that is achieved (i.e.
80.02%) by using unboosted decision tree classifier.
Abstract: The ability of UML to handle the modeling process of complex industrial software applications has increased its popularity to the extent of becoming the de-facto language in serving the design purpose. Although, its rich graphical notation naturally oriented towards the object-oriented concept, facilitates the understandability, it hardly successes to report all domainspecific aspects in a satisfactory way. OCL, as the standard language for expressing additional constraints on UML models, has great potential to help improve expressiveness. Unfortunately, it suffers from a weak formalism due to its poor semantic resulting in many obstacles towards the build of tools support and thus its application in the industry field. For this reason, many researches were established to formalize OCL expressions using a more rigorous approach. Our contribution join this work in a complementary way since it focuses specifically on OCL predefined properties which constitute an important part in the construction of OCL expressions. Using formal methods, we mainly succeed in expressing rigorously OCL predefined functions.
Abstract: There are three approaches to complete Bayesian
Network (BN) model construction: total expert-centred, total datacentred,
and semi data-centred. These three approaches constitute the
basis of the empirical investigation undertaken and reported in this
paper. The objective is to determine, amongst these three
approaches, which is the optimal approach for the construction of a
BN-based model for the performance assessment of students-
laboratory work in a virtual electronic laboratory environment. BN
models were constructed using all three approaches, with respect to
the focus domain, and compared using a set of optimality criteria. In
addition, the impact of the size and source of the training, on the
performance of total data-centred and semi data-centred models was
investigated. The results of the investigation provide additional
insight for BN model constructors and contribute to literature
providing supportive evidence for the conceptual feasibility and
efficiency of structure and parameter learning from data. In addition,
the results highlight other interesting themes.