Abstract: Young patients suffering from Cerebral Palsy are
facing difficult choices concerning heavy surgeries. Diagnosis settled
by surgeons can be complex and on the other hand decision for
patient about getting or not such a surgery involves important
reflection effort. Proposed software combining prediction for
surgeries and post surgery kinematic values, and from 3D model
representing the patient is an innovative tool helpful for both patients
and medicine professionals. Beginning with analysis and
classification of kinematics values from Data Base extracted from
gait analysis in 3 separated clusters, it is possible to determine close
similarity between patients. Prediction surgery best adapted to
improve a patient gait is then determined by operating a suitable
preconditioned neural network. Finally, patient 3D modeling based
on kinematic values analysis, is animated thanks to post surgery
kinematic vectors characterizing the closest patient selected from
patients clustering.
Abstract: There are various kinds of medical equipment which
requires relatively accurate positional adjustments for successful
treatment. However, patients tend to move without notice during a
certain span of operations. Therefore, it is common practice that
accompanying operators adjust the focus of the equipment. In this
paper, tracking controllers for medical equipment are suggested to
replace the operators. The tracking controllers use AHRS sensor
information to recognize the movements of patients. Sensor fusion is
applied to reducing the error magnitudes through linear Kalman filters.
The image processing of optical markers is included to adjust the
accumulation errors of gyroscope sensor data especially for yaw
angles.
The tracking controller reduces the positional errors between the
current focus of a device and the target position on the body of a
patient. Since the sensing frequencies of AHRS sensors are very high
compared to the physical movements, the control performance is
satisfactory. The typical applications are, for example, ESWT or
rTMS, which have the error ranges of a few centimeters.
Abstract: The aim of this paper is to present the kinematic
analysis and mechanism design of an assistive robotic leg for
hemiplegic and hemiparetic patients. In this work, the priority is to
design and develop the lightweight, effective and single driver
mechanism on the basis of experimental hip and knee angles- data for
walking speed of 1 km/h. A mechanism of cam-follower with three
links is suggested for this purpose. The kinematic analysis is carried
out and analysed using commercialized MATLAB software based on
the prototype-s links sizes and kinematic relationships. In order to
verify the kinematic analysis of the prototype, kinematic analysis data
are compared with the experimental data. A good agreement between
them proves that the anthropomorphic design of the lower extremity
exoskeleton follows the human walking gait.
Abstract: Along with the advances in medicine, providing medical information to individual patient is becoming more important. In Japan such information via Braille is hardly provided to blind and partially sighted people. Thus we are researching and developing a Web-based automatic translation program “eBraille" to translate Japanese text into Japanese Braille. First we analyzed the Japanese transcription rules to implement them on our program. We then added medical words to the dictionary of the program to improve its translation accuracy for medical text. Finally we examined the efficacy of statistical learning models (SLMs) for further increase of word segmentation accuracy in braille translation. As a result, eBraille had the highest translation accuracy in the comparison with other translation programs, improved the accuracy for medical text and is utilized to make hospital brochures in braille for outpatients and inpatients.
Abstract: The main aim is to perform mutational analysis of CTLA4 gene Exon 1 in SLE patients. A total of 61 SLE patients fulfilling “American College of Rheumatology (ACR) criteria" and 61 controls were enrolled in this study. The region of CTLA4 gene exon 1 was amplified by using Step-down PCR technique. Extracted DNA of band 354 bp was sequenced to analyze mutations in the exon-1 of CTLA-4 gene. Further, protein sequences were identified from nucleotide sequences of CTLA4 Exon 1 by using Expasy software and through Blast P software it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. No variations were found after patients sequences were compared with that of the control sequence. Furthermore it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. Thus CTLA4 gene may not be responsible for an autoimmune disease SLE.
Abstract: It is crucial to quantitatively evaluate the treatment of
epilepsy patients. This study was undertaken to test the hypothesis that
compared to the healthy control subjects, the epilepsy patients have
abnormal resting-state connectivity. In this study, we used the
imaginary part of coherency to measure the resting-state connectivity.
The analysis results shown that compared to the healthy control
subjects, epilepsy patients tend to have abnormal rhythm brain
connectivity over their epileptic focus.
Abstract: Hearing impairment is the number one chronic
disability affecting many people in the world. Background noise is
particularly damaging to speech intelligibility for people with
hearing loss especially for sensorineural loss patients. Several
investigations on speech intelligibility have demonstrated
sensorineural loss patients need 5-15 dB higher SNR than the normal
hearing subjects. This paper describes Discrete Hartley Transform
Power Normalized Least Mean Square algorithm (DHT-LMS) to
improve the SNR and to reduce the convergence rate of the Least
Means Square (LMS) for sensorineural loss patients. The DHT
transforms n real numbers to n real numbers, and has the convenient
property of being its own inverse. It can be effectively used for noise
cancellation with less convergence time. The simulated result shows
the superior characteristics by improving the SNR at least 9 dB for
input SNR with zero dB and faster convergence rate (eigenvalue ratio
12) compare to time domain method and DFT-LMS.
Abstract: The aim of this study was to estimate the frequency of
EBV infection in Hodgkin's lymphoma (HL) and non-Hodgkin's
lymphoma (NHL) occurring in Jordanian patients. A total of 55
patients with lymphoma were examined in this study. Of 55 patients,
30 and 25 were diagnosed as HL and NHL, respectively. The four
HL subtypes were observed with the majority of the cases exhibited
the mixed cellularity (MC) subtype followed by the nodular sclerosis
(NS). The high grade was found to be the commonest subtype of
NHL in our sample, followed by the low grade. The presence of EBV
virus was detected by immunostating for expression of latent
membrane protein-1 (LMP-1). The frequency of LMP-1 expression
occurred more frequent in patients with HL (60.0%) than in patients
with NHL (32.0%). The frequency of LMP-1 expression was also
higher in patients with MC subtype (61.11%) than those patients with
NS (28.57%). No age or gender difference in occurrence of EBV
infection was observed among patient with HL. By contrast, the
prevalence of EBV infection in NHL patients aged below 50 was
lower (16.66%) than in NHL patients aged 50 or above (46.15%). In
addition, EBV infection was more frequent in females with NHL
(38.46%) than in male with NHL (25%). In NHL cases, the
frequency of EBV infection in intermediate grade (60.0%) was high
when compared with frequency of low (25%) or high grades (25%).
In conclusion, analysis of LMP-1 expression indicates an important
role for this viral oncogene in the pathogenesis of EBV-associated
malignant lymphomas. These data also support the previous findings
that people with EBV may develop lymphoma and that efforts to
maintain low lymphoma should be considered for people with EBV
infection.
Abstract: In this study, the Multi-Layer Perceptron (MLP)with Back-Propagation learning algorithm are used to classify to effective diagnosis Parkinsons disease(PD).It-s a challenging problem for medical community.Typically characterized by tremor, PD occurs due to the loss of dopamine in the brains thalamic region that results in involuntary or oscillatory movement in the body. A feature selection algorithm along with biomedical test values to diagnose Parkinson disease.Clinical diagnosis is done mostly by doctor-s expertise and experience.But still cases are reported of wrong diagnosis and treatment. Patients are asked to take number of tests for diagnosis.In many cases,not all the tests contribute towards effective diagnosis of a disease.Our work is to classify the presence of Parkinson disease with reduced number of attributes.Original,22 attributes are involved in classify.We use Information Gain to determine the attributes which reduced the number of attributes which is need to be taken from patients.The Artificial neural networks is used to classify the diagnosis of patients.Twenty-Two attributes are reduced to sixteen attributes.The accuracy is in training data set is 82.051% and in the validation data set is 83.333%.
Abstract: Vernonia divergens Benth., commonly known as
“Insulin Plant” (Fam: Asteraceae) is a potent sugar killer. Locally the
leaves of the plant, boiled in water are successfully administered to a
large number of diabetic patients. The present study evaluates the
putative anti-diabetic ingredients, isolated from the in vivo and in
vitro grown plantlets of V. divergens for their antimicrobial and
anticancer activities. Sterilized explants of nodal segments were
cultured on MS (Musashige and Skoog, 1962) medium in presence of
different combinations of hormones. Multiple shoots along with
bunch of roots were regenerated at 1mg l-1 BAP and 0.5 mg l-1 NAA.
Micro-plantlets were separated and sub-cultured on the double
strength (2X) of the above combination of hormones leading to
increased length of roots and shoots. These plantlets were
successfully transferred to soil and survived well in nature. The
ethanol extract of plantlets from both in vivo & in vitro sources were
prepared in soxhlet extractor and then concentrated to dryness under
reduced pressure in rotary evaporator. Thus obtainedconcentrated
extracts showed significant inhibitory activity against gram
negative bacteria like Escherichia coli and Pseudomonas
aeruginosa but no inhibition was found against gram positive
bacteria. Further, these ethanol extracts were screened for in vitro
percentage cytotoxicity at different time periods (24 h, 48 h and 72 h)
of different dilutions. The in vivo plant extract inhibited the growth of
EAC mouse cell lines in the range of 65, 66, 78, and 88% at 100, 50,
25 & 12.5μg mL-1 but at 72 h of treatment. In case of the extract of in
vitro origin, the inhibition was found against EAC cell lines even at
48h. During spectrophotometric scanning, the extracts exhibited
different maxima (ʎ) - four peaks in in vitro extracts as against single
in in vivo preparation suggesting the possible change in the nature of
ingredients during micropropagation through tissue culture
techniques.
Abstract: Von Willebrand-s disease is the most common
inherited bleeding disorder in humans, it
caused by qualitative abnormalities of the von Willebrand factor
(vWF). Our objective is to determine the prevalence of this disease at
part of the Algerian population in the East and the South by a
biological diagnosis based on specific biological tests (automated
platelet count, the bleeding time (TS), the time of cephalin + activator
(TCA), measure of the prothrombin rate (TP), vWF rate and factor
VIII rate, Molecular electrophoresis of vWF multimers in agarose gel
in the presence of SDS). Four patients of type III or severe
Willebrand-s disease were found on 200 suspect cases. All cases are
showed a deficit in vWF rate (< 5%), and factor VIII (P
Abstract: Noise level has critical effects on the diagnostic
performance of signal-averaged electrocardiogram (SAECG), because
the true starting and end points of QRS complex would be masked by
the residual noise and sensitive to the noise level. Several studies and
commercial machines have used a fixed number of heart beats
(typically between 200 to 600 beats) or set a predefined noise level
(typically between 0.3 to 1.0 μV) in each X, Y and Z lead to perform
SAECG analysis. However different criteria or methods used to
perform SAECG would cause the discrepancies of the noise levels
among study subjects. According to the recommendations of 1991
ESC, AHA and ACC Task Force Consensus Document for the use of
SAECG, the determinations of onset and offset are related closely to
the mean and standard deviation of noise sample. Hence this study
would try to perform SAECG using consistent root-mean-square
(RMS) noise levels among study subjects and analyze the noise level
effects on SAECG. This study would also evaluate the differences
between normal subjects and chronic renal failure (CRF) patients in
the time-domain SAECG parameters.
The study subjects were composed of 50 normal Taiwanese and 20
CRF patients. During the signal-averaged processing, different RMS
noise levels were adjusted to evaluate their effects on three time
domain parameters (1) filtered total QRS duration (fQRSD), (2) RMS
voltage of the last QRS 40 ms (RMS40), and (3) duration of the low
amplitude signals below 40 μV (LAS40). The study results
demonstrated that the reduction of RMS noise level can increase
fQRSD and LAS40 and decrease the RMS40, and can further increase
the differences of fQRSD and RMS40 between normal subjects and
CRF patients. The SAECG may also become abnormal due to the
reduction of RMS noise level. In conclusion, it is essential to establish
diagnostic criteria of SAECG using consistent RMS noise levels for
the reduction of the noise level effects.
Abstract: The paper is intended to declare and apply ethics, i. e.
moral principles, rules in marketing environment. Ethical behavior of
selected pharmaceutical companies in the Slovak Republic is the
object of our research. The aim of our research is to determine
perception of ethical behavior of the pharmaceutical industry in
Slovakia by the medicine representatives in comparison with the
assessment of doctors and patients. The experimental sample
included 90 participants who were divided into three groups:
medicine representatives of the pharmaceutical companies (N=30),
doctors (N=30) and patients (N=30). The research method was a
Questionnaire of ethical behavior, created by us, that describes
individual areas included in the Code of ethics of the pharmaceutical
industry in Slovakia. The results showed influence of professional
status on ethical behavior perception, not gender. Higher perception
was indicated at patients rather than doctors and medicine
representatives.
Abstract: Deaths from cardiovascular diseases have decreased substantially over the past two decades, largely as a result of advances in acute care and cardiac surgery. These developments have produced a growing population of patients who have survived a myocardial infarction. These patients need to be continuously monitored so that the initiation of treatment can be given within the crucial golden hour. The available conventional methods of monitoring mostly perform offline analysis and restrict the mobility of these patients within a hospital or room. Hence the aim of this paper is to design a Portable Cardiac Telemedicine System to aid the patients to regain their independence and return to an active work schedule, there by improving the psychological well being. The portable telemedicine system consists of a Wearable ECG Transmitter (WET) and a slightly modified mobile phone, which has an inbuilt ECG analyzer. The WET is placed on the body of the patient that continuously acquires the ECG signals from the high-risk cardiac patients who can move around anywhere. This WET transmits the ECG to the patient-s Bluetooth enabled mobile phone using blue tooth technology. The ECG analyzer inbuilt in the mobile phone continuously analyzes the heartbeats derived from the received ECG signals. In case of any panic condition, the mobile phone alerts the patients care taker by an SMS and initiates the transmission of a sample ECG signal to the doctor, via the mobile network.
Abstract: Our Medicine-oriented research is based on a medical
data set of real patients. It is a security problem to share
patient private data with peoples other than clinician or hospital
staff. We have to remove person identification information
from medical data. The medical data without private data
are available after a de-identification process for any research
purposes. In this paper, we introduce an universal automatic
rule-based de-identification application to do all this stuff on an
heterogeneous medical data. A patient private identification is
replaced by an unique identification number, even in burnedin
annotation in pixel data. The identical identification is used
for all patient medical data, so it keeps relationships in a data.
Hospital can take an advantage of a research feedback based
on results.
Abstract: The study deals with the modelling of the gas flow during heliox therapy. A special model has been developed to study the effect of the helium upon the gas flow in the airways during the spontaneous breathing. Lower density of helium compared with air decreases the Reynolds number and it allows improving the flow during the spontaneous breathing. In the cases, where the flow becomes turbulent while the patient inspires air the flow is still laminar when the patient inspires heliox. The use of heliox decreases the work of breathing and improves ventilation. It allows in some cases to prevent the intubation of the patients.
Abstract: Biological, psychological and social experiences and
perceptions of healthcare services in patients medically diagnosed of
coronary heart disease were investigated using a sample of 10
participants whose responses to the in-depth interview questions
were analyzed based on inter-and-intra-case analyses. The results
obtained revealed that advancing age, single status, divorce and/or
death of spouse and the issue of single parenting negatively impacted
patients- biopsychosocial experiences. The patients- experiences of
physical signs and symptoms, anxiety and depression, past serious
medical conditions, use of self-prescribed medications, family
history of poor mental/medical or physical health, nutritional
problems and insufficient physical activities heightened their risk of
coronary attack. Collectivist culture served as a big source of relieve
to the patients. Patients- temperament, experience of different
chronic life stresses/challenges, mood alteration, regular drinking,
smoking/gambling, and family/social impairments compounded their
health situation. Patients were satisfied with the biomedical services
rendered by the healthcare personnel, whereas their psychological
and social needs were not attended to. Effective procedural treatment
model, a holistic and multidimensional approach to the treatment of
heart disease patients was proposed.
Abstract: Bleeding in the digestive duct is an important diagnostic parameter for patients. Blood in the endoscopic image can be determined by investigating the color tone of blood due to the degree of oxygenation, under- or over- illumination, food debris and secretions, etc. However, we found that how to pre-process raw images obtained from the capsule detectors was very important. We applied various image process methods suitable for the capsule endoscopic image in order to remove noises and unbalanced sensitivities for the image pixels. The results showed that much improvement was achieved by additional pre-processing techniques on the algorithm of determining bleeding areas.
Abstract: Purpose: Planning and dosimetry of different VMAT algorithms (SmartArc, Ergo++, Autobeam) is compared with IMRT for Head and Neck Cancer patients. Modelling was performed to rule out the causes of discrepancies between planned and delivered dose. Methods: Five HNC patients previously treated with IMRT were re-planned with SmartArc (SA), Ergo++ and Autobeam. Plans were compared with each other and against IMRT and evaluated using DVHs for PTVs and OARs, delivery time, monitor units (MU) and dosimetric accuracy. Modelling of control point (CP) spacing, Leaf-end Separation and MLC/Aperture shape was performed to rule out causes of discrepancies between planned and delivered doses. Additionally estimated arc delivery times, overall plan generation times and effect of CP spacing and number of arcs on plan generation times were recorded. Results: Single arc SmartArc plans (SA4d) were generally better than IMRT and double arc plans (SA2Arcs) in terms of homogeneity and target coverage. Double arc plans seemed to have a positive role in achieving improved Conformity Index (CI) and better sparing of some Organs at Risk (OARs) compared to Step and Shoot IMRT (ss-IMRT) and SA4d. Overall Ergo++ plans achieved best CI for both PTVs. Dosimetric validation of all VMAT plans without modelling was found to be lower than ss-IMRT. Total MUs required for delivery were on average 19%, 30%, 10.6% and 6.5% lower than ss-IMRT for SA4d, SA2d (Single arc with 20 Gantry Spacing), SA2Arcs and Autobeam plans respectively. Autobeam was most efficient in terms of actual treatment delivery times whereas Ergo++ plans took longest to deliver. Conclusion: Overall SA single arc plans on average achieved best target coverage and homogeneity for both PTVs. SA2Arc plans showed improved CI and some OARs sparing. Very good dosimetric results were achieved with modelling. Ergo++ plans achieved best CI. Autobeam resulted in fastest treatment delivery times.
Abstract: Oral health is particular important to the hospitalized
patients with chronic schizophrenia for an extreme high potential of the respiratory infections. Due to the degeneration of physical capability, patients of this kind typically fall dependent in the activity of daily living (ADL). A very high percentage of patients had dental
problems of which mostly could be easily avoid by easy regular tooth brushing. Purpose of the project is to develop a mechanism in helping the schizophrenia patients in rebuilding a tooth-cleaning habit. The
project observed and evaluated the tooth-cleaning behavior of 100
male patients in a psychiatric hospital, and found the majority of them
ignored such an activity in a three-month period of time. In the meantime, the primary care-givers were not aware or not convinced
the importance of such a need of dental hygiene, and thus few if any
tooth cleaning training or knowledge on dental hygiene were given to
the patients. The project then developed a program based on the numerous observations and discussions. The improvement program
included patients- group education, care-givers- training, and a
tool-kit for tooth-brush holding was erected. The project launched
with some incentive package. The outcomes were encouraging with
87% of the patients had rebuilt their tooth-brushing habits against
previous 22%, and the tooth cleaning kits were 100% kept against 22%
in the past. This project had significantly improved the oral health of
the patients. The project, included the procedure and the tool-kit
holder specific for this purpose, was a good examples for psychiatric
hospitals.