Abstract: Use and abuse of drugs by teens is very common and can have dangerous consequences. The drugs contribute to physical and sexual aggression such as assault or rape. Some teenagers regularly use drugs to compensate for depression, anxiety or a lack of positive social skills. Teen resort to smoking should not be minimized because it can be "gateway drugs" for other drugs (marijuana, cocaine, hallucinogens, inhalants, and heroin). The combination of teenagers' curiosity, risk taking behavior, and social pressure make it very difficult to say no. This leads most teenagers to the questions: "Will it hurt to try once?" Nowadays, technological advances are changing our lives very rapidly and adding a lot of technologies that help us to track the risk of drug abuse such as smart phones, Wireless Sensor Networks (WSNs), Internet of Things (IoT), etc. This technique may help us to early discovery of drug abuse in order to prevent an aggravation of the influence of drugs on the abuser. In this paper, we have developed a Decision Support System (DSS) for detecting the drug abuse using Artificial Neural Network (ANN); we used a Multilayer Perceptron (MLP) feed-forward neural network in developing the system. The input layer includes 50 variables while the output layer contains one neuron which indicates whether the person is a drug addict. An iterative process is used to determine the number of hidden layers and the number of neurons in each one. We used multiple experiment models that have been completed with Log-Sigmoid transfer function. Particularly, 10-fold cross validation schemes are used to access the generalization of the proposed system. The experiment results have obtained 98.42% classification accuracy for correct diagnosis in our system. The data had been taken from 184 cases in Jordan according to a set of questions compiled from Specialists, and data have been obtained through the families of drug abusers.
Abstract: Cortisol is important to our immune system, regulates our stress response, and is a factor in maintaining brain temperature. Saliva cortisol is a practical and useful non-invasive measurement that signifies the presence of the important hormone. Electrical activity in the jaw muscles typically rises when the muscles are moved during yawning and the electrical level is found to be correlated with the cortisol level. In two studies using identical paradigms, a total of 108 healthy subjects were exposed to yawning-provoking stimuli so that their cortisol levels and electrical nerve impulses from their jaw muscles was recorded. Electrical activity is highly correlated with cortisol levels in healthy people. The Hospital Anxiety and Depression Scale, Yawning Susceptibility Scale, General Health Questionnaire, demographic, health details were collected and exclusion criteria applied for voluntary recruitment: chronic fatigue, diabetes, fibromyalgia, heart condition, high blood pressure, hormone replacement therapy, multiple sclerosis, and stroke. Significant differences were found between the saliva cortisol samples for the yawners as compared with the non-yawners between rest and post-stimuli. Significant evidence supports the Thompson Cortisol Hypothesis that suggests rises in cortisol levels are associated with yawning. Ethics approval granted and professional code of conduct, confidentiality, and safety issues are approved therein.
Abstract: Background: Sickle Cell Disease (SCD) is of major public-health concern globally, with majority of patients living in Africa. Despite its relevance, there is a dearth of research to determine the socio-demographic distribution and psychosocial impact of SCD in Africa. The objective of this study therefore was to examine the socio-demographic distribution and psychosocial consequences of SCD among patients in Ghana and to assess their quality of life and coping mechanisms. Methods: A cross-sectional research design was used, involving the completion of questionnaires on socio-demographic characteristics, quality of life of individuals, anxiety and depression. Participants were 387 male and female patients attending a sickle cell clinic in a public hospital. Results: Results showed no gender and marital status differences in anxiety and depression. However, there were age and level of education variances in depression but not in anxiety. In terms of quality of life, patients were more satisfied by the presence of love, friends, relatives as well as home, community and neighbourhood environment. While pains of varied nature and severity were the major reasons for attending hospital in SCD condition, going to the hospital as well as having Faith in God was the frequently reported mechanisms for coping with an unbearable SCD attacks. Multiple regression analysis showed that some socio-demographic and quality of life indicators had strong associations with anxiety and/or depression. Conclusion: It is recommended that a multi-dimensional intervention strategy incorporating psychosocial dimensions should be considered in the treatment and management of SCD.
Abstract: The purpose of this study is to investigate the efficacy of solution-focused group therapy on improving the depressed mothers of child abuser families. This study was carried out in the form of a semi-pilot, pre-test and post-test on two groups (experimental and control). Subjects include all mothers and their children that are the members of Shush and Naser Khosro child home. Beck Depression Inventory and Child Trauma Questionnaire were used to collect data. First, child abuse questionnaire was completed by children, Then Beck Depression Inventory was completed by their mothers that 22 of them were recognized as depressed and randomly divided in two groups of experimental and control. After applying pre-test for both of these groups, the intervention of solution- focused group therapy was performed in five sessions on experimental group. Finally, post-test was applied on both groups and subsequently in a month, follow-up test was performed. T-test, multivariate variance, and repeated measurement analysis of variance were used to analyze the data. According to the findings, it can be concluded that this therapy leads to the improvement of depressed mother's mood. As a result, the intervention of solution-focused group therapy is useful in order to improve the depressing mood of mothers of child abuser families.
Abstract: Cortisol is essential to the regulation of the immune
system and pathological yawning is a symptom of multiple sclerosis
(MS). Electromyography activity (EMG) in the jaw muscles typically
rises when the muscles are moved – extended or flexed; and yawning
has been shown to be highly correlated with cortisol levels in healthy
people as shown in the Thompson Cortisol Hypothesis. It is likely
that these elevated cortisol levels are also seen in people with MS.
The possible link between EMG in the jaw muscles and rises in saliva
cortisol levels during yawning were investigated in a randomized
controlled trial of 60 volunteers aged 18-69 years who were exposed
to conditions that were designed to elicit the yawning response.
Saliva samples were collected at the start and after yawning, or at the
end of the presentation of yawning-provoking stimuli, in the absence
of a yawn, and EMG data was additionally collected during rest and
yawning phases. Hospital Anxiety and Depression Scale, Yawning
Susceptibility Scale, General Health Questionnaire, demographic,
and health details were collected and the following exclusion criteria
were adopted: chronic fatigue, diabetes, fibromyalgia, heart
condition, high blood pressure, hormone replacement therapy,
multiple sclerosis, and stroke. Significant differences were found
between the saliva cortisol samples for the yawners, t (23) = -4.263, p
= 0.000, as compared with the non-yawners between rest and poststimuli,
which was non-significant. There were also significant
differences between yawners and non-yawners for the EMG
potentials with the yawners having higher rest and post-yawning
potentials. Significant evidence was found to support the Thompson
Cortisol Hypothesis suggesting that rises in cortisol levels are
associated with the yawning response. Further research is underway
to explore the use of cortisol as a potential diagnostic tool as an assist
to the early diagnosis of symptoms related to neurological disorders.
Bournemouth University Research & Ethics approval granted:
JC28/1/13-KA6/9/13. Professional code of conduct, confidentiality,
and safety issues have been addressed and approved in the Ethics
submission. Trials identification number: ISRCTN61942768.
http://www.controlled-trials.com/isrctn/
Abstract: The purpose of this paper is to examine the effects and
relationship of stress and social support towards the quality of life
among flood victims in Malaysia. A total of 764 respondents took
part in the survey via convenience sampling. The Depression,
Anxiety and Stress scale (DASS) was utilized to measure stress while
The Multidimensional Scale of Perceived Social Support was used to
measure social support. To measure quality of life, the combination
of WHO Quality of Life – BREF (WHOQOL-BREF) and The Impact
of Event Scale – Revised (IES-R) were utilized. The findings of this
study indicate that there were significant correlations between
variables in the study. The findings showed a significant negative
relation between stress and quality of life; and significant positive
correlations between support from family as well as support from
friends with quality of life. Stress and support from family were
found to be significant predictors that influence the quality of life
among flood victims.
Abstract: The present study aimed to determine the
effectiveness of Metaphor therapy on depression among female
students. The sample included 60 female students with depression
symptoms selected by simple sampling and randomly divided into
two equal groups (experimental and control groups). Beck
Depression Inventory was used to measure the variables. This was an
experimental study with a pre-test/post-test design with control
group. Eight metaphor therapy sessions were held for the
experimental group. A post-test was administered to both groups.
Data were analyzed using multivariate analysis of covariance
(MANCOVA). Results showed that the Metaphor therapy decreased
depression in the experimental group compared to the control group.
Abstract: This study examined the mental health and behavioral
problems in early adolescence with the instrument of Achenbach
System of Empirically Based Assessment (ASEBA). The purpose of
the study was stratified sampling method was used to collect data
from 1975 participants. Multiple regression models and hierarchical
regression models were applied to examine the relations between the
background variables and internalizing problems, and the ones
between students’ performance and internalizing problems. The
results indicated that several background variables as predictors could
significantly predict the anxious/depressed problem; reading and
social study scores could significantly predict the anxious/depressed
problem. However the class as a hierarchical macro factor did not
indicate the significant effect. In brief, the majority of these models
represented that the background variables, behaviors and academic
performance were significantly related to the anxious/depressed
problem.
Abstract: This study examined whether big five personality traits
affect game addiction with control of psychological, social, and
demographic factors. Specifically, using data from a survey of 789
game users in Korea, we conducted a regression analysis to see the
associations of psychological (loneliness/depression), social (activities
with family/friends), self-efficacy (game/general), gaming (daily
gaming time/perception), demographic (age/gender), and personality
traits (extraversion, neuroticism conscientiousness, agreeableness, &
openness) with the degree of game addiction. Results showed that
neuroticism increase game addiction with no effect of extraversion on
the addiction. General self-efficacy negatively affected game
addiction, whereas game self-efficacy increased the degree of game
addiction. Loneliness enhanced game addiction while depression
showed a negative effect on the addiction. Results and implications are
discussed.
Abstract: Socio-economic development, which is seen around
the world today, has contributed to the emergence of new problems
of a social nature. Different political, historical, geographical or
economic conditions cause that, in addition to global issues of social
policy such as an aging population, unemployment, migration,
countries, regions, there are also specific new problems that require
diagnosis, individualized approach and efficient, planned solutions.
These should include, among others, digital addiction, peer violence,
obesity among children, the problem of ‘legal highs’, stress,
depression, diseases associated with environmental pollution etc. The
central authorities, selected most often with the tools specific to
representative democracy, that is, the general election, for many
reasons, inter alia, organizational, communication, are not able to
effectively diagnose their intensity, territorial distribution, and thus to
effectively fight them. This article aims to show how in Poland,
citizens influence solving problems related to the broader social
policy implemented at the local government level and indicates the
possibilities of improving those solutions. The conclusions of
theoretical analysis have been supported by empirical studies, which
tested the use of instruments of participatory democracy in the
planning and creation of communal strategies for solving social
problems in one of the Polish voivodeships.
Abstract: Auditory hallucinations among the most invalidating
and distressing experiences reported by patients diagnosed with
schizophrenia, leading to feelings of powerlessness and helplessness
towards their illness. In more severe cases, these auditory
hallucinations can take the form of commanding voices, which are
often related to high suicidality rates in these patients. Several
authors propose that the meanings attributed to the hallucinatory
experience, rather than characteristics like form and content, can be
determinant in patients’ reactions to hallucinatory activity,
particularly in the case of voice-hearing experiences. In this study, 48
patients diagnosed with paranoid schizophrenia presenting auditory
hallucinations were studied. Multiple regression analyses were
computed to study the influence of several developmental aspects,
such as family and social dynamics, bullying, depression, and sociocognitive
variables on the auditory hallucinations, on patients’
attributions and relationships with their voices, and on the resulting
invalidation of hallucinatory experience. Overall, results showed how
relationships with voices can mirror several aspects of interpersonal
relationship with others, and how self-schemas, depression and actual
social relationships help shaping the voice-hearing experience. Early
experiences of victimization and submission help predict the
attributions of omnipotence of the voices, and increased hostility
from parents seems to increase the malevolence of the voices,
suggesting that socio-cognitive factors can significantly contribute to
the etiology and maintenance of auditory hallucinations. The
understanding of the characteristics of auditory hallucinations and the
relationships patients established with their voices can allow the
development of more promising therapeutic interventions that can be
more effective in decreasing invalidation caused by this devastating
mental illness.
Abstract: This paper analyzes the conceptual framework of three
statistical methods, multiple regression, path analysis, and structural
equation models. When establishing research model of the statistical
modeling of complex social phenomenon, it is important to know the
strengths and limitations of three statistical models. This study
explored the character, strength, and limitation of each modeling and
suggested some strategies for accurate explaining or predicting the
causal relationships among variables. Especially, on the studying of
depression or mental health, the common mistakes of research
modeling were discussed.
Abstract: Cortisol is essential to the regulation of the immune
system and yawning is a pathological symptom of multiple sclerosis
(MS). Electromyography activity (EMG) in the jaw muscles typically
rises when the muscles are moved and with yawning is highly
correlated with cortisol levels in healthy people. Saliva samples from
59 participants were collected at the start and after yawning, or at the
end of the presentation of yawning-provoking stimuli, in the absence
of a yawn, together with EMG data and questionnaire data: Hospital
Anxiety and Depression Scale, Yawning Susceptibility Scale,
General Health Questionnaire, demographic, health details. Exclusion
criteria: chronic fatigue, diabetes, fibromyalgia, heart condition, high
blood pressure, hormone replacement therapy, multiple sclerosis,
stroke. Significant differences were found between the saliva cortisol
samples for the yawners, t (23) = -4.263, p = 0.000, as compared with
the non-yawners between rest and post-stimuli, which was nonsignificant.
Significant evidence was found to support the Thompson
Cortisol Hypothesis suggesting that rises in cortisol levels are
associated with yawning. Further research is exploring the use of
cortisol as an early diagnostic tool for MS. Ethics approval granted
and professional code of conduct, confidentiality, and safety issues
are approved therein.
Abstract: Chemotherapy and radiotherapy are one of the major
treatment modalities that play important role in the management of a
number of different cancers. This study for the first time evaluates the
toxicity of these treatment modalities and its impact on quality of life
of cancer patients in Pakistan. The study also for the first time
determines what cancer patients of different ages and cancer stages
believe would be an effective intervention to manage their
psychosocial needs and treatment induced toxicity. The article also
provides evidence based approach for the use of variety of
interventions to mange cancer treatment induced morbidity and
toxicity. In light of the present study and reviewed research data,
evidence based recommendations are also made for selection of
appropriate interventions to manage Pain, Nausea and Vomiting,
Anxiety and Depression, Fatigue and Overall QOL of cancer
survivors.
Abstract: Analyzing brain signals of the patients suffering from the state of depression may lead to interesting observations in the signal parameters that is quite different from a normal control. The present study adopts two different methods: Time frequency domain and nonlinear method for the analysis of EEG signals acquired from depression patients and age and sex matched normal controls. The time frequency domain analysis is realized using wavelet entropy and approximate entropy is employed for the nonlinear method of analysis. The ability of the signal processing technique and the nonlinear method in differentiating the physiological aspects of the brain state are revealed using Wavelet entropy and Approximate entropy.
Abstract: A variety of routing techniques are available to develop surface runoff hydrographs from rainfall. The selection of runoff routing method is very vital as it is directly related to the type of watershed and the required degree of accuracy. There are different modelling softwares available to explore the rainfall-runoff process in urban areas. XPSTORM, a link-node based, integrated stormwater modelling software, has been used in this study for developing surface runoff hydrograph for a Golf course area located in Rockhampton in Central Queensland in Australia. Four commonly used methods, namely SWMM runoff, Kinematic wave, Laurenson, and Time-Area are employed to generate runoff hydrograph for design storm of this study area. In runoff mode of XPSTORM, the rainfall, infiltration, evaporation and depression storage for subcatchments were simulated and the runoff from the subcatchment to collection node was calculated. The simulation results are presented, discussed and compared. The total surface runoff generated by SWMM runoff, Kinematic wave and Time-Area methods are found to be reasonably close, which indicates any of these methods can be used for developing runoff hydrograph of the study area. Laurenson method produces a comparatively less amount of surface runoff, however, it creates highest peak of surface runoff among all which may be suitable for hilly region. Although the Laurenson hydrograph technique is widely acceptable surface runoff routing technique in Queensland (Australia), extensive investigation is recommended with detailed topographic and hydrologic data in order to assess its suitability for use in the case study area.
Abstract: Aim- Study was undertaken to investigate the effect of altered behavioral condition like depression on various oxidative stress markers and biochemical parameters in rats. Methods- Rats were subjected for short (21 days) and long term (84 days) social isolation; the rats displayed an increase in depression on force swim test relative to control. Various markers of oxidative stress like lipid per oxidation (LPO), reduced glutathione (GSH), Supers oxide dismutase (SOD), catalase (CAT) and biochemical parameters like SGOT, SGPT, and blood glucose were determined. Results- There was significant increase in the level of LPO and decrease in the levels of GSH, SOD and CAT after long term isolation. Biochemical parameters were significantly altered after social isolation. Conclusion- Increased oxidative stress in depression which may leads to alteration of biochemical parameters.
Abstract: Upper gastrointestinal endoscopy is a commonly performed diagnostic and therapeutic procedure and has many adverse effects like cardiopulmonary complications, complications related to sedation, infectious complications, bleeding and perforation. So this study was undertaken to evaluate important variables like patient’s age, gender and stage of the procedure in relation to the cardiopulmonary changes during diagnostic upper gastrointestinal endoscopy by monitoring oxygen saturation, blood pressure, heart rate and electrocardiogram. This is a prospective longitudinal hospital based study involving a total of 140 consecutive patients, at Sri. B. M. Patil Medical College, Hospital and Research Centre. Cardiopulmonary changes during upper gastrointestinal endoscopy are more common in the age groups of 51-60 years, with equal frequency in both male and female. Oxygen saturation levels decreased by about 4% in both sexes during introduction of endoscopy. Mild to moderate hypoxia was found in 32% of the study group. Severe hypoxia was found in 5% of the patients, mostly in those patients who are above 50 years of age. Tachycardia was noted in 88% of the study group patients. Blood pressure increased to hypertension levels in 22 patients (15.7%) which returned to normal within few minutes after the procedure. S-T depression was noticed in 4% of patients and T wave inversion in 8% of patients during upper gastrointestinal endoscopy. All these changes disappeared after 10 minutes after the endoscopy. Cardiopulmonary changes are common during upper gastrointestinal endoscopy. Maximum changes in oxygen saturation, heart rate and blood pressure occurred immediately after the introduction of endoscope. The cardiopulmonary changes did not manifest into any identifiable clinical symptoms. The rate of recovery was faster in younger age groups and women.
Abstract: In clinical practice, the selection of an antidepressant often degrades to lengthy trial-and-error. In this work we employ a normalized wavelet power of alpha waves as a biomarker of antidepressant treatment response. This novel EEG metric takes into account both non-stationarity and intersubject variability of alpha waves. We recorded resting, 19-channel EEG (closed eyes) in 22 inpatients suffering from unipolar (UD, n=10) or bipolar (BD, n=12) depression. The EEG measurement was done at the end of the short washout period which followed previously unsuccessful pharmacotherapy. The normalized alpha wavelet power of 11 responders was markedly different than that of 11 nonresponders at several, mostly temporoparietal sites. Using the prediction of treatment response based on the normalized alpha wavelet power, we achieved 81.8% sensitivity and 81.8% specificity for channel T4.
Abstract: The paper aims at evaluating the effects of heavy groundwater withdrawal and artificial groundwater recharge of an ex-mining pond to the aquifer system of the Langat Basin through the three-dimensional (3D) numerical modeling. Many mining sites have been left behind from the massive mining exploitations in Malaysia during the England colonization era and from the last few decades. These sites are able to accommodate more than a million cubic meters of water from precipitation, runoff, groundwater, and river. Most of the time, the mining sites are turned into ponds for recreational activities. In the current study, an artificial groundwater recharge from an ex-mining pond in the Langat Basin was proposed due to its capacity to store >50 million m3 of water. The location of the pond is near the Langat River and opposite a steel company where >4 million gallons of groundwater is withdrawn on a daily basis. The 3D numerical simulation was developed using the Groundwater Modeling System (GMS). The calibrated model (error about 0.7 m) was utilized to simulate two scenarios (1) Case 1: artificial recharge pond with no pumping and (2) Case 2: artificial pond with pumping. The results showed that in Case 1, the pond played a very important role in supplying additional water to the aquifer and river. About 90,916 m3/d of water from the pond, 1,173 m3/d from the Langat River, and 67,424 m3/d from the direct recharge of precipitation infiltrated into the aquifer system. In Case 2, due to the abstraction of groundwater from a company, it caused a steep depression around the wells, river, and pond. The result of the water budget showed an increase rate of inflow in the pond and river with 92,493m3/d and 3,881m3/d respectively. The outcome of the current study provides useful information of the aquifer behavior of the Langat Basin.