Abstract: Childhood obesity is an important clinical problem, because it may lead to chronic diseases during the adulthood period of the individual. Obesity is a metabolic disease associated with low-grade inflammation. The liver occurs at the center of metabolic pathways. Adropin, fibroblast growth factor-21 (FGF-21) and fetuin A are hepatokines. Due to the immense participation of the liver in glucose metabolism, these liver derived factors may be associated with insulin resistance (IR), which is a phenomenon discussed within the scope of obesity problems. The aim of this study is to determine the concentrations of adropin, FGF-21 and fetuin A in childhood obesity, to point out possible differences between the obesity groups and to investigate possible associations among these three hepatokines in obese and morbid obese children. A total of 132 children were included in the study. Two obese groups were constituted. The groups were matched in terms of mean±SD values of ages. Body mass index values of the obese and morbid obese groups were 25.0±3.5 kg/m2 and 29.8±5.7 kg/m2, respectively. Anthropometric measurements including waist circumference, hip circumference, head circumference, and neck circumference were recorded. Informed consent forms were taken from the parents of the participants and the Ethics Committee of the institution approved the study protocol. Blood samples were obtained after an overnight fasting. Routine biochemical tests including glucose- and lipid-related parameters were performed. Concentrations of the hepatokines (adropin, FGF-21, fetuin A) were determined by enzyme-linked immunosorbent assay. Insulin resistance indices such as homeostasis model assessment for IR (HOMA-IR), alanine transaminase-to aspartate transaminase ratio (ALT/AST), diagnostic obesity notation model assessment laboratory index, diagnostic obesity notation model assessment metabolic syndrome index as well as obesity indices such as diagnostic obesity notation model assessment-II index, and fat mass index were calculated using the previously derived formulas. Statistical evaluation of the study data as well as findings of the study were performed by SPSS for Windows. Statistical difference was accepted significant when p < 0.05. Statistically significant differences were found for insulin, triglyceride, high density lipoprotein cholesterol levels of the groups. A significant increase was observed for FGF-21 concentrations in the morbid obese group. Higher adropin and fetuin A concentrations were observed in the same group in comparison with the values detected in the obese group (p > 0.05). There was no statistically significant difference between the ALT/AST values of the groups. In all of the remaining IR and obesity indices, significantly increased values were calculated for morbid obese children. Significant correlations were detected between HOMA-IR and each of the hepatokines. The highest one was the association with fetuin A (r = 0.373, p = 0.001). In conclusion, increased levels observed in adropin, FGF-21 and fetuin A have shown that these hepatokines possess increasing potential going from the obese to morbid obese state. Out of the correlations found with IR index, the most affected hepatokine was fetuin A, the parameter possibly used as the indicator of the advanced obesity stage.
Abstract: This study aimed to provide a practical, systematic, and comprehensive intervention for children with Autism Spectrum Disorder (ASD). A pilot study of quasi-experimental pre-post intervention with control group design was conducted to evaluate if the mathematical intervention (Project MIND - Math Is Not Difficult) increases the math comprehension of children with ASD Children with ASD in the primary grades (K-1, 2) participated in math interventions to enhance their math comprehension and cognitive ability. The Bracken basic concept scale was used to evaluate subjects’ language skills, cognitive development, and school readiness. The study found that our systemic interventions of Project MIND significantly improved the mathematical and cognitive abilities in children with autism. The results of this study may lead to a major change in effective and adequate health care services for children with ASD and their families. All statistical analyses were performed with the IBM SPSS Statistics Version 25 for Windows. The significant level was set at 0.05 P-value.
Abstract: Association between insulin resistance (IR) and hematological parameters has long been a matter of interest. Within this context, body mass index (BMI), red blood cells, white blood cells and platelets were involved in this discussion. Parameters related to platelets associated with IR may be useful indicators for the identification of IR. Platelet indices such as mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) are being questioned for their possible association with IR. The aim of this study was to investigate the association between platelet (PLT) count as well as PLT indices and the surrogate indices used to determine IR in morbid obese (MO) children. A total of 167 children participated in the study. Three groups were constituted. The number of cases was 34, 97 and 36 children in the normal BMI, MO and metabolic syndrome (MetS) groups, respectively. Sex- and age-dependent BMI-based percentile tables prepared by World Health Organization were used for the definition of morbid obesity. MetS criteria were determined. BMI values, homeostatic model assessment for IR (HOMA-IR), alanine transaminase-to-aspartate transaminase ratio (ALT/AST) and diagnostic obesity notation model assessment laboratory (DONMA-lab) index values were computed. PLT count and indices were analyzed using automated hematology analyzer. Data were collected for statistical analysis using SPSS for Windows. Arithmetic mean and standard deviation were calculated. Mean values of PLT-related parameters in both control and study groups were compared by one-way ANOVA followed by Tukey post hoc tests to determine whether a significant difference exists among the groups. The correlation analyses between PLT as well as IR indices were performed. Statistically significant difference was accepted as p-value < 0.05. Increased values were detected for PLT (p < 0.01) and PCT (p > 0.05) in MO group compared to those observed in children with N-BMI. Significant increases for PLT (p < 0.01) and PCT (p < 0.05) were observed in MetS group in comparison with the values obtained in children with N-BMI (p < 0.01). Significantly lower MPV and PDW values were obtained in MO group compared to the control group (p < 0.01). HOMA-IR (p < 0.05), DONMA-lab index (p < 0.001) and ALT/AST (p < 0.001) values in MO and MetS groups were significantly increased compared to the N-BMI group. On the other hand, DONMA-lab index values also differed between MO and MetS groups (p < 0.001). In the MO group, PLT was negatively correlated with MPV and PDW values. These correlations were not observed in the N-BMI group. None of the IR indices exhibited a correlation with PLT and PLT indices in the N-BMI group. HOMA-IR showed significant correlations both with PLT and PCT in the MO group. All of the three IR indices were well-correlated with each other in all groups. These findings point out the missing link between IR and PLT activation. In conclusion, PLT and PCT may be related to IR in addition to their identities as hemostasis markers during morbid obesity. Our findings have suggested that DONMA-lab index appears as the best surrogate marker for IR due to its discriminative feature between morbid obesity and MetS.
Abstract: With the development of the automotive technology and electric vehicle, the contribution of the wind noise on the interior noise becomes the main source of noise. The main transfer path which the exterior excitation is transmitted through is the greenhouse panels and side windows. Simulating the wind noise transmitted into the vehicle accurately in the early development stage can be very challenging. The basic methodologies of this study were based on the Lighthill analogy; the exterior flow field around a passenger car was computed using unsteady Computational Fluid Dynamics (CFD) firstly and then a Finite Element Method (FEM) was used to compute the interior acoustic response. The major findings of this study include: 1) The Sound Pressure Level (SPL) response at driver’s ear locations is mainly induced by the turbulence pressure fluctuation; 2) Peaks were found over the full frequency range. It is found that the methodology used in this study could predict the interior wind noise induced by the exterior aerodynamic excitation in industry.
Abstract: Whole building energy simulation models are widely used for predicting future energy consumption, performance diagnosis and optimum control. Black box building energy modeling approach has been heavily studied in the past decade. The thermal response of a building can also be modeled using a network of interconnected resistors (R) and capacitors (C) at each node called R-C network. In this study, a model building, Case 600, as described in the “Standard Method of Test for the Evaluation of Building Energy Analysis Computer Program”, ASHRAE standard 140, is studied along with a 3R2C thermal network model and the ASHRAE clear sky solar radiation model. Although building an energy model involves two important parts of building component i.e., the envelope and internal mass, the effect of building internal mass is not considered in this study. All the characteristic parameters of the building envelope are evaluated as on Case 600. Finally, monthly building energy consumption from the thermal network model is compared with a simple-box energy model within reasonable accuracy. From the results, 0.6-9.4% variation of monthly energy consumption is observed because of the south-facing windows.
Abstract: Morbid obesity is a health threatening condition particularly in children. Generally, it leads to the development of metabolic syndrome (MetS) characterized by central obesity, elevated fasting blood glucose (FBG), triglyceride (TRG), blood pressure values and suppressed high density lipoprotein cholesterol (HDL-C) levels. However, some ambiguities exist during the diagnosis of MetS in children below 10 years of age. Therefore, clinicians are in the need of some surrogate markers for the laboratory assessment of pediatric MetS. In this study, the aim is to develop an index, which will be more helpful during the evaluation of further risks detected in morbid obese (MO) children. A total of 235 children with normal body mass index (N-BMI), with varying degrees of obesity; overweight (OW), obese (OB), MO as well as MetS participated in this study. The study was approved by the Institutional Ethical Committee. Informed consent forms were obtained from the parents of the children. Obesity states of the children were classified using BMI percentiles adjusted for age and sex. For the purpose, tabulated data prepared by WHO were used. MetS criteria were defined. Systolic and diastolic blood pressure values were measured. Parameters related to glucose and lipid metabolisms were determined. FBG, insulin (INS), HDL-C, TRG concentrations were determined. Diagnostic Obesity Notation Model Assessment Laboratory (DONMALAB) Index [ln TRG/HDL-C*INS] was introduced. Commonly used insulin resistance (IR) indices such as Homeostatic Model Assessment for IR (HOMA-IR) as well as ratios such as TRG/HDL-C, TRG/HDL-C*INS, HDL-C/TRG*INS, TRG/HDL-C*INS/FBG, log, and ln versions of these ratios were calculated. Results were interpreted using statistical package program (SPSS Version 16.0) for Windows. The data were evaluated using appropriate statistical tests. The degree for statistical significance was defined as 0.05. 35 N, 20 OW, 47 OB, 97 MO children and 36 with MetS were investigated. Mean ± SD values of TRG/HDL-C were 1.27 ± 0.69, 1.86 ± 1.08, 2.15 ± 1.22, 2.48 ± 2.35 and 4.61 ± 3.92 for N, OW, OB, MO and MetS children, respectively. Corresponding values for the DONMALAB index were 2.17 ± 1.07, 3.01 ± 0.94, 3.41 ± 0.93, 3.43 ± 1.08 and 4.32 ± 1.00. TRG/HDL-C ratio significantly differed between N and MetS groups. On the other hand, DONMALAB index exhibited statistically significant differences between N and all the other groups except the OW group. This index was capable of discriminating MO children from those with MetS. Statistically significant elevations were detected in MO children with MetS (p < 0.05). Multiple parameters are commonly used during the assessment of MetS. Upon evaluation of the values obtained for N, OW, OB, MO groups and for MO children with MetS, the [ln TRG/HDL-C*INS] value was unique in discriminating children with MetS.
Abstract: In this paper, there is concentration on collaborative transportation planning (CTP) among multiple carriers with pickup and delivery requests and time windows. This problem is a vehicle routing problem with constraints from standard vehicle routing problems and new constraints from a real-world application. In the problem, each carrier has a finite number of vehicles, and each request is a pickup and delivery request with time window. Moreover, each carrier has reserved requests, which must be served by itself, whereas its exchangeable requests can be outsourced to and served by other carriers. This collaboration among carriers can help them to reduce total transportation costs. A mixed integer programming model is proposed to the problem. To solve the model, a hybrid algorithm that combines Genetic Algorithm and Simulated Annealing (GASA) is proposed. This algorithm takes advantages of GASA at the same time. After tuning the parameters of the algorithm with the Taguchi method, the experiments are conducted and experimental results are provided for the hybrid algorithm. The results are compared with those obtained by a commercial solver. The comparison indicates that the GASA significantly outperforms the commercial solver.
Abstract: This paper presents a configuration software solution in Linux, which is used for the control of space environment simulator. After introducing the structure and basic principle, it is said that the developing of QT software frame and the dynamic data exchanging between PLC and computer. The OPC driver in Linux is also developed. This driver realizes many-to-many communication between hardware devices and SCADA software. Moreover, an algorithm named “Scan PRI” is put forward. This algorithm is much more optimizable and efficient compared with "Scan in sequence" in Windows. This software has been used in practical project. It has a good control effect and can achieve the expected goal.
Abstract: Blood cell analysis plays a significant role in the diagnosis of human health. As an alternative to the traditional technique conducted by laboratory technicians, this paper presents an automatic white blood cell (leukocyte) detection system using Image Stitching and Color Overlapping Windows. The advantage of this method is to present a detection technique of white blood cells that are robust to imperfect shapes of blood cells with various image qualities. The input for this application is images from a microscope-slide translation video. The preprocessing stage is performed by stitching the input images. First, the overlapping parts of the images are determined, then stitching and blending processes of two input images are performed. Next, the Color Overlapping Windows is performed for white blood cell detection which consists of color filtering, window candidate checking, window marking, finds window overlaps, and window cropping processes. Experimental results show that this method could achieve an average of 82.12% detection accuracy of the leukocyte images.
Abstract: In this paper, we present the use of the discriminant analysis to select evolutionary algorithms that better solve instances of the vehicle routing problem with time windows. We use indicators as independent variables to obtain the classification criteria, and the best algorithm from the generic genetic algorithm (GA), random search (RS), steady-state genetic algorithm (SSGA), and sexual genetic algorithm (SXGA) as the dependent variable for the classification. The discriminant classification was trained with classic instances of the vehicle routing problem with time windows obtained from the Solomon benchmark. We obtained a classification of the discriminant analysis of 66.7%.
Abstract: In the recent years, a fundamental revolution in the Mobile Phone technology from just being able to provide voice and short message services to becoming the most essential part of our lives by connecting to network and various app stores for downloading software apps of almost every activity related to our life from finding location to banking from getting news updates to downloading HD videos and so on. This progress in Smart Phone industry has modernized and transformed our way of living into a trouble-free world. The smart phone has become our personal computers with the addition of significant features such as multi core processors, multi-tasking, large storage space, bluetooth, WiFi, including large screen and cameras. With this evolution, the rise in the security threats have also been amplified. In Literature, different threats related to smart phones have been highlighted and various precautions and solutions have been proposed to keep the smart phone safe which carries all the private data of a user. In this paper, a survey has been carried out to find out the most secure and the most unsecure smart phone operating system among the most popular smart phones in use today.
Abstract: The use of Inverse Discrete Fourier Transform (IDFT) implemented in the form of Inverse Fourier Transform (IFFT) is one of the standard method of reconstructing Magnetic Resonance Imaging (MRI) from uniformly sampled K-space data. In this tutorial, three of the major problems associated with the use of IFFT in MRI reconstruction are highlighted. The tutorial also gives brief introduction to MRI physics; MRI system from instrumentation point of view; K-space signal and the process of IDFT and IFFT for One and two dimensional (1D and 2D) data.
Abstract: Having done in this study, air-conditioning
automation for patisserie shopwindow was designed. In the cooling
sector it is quite important to cooling up the air temperature in the
shopwindow within short time interval. Otherwise the patisseries
inside of the shopwindow will be spoilt in a few days. Additionally
the humidity is other important parameter for the patisseries kept in
shopwindow. It must be raised up to desired level in a quite short
time. Traditional patisserie shopwindows only allow controlling
temperature manually. There is no humidity control and humidity is
supplied by fans that are directed to the water at the bottom of the
shopwindows. In this study, humidity and temperature sensors
(SHT11), PIC, AC motor controller, DC motor controller, ultrasonic
nebulizer and other electronic circuit members were used to simulate
air conditioning automation for patisserie shopwindow in proteus
software package. The simulation results showed that temperature
and humidity values are adjusted in desired time duration by openloop
control technique. Outer and inner temperature and humidity
values were used for control mechanism.
Abstract: A lightpipe is an about 99 percent specular reflective
mirror pipe or duct that is used for the transmission of the daylight
from the outside into a building. The lightpipes are usually used in
the daylighting buildings, in the residential, industrial and
commercial sectors. This paper is about the performances of a
lightpipe installed in a laboratory (3 m x 2.6 m x 3 m) without
windows. The aim is to analyse the luminous intensity distribution
for several sky/sun conditions. The lightpipe was monitored during
the year 2006. The lightpipe is 1 m long and the diameter of the top
collector and of the internal diffuser device is 0.25 m. In the
laboratory there are seven illuminance sensors: one external is
located on the roof of the laboratory and six internal sensors are
connected to a data acquisition system. The internal sensors are
positioned under the internal diffusive device at an height of 0.85 m
from the floor to simulate a working plane. The numerical data are
obtained through a simulation software. This paper shows the
comparison between the experimental and numerical results
concerning the behavior of the lightpipe.
Abstract: In hypersonic environments, the aerothermal effect
makes it difficult for the optical side windows of optical guided
missiles to withstand high heat. This produces cracking or breaking,
resulting in an inability to function. This study used computational
fluid mechanics to investigate the external cooling jet conditions of
optical side windows. The turbulent models k-ε and k-ω were
simulated. To be in better accord with actual aerothermal
environments, a thermal radiation model was added to examine
suitable amounts of external coolants and the optical window
problems of aero-thermodynamics. The simulation results indicate that
when there are no external cooling jets, because airflow on the optical
window and the tail groove produce vortices, the temperatures in these
two locations reach a peak of approximately 1600 K. When the
external cooling jets worked at 0.15 kg/s, the surface temperature of
the optical windows dropped to approximately 280 K. When adding
thermal radiation conditions, because heat flux dissipation was faster,
the surface temperature of the optical windows fell from 280 K to
approximately 260 K. The difference in influence of the different
turbulence models k-ε and k-ω on optical window surface temperature
was not significant.
Abstract: This research aims to develop and evaluate a training
course to promote learning activities of 2nd year, Suan Sunandha
Rajabhat University, faculty of education students using multiple
intelligences theory. The process is divided into two phases: Phase 1
development of training course to promote learning activities
consisting of principles, objectives of the course, structure, training
duration, content, training materials, training activities, media
training, monitoring, measurement and evaluation quality of the
course. Phase 2 evaluation efficiency of training course was to use
the improved curriculum with experimental group which is 2nd year,
Suan Sunandha Rajabhat University, faculty of education students
was drawn randomly 152 students. The experimental pattern was
randomized Control Group Pre-Test Post-Test Design, Analysis Data
by t-Test with the software SPFSS for Windows. Research has shown
that: 1). the ability of teaching and learning according to the theory of
multiple intelligences after training is higher than before training
significantly in statistic at .01 level, 2). The satisfaction of students
to the training courses was overall at the highest level.
Abstract: Real-time embedded systems should benefit from
component-based software engineering to handle complexity and
deal with dependability. In these systems, applications should not
only be logically correct but also behave within time windows.
However, in the current component based software engineering
approaches, a few of component models handles time properties in
a manner that allows efficient analysis and checking at the
architectural level. In this paper, we present a meta-model for
component-based software description that integrates timing
issues. To achieve a complete functional model of software
components, our meta-model focuses on four functional aspects:
interface, static behavior, dynamic behavior, and interaction
protocol. With each aspect we have explicitly associated a time
model. Such a time model can be used to check a component-s
design against certain properties and to compute the timing
properties of component assemblies.
Abstract: A frequency grouping approach for multi-channel
instantaneous blind source separation (I-BSS) of convolutive
mixtures is proposed for a lower net residual inter-symbol
interference (ISI) and inter-channel interference (ICI) than the
conventional short-time Fourier transform (STFT) approach. Starting
in the time domain, STFTs are taken with overlapping windows to
convert the convolutive mixing problem into frequency domain
instantaneous mixing. Mixture samples at the same frequency but
from different STFT windows are grouped together forming unique
frequency groups.
The individual frequency group vectors are input to the I-BSS
algorithm of choice, from which the output samples are dispersed
back to their respective STFT windows. After applying the inverse
STFT, the resulting time domain signals are used to construct the
complete source estimates via the weighted overlap-add method
(WOLA). The proposed algorithm is tested for source deconvolution
given two mixtures, and simulated along with the STFT approach to
illustrate its superiority for fairly motionless sources.
Abstract: Median filters with larger windows offer greater smoothing and are more robust than the median filters of smaller windows. However, the larger median smoothers (the median filters with the larger windows) fail to track low order polynomial trends in the signals. Due to this, constant regions are produced at the signal corners, leading to the loss of fine details. In this paper, an algorithm, which combines the ability of the 3-point median smoother in preserving the low order polynomial trends and the superior noise filtering characteristics of the larger median smoother, is introduced. The proposed algorithm (called the combiner algorithm in this paper) is evaluated for its performance on a test image corrupted with different types of noise and the results obtained are included.