Abstract: Information system risk management helps to reduce
or eliminate risk by implementing appropriate controls. In this paper,
we propose a quantification model of controls impact on information
system risks by automatizing the residual criticality estimation step of
FMECA which is based on a inductive reasoning. For this, we defined
three equations based on type and maturity of controls. For testing,
the values obtained with the model were compared to estimated
values given by interlocutors during different working sessions and
the result is satisfactory. This model allows an optimal assessment of
controls maturity and facilitates risk analysis of information system.
Abstract: Risk management in banking sector is a key issue
linked to financial system stability and its importance has been
elevated by technological developments and emergence of new
financial instruments. In this paper, we improve the model previously
defined for quantifying internal control impact on banking risks by
automatizing the residual criticality estimation step of FMECA. For
this, we defined three equations and a maturity coefficient to obtain
a mathematical model which is tested on all banking processes and
type of risks. The new model allows an optimal assessment of residual
criticality and improves the correlation rate that has become 98%.
Abstract: Municipal Solid Waste (MSW) disposed in landfill sites decompose under anaerobic conditions and produce gases which mainly contain carbon dioxide (CO2) and methane (CH4). Methane has the potential of causing global warming 25 times more than CO2, and can potentially affect human life and environment. Thus, this research aims to determine MSW generation and the annual CH4 emissions from the generated waste in Oman over the years 1971-2030. The estimation of total waste generation was performed using existing models, while the CH4 emissions estimation was performed using the intergovernmental panel on climate change (IPCC) default method. It is found that total MSW generation in Oman might be reached 3,089 Gg in the year 2030, which approximately produced 85 Gg of CH4 emissions in the year 2030.
Abstract: In the knowledge-based economy, innovation is considered essential in order to achieve survival and growth in organizations. On the other hand, knowledge management is currently understood as one of the keys to innovation process. Both factors are generally admitted as generators of competitive advantage in organizations. Specifically, activities on R&D&I and those that generate internal knowledge have a positive influence in innovation results. This paper examines this effect and if it is similar or not is what we aimed to quantify in this paper. We focus on the impact that proportion of knowledge workers, the R&D&I investment, the amounts destined for ICTs and training for innovation have on the variation of tangible and intangibles returns for the sector of high and medium technology in Spain. To do this, we have performed an empirical analysis on the results of questionnaires about innovation in enterprises in Spain, collected by the National Statistics Institute. First, using clusters methodology, the behavior of these enterprises regarding knowledge management is identified. Then, using SEM methodology, we performed, for each cluster, the study about cause-effect relationships among constructs defined through variables, setting its type and quantification. The cluster analysis results in four groups in which cluster number 1 and 3 presents the best performance in innovation with differentiating nuances among them, while clusters 2 and 4 obtained divergent results to a similar innovative effort. However, the results of SEM analysis for each cluster show that, in all cases, knowledge workers are those that affect innovation performance most, regardless of the level of investment, and that there is a strong correlation between knowledge workers and investment in knowledge generation. The main findings reached is that Spanish high and medium technology companies improve their innovation performance investing in internal knowledge generation measures, specially, in terms of R&D activities, and underinvest in external ones. This, and the strong correlation between knowledge workers and the set of activities that promote the knowledge generation, should be taken into account by managers of companies, when making decisions about their investments for innovation, since they are key for improving their opportunities in the global market.
Abstract: The occurrences of precipitation, also commonly
referred as rain, in the form of "convective" and "stratiform" have
been identified to exist worldwide. In this study, the radar return
echoes or known as reflectivity values acquired from radar scans
have been exploited in the process of classifying the type of rain
endured. The investigation use radar data from Malaysian
Meteorology Department (MMD). It is possible to discriminate the
types of rain experienced in tropical region by observing the vertical
characteristics of the rain structure. .Heavy rain in tropical region
profoundly affects radiowave signals, causing transmission
interference and signal fading. Required wireless system fade margin
depends on the type of rain. Information relating to the two
mentioned types of rain is critical for the system engineers and
researchers in their endeavour to improve the reliability of
communication links. This paper highlights the quantification of
percentage occurrences over one year period in 2009.
Abstract: High Performance Liquid Chromatography (HPLC)
method was developed and validated for simultaneous estimation of
6-Gingerol(6G) and 6-Shogaol(6S) in joint pain relief gel containing
ginger extract. The chromatographic separation was achieved by
using C18 column, 150 x 4.6mm i.d., 5μ Luna, mobile phase
containing acetonitrile and water (gradient elution). The flow rate
was 1.0 ml/min and the absorbance was monitored at 282 nm. The
proposed method was validated in terms of the analytical parameters
such as specificity, accuracy, precision, linearity, range, limit of
detection (LOD), limit of quantification (LOQ), and determined
based on the International Conference on Harmonization (ICH)
guidelines. The linearity ranges of 6G and 6S were obtained over 20-
60 and 6-18 μg/ml respectively. Good linearity was observed over the
above-mentioned range with linear regression equation Y= 11016x-
23778 for 6G and Y = 19276x-19604 for 6S (x is concentration of
analytes in μg/ml and Y is peak area). The value of correlation
coefficient was found to be 0.9994 for both markers. The limit of
detection (LOD) and limit of quantification (LOQ) for 6G were
0.8567 and 2.8555 μg/ml and for 6S were 0.3672 and 1.2238 μg/ml
respectively. The recovery range for 6G and 6S were found to be
91.57 to 102.36 % and 84.73 to 92.85 % for all three spiked levels.
The RSD values from repeated extractions for 6G and 6S were 3.43
and 3.09% respectively. The validation of developed method on
precision, accuracy, specificity, linearity, and range were also
performed with well-accepted results.
Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: From the start, the importance of having a plan to
sustain tourism was acknowledged. The correct methods to monitor
that type of tourism have been researched. Thus, we propose in this
work to analyze the applicability of a monitoring and assistance
method on the understanding of the tourism sustainability in a small
size destiny or getaway. In this study, the subject is Lagoa da
Confusão, in the state of Tocantins and the analysis was carried out
through the efficiency of the local indicators, according to the WOT
approach. We concluded that the sustainable tourism key points that
were analyzed demonstrated to be important evaluation and
quantification tools for the proposed tasks to be developed in the
mentioned destiny. This is a study of an interdisciplinary character
and the deductive method was chosen as the guiding line.
Abstract: The consumption of food contaminated with molds
(microscopic filamentous fungi) and their toxic metabolites results in
the development of food-borne mycotoxicosis. The spores of molds
are ubiquitously spread in the environment and can be detected
everywhere. Ochratoxin A is a toxic and potentially carcinogenic
fungal toxin found in a variety of food commodities. In this study, the
mycological quality of various ready-to-eat local and imported pork
meat and meat byproducts sold in Egyptian markets were assessed
and the presence of various molds was determined in pork used as a
raw material, edible organs as liver and kidney as well as in
fermented raw meat by-products. The study assessed the mycological
quality of pork raw meat and their by-products sold in commercial
shops in Cairo, Egypt. Mycological analysis was conducted on
(n=110) samples which included pig’s livers and kidneys from
Egyptian Bassatin slaughter house; local and imported processed
pork meat by-products from Egyptian pork markets. The isolates
were identified using traditional mycological and biochemical tests.
All kidney and liver samples were positive to molds growth while all
byproducts were negative. Ochratoxin A levels were quantitatively
analyzed using the high performance liquid chromatography (HPLC)
and the highest results were present in kidney 7.51 part per billion
(ppb) followed by minced meat 6.19 ppb generally the local samples
showed higher levels than the imported ones. To the best of our
knowledge, this is the first report on mycotoxins detection and
quantification from pork by-products in Egypt.
Abstract: Tuberculosis (TB) remains a leading cause of
infectious mortality. It is primarily transmitted by the respiratory
route, individuals with active disease may infect others through
airborne particles which releases when they cough, talk, or sing and
subsequently inhale by others. In order to study the effect of the
Bacilli Calmette-Guerin (BCG) vaccine after vaccination of TB
patient, a Vaccinated Susceptible Infected and Recovered (VSIR)
mathematical model is being developed to achieve the desired
objectives. The mathematical model, so developed, shall be used to
quantify the effect of BCG Vaccine to protect the immigrant young
adult person. Moreover, equations are to be established for the
disease endemic and free equilibrium states and subsequently utilized
in disease stability analysis. The stability analysis will give a
complete picture of disease annihilation from the total population if
the total removal rate from the infectious group should be greater
than total number of dormant infections produced throughout
infectious period.
Abstract: Surf is an increasingly popular sport and its performance evaluation is often qualitative. This work aims at using a smartphone to collect and analyze the GPS and inertial sensors data in order to obtain quantitative metrics of the surfing performance. Two approaches are compared for detection of wave rides, computing the number of waves rode in a surfing session, the starting time of each wave and its duration. The first approach is based on computing the velocity from the Global Positioning System (GPS) signal and finding the velocity thresholds that allow identifying the start and end of each wave ride. The second approach adds information from the Inertial Measurement Unit (IMU) of the smartphone, to the velocity thresholds obtained from the GPS unit, to determine the start and end of each wave ride. The two methods were evaluated using GPS and IMU data from two surfing sessions and validated with similar metrics extracted from video data collected from the beach. The second method, combining GPS and IMU data, was found to be more accurate in determining the number of waves, start time and duration. This paper shows that it is feasible to use smartphones for quantification of performance metrics during surfing. In particular, detection of the waves rode and their duration can be accurately determined using the smartphone GPS and IMU.
Abstract: Quantification of cardiac function is performed by
calculating blood volume and ejection fraction in routine clinical
practice. However, these works have been performed by manual
contouring, which requires computational costs and varies on the
observer. In this paper, an automatic left ventricle segmentation
algorithm on cardiac magnetic resonance images (MRI) is presented.
Using knowledge on cardiac MRI, a K-mean clustering technique is
applied to segment blood region on a coil-sensitivity corrected image.
Then, a graph searching technique is used to correct segmentation
errors from coil distortion and noises. Finally, blood volume and
ejection fraction are calculated. Using cardiac MRI from 15 subjects,
the presented algorithm is tested and compared with manual
contouring by experts to show outstanding performance.
Abstract: Environmental impact assessment techniques have
been developed as a result of the worldwide efforts to reduce the
environmental impact of global warming. By using the quantification
method in the construction industry, it is now possible to manage the
greenhouse gas is to systematically evaluate the impact on the
environment over the entire construction process. In particular, the
proportion of greenhouse gas emissions at the production stage of
construction material occupied is high, and efforts are needed in
particular in the construction field.
In this research, intended for concrete products for the construction
materials, by using the LCA method, we compared the results of
environmental impact assessment and carbon emissions of developing
products that have been applied low-carbon technologies compared to
existing products. As a results, by introducing a raw material of
industrial waste, showed carbon reduction. Through a comparison of
the carbon emission reduction effect of low carbon technologies, it is
intended to provide academic data for the evaluation of greenhouse
gases in the construction sector and the development of low carbon
technologies of the future.
Abstract: The research presented in this paper has been focused
on analysing the impact of traffic on the sustainable development of
tourism in Croatia's Dubrovacko-Neretvanska County by the year
2020, based on the figures and trends reported in 2014 and using the
relevant variables that characterise the synergy of traffic and tourism
in, speaking from the geographic viewpoint, the most problematic
county in the Republic of Croatia. The basic hypothesis has been
confirmed through scientifically obtained research results, through
the quantification of the model's variables and the direct growth rates
of the designed model. On the basis of scientific insights into the
sustainable development of traffic and tourism in Dubrovacko-
Neretvanska County, it is possible to propose a new information
model for traffic at the service of the sustainable development of
tourism in the County for the period 2014-2020.
Abstract: Prior to quantifying the variables of the information
model for using school terminology in Croatia's region of Dalmatia
from 1884 to 2014, the most relevant model variables had to be
determined: historical circumstances, standard of living, education
system, linguistic situation, and media. The research findings show
that there was no significant transfer of the 1884 school terms into
1949 usage; likewise, the 1949 school terms were not widely used in
2014. On the other hand, the research revealed that the meaning of
school terms changed over the decades. The quantification of the
variables will serve as the groundwork for creating an information
model for using school terminology in Dalmatia from 1884 to 2014
and for defining direct growth rates in further research.
Abstract: In the present work, the effects of additives, including
contents of the added antioxidants and type of the selected metallic
stearates (either calcium stearate (CaSt) or zinc stearate (ZnSt)), on
the thermal stabilities of carbon black (CB)/high density polyethylene
(HDPE) compounds were studied. The results showed that the AO
contents played a key role in the thermal stabilities of the CB/HDPE
compounds — the higher the AO content, the higher the thermal
stabilities. Although the CaSt-containing compounds were slightly
superior to those with ZnSt in terms of the thermal stabilities, the
remaining solid residue of CaSt after heated to the temperature of 600
°C (mainly calcium carbonate (CaCO3) as characterized by the X-ray
diffraction (XRD) technique) seemed to catalyze the decomposition
of CB in the HDPE-based compounds. Hence, the quantification of
CB in the CaSt-containing compounds with a muffle furnace gave an
inaccurate CB content — much lower than actual value. However,
this phenomenon was negligible in the ZnSt-containing system.
Abstract: We present a dedicated video-based monitoring
system for quantification of patient’s attention to visual feedback
during robot assisted gait rehabilitation. Two different approaches for
eye gaze and head pose tracking are tested and compared. Several
metrics for assessment of patient’s attention are also presented.
Experimental results with healthy volunteers demonstrate that
unobtrusive video-based gaze tracking during the robot-assisted gait
rehabilitation is possible and is sufficiently robust for quantification
of patient’s attention and assessment of compliance with the
rehabilitation therapy.
Abstract: In the past, the most comprehensively adopted light
source was incandescent light bulbs, but with the appearance of LED
light sources, traditional light sources have been gradually replaced by
LEDs because of its numerous superior characteristics. However,
many of the standards do not apply to LEDs as the two light sources
are characterized differently. This also intensifies the significance of
studies on LEDs. As a Kansei design study investigating the visual
glare produced by traffic arrows implemented with LEDs, this study
conducted a semantic analysis on the styles of traffic arrows used in
domestic and international occasions. The results will be able to
reduce drivers’ misrecognition that results in the unsuccessful arrival
at the destination, or in traffic accidents. This study started with a
literature review and surveyed the status quo before conducting
experiments that were divided in two parts. The first part involved a
screening experiment of arrow samples, where cluster analysis was
conducted to choose five representative samples of LED displays. The
second part was a semantic experiment on the display of arrows using
LEDs, where the five representative samples and the selected ten
adjectives were incorporated. Analyzing the results with
Quantification Theory Type I, it was found that among the
composition of arrows, fletching was the most significant factor that
influenced the adjectives. In contrast, a “no fletching” design was
more abstract and vague. It lacked the ability to convey the intended
message and might bear psychological negative connotation including
“dangerous,” “forbidden,” and “unreliable.” The arrow design
consisting of “> shaped fletching” was found to be more concrete and
definite, showing positive connotation including “safe,” “cautious,”
and “reliable.” When a stimulus was placed at a farther distance, the
glare could be significantly reduced; moreover, the visual evaluation
scores would be higher. On the contrary, if the fletching and the shaft
had a similar proportion, looking at the stimuli caused higher
evaluation at a closer distance. The above results will be able to be
applied to the design of traffic arrows by conveying information
definitely and rapidly. In addition, drivers’ safety could be enhanced
by understanding the cause of glare and improving visual
recognizability.
Abstract: Protein kinases participate in a myriad of cellular
processes of major biomedical interest. The in vivo substrate
specificity of these enzymes is a process determined by several
factors, and despite several years of research on the topic, is still
far from being totally understood. In the present work, we have
quantified the contributions to the kinase substrate specificity of
i) the phosphorylation sites and their surrounding residues in the
sequence and of ii) the association of kinases to adaptor or scaffold
proteins. We have used position-specific scoring matrices (PSSMs),
to represent the stretches of sequences phosphorylated by 93 families
of kinases. We have found negative correlations between the number
of sequences from which a PSSM is generated and the statistical
significance and the performance of that PSSM. Using a subset
of 22 statistically significant PSSMs, we have identified specificity
determinant residues (SDRs) for 86% of the corresponding kinase
families. Our results suggest that different SDRs can function as
positive or negative elements of substrate recognition by the different
families of kinases. Additionally, we have found that human proteins
with known function as adaptors or scaffolds (kAS) tend to interact
with a significantly large fraction of the substrates of the kinases to
which they associate. Based on this characteristic we have identified
a set of 279 potential adaptors/scaffolds (pAS) for human kinases,
which is enriched in Pfam domains and functional terms tightly
related to the proposed function. Moreover, our results show that
for 74.6% of the kinase–pAS association found, the pAS colocalize
with the substrates of the kinases they are associated to. Finally, we
have found evidence suggesting that the association of kinases to
adaptors and scaffolds, may contribute significantly to diminish the
in vivo substrate crossed-specificity of protein kinases. In general, our
results indicate the relevance of several SDRs for both the positive
and negative selection of phosphorylation sites by kinase families and
also suggest that the association of kinases to pAS proteins may be
an important factor for the localization of the enzymes with their set
of substrates.
Abstract: The centre of rotation of the hip joint is needed for an
accurate simulation of the joint performance in many applications
such as pre-operative planning simulation, human gait analysis, and
hip joint disorders. In human movement analysis, the hip joint center
can be estimated using a functional method based on the relative
motion of the femur to pelvis measured using reflective markers
attached to the skin surface. The principal source of errors in
estimation of hip joint centre location using functional methods is
soft tissue artefacts due to the relative motion between the markers
and bone. One of the main objectives in human movement analysis is
the assessment of soft tissue artefact as the accuracy of functional
methods depends upon it. Various studies have described the
movement of soft tissue artefact invasively, such as intra-cortical
pins, external fixators, percutaneous skeletal trackers, and Roentgen
photogrammetry. The goal of this study is to present a non-invasive
method to assess the displacements of the markers relative to the
underlying bone using optical motion capture data and tissue
thickness from ultrasound measurements during flexion, extension,
and abduction (all with knee extended) of the hip joint. Results show
that the artefact skin marker displacements are non-linear and larger
in areas closer to the hip joint. Also marker displacements are
dependent on the movement type and relatively larger in abduction
movement. The quantification of soft tissue artefacts can be used as a
basis for a correction procedure for hip joint kinematics.